RSC Advances
·
2014
·Vol. 4
·期 106
·61948-61959
·
IF 3.708
Manhong Tan,Jia Luo,Ying Tian
As gemcitabine and curcumin have different targets in colon cancer cells, combination of them may bring benefits. Here, curcumin and gemcitabine were formulated into a biodegradable polymer platform for combination therapy for treatment of colon cancer. In doing so, a FDA approved biodegradable polymer mPEG-PLA (methoxyl-polyethylen glycol-block-polylactide) was chosen as a drug carrier. At first, a mPEG-PLA/Gem conjugate was designed. Thereafter, simply using this drug conjugate to encapsulate curcumin, polymeric micelles loaded with both curcumin and gemcitabine were obtained. Varying the feed ratio of the two drugs, a series of micelles with different ratios of curcumin and gemcitabine could be prepared. The as-prepared dual drug loaded nanoparticles showed spherical structures with mean diameters ranging from 118 nm to 149 nm by DLS. In vitro, M(Cur/Gem) almost showed greater synergy than free combination of curcumin/gemcitabine. In vivo, better antitumor effect and lower systemic toxicity of M(Cur/Gem) were observed on a murine xenograft model. The present study provides the possibility of combining curcumin and gemcitabine in a nanoparticle formulation, and translation of this combination may bring benefits for future clinical use.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2017
·Vol. 7
·期 1
·1-25
·
IF 4.259
Pignanelli Christopher,Ma Dennis,Noel Megan,Ropat Jesse,Mansour Fadi,Curran Colin,Pupulin Simon,Larocque Kristen,Wu Jianzhang,Liang Guang,Wang Yi,Pandey Siyaram
Recently, research has focused on targeting the oxidative and metabolic vulnerabilities in cancer cells. Natural compounds like curcumin that target such susceptibilities have failed further clinical advancements due to the poor stability and bioavailability as well as the need of high effective doses. We have synthesized and evaluated the anti-cancer activity of several monocarbonyl analogs of curcumin. Interestingly, two novel analogs (Compound A and I) in comparison to curcumin, have increased chemical stability and have greater anti-cancer activity in a variety of human cancer cells, including triple-negative, inflammatory breast cancer cells. In particular, the generation of reactive oxygen species was selective to cancer cells and occurred upstream of mitochondrial collapse and execution of apoptosis. Furthermore, Compound A in combination with another cancer-selective/pro-oxidant, piperlongumine, caused an enhanced anti-cancer effect. Most importantly, Compound A was well tolerated by mice and was effective in inhibiting the growth of human triple-negative breast cancer and leukemia xenografts in vivo when administered intraperitoneally. Thus, exploiting oxidative vulnerabilities in cancer cells could be a selective and efficacious means to eradicate malignant cells as demonstrated by the curcumin analogs presented in this report with high therapeutic potential.
研究领域:
肿瘤学
·
药理学
·
化学生物学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jingfei Wang,Ying Ma,Qingye Meng,Yongyan Yang,Ruiting Zhang,Shuangling Zhong,Yan Gao,Wenqi He,Xuejun Cui
Skin could protect our body and regenerate itself to against dysfunctional and disfiguring scars when faced with external injury. As wound dressings, hydrogels are biocompatible, hydrophilic and have a 3D structure similar to the extracellular matrix (ECM). In particular, hydrogels with drug-releasing capabilities are in acute wound healing. In this paper, photocrosslinked hydrogels served as wound dressing based on sodium carboxymethylcellulose (CMC) were prepared to promote wound healing. Photocrosslinked hydrogels were prepared by grafting lysine and allyl glycidyl ether (AGE) onto CMC and encapsulating curcumin (Cur). The synthesized hydrogels had the unique 3D porous structure with a swelling ratio up to 1300 % in aqueous solution. The drug release ratios of the hydrogels were 20.8 % in acid environment, and 14.4 % in alkaline environment. Notably, the hydrogels showed good biocompatibility and antibacterial properties and also exhibited the ability to accelerate the process of skin wound healing while prevent inflammation and scar formation when applied to a mouse skin wound model. As a result, the prepared hydrogels Gel-CLA@Cur showed great potential in wound healing.
