SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Chengna Xu,Ji Zhou,Yong Ye,Bin Tang
Peroxidase-like reaction process involving o-phenylenediamine (OPD) and silver nanoprisms in the presence of hydrogen peroxide (H 2 O 2 ) was monitored using time-resolved ultraviolet–visible (UV–Vis) absorption spectroscopy. The oxidation of OPD and etching of silver nanoprisms were investigated by analyzing the dynamic spectral data. Two-dimensional correlation spectroscopy (2D-COS) and principal component analysis (PCA) were employed to gain insights into the correlation between catalytic oxidation of OPD and etching of silver nanoprisms. It was found that OPD offered significant protection effect for silver nanoprisms so that morphologies of silver nanoprisms maintained at the beginning period after addition of H 2 O 2 . Moreover, silver nanoprisms accelerated the oxidation of OPD by H 2 O 2 , demonstrating enzymatic mimicking activity of silver nanoprisms. The combination of time-resolved UV–Vis absorption spectroscopy and spectral calculation methods could be used for exploration of complex reaction systems with spectral variations.
研究领域:
纳米技术
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催化
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光谱学
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材料科学
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DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Nan Wang,Tingxue Fang,Tinghui An,Yuhao Wang,Jiaqi Li,Shuming Yu,Honghai Sun,Dong Xiang,Xiangjie Bo,Kedi Cai
Li-O 2 batteries urgently needs high discharge capacity and stable cycling performance, requiring effective and reliable bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, Hovenia acerba Lindl -like heterostructure composed of cobalt sulfide and tin dioxide supported on carbon substrate (CoS/SnO 2 @C) is prepared via CO 2 laser irradiation technology. The half-wave potential of CoS/SnO 2 @C for the ORR is 0.88 V, while the overpotential of the OER at 10 mA cm −2 is as low as 270 mV. The Li-O 2 batteries employing the bifunctional CoS/SnO 2 @C catalyst displays a high discharge specific capacity of 3332.25 mAh g −1 and long cycling life of 226 cycles. Additionally, theory calculations demonstrate that the construction of heterostructure decreases energy barrier of the rate-determining step (RDS) for both ORR and OER. Notably, SnO 2 behaves as the electronic promoter to optimize the electronic structure of heterostructure interface and triggers charge redistribution of CoS, which weakens the adsorption strength of the * O-intermediates and allows to break the linear scaling relationship, thus further enhancing the catalytic performance of CoS/SnO 2 @C. This research furnishes directions for the design of heterogeneous catalysts, highlighting its great potential for application in rechargeable Li-O 2 batteries.
研究领域:
材料科学
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电化学
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能源存储与转换
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2025
·
IF 7.2
Yanmei Cui,Yerong Huang,Jie Mi,Jiancheng Wang,Mengmeng Wu
It is unclear about H 2 O-induced effects on H 2 S-absoprion/COS-release behavior during high-temperature coal gas cleaning with Zn-based sorbents. This work aims at clarifying the aforementioned effect. The results reveal that the presence of 5–10 vol% H 2 O reduces the sulfur capacity of sorbents by 41–55%, while also decreasing the amount of released COS before H 2 S-breakthrough ( A-COS BT ) by 97%–99%. For wet coal gas desulfurization, the CO-H 2 S reaction accounts for nearly all of the COS released, while the contribution from the CO 2 -H 2 S reaction is negligible. Both Ni- and Ce-doping decrease A-COS BT of sorbents by 85%–89% and 92%–94%, respectively. Moreover, Ni-doping enhances the H 2 S-uptake capacity of sorbents by 32%–103%, which is mainly ascribed to the weakening of Zn-O bond. The performance of the Ni-Ce co-doped desulfurizer lies between those of the sorbents doped solely with Ni and Ce, respectively. Furthermore, co-doped sorbents could maintain 82%–92% of initial sulfur capacity and strong ability of inhibiting COS-formation during multiple sulfidation-regeneration cycles. It provides new insights for H 2 O-induced effects on H 2 S-absorption/COS-release behavior during hot coal gas cleaning.
