COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2019
·
IF 6.282
Tao Zhang,Yue Xu,Hongfu Li,Boming Zhang
In this study, the effect of carbon fiber (CF) surface chemistry and grafting of nano-SiO 2 on CF surface with respect to the interfacial adhesion of CF-reinforced nylon 6 composites was investigated. CFs were oxidized and reacted with poly(oxypropylene) diamines to modify the surface chemistry. The oxidized CFs were modified with 3-aminopropyltriethoxysilane and then grafted with SiO 2 nanoparticles. Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microcopy (SEM), and atomic force microscopy (AFM) were used to characterize the chemistry and topographies of the CF surface. The transverse fiber bundle strength of CF oxidized and grafted nano-SiO 2 increased to 31.92 MPa and 39.35 MPa, respectively, from 12.57 MPa for untreated CF. The results indicated that the reaction between the carboxyl group and nylon 6 led to chemical bonding at the interface and it meanwhile was strengthened and toughened by uniformly distributed SiO 2 nanoparticles on the CF surface.
研究领域:
材料科学
·
复合材料
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 107
·88382-88391
·
IF 3.84
Chunhua Wang,Feng Hu,Kejian Yang,Tianhui Hu,Wenzhi Wang,Rusheng Deng,Qibin Jiang,Hailiang Zhang
A novel star-branched nylon 6 with hexafunctional cyclotriphosphazene core was synthesized using hexa(4-carboxylphenoxy)cyclotriphosphazene (HCPCP) with six carboxyl groups as multifunctional agent in the hydrolytic ring-opening polymerization of ε-caprolactam, and then used for the investigation of mechanical properties, crystallization and rheology behaviors. Star-branching structure and molecular weight have great effects on its properties. Compared with linear nylon 6, star-branched nylon 6 has lower relative viscosity and higher melt flow rate while its mechanical properties can be almost retained by the use of star-branching and an appropriate molecular weight. Research on crystallization behavior indicates that the degree of crystallinity (Xc) of star-branched nylon 6 decreases slightly, but its crystal structure still belongs to α form. The peak crystallization temperature (Tc) and crystallization rate (1/t1/2) of star-branched nylon 6 are significantly higher than that of linear nylon 6 because of heterogeneous nucleation induced by HCPCP core, which is beneficial for the use of rapid molding process. As the molecular weight increases, the Tc and 1/t1/2 of star-branched nylon 6 first increase and then decrease. Capillary rheometer measurement exhibits that the shear viscosity of star-branched nylon 6 decreases with decreasing molecular weight, and the shear viscosity of star-branched nylon 6 with an appropriate molecular weight shows a low value and little or no sensitivity to shear rate and temperature. Such rheology behavior allows for processing at low temperature and low pressure and reduces system cost.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymer-Plastics Technology and Materials
·
2020
·
IF 0
Weijie Ding,Yunfei Zhou,Wenqi Wang,Jikui Wang
In this paper, a novel method has been successfully developed to prepare the polyamide 6/polystyrene/montmorillonite (APA6/PS/MMT) blends. The X-ray diffraction analysis, differential scanning calorimetry, scanning electron microscopy analysis, contact angle measurement, water absorption measurement, thermogravimetric analysis and mechanical properties test were performed separately to study the effects of P(St-co-IEM)-MMT-MPS on crystallinity, morphology, water resistance, thermal stability and mechanical properties. The results indicate the addition of MMT can promote the formation of the γ-phase. Moreover, it can improve the interfacial compatibility, water resistance, thermal stability and toughness.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
Frontiers in Microbiology
·
2018
·
IF 4.019
Chen Xin,Tang Hongzhi,Liu Yongdi,Xu Ping,Xue Yong,Lin Kuangfei,Cui Changzheng
3-Hydroxybenzoate 6-hydroxylase, an NADH-dependent flavoprotein, can convert 3-hydroxybenzoate which is an important intermediate in the biodegradation of many aromatic hydrocarbons. 3-Hydroxybenzoate is metabolized by entering the TCA cycle through the gentisate pathway. We found a putative 3HB6H gene from a cluster that potentially encodes for gentisic acid degradation from a halophilic Martelella sp. strain AD-3. The corresponding protein was expressed with an N-terminal His-tag and purified by Ni2+-nitrilotriacetic acid affinity chromatography. The protein showed an overexpressed band of about 46 kDa by SDS–PAGE, and it was also proven that the enzyme contains FAD by absorption spectroscopy and HPLC analysis. The optimal activity of 3HB6H from strain AD-3 was observed in phosphate buffer (pH 8.0) at 37∘C without salinity (NaCl) and metal salts. The Km values of 3-hydroxybenzoate 6-hydroxylase were determined to be 72.6 ± 10.1 μM and 104.1 ± 18.2 μM for 400 μM NADH and 3-hydroxybenzoate, respectively. Site-directed mutagenesis showed that residues 305, 306 and 308 are important for FAD binding. In addition, we found that Tyr221 and Gln305 of 3HB6H from strain AD-3 are involved in substrate binding.
