PeerJ
·
2019
·
IF 2.353
Weilong Zhang,Yang Wu,Jin Wang,Juan Liu,Haifeng Lu,Shuijing Zhai,Qiaohui Zhong,Siyu Liu,Wanying Zhong,Chunling Huang,Xiaoxiang Yu,Wenhui Zhang,Yongheng Chen
Rutile nano-titanium dioxide (RNTD) characterized by loose particles with diameter in 20–50 nm has a very large surface area for adsorption of Tl, a typical trace metal that has severe toxicity. The increasing application of RNTD and widespread discharge of Tl-bearing effluents from various industrial activities would increase the risk of their co-exposure in aquatic environments. The adsorption behavior of Tl(I) (a prevalent form of Tl in nature) on RNTD was studied as a function of solution pH, temperature, and ion strength. Adsorption isotherms, kinetics, and thermodynamics for Tl(I) were also investigated. The adsorption of Tl(I) on RNTD started at very low pH values and increased abruptly, then maintained at high level with increasing pH >9. Uptake of Tl(I) was very fast on RNTD in the first 15 min then slowed down. The adsorption of Tl(I) on RNTD was an exothermic process; and the adsorption isotherm of Tl(I) followed the Langmuir model, with the maximum adsorption amount of 51.2 mg/g at room temperature. The kinetics of Tl adsorption can be described by a pseudo-second-order equation. FT-IR spectroscopy revealed that -OH and -TiOO-H play an important role in the adsorption. All these results indicate that RNTD has a fast adsorption rate and excellent adsorption amount for Tl(I), which can thus alter the transport, bioavailability and fate of Tl(I) in aqueous environment.
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高影响因子
POLYMER
·
2019
·
IF 3.771
Yao Liu,Hao Peng,Pingping Wu,Huaizhi Liu,Jiuyang Zhang
Emissive organometallic polymers integrated with the properties of conventional polymers have attracted increasing attention from researchers. Copper (I)-thioether (Cu(I)-thioether) complexes of small molecule has been extensively reported, which is in sharply contrast with much less investigated Cu(I)-thioether polymers. In this work, Cu(I)-thioether coordination structure has been successfully combined with polymer ligands to form emissive polymer networks . The resulted hybrid networks overcame many challenges in the Cu(I)-thioether small compounds. The as-prepared Cu(I)-thioether networks exhibited much improved thermal stability (degradation temperature: 220 °C) compared with Cu(I)-thioether molecular clusters. Besides, the Cu(I)-thioether networks can be processed into uniform free-standing film with excellent stretchability (breaking strain up to 200%) which cannot be realized in the Cu(I)-thioether small molecular system. Finally, the luminescent property of copper-thiother was inherited in the polymer networks and emissive polymer films with good transparency, excellent thermal stability and high stretchability. Interestingly, the dynamic coordination between thioether and copper (I) enabled the self-healing ability of the polymer films. The damaged emissive and stretchable films were able to be autonomous self-healed under ambient conditions. This work sheds lights on the design and fabrication of Cu(I)-thioether materials for advanced applications.
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ANALYST
·
2019
·Vol. 145
·期 3
·873-879
·
IF 4.019
Minghan Wang,Junjie Liu,Xiaoli Qin,Xin Nie,Yifan Dong,Xu Liang,Zhiwei Zhu,Di Yang,Yuanhua Shao
In this work, an Au–Ag alloy nanourchin (Au–Ag alloy NU) based electrochemiluminescent (ECL) sensor for the measurement of cardiac troponin I (cTnI) was developed. The as-prepared Au–Ag alloy NUs exhibited higher specific surface area and better conductivity owing to their unique urchin-like morphology, which resulted in excellent electrocatalytic activity towards H2O2 in the luminol–H2O2 ECL system. We have found that the Au–Ag alloy NUs could enhance the ECL signal in the luminol–H2O2 solution. Based on these facts, a facile and label-free ECL immunosensor has been constructed for the analysis of cTnI, a cardiac biomarker, with a wide linear range of 3.5 pg mL−1–350 μg mL−1. This novel ECL immunosensor has good stability and reproducibility, showing potential application in clinical diagnostics. In addition, a non-enzymatic electrochemical sensor for H2O2 was also fabricated, with a wide linear detection range of 100 nM–200 μM, a low limit of detection of 45 nM and a fast response time (less than 2 s).
