ACS Nano
·
2022
·
IF 18.027
Yanan Wang,Minju Pu,Jiahui Yan,Jingwen Zhang,Huichao Wei,Liangmin Yu,Xuefeng Yan,Zhiyu He
Calcium overload is one of the early determinants of the core cellular events that contribute to the pathogenesis of acute kidney injury (AKI), which include oxidative stress, ATP depletion, calcium overload, and inflammatory response with self-amplifying and interactive feedback loops that ultimately lead to cellular injury and renal failure. Excluding adjuvant therapy, there are currently no approved pharmacotherapies for the treatment of AKI. Using an adipic dihydride linker, we modified the hyaluronic acid polymer chain with a potent antioxidant, bilirubin, to produce an amphiphilic conjugate. Subsequently, we developed a kidney-targeted and reactive oxygen species (ROS)-responsive drug delivery system based on the flash nanocomplexation method to deliver a well-known intracellular calcium chelator, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid acetoxymethyl ester (BAPTA-AM, BA), with the goal of rescuing renal cell damage via rapidly scavenging of intracellularly overloaded Ca2+. In the ischemia–reperfusion (I/R) induced AKI rat model, a single dose of as-prepared formulation (BA 100 μg·kg–1) 6 h post-reperfusion significantly reduced renal function indicators by more than 60% within 12 h, significantly alleviated tissular pathological changes, ameliorated tissular oxidative damage, significantly inhibited apoptosis of renal tubular cells and the expression of renal tubular marker kidney injury molecule 1, etc., thus greatly reducing the risk of kidney failure. Mechanistically, the treatment with BA-loaded NPs significantly inhibited the activation of the ER stress cascade response (IRE1-TRAF2-JNK, ATF4-CHOP, and ATF6 axis) and regulated the downstream apoptosis-related pathway while also reducing the inflammatory response. The BA-loaded NPs hold great promise as a potential therapy for I/R injury-related diseases.
研究领域:
药理学
·
纳米技术
·
肾脏生理学
·
治疗学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2021
·Vol. 328
·期 1
·137-147
·
IF 1.371
Wang Zhongtang,Xie Yun,Lin Jinxian,Li Zejun,Tan Zhaoyi
New method was developed to analyze Pu and Am sequentially for soil and sediment by inductively coupled plasma mass spectrometry (ICPMS). The developed method uses conc. HNO 3 to leach Pu and Am, Fe(OH) 3 coprecipitation to remove alkali and alkaline metals, extraction chromatographic separation using UTEVA, DGA and TEVA resins to remove interfering elements (IEs) and separate Pu and Am from each other, and sector field-ICPMS to measure Pu and Am. The analysis of four standard reference materials showed that both Pu isotopes and 241 Am were accurately determined by this method, as a result of its excellent decontamination ability of IEs. Especially the high decontamination factor of Pu [DF(Pu), 4.2 × 10 2 ] in Am fraction and high DF(Am) (7.0 × 10 3 ) in Pu fraction sufficiently eliminated the cross interference between 241 Pu and 241 Am in ICPMS measurement. In addition, stable and high chemical recoveries were achieved for Pu (71–91%) and Am (70–88%). The low LODs of Pu isotopes, short analytical time (14 h) and high DFs of IEs allows this method to sequentially analyze Pu and Am, for both global fallout and nuclear accident sourced samples.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Xiaobing Tang,Aihua Sun,Chengyi Chu,Chongyang Wang,Zhenzhong Liu,Jianjun Guo,Gaojie Xu
Multiresponsive photonic hydrogels (MRPHs) were prepared by magnetically controlled self-assembly of Fe 3 O 4 @C nanoparticles and these are sensitive to temperature, humidity, compression, tension and ethanol. This exhibits brilliant structural color thanks to the combination of AM and NIPAM monomers. Along with the increase of compression and tension on the MRPHs, the reflection peak of the samples blue shifts. When exposed MRPHs in environments with different humidity, its structure color red shifts as the humidity increases from 33% RH to 95% RH. Besides, the reflection peak redshift was observed when the MRPHs was immersed in absolute ethyl alcohol. This work may provide a new way to prepare smart photonic hydrogel with integrated functions of mechano-, humidity-, temperature- and solvent- responses.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 30
·14578-14585
·
IF 3.925
Zhengji Yin,Junli Peng,Zhen Qiao,Yanru Zhang,Ningning Wei
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel, which is predominantly expressed in primary afferent neurons. TRPA1, as a chemical, mechanical and temperature sensor, is closely related to some inflammatory diseases and respiratory diseases. Fluorescent probes provide a useful tool to understand the function of ion channels because of their high selectivity, high sensitivity and excellent spatio-temporal resolution. In this study, a 4-Am agonist screened by an electrophysiological assay was used as a targeting group. We designed and synthesized a small molecule fluorescent probe named DPCC based on a molecular rotation mechanism. DPCC is applied to visualize the TRPA1 channel in living cells and screen TRPA1 channel regulators. Our data suggested that the DPCC probe has a high specificity and desired resolution, and may serve as an effective tool for understanding the TRPA1 channel.