研究领域:
微生物学
·
酶学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 12
·6777
·
IF 4.9
Zetao Yu,Jing Wang,Wenqiang Xia,Yuemin Wang,Yafen Zhang,Jintian Tang,Haifeng Cui,Xiaoying Yang,Chenchen Bao,Zihong Ye
Inflammatory responses and tumor developments are closely related, with interleukin-6 (IL-6) playing important roles in both processes. IL-6 has been extensively identified as a potential tumor biomarker. This study developed an isotope dilution mass spectrometry (IDMS) method for quantifying IL-6 based on signature peptides. These peptides were screened by excluding those with missed cleavage or post-translational modification. The method’s accuracy was verified using amino acid-based IDMS, in which purified IL-6 protein samples were quantified after hydrolyzing them into amino acids, and no significant difference was observed (p-value < 0.05). The method demonstrated good linearity and sensitivity upon testing. The specificity and matrix effect of the method were verified, and a precision study showed that the coefficient of variation was less than 5% for both the intra-day and inter-day tests. Compared to immunoassays, this method offers distinct advantages, such as the facilitation of multi-target analysis. Furthermore, the peptides used in this study are much more convenient for storage and operation than the antibodies or purified proteins typically used in immunoassays.
研究领域:
生物化学
·
医学检验
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
·
2022
·Vol. 322
·期 6
·G553
·
IF 4.871
Yan-Yan Fan,Yue Zhang,Rui-Fang Fan,Tao Wang,Xiao Yu,Li-Fei Zheng,Jin-Xia Zhu
Download figureDownload PowerPoint Patients with Parkinson’s disease (PD) often suffer from delayed gastric emptying, but the underlying mechanism remains unclear. We have shown previously that a PD rat model comprising bilateral substantia nigra destruction by 6-hydroxydopamine (6-OHDA rats) exhibits gastroparesis with alteration of neural nitric oxide synthase (nNOS) and acetylcholine in gastric corpus. However, changes in pyloric motility in the 6-OHDA rats have not been characterized. Solid gastric emptying test, immunofluorescence, Western blot, and in vitro pyloric motility recordings were used to assess pyloric motor function in the 6-OHDA rats. The 6-OHDA-treated rats displayed delayed solid gastric emptying and a lower basal pyloric motility index. In the 6-OHDA rats, high K+-induced transient contractions were weaker in pyloric sphincters. Electric field stimulation (EFS)-induced pyloric sphincter relaxation was lower in the 6-OHDA rats. NG-nitro-l-arginine methyl ester (l-NAME), a nonselective inhibitor of NOS, markedly inhibited the EFS-induced relaxation in both control and 6-OHDA rats. Pretreatment of tetrodotoxin abolished the effect of EFS on the pyloric motility. In addition, nNOS-positive neurons were extensively distributed in the pyloric myenteric plexus, whereas the number of nNOS-immunoreactive neurons and the protein expression of nNOS were significantly decreased in the pyloric muscularis of 6-OHDA rats. However, sodium nitroprusside-induced pyloric relaxations were similar between the control and 6-OHDA rats. These results indicate that the pyloric sphincters of 6-OHDA rats exhibit both weakened contraction and relaxation. The latter may be due to reduced nNOS in the pyloric myenteric plexus. The dysfunction of the pyloric sphincter might be involved in the delayed gastric emptying.NEW & NOTEWORTHY Reduced nitrergic neurons in pyloric myenteric plexus potently contributed to the attenuated relaxation in 6-hydroxydopamine (6-OHDA) rats, subsequently affecting gastric emptying. SNP could well improve the relaxation of pylori in 6-OHDA rats. The present study provides new insight into the diagnosis and treatment of delayed gastric emptying in patients with PD.
