RSC Advances
·
2015
·Vol. 5
·期 30
·23181-23188
·
IF 3.84
Wenxiu Li,Hua Dong,Guannan Tang,Ting Ma,Xiaodong Cao
Janus and microcapsule particles are very attractive for drug delivery applications due to their capability of targeted and/or programmed drug release. In this paper, a facile yet robust strategy is reported for the first time to fabricate both Janus and microcapsule particles in a simple microfluidic device via the same protocol. According to the classic spreading and partial wetting theory, the key point to fabricate Janus and microcapsule particles in single emulsions is that the two immiscible components should undergo a precisely controlled phase separation, i.e., dewetting for Janus particles and wetting for microcapsule particles. Herein we show that this requirement can be satisfied simply by a subtle choice of organic solvents for the dispersed phase. As a model hybrid material, PLGA/PCL Janus and microcapsule particles are obtained via switching the organic solvent between dimethyl carbonate and dichloromethane. ATR-FTIR spectra and acetone treatment demonstrate that PLGA and PCL occupy their own hemisphere in the Janus particles. In contrast, the shell on the microcapsule particle surface is composed of only PLGA, and the core is composed of PCL in which tiny PLGA beads are embedded. The applications of PLGA/PCL Janus and microcapsule particles in drug delivery are characterized via an in vitro degradation test. The results prove that Janus and microcapsule particles exhibit distinct degradation behaviors, implying their capability of programmable drug delivery in different manners.
研究领域:
生物医学工程
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制药科学
·
材料科学
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DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Yi Chen,Xing Zhao,Chen Luo,Yan Shao,Ming-Bo Yang,Bo Yin
Despite tremendous advances in the preparation of smart materials, it remains a great challenge to integrate shape memory and self-healing properties into one material system, which have received increasing interests because of their many potential applications. Herein, the PCL/TPU blends are prepared as shape memory matrix by simple solution blending. Then the polydopamine (PDA) nanospheres acted as photothermal fillers were incorporated into PCL/TPU blends which enables the system to exhibit excellent light-response shape memory effect with a shape recovery ratio of 100%. Besides, the nanocomposites also own good self-healing performance because of the microporous structure. The surface crack can be healed in 150 s under light irradiation, and the healing efficiency can reach 78.53%. Therefore, the fast light-response shape memory effect and rapidly self-healing property, along with the facile fabrication processes, make PCL/TPU/PDA nanocomposites ideal for a variety of applications, such as biomedical microdevices, artificial muscles and soft robotics.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Birui Yang,Gong Li,Zhimeng Deng,Fangnan He,Yuxiang Wang,Jie Liang,Yong Sun,Yujiang Fan,Xingdong Zhang
Fiber-reinforced hydrogels are widely utilized in biomedical field; however, their mechanical strength and biological functionality are constrained by the poor integration between the fibrous components and the hydrogel matrix. Herein, we developed a biomimetic composite hydrogel (H-P-MA) with effective molecular integration through covalently photopolymerization between a GelMA/HAMA/DopaMA hydrogel network and reactive surface-functionalized PCLMA short fibers created by plasma technology. The H-P-MA composite hydrogel presented a micro-nano topological structure similar to that of the extracellular matrix (ECM) and exhibited superior mechanical properties as well as adhesion capabilities through strong covalent bonding between fibers and matrix, thereby facilitating better cell proliferation. This strategy provides a reliable pathway for developing composite hydrogel materials with ECM biomimicry.