研究领域:
材料科学
·
药学
·
生物医学工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Longjiang Tian,Xinran You,Jingbo Liu,Yajuan Li,Shanglin Li,Xuemin Jin,Shugang Li,Fei Pan,Zhipeng Yu,Ting Zhang,Zhiyang Du
The fusion assembly strategy of supramolecular chemistry combined with dynamic covalent chemistry has provided novel insights into the design of precision nutrition and intelligent drug delivery carriers. This work involved the development of a supramolecular self-assembly originating from entropy- and enthalpy-driven dynamic covalent bonding on Schiff bases between egg white-derived peptide Gln-Ile-Gly-Leu-Phe (QIGLF) and glutaraldehyde (GA), denoted QIGLF–GA. The assembly exhibited outstanding assembly characteristics and multiwavelength autofluorescence properties. Benefiting from the potent facilitation of the dynamic covalent interaction of Schiff base on the noncovalent assembly force network, QIGLF–GA was afforded an encapsulation capacity of curcumin (Cur) of more than 22% (≫ 10%) and rationally inhibited P-glycoprotein-mediated cellular efflux and markedly elevated the efficacy of Cur in overcoming the intestinal epithelial absorption barrier to the circulation with the help of endocytosis. Furthermore, QIGLF–GA-Cur features responsive release under weakly acidic conditions, which dramatically contributes to the intracellular bioavailability of Cur.
研究领域:
营养学
·
药物递送
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生物化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Yue Chen,Shengqi Li,Na Zhang,Ke Zhang,Xiaoqiang Chen
Oleogels have significant potential for delivering lipid-soluble bioactive compounds. We here prepared a tea polysaccharide conjugate (TPC)-Xanthan gum (XG) complex using the emulsion template method and investigated its curcumin (Cur) loading capacity and in vitro digestion mechanisms. Results unveiled that XG interacts non-covalently with TPC, primarily through electrostatic interactions and hydrogen bonding, enhancing emulsion template formation and stabilization. In addition, XG improved the oleogel’s oil-binding capacity, gel strength, hardness, apparent viscosity, and other gel properties. Meanwhile, the complex oleogel-loaded Cur exhibited a high Cur encapsulation efficiency (>80%), increased antioxidant activity, an augmented free fatty acid release rate, and improved Cur bioaccessibility (>50%) and digestive stability. These findings provide a novel approach to designing oleogels for the effective delivery of lipid-soluble bioactive compounds.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
BMC Oral Health
·
2024
·Vol. 24
·期 1
·1-11
·
IF 2.6
Liu Chengcheng,Chen Ying,Bai Huimin,Niu Yulong,Wu Yafei
Background Periodontitis is a chronic inflammatory disease that occurs in tooth-supporting tissues. Controlling inflammation and alleviating periodontal tissue destruction are key factors in periodontal therapy. This study aimed to develop an in situ curcumin/zinc oxide (Cur/ZNP) hydrogel and investigate its characteristics and effectiveness in the treatment of periodontitis. Methods Antibacterial activity and cytotoxicity assays were performed in vitro. To evaluate the effect of the in situ Cur/ZNP hydrogel on periodontitis in vivo, an experimental periodontitis model was established in Sprague‒Dawley rats via silk ligature and inoculation of the maxillary first molar with Porphyromonas gingivalis . After one month of in situ treatment with the hydrogel, we examined the transcriptional responses of the gingiva to the Cur/ZNP hydrogel treatment and detected the alveolar bone level as well as the expression of osteocalcin (OCN) and osteoprotegerin (OPG) in the periodontal tissues of the rats. Results Cur/ZNPs had synergistic inhibitory effects on P. gingivalis and good biocompatibility. RNA sequencing of the gingiva showed that immune effector process-related genes were significantly induced by experimental periodontitis. Carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1), which is involved in the negative regulation of bone resorption, was differentially regulated by the Cur/ZNP hydrogel but not by the Cur hydrogel or ZNP hydrogel. The Cur/ZNP hydrogel also had a stronger protective effect on alveolar bone resorption than both the Cur hydrogel and the ZNP hydrogel. Conclusion The Cur/ZNP hydrogel effectively inhibited periodontal pathogenic bacteria and alleviated alveolar bone destruction while exhibiting favorable biocompatibility.
研究领域:
牙科学
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药理学
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材料科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Menghe Li,Qunjie Chen,Ru Yang,Yifei Wang,Qiuying Liu,Chaoxi Wu
Curdlan possesses intrinsic macrophage-binding ability, making it a promising platform for targeted drug delivery. However, constructing curdlan–drug complexes with well-defined structures and predictable biological functions remains challenging due to difficulties in controlling curdlan conformations. In this study, we developed a self-assembling nanogel system composed of low-molecular-weight curdlan (LCD) and curcumin. Molecular dynamics simulations and circular dichroism analyses revealed two interaction modes—curcumin bound to the triple-helix surface and encapsulated within the single-helix core—which together drive the spontaneous formation of stable LCD–curcumin nanogels. FTIR, DSC, SEM, and DLS characterizations confirmed their structural integrity and preserved helical organization. Cell-based evaluations showed that the nanogels mitigated curcumin cytotoxicity, enhanced its anti-inflammatory activity, and promoted uptake by RAW264.7 macrophages. Studies in a mouse model of ulcerative colitis demonstrated improved curcumin bioavailability, stronger therapeutic effects, and good systemic safety. Overall, these results indicate that LCD–curcumin nanogels possess controlled helical structures and potent anti-inflammatory properties, highlighting their potential as an effective nanomedicine for inflammatory disorders.