研究领域:
神经科学
·
胃肠生理学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Pengfei Yang,Yanan Liu,Gowan-Hugh Whalley,Chengzhi Guo,Ya Li,A.Ozgur Yazaydin,Zhongyi Jiang,Marc-Olivier Coppens,Yang Lan
Graphene oxide (GO) membranes exhibit promising potential in nanofiltration due to their controllable transport channel size and low transport resistance of water molecules, resulting in exceptional water permeability. However, the trade-off between water flux and rejection ratio stemming from tightly packed interlayers poses a challenge to the application of GO membranes in nanofiltration. To overcome this trade-off, a practical method is urgently needed to regulate the interlayer space of GO membranes. In this study, a macrocyclic molecule with a rigid porous structure, cucurbit[6]uril (CB[6]), has been introduced to enlarge and precisely adjust the interlayer distance of GO membranes, effectively addressing the trade-off dilemma. The interlayer distance can be precisely adjusted within a range of 0.46 to 1.35 nm, making it suitable for the removal of small organic molecules from wastewater. Through the optimization of GO and CB[6] quantities, the GO membrane containing 20 µg GO and 49.9 wt% CB[6] (CB6GO-4) demonstrates a high pure water flux (PWF) exceeding 171.3 L m -2 h −1 bar −1 , more than 5.9 times higher than a pure GO membrane (28.8 L m -2 h −1 bar −1 ), alongside a dye rejection ratio over 92 %, indicating the promising potential of CB[6]-intercalated GO membranes in removing organics from industrial saline wastewater.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Shuting Zhang,Jianwen Wei,Linlin Geng,Lin Ge,Lei Liao
Novel bifunctionalized amine-based protic ionic liquid/KIT-6 composite adsorbents for carbon dioxide (CO 2 ) adsorption have been prepared by impregnating amine-based protic ionic liquids of different types (tetraethylenepentamine nitrate, [TEPA][NO 3 ], or tetraethylenepentamine lysinate, [TEPA][Lys]) and concentrations (20, 30, 40, and 50 wt%) onto N-[3-(trimethoxysilyl)propyl]ethylenediamine-grafted KIT-6. These innovative hybrid adsorbents exhibited remarkable CO 2 adsorption performance and thermal stability. In particular, the adsorbent with 40 wt% [TEPA][Lys] loading exhibited the highest adsorption capacity at 90 ℃ (3.670 mmol·g −1 ), which was almost 5 times higher than that of the original carrier KIT-6 (0.850 mmol·g −1 ). This excellent adsorption performance can be ascribed to the synergistic effect of strong affinity between the amine groups and CO 2 and high porosity of the support. After five adsorption/desorption cycles, the CO 2 adsorption by the adsorbents demonstrated significant regeneration, and the saturated adsorption capacities of 2N-K6-P30 and 2N-K6-L40 were only 8.98 % and 7.77 % lower than those of the original ones, respectively. In addition, the infrared results revealed that CO 2 adsorption is a synergistic process of physical and chemical adsorption, in which chemisorption is dominated, and the CO 2 adsorption mechanism is consistent with the zwitterion mechanism. In conclusion, the bifunctionalized amine-based protic ionic liquid/KIT-6 adsorbents can be suggested as potential/recyclable materials for efficient removal of CO 2 from industrial flue gases after desulfurization.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 2
·1-11
·
IF 2.6
Zhang Enlei,Chen Jiaojiao,Xu Rui,Song Xiaowen,Zhang Bengui,Wang Guosheng
In this work, the different shaped CoSn(OH) 6 nanocrystallines were prepared by hydrothermal method. The morphology, microstructure, and composition of the prepared nanocrystallines were characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and other methods. The optical properties of CoSn(OH) 6 nanocrystallines with different morphologies were analyzed using UV–vis DRS. With the reduction of 4-nitrophenol as a model reaction, the photocatalytic performance of CoSn(OH) 6 nanocrystallines with the different morphologies was investigated. The results show that the CoSn(OH) 6 nanorings significantly improved the photocatalytic reduction 4-nitrophenol performance. The conversion rate of 4-nitrophenol reached 94% within 6 min. Finally, a potential mechanism for the photocatalytic process of CoSn(OH) 6 nanorings is discussed.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 16