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高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 31
·4801-4810
·
IF 5.047
Dandan Sheng,Jinxiu Li,Chengchong Ai,Sijia Feng,Ting Ying,Xingwang Liu,Jiangyu Cai,Xiaoquan Ding,Wenhe Jin,He Xu,Jun Chen,Shiyi Chen
Tendons can transmit mechanical force from muscles to bones for movement. However, the mechanical strength of tendons is compromised after surgery, thus causing a high rate of tendon retear. Hence, the design and preparation of biodegradable materials with excellent mechanical properties have become an urgent demand for sports medicine. In this study, biomimetic polycaprolactone (PCL)/gelatin (Gel)-aligned scaffolds were fabricated for the mechanical restoration of the injured tendon in a rabbit model. The diameter of nanofibers was about 427.82 ± 56.99 nm, which was approximate to that of the native collagen fibrils; the directional consistency of the nanofibers in PCL/Gel-aligned scaffolds reached 77.33 ± 3.22%, which were ultrastructurally biomimetic. Compared to the observations for the control group, the in vitro mechanical results showed that the PCL/Gel-aligned scaffolds (P/G-A) were anisotropic in terms of failure load, tensile strength, and Young's modulus. After verifying their good cytocompatibility, the scaffolds were implanted into the rabbit patellar tendon in situ. The biomechanical properties of the repaired tendon in P/G-A reached 343.97 ± 65.30 N in failure load, 85.99 ± 16.33 MPa in tensile strength, 590.84 ± 201.87 MPa in Young's modulus, and 171.29 ± 61.50 N mm−1 in stiffness in vivo at 8 weeks post operation. In a word, our results demonstrated that P/G-A could support the regenerated tissue of injured patellar tendons to restore the biomechanical strength in a rabbit model. This suggested that the PCL/Gel-aligned scaffolds can pave a promising way to improve the healing of injured tendons in the clinic in the future.
研究领域:
生物材料
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组织工程
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运动医学
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生物力学
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DOI
PubMed
高影响因子
Journal of Functional Biomaterials
·
2022
·Vol. 13
·期 4
·303
·
IF 4.901
Qihan Yuan,Qianqian Zhang,Xuecheng Xu,Yuqing Du,Jidong Xu,Yu Song,Yuanfei Wang
Enamel demineralization around brackets is a relatively common complication of fixed orthodontic treatment, which seriously affects the aesthetics of teeth. In this study, a novel orthodontic adhesive containing polycaprolactone–gelatin–silver nanoparticles (PCL–gelatin–AgNPs) composite fibers was prepared to prevent enamel demineralization of orthodontic treatment. First, PCL–gelatin–AgNPs fibers film prepared by electrospinning was made into short fibers and added to traditional orthodontic adhesives (Transbond XT, 3M Unitek) in three different ratios to design a series of composite adhesives containing antibacterial materials. The antimicrobial performance of the control product and the three samples were then evaluated by bacterial live/dead staining, colony-forming unit (CFU) counts, tensile bond strength (TBS), and adhesive residue index (ARI) scores. The composite adhesives’ antimicrobial properties increased with the increasing content of PCL–gelatin–AgNPs short fibers. The addition of complex antimicrobial fibers to 3M Transbond XT adhesive can significantly reduce the CFU of bacterial biofilms (p< 0.05). The bacterial survival rate on the surface of the specimen decreased with the increase of PCL–gelatin–AgNPs short fibers (p< 0.05). The TBS and ARI values (n= 10) indicated that adding PCL–gelatin–AgNPs short fibers had no significant adverse effect on adhesion. Therefore, adding PCL–gelatin–AgNPs short fibers makes it possible to fabricate orthodontic adhesives with strong antibacterial properties without compromising the bonding ability, which is essential for preventing enamel demineralization around the brackets.Keywords:PCL–gelatin–AgNPs fibers;orthodontic adhesive;antibacterial property;tensile bonding strength;Streptococcus mutans
研究领域:
牙科材料
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正畸学
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生物材料
·
抗菌研究
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DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2013
·Vol. 101
·期 8
·1359-1366
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IF 2.308
Yu-fei Wang,Hong-feng Guo,Da-jun Ying
Dural closure after the neurosurgery can prevent postoperative complications. Although many types of dural substitute have been developed, most of them lack functional and structural characteristics compared with the natural dura mater. In this study, we used electrospinning method to fabricate a multilayer scaffold to promote dural repair. The inner layer of the scaffold that faces the brain tissue is composed of poly-lactic acid (PLA) to reduce tissue adhesion. The middle layer of the scaffold is composed of poly-ɛ-caprolactone and PLA, which provides a watertight seal. The outer layer of the scaffold contains a large amount of collagen to promote cell attachment and proliferation. The results from in vitro study and an animal model have shown that this multilayer fibrous scaffold has sufficient mechanic strength and biochemical properties to enhance dural repair. Therefore, fabrication of scaffold with multiple functional and structural layers may provide a novel approach for tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1359–1366, 2013.