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DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2022
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IF 5.364
Qiyao Yang,Qi Dai,Xiaoyan Bao,Yi Zhou,Yiying Lu,Haiqing Zhong,Linjie Wu,Yinglu Guo,Lihong Liu,Xin Tan,Yiyi Xia,Min Han,Qichun Wei
Boron neutron capture therapy (BNCT) is becoming a promising radiation treatment technique dealing with tumors due to its cellular targeting specificity. In this article, based on the biocompatible chitosan oligosaccharide (COS), we designed a boron delivery system using carborane (CB) as a boron drug with cRGD peptide modification and paclitaxel (PTX) loaded in the hydrophobic core. The nanoparticles (cRGD-COS-CB/PTX) realized the boron delivery into tumor sites with an enhanced permeability and retention (EPR) effect and an active targeting effect achieved by the cRGD–integrin interaction on the surface of tumor cells. The uniform spherical nanoparticles can be selectively taken by hepatoma cells rather than normal hepatocytes. In vivo experiments showed that the nanoparticles had a targeting effect on tumor sites in both subcutaneous and orthotopic tumor models, which was an encouraging result for radiotherapy for liver cancer. To sum up, the nanoparticles we produced proved to be promising dual-functionalized nanoparticles for radiotherapy and chemotherapy.
研究领域:
癌症研究
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纳米技术
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放射治疗
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药学
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生物医学工程
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DOI
PubMed
高影响因子
Science China-Materials
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2022
·Vol. 65
·期 12
·3479-3489
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IF 8.64
Li Xiaopeng,Zhang Hong,Wang Yang,Wang Haozhi,Wang Jiajun,Zhang Jinfeng,Qiu Liuzhe,Deng Yida,Han Xiaopeng,Hu Wenbin
Spin regulation of active sites is sparking much interest in boosting oxygen electrocatalytic performance. However, in amorphous electrocatalysts, the design principle of spin regulation to promote catalytic activity remains unclear. Herein, we synthesized a series of heteroatom-doped amorphous transition metal sulfides with regulated spin states using a one-step hydrothermal process. Especially in Mo-doped CoS, the spin state of Co 2+ was successfully modulated to the low-spin state, which could optimize the adsorption free energy of various intermediates, improving the oxygen reduction reaction kinetics. The fabricated Zn-air batteries (ZABs) delivered good cycle stability (over 100 h). The large ZAB (100 cm 2 ) exhibited a high discharge voltage (1.25 V under 0.5 A) and a superior overall mass-energy density (93 W h kg −1 ), which illuminated a 2.5-m light-emitting-diode ribbon for over seven days. This work provides new insight into the mechanism of engineering spin states in amorphous materials for oxygen electrocatalysis.
研究领域:
材料科学
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电化学
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催化
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Xiujing Yin,Song Liu,Yukun Qin,Ronge Xing,Kecheng Li,Chunlin Yu,Xiaolin Chen,Pengcheng Li
Chitooligosaccharide grafted with β-aminobutyric acid based on the idea of bioactive molecular splicing was prepared, and the differences in drought resistance activity before and after grafting were compared. The mechanism was investigated by comparing the differences of the derivative with the Control and Drought about metabolomes . The results showed that the expected derivative was successfully synthesized, named COS-BABA, and had better drought resistance-inducing activity than the raw materials. We suggest that COS-BABA induced drought resistance through second messenger-induced activation of signaling pathways related to traumatic acid and indol-3-lactic acid, which enhanced nucleic acid metabolism to accumulate nucleotides and decreased some amino acids to facilitate protein synthesis . These proteins are regulated to strengthen photosynthesis , resulting in the promotion of carbohydrate metabolism. The accumulation of unsaturated fatty acids stabilized the cell membrane structure and prevented nonstomatal water dissipation. This study provides ideas for the development of more effective drought resistance inducers.
