ANALYTICA CHIMICA ACTA
·
2015
·
IF 4.513
Miyi Yang,Xiaoling Wu,Yuhan Jia,Xuefei Xi,Xiaoling Yang,Runhua Lu,Sanbing Zhang,Haixiang Gao,Wenfeng Zhou
In this work, a novel effervescence-assisted microextraction technique was proposed for the detection of four fungicides . This method combines ionic liquid-based dispersive liquid–liquid microextraction with the magnetic retrieval of the extractant. A magnetic effervescent tablet composed of Fe 3 O 4 magnetic nanoparticles , sodium carbonate, sodium dihydrogen phosphate and 1-hexyl-3-methylimidazolium bis(trifluoromethanesulfonimide) was used for extractant dispersion and retrieval. The main factors affecting the extraction efficiency were screened by a Plackett–Burman design and optimized by a central composite design. Under the optimum conditions, good linearity was obtained for all analytes in pure water model and real water samples. Just for the pure water, the recoveries were between 84.6% and 112.8%, the limits of detection were between 0.02 and 0.10 μg L −1 and the intra-day precision and inter-day precision both are lower than 4.9%. This optimized method was successfully applied in the analysis of four fungicides (azoxystrobin, triazolone, cyprodinil , trifloxystrobin) in environmental water samples and the recoveries ranged between 70.7% and 105%. The procedure promising to be a time-saving, environmentally friendly, and efficient field sampling technique.
研究领域:
分析化学
·
环境科学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Pingan Tan,Xiaoyan Zhong,Jingsong Liu,Fei Yang,Chong Xian,Honglan Yuan
Ni 0.6 Zn 0.4 Fe 2 O 4 (NZF-Zn 0.4 ) ferrites with different Al–Si–B–Pb (ASBP) glass additions were synthesized via a solid-phase reaction method at 1175 °C. The inclusion of ASBP-glass significantly enhances the grain size, density, shrinkage, and magnetic properties of NZF-Zn 0.4 ferrites without introducing impurity phases. The prepared NZF-Zn 0.4 -1 wt%ASBP ferrites not only exhibit appropriate radial shrinkage but also possess a dense microstructure and outstanding magnetic properties. Subsequently, Y 2.4 Bi 0.5 Al 0.1 Fe 3 O 4 (YIG-Al 0.1 ) ferrites and NZF-Zn 0.4 -1 wt%ASBP ferrites were chosen as the outer rings and inner cores, respectively. Tightly interconnected YIG-Al 0.1 /NZF-Zn 0.4 –1wt.% ASBP ferrite composite substrates were successfully co-fired within the temperature range of 1175 °C–1225 °C following co-pressing. Furthermore, YIG-Al 0.1 /NZF-Zn 0.4 -1 wt%ASBP composite substrates, co-fired at 1175 °C, exhibit a lack of impurity phases in the interface region, minimal element diffusion, and exceptional electromagnetic properties (NZF-Zn 0.4 -1 wt%ASBP: M s = 81.88 ± 0.05 emu/g; YIG-Al 0.1 : ε r = 18.28 ± 0.05@11.17 GHz, tanδ = 3.14 ± 0.55 × 10 −4 , M s = 21.62 ± 0.55 emu/g). The wide co-firing temperature range of YIG-Al 0.1 /NZF-Zn 0.4 -1 wt%ASBP composite substrates significantly enhances the shrinkage matching rate of two-phase ferrites, and its exceptional electromagnetic properties hold significant potential for applications in RF band circulators.
