JOURNAL OF THE AMERICAN CERAMIC SOCIETY
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2021
·Vol. 104
·期 7
·3365-3375
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IF 3.784
Jindi Wang,Shuai Huang,Yu Yan,Mengmeng Shang
In this work, using Ca 10.5 (PO 4 ) 7 as the structural model, a number of Eu 3+ -doped [Ca 9 Na 3x Y 1-x (PO 4 ) 7 (CNYP-I, 0 ≤ x ≤ 1/2) ← Ca 10.5 (PO 4 ) 7 → Ca 9+y Na 3/2-y/2 Y (1-y)/2 (PO 4 ) 7 (CNYP-II, 0 ≤ y ≤ 1)] phosphors were designed and synthesized through the heterovalent substitution of Y 3+ and Na + to Ca 2+ . The substitution mechanism, composition structure, luminescence performance, and thermal stability of Eu 3+ -doped CNYP-I (0 ≤ x ≤ 1/2) as well as the solid solutions of CNYP-II (0 ≤ y ≤ 1), were discussed in detail. The morphology and element composition of CNYP-I (0 ≤ x ≤ 1/2) and CNYP-II (0 ≤ y ≤ 1) solid solutions were analyzed by SEM and EDS. The PL spectra of the specimens were containing the predominant red peak of emission at 612 nm caused via the transition of 5 D 0 - 7 F 2 , indicating that Eu 3+ occupies the low-symmetry center. Moreover, the site symmetry Eu 3+ occupied changed with the x/y value. The luminous intensity of Eu 3+ -doped CNYP-I (0 ≤ x ≤ 1/2) and CNYP-II (0 ≤ y ≤ 1) phosphors at 150°C maintained about 60% of room temperature. The representative compound CNYP-I (x = 1/3) was used as the red phosphor to prepare a near-UV based white LEDs along with Ra of 80.9 and CCT of 4100 K.
研究领域:
材料科学
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光学工程
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Yuli Shi,Haojian Zhang,Xiaomin Hong,Xiaodong Wang
Four solvents (ethanol, isopropanol, ethylene glycol (EG), and N,N-dimethylformamide (DMF)) that can be mixed with water in any ratio were selected to determine the dissolution performance of 7-amino-4-methylcoumarin by the classical shake-flask method. The measured temperature range began at 278.15 K and ended at 303.15 K, and the pressure environment was controlled at standard atmospheric pressure (101.1 kPa). Results reveal that with the addition of organic solvents, the solubilization effect of 7-amino-4-methylcoumarin was very significant and the larger the amount of addition, the more obvious was the effect of solubilization. Not only that, the temperature change had a non-negligible effect on the dispersion of 7-amino-4-methylcoumarin; the temperature increased monotonically, and the better was the dissolution. When the external conditions were kept constant, the addition of DMF made the solubilization effect of 7-amino-4-methylcoumarin most obvious among all organic solvents used. This study involved three models, including the Jouyban–Acree model and its two variants (van’t Hoff–Jouyban–Acree model and Apelblat–Jouyban–Acree model), which were used to correlate the solubility data of 7-amino-4-methylcoumarin in aqueous cosolvent mixtures. The relative average deviation (RAD) and root-mean-square deviation (RMSD) reaches to 3.47 × 10–2 and 1.79 × 10–3 rooting in the van’t Hoff–Jouyban–Acree model. The relevant parameters obtained through model calculation and experimental means are essential for product synthesis, separation, and purification processes.