研究领域:
纳米医学
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药物递送
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生物材料
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炎症性疾病
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高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Li Jia,Pang Guobao,Liu Lizhen,Zhang Liwei,Wu Lihua,Xu Yannan
Radiation skin injury (RSI) is a common side effect of radiation therapy for cancer patients, and bacterial infection at the RSI site usually hinders the healing process of the radiation skin injury, thus affecting the subsequent treatment regimen of the patient. To address this issue, we developed a dual network hydrogel containing the natural phenolic antioxidant curcumin. The hydrogel possesses good mechanical and swelling properties to effectively isolate radioactive skin wounds from the external environment, while curcumin released from the hydrogel can effectively inhibit bacterial infections in RSI. In addition, curcumin is able to regulate intracellular redox balance by affecting GSH transferase homologs in cell membranes, thereby reducing the inflammatory response at the wound site. The synergistic effect of antibacterial/anti-inflammatory action produced by the hydrogel effectively accelerates the rate of healing of RSI, providing valuable insights into the clinical management of radiation dermatitis.
✓ 已验证
产品关联
DOI
高影响因子
Aquaculture Reports
·
2025
·
IF 3.7
Jing Ni,Mao Lin,Ruifang Wang,Ying Ma,Hejian Xiong
Curcumin (Cur) is a polyphenolic compound with pharmacological properties, including anti-inflammatory, antioxidant, and anticancer activities. However, its low solubility and poor stability limit its absorption in vivo. Our laboratory previously synthesized a highly water-soluble valine-curcumin (Val-Cur), increasing its solubility by approximately 9000 times. In this study, based on the evaluation of the antibacterial ability of Val-Cur against three common aquatic pathogens ( Aeromonas hydrophila , Edwardsiella tarda , and Aeromonas veronii ), Val-Cur was added to the feed of juvenile largemouth bass, and for the first time, HPLC was used for Val-Cur detection in vivo; additionally, its pharmacokinetics and effects on disease resistance in fish were investigated. Following a single oral dose (10 mg/kg) of Cur or Val-Cur to largemouth bass, the drug concentration in blood exceeded that in the liver and muscle within 48 h. Compared with Cur, Val-Cur exhibited a delayed peak time in blood, a higher peak concentration (C max = 4.404 μg/mL), a 149 % increase in retention time, and a total drug clearance of 0.005 L·(h·kg) −1 (a 20.4-fold decrease). In the liver and muscle, Val-Cur showed a peak concentration (C max ) 9–10 times higher than Cur, with a 74 %-103 % increase in retention duration and a 15- to 16-fold decrease in clearance. Fecal analysis revealed that Cur excretion was more than five times that of Val-Cur excretion. Compared to those that fed the basal diet (CK) or the diet supplemented with 60 mg/kg curcumin (Cur), the survival rate of largemouth bass infected with Aeromonas hydrophila was significantly higher in the group that fed a diet supplemented with 60 mg/kg Val-Cur. Additionally, the Val-Cur-supplemented diet better preserved the integrity of the intestinal tissue structure. This study provides a valuable theoretical foundation for elucidating the mechanisms of Val-Cur and supports the application of water-soluble curcumin in aquaculture.