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高影响因子
PROCESS BIOCHEMISTRY
·
2018
·
IF 2.616
Junjie Wu,Dewei Xie,Xujun Chen,Ya-Jie Tang,Lixin Wang,Jingli Xie,Dongzhi Wei
The inhibitory mechanism during the reaction between peptides from Phascolosoma esculenta and angiotensin I converting enzyme (ACE) was studied. Thermodynamics features of the peptide-ACE binding reaction measured by isothermal titration calorimetry (ITC) assay, combining with the decrease of ACE inhibition within 24 h implied that Gly-Asn-Gly-Ser-Gly-Tyr-Val-Ser-Arg decomposed during the reaction and played as a substrate-type inhibitor. The hydrolysate Gly-Asn-Gly-Ser-Gly-Tyr-Val (GNGSGYV) without ACE inhibitory activity was identified by UPLC & Q-TOF MS, while the hydrolysate Ser-Arg (SR) showed competitive inhibition of ACE with IC 50 value of 790 μM. However, GNGSGYV and SR have synergistic effect on ACE and result in an ACE inhibitory IC 50 value of 170 μM. The synergistic mechanism illustrated by two-step molecular docking discovered that SR firstly attacked the catalytic Zn of ACE and formed coordinate bond, and then GNGSGYV bound with the arginine of SR and residues along the channel of ACE active site by hydrogen bonds to block the substrate from entering. The circular dichroism spectra also verified that SR and GNGSGYV significantly changed the secondary structure of ACE.
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高影响因子
GLYCOCONJUGATE JOURNAL
·
2016
·Vol. 34
·期 1
·3-12
·
IF 1.828
Wang Dongdong,DanXu,Sun Yuelin,Wu Yuanyuan,Ma Lili,Duan Jinyou
In this study, we synthesized a novel water-soluble low molecular chitosan (LMC) derivative through Vilsmeier reaction and reductive amination reaction. The derivative was characterized by UV-visible spectroscopy, 1 H NMR, FTIR and SEM techniques. The results showed that the derivative effectively reduced the cell viability rate, inhibited cell metastasis, induced cell apoptosis and dissipated mitochondrial membrane potential (ΔΨm). Moreover, the antitumor activity was strengthened with the increase of the degree of substitution of tanshinone I (TanI). These findings provided important support for developing new water-soluble antitumor agent and expand the scope of application of LMC.