研究领域:
药理学
·
生物物理学
·
细胞生物学
·
神经科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Lin Liu,Shimiao Wu,Jingya Xiu,Yang Liu,Bingrong Hong,Yihong Peng,Lingao Yin,Yilin Song,Ziqi Li,Ziyun Lin,Degong Yang,Chunrong Yang
The myocardial ischemia-reperfusion injury (MIRI) is an acute and serious disease with complex pathogenesis, which is intricately associated with oxidative stress, calcium overload, and inflammation. Currently, widely utilized antioxidant or anti-inflammatory strategies present challenges in effectively reversing tissue damage. In this study, a biomimetic targeted mesoporous polydopamine nanoparticle (MR/B@PM) loaded with rapamycin (RAPA) and calcium chelating agent (BAPTA-AM) was successfully constructed, and precise delivery was achieved by a platelet membrane (PM). MR/B@PM facilitated targeted delivery to cardiomyocytes (26-fold) and enhanced intracellular uptake (1.75-fold) compared to MR/B, which was mainly attributed to the natural infarct homing ability of PM and the high affinity between PM and myocardial cells. MR/B@PM significantly inhibited 85.78% of hypoxia-reoxygenation (H/R)-induced cell apoptosis and exerted favorable inhibitory effects on myocardial injury with reduced CK-MB and LDH to 7.61 and 19.43 pg/mL compared to the H/R group. It was proved that MPDA acted as a combined effect with BAPTA-AM and RAPA to inhibit cardiomyocyte apoptosis and modulate the inflammatory response by scavenging ROS and reducing calcium overload. And in the MIRI rat model, MR/B@PM has been demonstrated to significantly reduce serum levels of CK-MB and LDH, while effectively suppressing inflammatory responses. Notably, MR/B@PM effectively reduced infarct size to 19.51% and prevented cardiac remodeling caused by MIRI. This designed nanoplatform comprehensively regulated the multiple pathogenesis of MIRI, which provided an effective strategy and mechanism for the treatment of MIRI.
研究领域:
纳米医学
·
心脏病学
·
药学
·
生物医学工程
·
炎症研究
·
氧化应激
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Nanke Ma,Yuwei Chen,Liya Wang,Ping Tan,Nayu Chen,Yuan Jin,Jian Song,Guangli Li
Conductive hydrogels have garnered significant attention for flexible electronics, yet simultaneously achieving optimal mechanical robustness and electrical performance under harsh conditions remains challenging. Herein, an ion/electron dual-mode conductive Ag/AgCl@Agar/P(AM- co -HEAA) hydrogel was developed for wearable motion detection and electrophysiological signal monitoring. The hydrogel exhibited outstanding mechanical properties, including excellent stretchability (2207 %), high tensile stress (0.32 MPa), and remarkable toughness (3.90 MJ/m 3 ). As a strain sensor, it displayed high sensitivity (GF of 4.17 within 1100–1400 % strain), stable and reproducible resistance signal output across both micro-strains (0.01–0.1 %) and macro-strains (200–1400 %), and excellent working durability and reliability (200 cycles at 200 % strain). Notably, it also demonstrated reliable sensing performance even at −20 °C due to the ion/electron hybrid conductive mechanism. These unique properties enabled the hydrogel successfully applied in real-time human motion detection and human-machine interaction. Moreover, the hydrogel semi-dry electrodes displayed low potential drift (4.64 μV/min) and electrode-scalp impedance (13.2 ± 1.6 kΩ at 10 Hz). Significantly, the hydrogel electrodes achieve clinical-grade ECG and EEG signal acquisition, comparable to commercial wet electrodes. These superior properties, combined with facile fabrication, make this multifunctional hydrogel a promising candidate for next-generation wearable devices in motion monitoring and human–machine interactions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Xian Lu,Yisheng Shao,Naiyun Gao,Juxiang Chen,Huiping Deng,Wenhai Chu,Na An,Fangyuan Peng
This study investigated the UV/persulfate (UV/PS) and UV/chlorine processes as alternative method for the removal of clofibric acid (CA). The formation of disinfection byproducts (DBPs) during subsequent chlor(am)ination was also evaluated. The degradation of CA followed the pseudo-first order kinetics. The second-order rate constants of CA with SO4 − , OH and Cl were respectively determined as k SO 4 - ,CA = (1.73 ± 0.01) × 10 9 M −1 s −1 , k OH ,CA = (2.72 ± 0.08) × 10 9 M −1 s −1 and k Cl ,CA = (9.76 ± 0.15) × 10 10 M −1 s −1 . The degradation rate constant increased with increasing oxidant dosage in UV/PS and UV/chlorine processes. The degradation rate constant was found to be the highest at pH 9 and decreased dramatically at pH 11 in UV/PS process. For UV/chlorine, the rate constant continuously decreased with increasing pH from 3 to 11. Presence of HCO 3 − and Cl − had different effects (promotion and/or inhibition) on CA degradation in both processes. An inhibition effect was observed in the presence of NOM for the two UV-based processes. The higher CA removal in real water suggested the two processes were suitable for treating water containing CA, and the UV/chlorine was more cost-effective than UV/PS based on the total cost of electrical energy. Compared with the chlor(am)ination of CA, the UV/PS and UV/chlorine pre-oxidation significantly impacted the DBP formation during subsequent chlor(am)ination, which indicated the application of the two UV-based processes needs to be carefully balanced against the downstream effect on DBP formation.