研究领域:
材料科学
·
磁性材料
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产品关联
DOI
高影响因子
POLYMER INTERNATIONAL
·
2011
·Vol. 60
·期 9
·1355-1361
·
IF 2.056
Xiaonan Zhu,Yihu Song,Shaohui Chen,Peihua Du,Qiang Zheng
An acrylate processing aid (ACR)-based ionomer containing lanthanide (La(III)) ion was synthesized and the influences of the ionomer on thermal stability, fusion time, transparency and tensile properties of rigid poly(vinyl chloride) (PVC) were investigated. Results revealed that the ionomer with a suitable La(III) content behaved as a good stabilizer as well as processing aid to the rigid PVC product. The ionomer could accelerate fusion of PVC much more quickly than ACR because of the strong interaction between La(III) carboxylate and PVC. Moreover, it exhibited a stabilizing efficiency comparable to lanthanum and calcium stearates (LaSt 3 and CaSt 2 ). The composite stabilizer of ionomer/zinc stearate (ZnSt 2 ) exhibited an ability to improve initial discoloration better than LaSt 3 /ZnSt 2 and CaSt 2 /ZnSt 2 because the ionomer could form a complex with ZnSt 2 much more slowly than LaSt 3 and CaSt 2 . The compounds stabilized using ionomer/ZnSt 2 exhibited a transparency comparable to those stabilized using organotin or liquid barium/zinc stabilizers, which was much better than those stabilized using LaSt 3 /ZnSt 2 and CaSt 2 /ZnSt 2 . Copyright © 2011 Society of Chemical Industry
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
·
2018
·
IF 1.144
Miao Shiding,He Shuai,Xue Yuli,Nian Hongen,Wang Jian,Zhang Peng,Zhu Fujie,Wen Wanglin
Food grade (K2CO3 wt.%>99.0%, GB/T 25588-2010) potassium carbonate (K2CO3) has been extracted from low concentration [K+] solutions of K2CO3-Na2CO3-H2O,
which refers to a subsystem of brine water in the Lop Nor Lake in West China. Procedures of the isothermal evaporation, crystallization, CO2 acidification, filtration, and calcination were employed to prepare the K2CO3. This research focuses on the phase study
of metastable equilibria between K2CO3-Na2CO3-H2O and KHCO3-NaHCO3-H2O. The solubility, density, conductivity, and pH values were determined. Phase diagrams were plotted at temperatures of 298.2 and 313.2
K. At 298.2 K the ternary system of K2CO3-Na2CO3-H2O was found to have double salts in form of solid solutions Na2CO3·K2CO3·(6–12)H2O, which would hinder the process
of getting pure K2CO3 by the means of isothermal evaporation. In this protocol the high-pressure CO2 was charged to the ternary carbonate solution, and the K2CO3-Na2CO3-H2O was moved to bicarbonate system
KHCO3-NaHCO3-H2O. This quaternary system is of a simple co-saturation type of diagram, in which a solid solution (KHCO3·NaHCO3) was found to be greatly affected by temperatures. This finding affords efficient separation of KHCO3
from the KHCO3-NaHCO3-H2O solutions.
研究领域:
无机化学
·
化学工程
·
相平衡
·
矿物加工
·
资源回收
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DOI
高影响因子
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
·
2013
·Vol. 19
·期 2
·86-93
·
IF 1.107
Xiaonan Zhu,Yihu Song,Qiang Zheng
Acrylate processing aid (ACR)-based La(III)-neutralized ionomers with different acid and La(III) ion contents were synthesized. Increasing lanthanum content in the ionomers led to an increment in the size of the ionic aggregate. Increasing acid content resulted in an increasing glass transition temperature ascribed to ion aggregation and to the occurrence of dense hydrogen bonding. The influences of acid and ion contents of the ionomers on the fusion and thermal stabilization behaviors of poly(vinyl chloride) (PVC) were investigated. The results revealed that at the low acid content of 0.25 mmol/g of hydrolyzed ACR, the stabilization efficiency of the ionomers enhanced with an increase of ion content before the appearance of clusters. At acid contents of 1.80 and 2.90 mmol/g, the ionomers exhibited poor ability to stabilize PVC during processing. The fusion-promoting efficiency of the ionomers showed the same trend as the stabilization efficiency. Cluster formation and increasing acid content were also disadvantageous for ionomer use in promoting PVC fusion. J. VINYL ADDIT. TECHNOL., 19:86–93, 2013. © 2013 Society of Plastics Engineers
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 69
·64895-64901
·
IF 3.289
Fengli Qu,Lian Xia,Chuanxiang Wu,Lijie Liu,Guoliang Li,Jinmao You
A zirconium-based metal–organic frameworks (MOF), with 2-aminoterephthalic acid as linkers, named UiO-66-NH2, has been synthetized and characterized in a dispersive solid-phase extraction (DSPE) procedure in combination with high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) for the pre-concentration and detection of sialic acids (SAs) in serum samples. In this study, UiO-66-NH2 was employed for the first time as a novel DSPE sorbent for sample pretreatment. Parameters which influence the extraction efficiency such as the amount of MOF, nature of the desorption solvent and its amount, adsorption time and desorption time were investigated and optimized. Under the optimized conditions, better extraction results were obtained by UiO-66-NH2 based DSPE for the extraction of SAs from serum samples than traditional sample preparation methods. Detection limits of the method as low as 0.16 pmol for N-glycolylneuraminic acid (Neu5Gc) and 0.11 pmol for N-acetylneuraminic acid (Neu5Ac) were obtained, with determination coefficients (R2) higher than 0.9995 for the range 10–1000 pmol L−1, average recoveries of >91.3% at three different spiked levels (1, 5 and 10 ng mL−1), and relative standard deviation (RSD) values below 3.4%. The proposed method was demonstrated to be sensitive enough for determination of SAs from bio-samples.