研究领域:
药物化学
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物理化学
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制药工程
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Muhammad Yasir Nawabi,Waqar Uddin,Gang Hu,Saif Ullah,Zhaohui Fang,Saira Sardar
In this article, we presented an innovative work of distinguishing the two different positional heterosubstituents-aromatic isomers i.e. 4-hydroxycoumarin (4-HC) and 7-hydroxycoumarin (7-HC) on their perturbation effect by a novel analytical Belousov-Zhabotinskii (BZ) oscillator. In such BZ oscillator, the tetra-aza-macrocyclic copper complex ([CuL](ClO4)2) was used in which the ligand L is 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraeazacyclotetradeca-4,11 diene. Experimental data confirmed that, by discrete injection of these two isomers (4-HC and 7-HC) into the active BZ system with equal concentrations reflected in their inhibition time (t in ), but the tin produced by 4-HC was higher than the tin initiated by 7-HC. The interesting feature is that, with increasing concentrations (9.0 x 10 -5 to 3.6 x 10 4 ) of 4-HC constantly increase the tin and decreased the oscillation number (N) after the regeneration of oscillation. Whereas, the upsurge concentrations of 7-HC didn’t change the tin but reduced the N after regeneration of oscillation. Thus, the two isomers were identified. Based on the mechanistic approach of FKN (Field-Koros-Noyes) model, the reaction perturbation mechanism was discussed. A fleeting description is that both 4-HC and 7-HC isomers were oxidized by BrO 2 intermediate radical (which produce during the course of reaction) into salicylic acid and quinone respectively and the system was temporary freeze (t in ) as well. The products (salicylic acid and quinone) were identified by infra-red and Ultra-Visible spectroscopies.
研究领域:
分析化学
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物理化学
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DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2022
·
IF 5.168
Yudong Yin,Li Sun,Lixin Sheng,Liqiong Zhang,Jingjing Liu,Xiaoan Wen,Weibin Mo,Quande Wang,Keguang Cheng
In order to discover more effective and less toxic drugs in the field of anti-tumor, the backbone structure of 17 β -estradiol was modified, and 11 target compounds were synthesized. Compounds 5 and 10 , which exhibited better anti-tumor activity and higher selectivity (more than 10-fold), were chosen for further biological investigation. Flow cytometry results indicated that 5 and 10 could arrest MCF-7 cells in the G2 phase and induce apoptosis . Immunohistochemical analysis revealed that 5 and 10 could bind to the estradiol receptor alpha in MCF-7 cells. Western blotting and real-time PCR assays were performed to detect the effects of compounds on apoptosis-related targets at the protein and gene levels. These results showed that both 5 and 10 could dosed-dependently increase the expression of Apaf-1, Bax, caspase-3,8,9 and reduce the expression levels of the anti-apoptotic factors Bcl-2 and Bcl-xL. Besides, the Human apoptosis array assay demonstrated the expression level of death receptor Trail R2/DR5 was upregulated obviously while the expression of TNF R1, IAPs and Hsp27/60/70 were downregulated. On the whole, 5 induced MCF-7 cell death through the endogenous pathway in mitochondria and the exogenous pathway with death receptor Trail R2/DR5.
研究领域:
肿瘤学
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药理学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
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IF 1.5
Xiaoling Guo,Jinlian Li,Jiwen Cui,Yuhua Wang,Hongfu Gao,Sue Hao,Dongmei Wu
It is highly desirable to develop cost-effective and sensitive cell sensors to evaluate cytotoxicity of anticancer drugs. For the first time, a simple and cheap poly calcein modified electrode(PCA/GCE) prepared by one-step in situ polymerization was applied for study the electrochemical behavior of MCF-7 cells. Since the negative charge and unique properties of calcein can increase sensitivity, the resulting linear scanning of the MCF-7 cells on electrode exhibited two anodic peak that was ascribe to xanthine/guanine(signal) and hypoxanthine/adenine (signal). Meanwhile, the nonlinear exponent relationships between peak current (I pa ) and cell concentration (C) in the wide concentration range were firstly demonstrated. Two independent index equation based on two signal were I pa (signal) = 7.458 − 6.415e (-C/52380) (R 2 = 0.986) and I pa (signal) = 4.023 − 3.773e (-C/228700) (R 2 = 0.984) with the low detection limit of 3000 cells mL -1 , respectively. Electrochemical responses based on two signals of MCF-7 cells was applied to evaluate cytotoxicity effect of cyclophosphamide (CTX) on MCF-7 cells, the result was in good agreement with that of MTT method. This proposed method could be used to evaluate cytotoxicity of drug.