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高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Xionghua Sun,Xuelei Wan,Li Chen,Yadong Cui,Xihua Chen,Jian Zhang,Xiaogang Jiang
The senescence of alveolar epithelial cells is one of the characteristics of mitomycin pulmonary toxicity, but the direct target of mitomycin-induced alveolar epithelial cell senescence remains unclear. In this study, a method of small-molecule ligand–protein interaction by pulldown/mass spectrometry identified peroxiredoxin I (Prdx I) as the target of mitomycin-induced alveolar epithelial cell senescence, and mitomycin was shown to significantly inhibit the peroxidase activity of Prdx I. Consequently, the levels of cellular reactive oxygen species (ROS) increased, leading to the activation of mitogen-activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal-regulated protein kinases 1/2 (ERK 1/2) and, accordingly, to the increased expression of p53. Both a Prdx I activator and Prdx I overexpression alleviated mitomycin-induced alveolar cell senescence. A ROS scavenger inhibited MEK1/2-ERK1/2-p53 activation and then attenuated the senescence of alveolar epithelial cells triggered by mitomycin. Thus, Prdx I can serve as the first target of mitomycin-induced alveolar epithelial cell senescence, which might represent a promising approach to reduce mitomycin-induced lung toxicity.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Hongfei Wang,Chao Li,Tie Geng,Na Du,Wanguo Hou
Layered double hydroxides (LDHs) are one type of potential emulsifiers for Pickering emulsions. Surface modification can regulate their surface properties, thereby affecting their emulsifying behavior. However, there is still a lack of full understanding of the impact of surface modification on their surface properties. In the current work, one Mg 3 Al-Cl LDH was modified using oleic acid (OA), obtaining six OA-modified products with different OA loadings. Their contact angles and relative dielectric constants were determined, and their surface properties including the interfacial free energies ( γ ) and solubility parameters ( δ ) were then estimated from the data. Their apparent molar volumes were estimated using the γ and δ data. OA molecules are coated on the LDH surface via the bidentate bonding mode to form monolayers. The OA modification has no obvious impact on the structure and morphology of LDH particles, but can significantly affect their surface properties. This work provides a better understanding of the dependence of surface properties of LDHs on the surface modification.
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Small Methods
·
2024
·Vol. 8
·期 12
·2400143
·
IF 10.7
Shouying Mu,Ye He,YueLi Wang,Wei Chen,Chunyan Lv,Xiaojuan Liang,Weidong Xiang,Zhaopin Chen
Perovskite quantum dots can form various forms such as nanowires, nanorods, and nanosheets through self-assembly. Nanoscale self-assembly can be used to fabricate materials with excellent device properties. This study introduces AuBr 3 into CsPb(Br/I) 3 quantum dots, causing them to assemble into nanowires. The nanowires form because part of Au 3+ is surface-doped to replace Pb 2+ , and the [PbX6] 4− octahedral structure is distorted. The symmetry of the structural surface is broken, and a dipole-moment-induced field is generated, thus promoting self-assembly. Moreover, the presence of Au nanoparticles (NPs) causes a localized surface plasmon resonance and generates strong van der Waals forces that promote self-assembly. Finally, to test other applications of perovskite nanowires, the solution method is used to prepare films by compounding the sample solution and polystyrene (PS) for backlighted displays.
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ACS Applied Materials & Interfaces
·
2012
·
IF 4.525
Jinxing Yu,Na Xu,Zhengping Liu,Liyuan Wang
Maleopimaric acid, cycloaddition reaction product of rosin with maleic anhydride, was reacted with hydroxylamine to afford N-hydroxy maleopimarimide, which was then further esterified with 2-diazo-1-naphthoquinone-4-sulfonyl chloride (2,1,4-DNQ-Cl) to give N-hydroxy maleopimarimide sulfonate. The carboxylic acid group of the compound was then protected by the reaction of this compound with vinyl ether compounds to give the corresponding molecular glass compounds. Upon irradiation to 365 nm light, the 2,1,4-DNQ group undergo photolysis not only to be converted into indene carboxylic acid but also generate a few amount of sulfonic acid which can catalyze the deprotection of the acid labile group. So, novel one-component positive-tone chemically amplified i-line photoresists can be formed by the molecular glass compounds. The lithographic performance of the resists was evaluated using i-line exposure system with high photosensitivity and resolution.