研究领域:
生物材料
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神经外科
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组织工程
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再生医学
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生物医学工程
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DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2026
·
IF 3.5
Haiqi Han,Liu Luo,Kai Chen,Shuxian Dong,Yumeng Ming,Qin Chen,Xinyue Zhang,Ziqiang Zhu,Dekun Zhang
Bone defects resulting from trauma, malignant tumors, or infections are common clinical conditions. Current clinical treatments for bone defects, however, are associated with secondary injury, poor morphological matching, and immune rejection, falling short of clinical needs. Multifunctional bioscaffolds with osteogenic induction capability have emerged as a highly promising therapeutic strategy. In this study, 3D printing technology was utilized to fabricate scaffolds integrating ROS scavenging and osteogenic differentiation dual functions, and their physicochemical properties and biocompatibility were systematically investigated. Polycaprolactone (PCL) and strontium-magnesium-doped calcium silicate (SMCS) were selected to prepare PCL/SMCS scaffolds with varying SMCS ratios. SMCS incorporation effectively enhanced scaffold hydrophilicity and accelerated degradation. Cell culture experiments confirmed good biocompatibility of the PCL/SMCS scaffolds. Subsequently, cerium-doped SMCS bioceramics were prepared via a post-impregnation process. Notably, the PCL/0.1M Ce-SMCS scaffold exhibited optimal compressive performance, achieving a strength of 22.78 MPa—a 26.42% increase over the PCL/4SMCS scaffold. Compared with PCL/4SMCS, Ce doping promoted cell proliferation and adhesion, conferred ROS scavenging ability, and in vitro osteogenic assays indicated that low-content Ce-SMCS enhanced osteogenic differentiation.
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PubMed
高影响因子
BIOMACROMOLECULES
·
2012
·
IF 5.479
Bei Feng,Hongbin Tu,Huihua Yuan,Hongju Peng,Yanzhong Zhang
In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give rise to detrimental influences on both the electrospinning process and the resultant fiber performance. A representative natural-synthetic hybrid of gelatin (GT) and polycaprolactone (PCL) (50:50) was employed to study the phase separation behavior in electrospinning of the GT/PCL composite fibers. Using trifluoroethanol (TFE) as the cosolvent of the two polymers, observation of visible sedimentation and flocculation from dynamic light scattering analysis of the GT/PCL/TFE mixture both showed that phase separation does occur in just a few hours. This consequently led to gradually deteriorated fiber morphologies (e.g., splash, fiber bonding, and varied fiber size) over time during electrospinning GT/PCL. Quantitative analysis also indicated that the ratio of GT to PCL in the resultant GT/PCL fibers was altered over time. To address the phase separation related issues, a tiny amount (<0.3%) of acetic acid was introduced to improve the miscibility, which enabled the originally turbid solution to become clear immediately and to be single-phase stable for more than 1 week. Nanofibers thus obtained also appeared to be thinner, smooth, and homogeneous with enhanced performance in wettability and mechanical properties. Given the versatility and widely uses of the electrospun GT/PCL and other similar natural-synthetic hybrid systems in constructing tissue-engineered scaffolds, this work may offer a facile and effective approach to achieve finer and compositionally homogeneous hybrid nanofibers for effective applications.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Yingfeng Wang,Ziyi Liao,Ming Huang,Kaizhun Li,Nengyu Pan,Hao Hou,Wei Ma,Maoli Yin
Post-surgical site infections (PSSI) pose significant challenges in clinic treatment, and the antibacterial modification of medical materials is an effective strategy to combat these issues. In this work, a monomeric N-halamines (DCDMH) was doped in PCL matrix via electrospinning process, and further processed using a conventional twisting method to yield nanofiber-based yarns. The micro/nano-structure of the PCL-based electrospun nanofibrous yarns (ENYs) enables the effective release of N-halamines and exhibits suitable storage stability after 30 days. The N-halamine modified ENYs effectively inhibited 100 % of E. coli O157:H7, S. aureus , and C. albicans within 1 min, resulting impressive antimicrobial capacities. The effect of N-halamines dosage on the morphology and mechanical properties of fabricated ENYs was assessed. Furthermore, the in vitro degradation, hemocompatibility, and protein adsorption properties of the synthesized nanofibrous yarns were also evaluated. The prepared ENYs with good hemocompatibility and antimicrobial properties, suggesting a novel approach for the development of medical materials, specifically for surgical sutures materials.