研究领域:
生物医学工程
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肿瘤学
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药物分析
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DOI
高影响因子
Microorganisms
·
2025
·Vol. 13
·期 3
·536
·
IF 4.2
Lina Yang,Can Tang,Yan Cui,Jianhua Zhang
Menaquinone-7 (MK-7) is recognized for its important biological activity, andBacillus subtilisis the preferred strain for its fermentative production. However, the limited phenotypic diversity among high-yielding strains complicates the development of rapid screening methods. To address this, we utilized the effect of MK-7 on transmembrane potential to develop a high-throughput screening (HTS) strategy for efficiently identifying strains with improved MK-7 production. Among various membrane potential fluorescent dyes tested, Rhodamine 123 was selected for quantifying intracellular MK-7 levels due to its effective staining and minimal impact on cell growth. By optimizing pretreatment protocols and staining conditions, we established an HTS protocol that combines fluorescence-activated cell sorting with HPLC to identify strains with increased MK-7 production. A linear correlation was observed between mean MK-7 content and average fluorescence intensity (R2= 0.9646). This approach was applied to mutant libraries generated through atmospheric room temperature plasma mutagenesis. After three cycles of mutagenesis and screening, the mutant AR03-27 was identified, showing an 85.65% increase in MK-7 yield compared to the original SJTU2 strain. Resequencing analysis revealed that the top three mutants contained mutations in genes related to membrane transport, suggesting their potential role in enhancing MK-7 yield.
研究领域:
微生物学
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生物化学
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合成生物学
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DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2021
·
IF 2.646
Lin Ye,Qing Yao,Fengnan Xu,Liu He,Jieqiong Ding,Ruolei Xiao,Liqiong Ding,Binhua Luo
Due to the low bioavailability and severe toxic side effects caused by the lack of selectivity of traditional chemotherapy drugs, the targeted delivery of chemotherapy drugs has become the key to tumor treatment. The activity and transmembrane potential of mitochondria in cancer cells were significantly higher than that of normal cells, making them a potential target for chemotherapeutic drug delivery. In this study, triphenylphosphine (TPP) based mitochondria targeting polylactic acid (PLLA) nanoparticles (TPP-PLLA NPs) were synthesized to improve the delivery efficiency of anticancer drugs. The carrier material was characterized by 1H NMR and FT-IR and 7-hydroxyl coumarin (7-HC) was successfully loaded into TPP-PLLA to form 7-HC/TPP-PLLA NPs. Further studies showed that TPP-PLLA NPs were primarily accumulated in the mitochondrial and 7-HC/TPP-PLLA NPs had higher antitumor activity. Taken together, our results indicated that TPP-PLLA NPs could be a promising mitochondria-targeted drug delivery system for cancer therapy.
研究领域:
药学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yang Gao,Yuyang Wang,Yanlin Jiang,Chaojie Bai,Zuoqun Zhang,Yawen Zhao,Congjie Gao,Lixin Xue
To improve interface compatibility between ZIF-7 particles (PTs) and polyamide (PA) and reverse osmosis (RO) performance of thin film nano-composite (TFN) membranes, ZIF-7-NH 2 (x) particles (PTs) with different levels of -NH 2 substitution were synthesized by reacting Zn(NO 3 ) 2 with mixed ligand under different preparation conditions. The impact of their residual surface functional groups (SFGs) on the formation of inter-phase covalent bonds (ICBs) in PA separating layers were investigated relating to the inter-phase compatibility and salt rejection performance of the formed composite RO membranes. Doping ZIF-7-NH 2 PTs with ICBs could avoid the expansion of PA in acidic condition. Surprisingly high chemical stability was observed for ZIF-7-NH 2 PTs wrapped in the PA separating layers in TN membranes in the pH range of 2–13. TN(50)-0.15 membranes with strong ICBs showed 3 times higher water flux of 76 L·m −2 ·h −1 under 5.5 MPa at a high salt rejection of 98.7 %.