研究领域:
环境科学
·
水处理工程
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Li’an Jiang,Song Tian,Yuhui Xie,Xue Lv,Shulin Sun
Traditional hydrogels with a single-crosslinked network structure suffer from poor stretchability, low sensitivity, and easy contamination, which seriously affect their practical application in the strain sensor field. To overcome these shortcomings, herein, a multiphysical crosslinking strategy (ionic crosslinking and hydrogen bonding) was designed to prepare a hydrogel strain sensor based on chitosan quaternary ammonium salt (HACC)-modified P(AM-co-AA) (acrylamide-co-acrylic acid copolymer) hydrogels. The ionic crosslinking for the double-network P(AM-co-AA)/HACC hydrogels was achieved by an immersion method with Fe3+ as crosslinking sites, which crosslinked with the amino group (−NH2) on HACC and the carboxyl group (−COOH) on P(AM-co-AA) and enabled the hydrogels to recover and reorganize rapidly, resulting in a hydrogel-based strain sensor with excellent tensile stress (3 MPa), elongation (1390%), elastic modulus (0.42 MPa), and toughness (25 MJ/m3). In addition, the prepared hydrogel exhibited high electrical conductivity (21.6 mS/cm) and sensitivity (GF = 5.02 at 0–20% strain, GF = 6.84 at 20–100% strain, and GF = 10.27 at 100–480% strain). Furthermore, the introduction of HACC endowed the hydrogel with excellent antibacterial properties (up to 99.5%) and excellent antibacterial activity against bacteria of three forms, bacilli, cocci, and spores. The flexible, conductive, and antibacterial hydrogel can be applied as a strain sensor for real-time detection of human motions such as joint movement, speech, and respiration, which exhibits a promising application prospect in wearable devices, soft robotic systems, and other fields.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Shaoping Ma,Fenfang Li,Zhijian Tan
Aqueous two-phase systems (ATPSs) have been used in the chiral resolution of various enantiomers in recent years. However, it is difficult to recycle and reuse the phase-forming components and chiral selectors in these applications. Therefore, a completely recyclable ATPS that is based on two temperature-responsive polymers, viz. , poly(MAH-β-CD-co-NIPAAm-DMAEMA-BMA) (P NDB-CD ) and poly(NVCL-AM) (P VAm ), was employed for the chiral separation of mandelic acid (MA) enantiomers. The two polymers can be recovered by simply adjusting the temperature; meanwhile, the polymer P NDB-CD can be used as a chiral selector. The factors that affect the chiral resolution process were also investigated. A maximum separation factor ( α ) of 1.49 was achieved via a one-step extraction under the following conditions: P VAm concentration of 14.0 wt%, P NDB-CD concentration of 9.0 wt%, MA concentration of 5.0 mg/g, and system pH of 4.0. Moreover, the two polymers can be easily recycled after the chiral separation process. The recyclable ATPS used for enantioseparation in the current study can provide new ideas for other applications by using enantioselective liquid–liquid extraction (ELLE).