研究领域:
植物科学
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农学
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分子生物学
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代谢组学
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DOI
PubMed
高影响因子
ACTA PHARMACOLOGICA SINICA
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2021
·Vol. 43
·期 4
·992-1000
·
IF 6.15
Wu Xiao-yan,Lv Jin-yan,Zhang Shi-qing,Yi Xin,Xu Zi-wei,Zhi Yuan-xing,Zhao Bo-xin,Pang Jian-xin,Yung Ken Kin Lam,Liu Shu-wen,Zhou Ping-zheng
Dysregulation of NLRP3 inflammasome results in uncontrolled inflammation, which participates in various chronic diseases. TWIK2 potassium channel mediates potassium efflux that has been reported to be an essential upstream mechanism for ATP-induced NLRP3 inflammasome activation. Thus, TWIK2 potassium channel could be a potential drug target for NLRP3-related inflammatory diseases. In the present study we investigated the effects of known K2P channel modulators on TWIK2 channel expressed in a heterologous system. In order to increase plasma membrane expression and thus TWIK2 currents, a mutant channel with three mutations (TWIK2 I289A/L290A/Y308A ) in the C-terminus was expressed in COS-7 cells. TWIK2 currents were assessed using whole-cell voltage-clamp recording. Among 6 known K2P channel modulators tested (DCPIB, quinine, fluoxetine, ML365, ML335, and TKDC), ML365 was the most potent TWIK2 channel blocker with an IC 50 value of 4.07 ± 1.5 μM. Furthermore, ML365 selectively inhibited TWIK2 without affecting TWIK1 or THIK1 channels. We showed that ML365 (1, 5 μM) concentration-dependently inhibited ATP-induced NLRP3 inflammasome activation in LPS-primed murine BMDMs, whereas it did not affect nigericin-induced NLRP3, or non-canonical, AIM2 and NLRC4 inflammasomes activation. Knockdown of TWIK2 significantly impaired the inhibitory effect of ML365 on ATP-induced NLRP3 inflammasome activation. Moreover, we demonstrated that pre-administration of ML365 (1, 10, 25 mg/kg, ip) dose-dependently ameliorated LPS-induced endotoxic shock in mice. In a preliminary pharmacokinetic study conducted in rats, ML365 showed good absolute oral bioavailability with F value of 22.49%. In conclusion, ML365 provides a structural reference for future design of selective TWIK2 channel inhibitors in treating related inflammatory diseases.
研究领域:
药理学
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免疫学
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炎症性疾病
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Jinxin Lan,Yao Wu,Changmei Lin,Jiazhen Chen,Ruiqi Zhu,Xiaojuan Ma,Shilin Cao
The worldwide spread of COVID-19 has put a higher requirement for personal medical protective clothing, developing protective clothing with sustained antibacterial and antiviral performance is the priority for safe and sustaining application. For this purpose, we develop a novel cellulose based material with sustained antibacterial and antiviral properties. In the proposed method, the chitosan oligosaccharide (COS) was subjected to a guanylation reaction with dicyandiamide in the presence of Scandium (III) triflate; because of the relatively lower molecular weight and water solubility of the COS, GCOS (guanylated chitosan oligosaccharide) with high substitution degree (DS) could be successfully synthetized without acid application. In this instance, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the GCOS were only 1/8 and 1/4 of that of COS. The introduction of GCOS onto the fiber endowed the fiber with extremely high antibacterial and antiviral performance, showing 100% bacteriostatic rate against Staphylococcus aureus and Escherichia coli and 99.48% virus load reduction of bacteriophage MS2. More importantly, the GCOS modified cellulosic fibers (GCOS-CFs) exhibit excellent sustained antibacterial and antiviral properties; namely, 30 washing cycles had negligible effect on the bacteriostatic rate (100%) and inhibition rate of bacteriophage MS2 (99.0%). Moreover, the paper prepared from the GCOS-CFs still exhibited prominent antibacterial and antiviral activity; inferring that the sheeting forming, press, and drying process have almost no effect on the antibacterial and antiviral performances. The insensitive of antibacterial and antiviral activity to water washing (spunlace) and heat (drying) make the GCOS-CFs a potential material applicable in the spunlaced non-woven fabric production.