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MOLECULAR CELL
·
2019
·
IF 14.548
Peng Wu,Tongtong Zhang,Baoyu Liu,Panyu Fei,Lei Cui,Rui Qin,Huaying Zhu,Danmei Yao,Ryan J. Martinez,Wei Hu,Chenyi An,Yong Zhang,Junwei Liu,Jiawei Shi,Juan Fan,Weiwei Yin,Jie Sun,Chun Zhou,Xun Zeng,Chenqi Xu,Jianan Wang,Brian D. Evavold,Cheng Zhu,Wei Chen,Jizhong Lou
Summary TCRs recognize cognate pMHCs to initiate T cell signaling and adaptive immunity. Mechanical force strengthens TCR-pMHC interactions to elicit agonist-specific catch bonds to trigger TCR signaling, but the underlying dynamic structural mechanism is unclear. We combined steered molecular dynamics (SMD) simulation, single-molecule biophysical approaches, and functional assays to collectively demonstrate that mechanical force induces conformational changes in pMHCs to enhance pre-existing contacts and activates new interactions at the TCR-pMHC binding interface to resist bond dissociation under force, resulting in TCR-pMHC catch bonds and T cell activation. Intriguingly, cancer-associated somatic mutations in HLA-A2 that may restrict these conformational changes suppressed TCR-pMHC catch bonds. Structural analysis also indicated that HLA polymorphism might alter the equilibrium of these conformational changes. Our findings not only reveal critical roles of force-induced conformational changes in pMHCs for activating TCR-pMHC catch bonds but also have implications for T cell-based immunotherapy.
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高影响因子
Marine Drugs
·
2020
·Vol. 18
·期 11
·526
·
IF 4.073
Bihong Hong,Jianlin He,Chaochun Fan,Chao Tang,Qingqing Le,Kaikai Bai,Siwen Niu,Meitian Xiao
In recent years, a large number of pharmacologically active compounds containing a butenolide functional group have been isolated from secondary metabolites of marine microorganisms. Butyrolactone I was found to be produced byAspergillus terreusisolated from several marine-derived samples. The hypoglycemic activity of butyrolactone I has aroused our great interest. In this study, we synthesized six racemic butenolide derivatives (namely BL-1–BL-6) by modifying the C-4 side chain of butyrolactone I. Among them, BL-3 and BL-5 improved the insulin resistance of HepG2 cells and did not affect the proliferation of RIN-m5f cell line, which indicated the efficacy and safety of BL-3 and BL-5. Furthermore, BL-3, BL-4, BL-5, and BL-6 displayed a significant protein tyrosine phosphatase 1B (PTP1B) inhibitory effect, while the enantiomers of BL-3 displayed different 50% percentage inhibition concentration (IC50) values against PTP1B. The results of molecular docking simulation of the BLs and PTP1B explained the differences of biological consequences observed between the enantiomers of BL-3, which supported BLs as PTP1B inhibitors, and also indicated that the chirality of C-4 might influence the inhibitory effect of the BLs. Our findings provide a novel strategy for the development of butyrolactone derivatives as potential PTP1B inhibitors for the treatment of type 2 diabetes mellitus.Keywords:butenolide;insulin resistance;secondary metabolites;chirality
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Adeel Abbas,Zhuoming Xu,Mohammad Nisar,Delong Li,Fu Li,Zhuanghao Zheng,Guangxing Liang,Ping Fan,Yue-Xing Chen
SnSe is a very strong anisotropic material; sometimes, strong anisotropy is unenviable for producing parts of thermoelectric (TE) devices. In order to study the efficient preparation of high-performance n-type polycrystalline SnSe with weak anisotropy, in this work, we combine mechanical alloying at 450 RPM for 10 h and spark plasma sintering at 773 K under 50 MPa pressure for the preparation of polycrystalline SnSe 0.95- x I x ( x = 0,0.01,0.02,0.03) samples, and investigate the TE properties. The prepared samples show very weak anisotropy. With iodine doping, increased carrier concentration is observed, in agreement with DFT calculations. A peak ZT ≈ 1.02 at 723 K is observed with I-doping of x = 0.02, which is about 225% higher than that of undoped sample with ZT ≈ 0.31 at 723 K in parallel direction, mainly attributed to the enhanced power factor and about 56% reduced thermal conductivity from 0.68 Wm −1 K −1 to 0.30 Wm −1 K −1 . TE properties in both directions are not much different, and the ratios of electrical and thermal conductivities in both directions are very close to unity.
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危险品化学品经营许可证（带存储）