研究领域:
分析化学
·
医学检验
·
生物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yinglan Li,Jie Xu,Qingran Guan,Huaizhen Zhang,Zhuang Ding,Qingpeng Wang,Zhengping Wang,Jun Han,Min Liu,Yanna Zhao
Solid dispersions (SDs) possess the potential to enhance the bioavailability of insoluble active pharmaceutical ingredients (APIs) by effectively converting them into amorphous state. However, SDs have a tendency to recrystallize unless appropriate excipients are employed. The objective of this study was to evaluate the ability of hypromellose acetate succinate HF (HPMCAS-HF) and Soluplus® to inhibit the recrystallization of β-carotene and improve its in vivo bioavailability through the fabrication of ternary β-carotene solid dispersions (SDs) with the aid of specific surfactant. Due to rapid micellization , the dissolution profiles of β-carotene SDs based on HPMCAS-HF/Span 20 (5:5, w/w) or Soluplus®/Span 20 (6:4, w/w) combinations exhibited significant improvement, which were almost 7–10 times higher than β-carotene bulk powder. DSC and PXRD analysis indicated a notable reduction in the crystallinity degree of β-carotene within the SDs. The stability study demonstrated a half-life of β-carotene in the SDs exceeding 30 days. Additionally, the in vivo pharmacokinetics analysis confirmed that the cellulose derivatives/surfactant combinations significantly enhanced the bioavailability of β-carotene by 1.37-fold and 2.3-fold, respectively. Notably, the HPMCAS-HF/Span 20 combination exhibited superior performance. Consequently, the HPMCAS-HF/Span 20 combination held potential for the advancement of an effective drug delivery system for β-carotene.
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Ke Zhang,Jinhuan Cheng,Qidi Hong,Wenjiang Dong,Xiaoai Chen,Guiping Wu,Zhenzhen Zhang
In this study, headspace solid-phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS) and electronic-nose (E-nose) analyses were performed to examine the comprehensive flavor profiles of robusta coffee during heat air drying. A total of 62 volatile compounds were identified by HS-SPME/GC-MS, the level of acids, aldehydes, alcohols and esters decreased during drying process, however, the relative content of hydrocarbons and acids increased. Principal component analysis of the E-nose results clearly differentiated the samples related to drying time, and it was found that samples of initial stages (0 h, 3 h, and 6 h) had strong positive with different sensors. Partial least squares-discriminant analysis (PLS-DA) indicated that alcohols, ketones, and esters were the main contributing compounds to the flavour of coffee beans. The VIP score of PLS-DA larger than one illustrated that T30/1, T70/2, PA/2, and P30/2 were positive with ketones, sulfur compounds, and esters. These results could provide theoretical evidence about the change rule in volatile compounds of coffee beans during drying process, and could be applied to other thermally sensitive tropical agricultural products.