研究领域:
材料科学
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生物技术
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纺织工程
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微生物学
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产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2024
·
IF 7.2
Xiuhong Huang,Liqin Zheng,Pengfei Li,Ziling Lin,Shaohong Huang,Changren Zhou
Bone defects have been a tough clinical challenge. The natural trabecular tissue reflects a balance between the minimal metabolic cost of maintenance and maximal network stability, with mitochondria being the energy suppliers for osteogenesis. Herein, a 3D printed trabecular bone-templated scaffold composed of polylactide (PLA) modified with europium (III)-organic ligands (polydopamine and chitooligosaccharide, PDA/COS@Eu) was fabricated (denoted as Tra-PLA/PDA/COS@Eu) to augment bone repair by facilitating mitochondrial function. First, the trabecular bone templated-scaffold provides superior mechanical performance and permeability in contrast to a computer aided designed (CAD) scaffold under a same volume fraction. Tra-PLA/PDA/COS@Eu scaffold up regulated PI3K/AKT/S6K/HIF-1α pathway and significantly promoted BMSCs proliferation and osteogenic differentiation. In addition, Tra-PLA/PDA/COS@Eu scaffold provided anti-inflammatory environment by promoting macrophages M2 polarization through COS, and significantly stimulated BMSCs osteogenesis with enhanced mitochondrial function and biosynthesis. Remarkably, Eu ions are the key ingredient in enhancing mitochondrial function and biosynthesis in BMSCs. Further studies showed that the above-mentioned facilitations in a rabbit bone defect model were found to be more significant with trabecular bone-templated scaffolds, as opposed to CAD scaffolds. In summary, this novel trabecular bone-templated scaffold targeting mitochondrial function has the potential to become an effective method in the treatment of large bone defects.
研究领域:
生物材料
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组织工程
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生物医学工程
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再生医学
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材料科学
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产品关联
DOI
高影响因子
ACS Pharmacology & Translational Science
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2024
·
IF 4.9
Quan Wang,Xinyue Liu,Han Yuan,Fengcai Zhang,Jiafei Wu,Dongjing Yang,Jiang Qian,Yi-You Huang,Guihong Chai,Hai-Bin Luo,Lei Guo
Idiopathic pulmonary fibrosis (IPF) is a debilitating, incurable, and life-threatening disease that lacks effective therapy. The overexpression of phosphodiesterase 10A (PDE10A) plays a vital role in pulmonary fibrosis (PF). However, the impact of selective PDE10A inhibitors on the tumor growth factor-β (TGF-β)/small mother against decapentaplegic (Smad) signaling pathway remains unclear. Herein, we have exploited a novel carbonyl sulfide (COS)/hydrogen sulfide (H2S)-donor hybrid PDE10A inhibitor called COS-2080 with a well-defined mechanism of H2S-releasing action. It exhibited highly potent inhibitory activity against PDE10A and excellent PDE subfamily selectivity. Moreover, COS-2080 demonstrated significant antifibrotic effects by inhibiting cell proliferation and mitigating fibroblast-to-myofibroblast transition (FMT). A dry powder inhalation formulation called COS-2080-DPI has been developed using the ultrasonic spray freeze drying (USFD) technique, demonstrating significant antifibrotic efficacy in mice with bleomycin-induced PF at a dosage approximately 600 times lower than pirfenidone. This remarkable antifibrotic efficacy of COS-2080 on TGF-β1-induced FMT could be primarily attributed to its inhibition of the Smad2/Smad3 phosphorylation. Moreover, COS-2080 effectively attenuated fibrosis in MRC-5 cells by activating the cAMP/protein kinase A (PKA)/CREB pathway and potentially increasing levels of p53 protein. Our findings suggest that effective inhibition of PDE10A potentially confers a protective effect on FMT in PF by impeding TGF-β signaling and activating the cAMP/PKA/CREB/p53 axis.
研究领域:
肺病学
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药理学
·
分子生物学
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DOI
PubMed
高影响因子
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