研究领域:
材料科学
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化学工程
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环境工程
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DOI
高影响因子
ANALYTICAL SCIENCES
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2022
·Vol. 38
·期 9
·1181-1188
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IF 1.967
Wang Cheng-Yan,Ge Qingmei,Jiang Nan,Cong Hang,Tao Zhu,Liu Mao,Fan Ying
Metal–organic frameworks (MOFs) including cucurbit[7]uril block (Q[7]·HAuCl 4 ) were employed to develop a diphenylamine (DPA) sensor in electrochemical method, the presence of HAuCl 4 improved the conductivity of the macrocyclic compound. To further enhance of the sensitivity, Au nanoparticles were inserted between the surface of glassy carbon electrode and Q[7]·HAuCl 4 MOFs (GCE-AuNPs-Q[7]·HAuCl 4 ). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) were applied for evaluation on the electrochemical behavior. For the electrochemical inertness of DPA, a label-free electrochemical sensor in 5 mM K 3 [Fe(CN) 6 ] solution was achieved, to produce a limit of detection as low as 4.6 µM in a linear range of 5–1000 µM with good reproducibility, high stability and acceptable anti-interference ability. Application of the proposed electrode for the quantitative determination of DPA in tap water and apple juice confirms its real value. Graphical abstract
研究领域:
分析化学
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材料科学
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电化学
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DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 102
·84303-84310
·
IF 3.84
Lian Duan,Yanling Chen,Kaixuan Zhang,Huoyan Luo,Jianxin Huang,Aihua Xu
The cobalt-based heterogeneous catalysts CoxOy-N/GAC were prepared by pyrolysis of a cobalt–phenanthroline complex on granular active carbon (GAC) in a nitrogen atmosphere, and tested for the degradation of Acid Orange 7 using hydrogen peroxide as a benign oxidant in a bicarbonate aqueous solution. Characterization by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, and electron spin resonance spectroscopy revealed the formation of a cobalt oxide nanoparticle shell with a metallic Co core on the surface of GAC; and the nitrogen substituted the selected carbon atoms during the pyrolysis process and bonded to cobalt. The catalysts were active for dye decolorization in an aqueous solution containing 10 mM H2O2 and 5 mM NaHCO3 at room temperature. They also presented good stability with nearly no loss of cobalt ions after the reaction, in comparison with the high leaching of Co (0.25 mg L−1) from the CoxOy/GAC catalyst without nitrogen. The production of intermediates, the formation of reactive radicals and the effect of HCO3− were also investigated to further explore the efficiency of the catalyst. This study can provide a promising way for the activation of the green oxidant H2O2 in a bicarbonate aqueous solution by heterogeneous cobalt catalysts for environmental remediation.
研究领域:
环境科学
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催化化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Guangyu Zhu,Juan Su,Chunxiao Yin,Huali Li,Yong Yao,Liuqin Zhang,Xiang Yao,Xiaohu Zhang,Fa-Qian Liu
Herein, zinc gluconate was used as zinc source to synthesize ZIF-7@ZnG nanoparticles (NPs), and modified with 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDS) to obtain ZIF-7@ZnG@PFDS superhydrophobic NPs. To improve the durability and wear resistance of superhydrophobic coating, epoxy resin (EP) was introduced as the connection layer to fabricate ZIF-7@ZnG@PFDS/EP superhydrophobic coating. The results show that the fabricated coating exhibits superior hydrophobicity (CA = 164°, SA = 3.7°) and manifests excellent performance in self-cleaning, anti-icing, anti-biofouling and anti-corrosion. It is worth mentioning that after 36 days of immersion in 3.5 wt% NaCl solution, the impedance modulus of the coating is three orders of magnitude higher than that of EP coating. The result of wire beam electrode (WEB) confirms that ZIF-7@ZnG@PFDS/EP coating has a self-healing property in the artificial damage area. Finally, the influence mechanism of ZIF-7@ZnG@PFDS nanoparticles on the corrosion process was discussed. We believe this work could provide a novel insight into the preparation and application of superhydrophobic coating based on MOFs material.
研究领域:
材料科学
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化学工程
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表面科学
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DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Xiao Yang,Junyi Wang,Haoran Liang,Rui Sun
A 1,8-diazabicyclo[5.4.0]undecane-7-ene (DBU)-mediated hydroalkylation of enamides with malonic acid diesters/β-carbonyl esters has been established, featuring no metal involvement, mild reaction conditions, and good functional group tolerance. The protocol enables the expedited preparation of a variety of β-amino esters. Preliminary mechanistic investigations, encompassing control experiments and capture experiments of key intermediates, have substantiated the proposed DBU-mediated hydroalkylation pathway.
研究领域:
有机化学
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合成化学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）