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Wenlan Wu,Mengyi Zhang,Yang Lin,Xuening Li,Ying Liang,Ju Liang
Despite the development of numerous prodrugs for tumor therapy, their clinical application remains limited due to issues such as non-targeted delivery, uncontrolled release, and excessively rapid drug release rates. In this study, we synthesized a dual-functional prodrug, glycyrrhizic acid-polyethylene glycol-disulfide curcumin (GA-PEG-SS-CUR), by conjugating glycyrrhizic acid (GA), which possesses liver-targeting capabilities, with the anticancer agent curcumin (CUR). GA-PEG-SS-CUR can self-assemble in aqueous solutions to form micelles with an approximate diameter of ∼140 nm. In vitro drug release studies demonstrated that GA-PEG-SS-CUR exhibits a sensitive glutathione (GSH) response and sustained release characteristics; after 72 hours, the drug release rate was 30.5% at low GSH concentrations and 46.7% at high GSH concentrations. Due to GA receptor-mediated targeting, the uptake of GA-PEG-SS-CUR in HepG2 cells was significantly higher than that in L02 cells, and the internalization of GA-PEG-SS-CUR in HepG2 cells was markedly greater compared to unmodified PEG-SS-CUR. Cytotoxicity assays indicated that GA-PEG-SS-CUR enhanced the cytotoxicity against tumor cells compared to free CUR, while exhibiting lower toxicity towards normal L02 cells. Pharmacokinetic studies revealed that the half-life of CUR in GA-PEG-SS-CUR was 8.3 times longer than that of free CUR, extending the in vivo circulation time, with CUR accumulation at the tumor site being 6 times greater than that of free CUR, indicating significant tumor-homing ability. Therefore, the developed GA-PEG-SS-CUR represents an ideal delivery system for curcumin in tumor therapy.
研究领域:
药学
·
生物化学
·
肿瘤学
·
纳米技术
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Rui Tian,Chaoyuan Zheng,Xingxiang Ji,Srinivas Janaswamy,Guihua Yang,Gaojin Lyu
Degradable regenerated cellulose (RC) composite films have prospects to replace plastic packaging. However, limitations such as lack of functionality, poor mechanical properties, inherent color, and the absence of antibacterial activity restrict their practical application. Herein, butyric anhydride esterified alkali lignin (BAL) encapsulated curcumin micro-nanoparticles were synthesized to develop high-antibacterial composite films. Uniform dispersion of the B-CMPs within the cellulose matrix is critical for enhancing the film's properties. Furthermore, the esterified lignin contributes to the photodynamic bactericidal properties of curcumin by reducing the light absorption of lignin's native chromophoric groups. Results suggest that in the presence of B-CMPs, the RC composite film exhibits a high visible light transmittance of 80.4 % and a tensile strength of 68 MPa. Under blue light excitation, an inhibition rate of 91 % and 92 % against Escherichia coli and Staphylococcus aureus , respectively, was obtained. In addition, the composite films exhibited improved barrier properties with water vapor permeability of 1.12 × 10 −12 g·cm·cm −2 ·s −1 ·Pa −1 and enhanced hydrophobicity (contact angle 82.3° vs. 46.2° for pure RC). These findings demonstrate that reducing reactive groups in lignin via esterification significantly enhances the functional integration of curcumin, yielding composite films with a superior balance of properties. This work offers novel insights into the high-value utilization of lignin toward developing packaging films to meet the growing demand for sustainable packaging materials.
研究领域:
生物材料
·
包装材料
·
纳米技术
·
光动力疗法
·
可持续材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Wenhui Chen,Huan Deng,Yuehan Dong,Xiangjie Wu,Zinuo Xia,Yang Zhou,Lin Yang,Zhijun Huang,Wenjin Xu,Peihu Xu,Haixing Xu
Osteochondral injuries, which could result in cartilage defects and damage to the subchondral bone, pose a significant challenge in the design of scaffolds for bone repair due to the different characteristics of bone and cartilage. In this study, we developed a double-network bilayer hydrogel scaffold composed of an upper layer and a lower layer reinforced with a ZnO nanoparticle. The double-network hydrogel consisted of carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA), and poly(vinyl alcohol) (PVA) networks. The upper and lower layers were, respectively, loaded with puerarin (Pue) and curcumin (Cur) to facilitate simultaneous repair of cartilage and bone. The scaffold exhibited better water absorption, mechanical properties (tensile strength: 0.8 MPa), self-healing capacity (healing efficiency ≥ 90%), and adhesion (adhesive stress: 0.1 MPa). Approximately 70% of Pue was rapidly released within the first 5 days, while Cur, encapsulated in ZnO, exhibited sustained release over a period of 20 d. In vitro cell experiments revealed that soluble extracts from the scaffolds were noncytotoxic and promoted elevated alkaline phosphatase (ALP) expression and calcium deposition in MC3T3-E1 subclone 14 (MC3T3-14) cells, thereby enhancing bone repair. Meanwhile, extracts fostered the proliferation of ATDC5 cells and glycosaminoglycan (GAG) production, contributing to cartilage repair. In conclusion, the bilayer hydrogel has good properties and is beneficial for the proliferation and differentiation of osteoblasts and chondrocytes.
研究领域:
生物材料学
·
组织工程
·
再生医学
·
骨科学
·
药剂学
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纳米医学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）