·13375-13381
·
IF 3.201
Haobo Han,Wenqi Chen,Jiebing Yang,Jiayuan Zhang,Quanshun Li,Yan Yang
The modification of 2-amino-6-chloropurine on polyamidoamine was performed to synthesize a derivative, AP-PAMAM, which was then employed as a carrier for p53 gene delivery to achieve anti-tumor efficacy. Using a human prostate tumor cell line PC-3 as a model, enhanced expression level of p53 gene could be detected by RT-PCR, qPCR and western blotting. Based on the successful p53 gene transfection, an obvious anti-proliferative effect could be obtained, which was identified to be associated with the simultaneous induction of cell apoptosis and cell cycle arrest at the G1 phase. The cell apoptosis was elucidated to be triggered by the activation of the mitochondria-dependent apoptotic signaling pathway. In addition, AP-PAMAM/p53 transfection could restrain the migration of tumor cells as demonstrated by wound healing and Transwell migration assays. Notably, AP-PAMAM-mediated p53 delivery exhibited a stronger inhibitory effect on both cell proliferation and migration than the PAMAM/p53 group. In summary, AP-PAMAM/p53 transfection provided a promising route to achieve the p53-based gene therapy.
研究领域:
分子生物学
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2020
·
IF 2.169
Lijun Zhen,Qiuyu Wei,Qilong Wang,Huiyun Zhang,Michael Adu-Frimpong,Caleb Kesse Firempong,Ximing Xu,Jiangnan Yu
6-Gingerol, an active herbal ingredient of ginger has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The aim of the present study was to enhance the oral bioavailability and brain distribution of 6-Gingerol via polymeric micelles. A polymeric micelles drug delivery system of 6-Gingerol consisting of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and Poly (ethylene glycol)-poly (ε-caprolactone) (PEG-PCL) was prepared via solvent injection method. The developed 6-Gingerol-loaded TPGS/PEG-PCL micelles (6-GTPMs) were characterized based on particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency (EE), drug loading (DL) and in vitro release profile. The pharmacokinetics and tissue distribution studies were also evaluated. The nanoformulation produced a particle size of 73.24 ± 2.84 nm with acceptable PDI (0.129 ± 0.03), zeta potential (−2.74 ± 0.92 mV), DL (4.64%) and EE (79.68%). The in vitro release profile showed that the 6-GTPMs enhanced the solubility of 6-Gingerol, while the pharmaceutical analysis in rats indicated that 6-GTPMs significantly improved the oral bioavailability of 6-Gingerol (about 3 folds) in circulation. The 6-GTPMs exhibited remarkable brain targetability in the tissue distribution analysis. Collectively, a 6-Gingerol polymeric micelle with enhanced oral bioavailability coupled with excellent brain distribution was successfully developed.
研究领域:
药剂学
·
生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jialin Yang,Jierui Wang,Qi Zhang,He Zhu,Shiping Zhu
The synthesis of monolithic MOF aerogel is a critical step in applying MOFs to many practical applications. MAF-6 (RHO-[Zn(eim) 2 ], Heim = 2-ethylimidazole) is a type of MOF materials with large cavities and apertures. However, it has been much less studied due to the difficulty in obtaining it via conventional synthesis protocols. Herein, a nearly pure MAF-6 monolith with macro/meso/microporous pore structure is synthesized in situ by emulsion template method, which exhibits hierarchical structure with high porosity (∼80 %), large specific surface area (up to 1135 m 2 /g), and excellent mechanical properties. In addition, the monoliths demonstrate excellent capability and stability to separate methanol/ethanol mixtures and high catalytic performance in the Knoevenagel reaction. This work provides an effective approach to prepare MAF-6 monoliths for potential application in catalysis, adsorption, separation, etc.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）