研究领域:
生物医学工程
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材料科学
·
微生物学
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产品关联
DOI
高影响因子
MATERIALS SCIENCE FORUM
·
2024
·
IF 0
Ha Nguyen Phuong,Duyen Nguyen Thu,Nguyen Thanh Liem,Vu Anh Doan
Chitosan (CS), with its non-toxic and antibacterial properties, and Poly(ε-caprolactone) (PCL), known for its biodegradability and biocompatibility, are crucial materials in medical applications. This study proposed a solution utilizing electrospinning to manufacture fibers with nanometer-sized core-shell structures from these materials, with CS serving as the fiber core and PCL forming the shell. The influence of manufacturing technology parameters on fiber size and morphology was thoroughly researched and investigated. The solvent system used, Chloroform/Dimethylformamide (DMF), ensured complete solubility, viscosity control, conductivity, and proper solvent evaporation. Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) results clearly demonstrated the morphology and internal structure of the nanofibers. The water contact angle (WCA) measurements of the fiber membrane showed almost no significant change over time, indicating strong hydrophobicity of the nanofibers. Additionally, the FTIR spectrum revealed distinct core-shell layers without any blending between them, while DSC analysis showed the thermal properties of fiber membranes. In summary, the electrospinning of nanofibers proved to be stable, producing thin fibers with an average diameter of approximately 400 nm. These findings are expected to significantly enhance the applicability of CS/PCL nanofibers across various fields, including healthcare and smart agriculture.
研究领域:
生物材料
·
医学工程
·
纳米技术
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DOI
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
·
2019
·Vol. 57
·期 8
·421-430
·
IF 2.596
Guohui Zhang,Panpan Wang,Xiaoxiao Zhang,Chunhui Xiang,Lili Li
Superhydrophobic polycaprolactone (PCL) membranes with hierarchical structure were fabricated via alternate electrospinning/electrospraying techniques. Electrospun PCL/methyl silicone oil (PCL/MSO) nanofibers were employed as substrate. PCL/MSO-PCL microspheres (PCL/MSO-PCL MS ) hierarchical membrane was prepared via electrosprayed PCL MS as an additional layer on the substrate. Field emission scanning electron microscopy images showed the formation of hierarchical PCL/MSO-PCL MS membranes. Compared to pure PCL fibers substrate (120 ± 1.3°), the water contact angle (WCA) of MSO-modified PCL membrane was 142 ± 0.7°. The most interesting observation was that the WCA of PCL MS without any modification could be achieved to 146 ± 2.8°. On this basis, PCL/MSO-PCL MS hierarchical membrane possessed superhydrophobic surface with 150 ± 0.6° of WCA. The excellent surface roughness and air-pocket capacity of hierarchical membranes would make the membranes more hydrophobic. The maximum oil ( n -hexane) adsorption capacity of PCL/MSO-PCL MS membrane was 32.53 g g −1 . Oil–water separation efficiencies of the superhydrophobic membranes were all higher than 99.93% after 10 cycles. The hierarchically structured PCL superhydrophobic membranes indicate the potential applications of environmentally friendly biopolymers as separation membranes. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019 , 57 , 421–430
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Kai Li,Dazhi Wang,Kuipeng Zhao,Kedong Song,Junsheng Liang
Controlled printing of biodegradable and bioresorbable polymers at desired 3D scaffold is of great importance for cell growth and tissue regeneration. In this work, a novel electrohydrodynamic jet 3D printing technology with the resultant effect of electrohydrodynamic force and thermal convection was developed, and its feasibility to fabricate controllable filament composite scaffolds was verified. This method introduces an effective thermal field under the needle to simultaneously enhance the ink viscosity, jetting morphology controllability and printing structure solidify. The fabrication mechanisms of thermal convection on jetting morphology and printed structures feature were investigated through theoretical analysis and experimental characterization. Under optimized conditions, a stable and finer jet was formed; then with the use of this jet, various 3D structures were directly printed at a high aspect ratio ~30. Furthermore, the PCL/PVP composite scaffolds with the controllable filament diameter (~10 μm) which is closed to living cells were printed. Cell culture experiments showed that the printed scaffolds had excellent cell biocompatibility and facilitated cellular proliferation in vitro. It is a great potential that the developed electrohydrodynamic jet 3D printing technology might provide a novel approach to directly print composite synthetic biopolymers into flexibly scale structures for tissue engineering applications.
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）