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Shuai Yuan,Yangjiayi Xiang,Lizhu Chen,Ping Xiang,Yan Li
The quantification of illicit drugs in wastewater has become a valuable tool for monitoring illicit drug abuse. The commonly utilized methods for detecting drugs in wastewater require a substantial sample volume, extended pretreatment durations, and intricate procedures. This study first employed polydopamine-coated magnetic nanocomposites as adsorbents for magnetic solid-phase extraction, combined with UPLC-MS/MS, to simultaneously determine the concentrations of eleven common illicit drugs in wastewater. The synthesis process for Fe 3 O 4 @PDA is straightforward and high-yield. Benefiting from the strong magnetic response, good dispersibility, and abundant binding sites of the prepared nanocomposites, the extraction of illicit drugs from wastewater could be achieved in just 15 min. The method exhibited satisfactory limits of quantitation (ranging from 5 to 10 ng/L), commendable accuracy (ranging from 90.59 % to 106.80 %), good precision (with RSDs below 10 %), and less sample consumption (only 1 mL). The efficacy of this method was successfully validated through its application to actual wastewater samples collected from ten wastewater treatment plants. The results indicated that morphine, codeine, methamphetamine, and ketamine were the predominant illicit drugs present in the samples. The method developed is able to meet the needs of common illicit drug monitoring and high-throughput analysis requirements.
研究领域:
环境科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2019
·
IF 2.606
Shaohui Xu,Zhu Jin,Zhipeng Zhang,Wei Huang,Yuanyuan Shen,Zhongmin Wang,Shengrong Guo
It is necessary for effective combinational effects that multiple chemotherapeutic agents enter and act on the same tumor cells simultaneously at a suitable ratio. Due to their individual physicochemical or biopharmaceutical properties, they cannot reach the same cells at its predetermined ratio after co-administration. Herein, we report a novel system with precise ratiometric co-loading, co-delivery and intracellular co-release of paclitaxel (PTX) and curcumin (CUR), to investigate their synergistic effects. We prepared the system by conjugating PTX and CUR at different ratios onto the same gold nanorods (GNRs). We demonstrated that PTX and CUR could be precisely ratiometric co-loaded to form dual-drug conjugated biotin-PEG modified GNRs (abbreviated as PTX/ [email protected] ), which could co-deliver dual drugs into tumor cells with a predetermined ratio and co-release them intracellularly. The PTX/ [email protected] with the mass ratio of PTX and CUR at 1:1 exhibited the best synergistic effect on multidrug resistant MCF-7/ADR cells while the free PTX and CUR mixture with the mass ratio of at 1:0.75 displayed the strongest synergism. Cytotoxicity studies showed that PTX/ [email protected] are superior to free drug mixture. Furthermore, PTX/ [email protected] could remarkably induce apoptosis of MCF-7/ADR cells under near-infrared irradiation. Moreover, we found that PTX/ [email protected] significantly inhibited P-glycoprotein (P-gp) expression in MCF-7/ADR cells.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Kaige Zhang,Shuangying Li,Yunhe Wang,Jing Fan,Guifen Zhu
For this work, a novel air-assisted liquid-liquid microextraction based on solidification of floating deep eutectic solvent (AA-LLME-SFDES), coupled with a high performance liquid chromatography (HPLC) method was developed for the detection of benzophenone and salicylate ultraviolet filters in water samples. Three types of fatty acid-based hydrophobic deep eutectic solvents (DESs) with low viscosity, low-density, and melting point close to room temperature were prepared and employed as extraction solvents. This air-assisted liquid-liquid microextraction was carried out in a glass centrifuge tube. Subsequently, the glass tube was introduced into ice-water bath and held for 3 min, during which the upper DES phase was solidified. The water phase was easily extracted using a syringe equipped with a long needle, and later, the glass tube was removed from ice-water bath. The solidified DES phase was immediately melted at room temperature and used for HPLC analysis. The response surface methodology was employed to optimize some influencing parameters such as the volume of the extraction solvent, the pH value of sample solution, the number of extraction cycles, and the addition of salt. A quadratic model, namely a central composite design, was used to replace the conventional single factor analysis. It was found that under optimal conditions, the limits of determination and quantification were 0.045–0.54 µg L −1 and 0.15–2.0 µg L −1 , respectively. The relative standard deviations for inter-day ( n = 5) and intra-day ( n = 5) precision were ≤ 4.2%, whereas the enrichment factors for the ultraviolet filters were obtained from 41 to 50. Furthermore, this novel method was successfully employed for the detection of benzophenone and salicylate ultraviolet filters from real water samples. The recoveries ranged from 87.5% to 105.8%, whereas the RSDs were lower than 3.6%.
研究领域:
分析化学
·
环境科学
·
化工
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）