研究领域:
化学
·
材料科学
·
分离科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 13
·5925-5932
·
IF 3.591
Cheng Zhou,Yan Chen,Mingjun Huang,Yi Ling,Liming Yang,Guochen Zhao,Jie Chen
A dual temperature-responsive triblock polymer (poly(N-isopropyl acrylamide)-block-poly(N,N-dimethyl acrylamide)-block-poly(acrylamide-co-acrylonitrile)) (P(AM-co-AN)-b-PDMA-b-PNIPAM) (NDAA) was obtained by sequential reversible addition–fragmentation chain transfer (RAFT) polymerization,with the uncharged UCST temperature-sensitive block P(AM-co-AN) and the classic LCST-type temperature-sensitive block PNIPAM. This well-defined thermo-responsive copolymer with tunable compositions exhibits a dual thermal response behavior in water. Properly designing the length of the block can make the block copolymer undergo a phase transition within the envisaged temperature range. When the concentration is 5 wt%, the UCST of the NDAA polymer is around 20 °C, and the LCST is around 31 °C. All three blocks of these polymers are soluble in water within 20–31 °C. At high temperature, PNIPAM hydrophobically aggregates into a core, and NDAA self-assembles into a core1 (PNIPAM)–shell (PDMA)–corona1 (P(AM-co-AN)) structure. In contrast, at low temperatures, P(AM-co-AN) forms hydrogen bonds and is insoluble in water, and NDAA self-assembles into a core2–shell–corona2 structure. In this way, it is possible to prepare spontaneously reversible micellar aggregates in water. After the concentration reaches the lowest critical concentration, the NDAA polymer can undergo a reversible gel behavior, that is, a phase transition occurs near the UCST and LCST. This change in the polarity of the micelle core opens up the possibility of dissolving different compounds in water just by changing the temperature.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Wenjie Zou,Lu Gong,Jun Huang,Zhijun Zhang,Chunbao Sun,Hongbo Zeng
Selective flocculation separation has been widely used in fine coal flocculation. In order to promote the adsorption selectivity of flocculants onto coal surface, hydrophobically modified polyacrylamide P(AM-NaAA-C 16 DMAAC) was synthesized. The adsorption of P(AM-NaAA-C 16 DMAAC) on model clay and coal surfaces (i.e., silica, alumina and asphaltene surfaces) was investigated using quartz crystal microbalance with dissipation (QCM-D) monitoring technique. Floc size distribution, Fourier transform infrared spectrum, zeta potential measurement and selective flocculation flotation test were also conducted to study the performance of P(AM-NaAA-C 16 DMAAC) in the separation of fine coal. QCM-D measurements showed that a thin and rigid adsorption layer was formed on silica and alumina surfaces after injecting 1 mM sodium hexapolyphosphate (Calgon). This pre-formed layer inhibited the further adsorption of P(AM-NaAA-C 16 DMAAC) on silica and alumina. Meanwhile, the asphaltene surface could not be passivated by calgon due to the weak and reversible adsorption. Thus, a significant amount of P(AM-NaAA-C 16 DMAAC) (20 mg/L) absorbed on the calgon-treated asphaltene surface in 100 mM KCl solution was detected. With 20 mg/L P(AM-NaAA-C 16 DMAAC) in 100 mM KCl and 1 mM calgon solution, the maximum diameters of 10%, 50% and 90% of the cumulative volume distributions of the floc, i.e., d 10 (20.29 μm), d 50 (45.55 μm) and d 90 (89.99 μm) of the coal floc were 7.42, 3.20 and 2.19 times of those of kaolinite floc, respectively. Clean coal with a combustible recovery of 80.87% and ash content of 9.78% was obtained at a dosage of 5 g/t of P(AM-NaAA-C 16 DMAAC) and 900 g/t kerosene. Experimental results demonstrated that selective flocculation flotation with P(AM-NaAA-C 16 DMAAC) could enhance the recovery of fine coal particles with a lower dosage of collector. Our work sheds lights on the fundamental and practical understanding of the hydrophobic interactions in the selective flocculation of coal in the industries, and rational development of flocculants with better selectivity and flocculation efficiency.
研究领域:
化学工程
·
材料科学
·
矿物加工工程
✓ 已验证
产品关联
DOI
高影响因子
Optical Materials Express
·
2018
·Vol. 8
·期 9
·2823-2831
·
IF 2.566
Rongping Ni,Bin Qian,Chang Liu,Xiaofeng Liu,Jianrong Qiu
Additive manufacturing (AM) techniques allow for the construction of sophisticated and hollow models based on the needs of customers, and they functionalize the raw materials (e.g., metal, polymer and ceramic) by structuring them. Here, we demonstrate a simple method for the realization of a three-dimensional architecture with long afterglow properties by curing organic resin doped with inorganic long persistent phosphors (LPPs) layer by layer through the stereolithography (SLA) technique. In our process, the LPPs made by solid state reaction were incorporated homogenously into a resin matrix and pre-designed 3D structures with the resolution of 0.1 mm were printed out. The high luminescence, considerable decay time and multi-color make these organic/inorganic composites reliable for applications in artifacts, crafts, toys and night indicators. It is also demonstrated that the resin containing SrAl2O4: Eu2+, Dy3+ phosphors can be used for fiber temperature sensing from 40 °C to 70 °C.
研究领域:
材料科学
·
增材制造
·
光子学
·
复合材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）