INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Wenlong Pang,Bin Li,Yufeng Wu,Shaonan Tian,Yu Zhang,Jun Yang
With global enforcement of plastic bans and restrictions, the biodegradable plastic, e.g., polylactic acid (PLA), has been extensively employed as a primary substitute for traditional petroleum-based plastics. However, the growing problem associated with PLA waste accumulation is posing grand environmental challenges. In addition, although PLA has the degrading property under natural conditions, the degradation process takes too long and the degradation products cannot be recycled. In this context, enzymatic degradation of PLA arouses great attention in scientific communities. This study aims at selecting the most cost-effective protease from various enzymes and optimizing the enzymolysis conditions towards the degradation of PLA. We will demonstrate that under an optimal temperature of 45 °C, a pH vale of 11, and an enzyme concentration of 0.6 mg mL −1 , the protease K would achieve a remarkable degradation efficiency (> 99 %) for PLA films within just 50 min. Finally, molecular dynamics (MD) simulation and molecular docking studies reveal the mechanism behind the protease-induced PLA degradation, providing a promising direction for waste treatment and resource utilization for future biodegradable plastics.
研究领域:
环境科学
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生物技术
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材料科学
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化学工程
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DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Hongtao Shi,Shuyu Zhao,Lian Chen,Yanyang Tian,Lifen Li,Yan Cao,Jiangyao Han,Liangran Zhang
To develop eco-friendly wood-plastic composites (WPCs) with enhanced performance, this study focused on improving the interfacial compatibility between polar plant fibers and the weakly polar polylactic acid (PLA) matrix by grafting glycidyl methacrylate (GMA) onto PLA via solid-phase modification. Using benzoyl peroxide as an initiator in a high-speed mixer, 10 PLA-g-glycidyl methacrylate (PLA-g-GMA) copolymers with varying grafting ratios were synthesized. The chemical structures of these copolymers were characterized using FTIR and 1H NMR spectroscopy. The results indicated that the grafting degree of PLA initially increased and then decreased with increasing GMA content, peaking at 15% GMA with a grafting rate of 9.62%. Bamboo plastic composites (BPCs) were prepared by hot-pressing PLA-g-GMA with bamboo flour (BF). Physical and mechanical testing showed that both water resistance and mechanical properties of the composites initially improved and then declined with increasing GMA content. Notably, the composite based on 13% GMA-modified PLA exhibited the best water resistance, with a 24 h water absorption of only 1.05%. Composites prepared with 15% GMA-modified PLA showed the best overall performance, showing increases in static flexural strength, elastic modulus, and impact strength by 168.86%, 94.06%, and 45.67%, respectively, compared to the unmodified composite. Additionally, the 15% GMA modification slowed soil-burial degradation. These findings indicate that moderate grafting of PLA significantly enhances interfacial adhesion and performance in biobased composites, providing a theoretical foundation and data support for the design of high-performance, environmentally friendly WPCs.
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PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 8
·2274-2282
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IF 6.183
Yue Cai,Zhuomin Xu,Qi Shuai,Fangtao Zhu,Jiao Xu,Xin Gao,Xuanrong Sun
Because of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, block copolymer micelles are widely utilized for chemotherapy drug delivery. In order to further improve the anti-tumor ability and reduce unwanted side effects of drugs, tumor-targeting peptides were used to functionalize the surface of polymer micelles so that the micelles can target tumor tissues. Herein, we synthesized a kind of PEG-PLA that is maleimide-terminated and then conjugated with a specific peptide F3 which revealed specific capacity binding to nucleolin that is overexpressed on the surface of many tumor cells. Then, F3 conjugated, paclitaxel loaded nanoparticles (F3-NP-PTX) were prepared as stable micelles that displayed an enhanced accumulation via a peptide-mediated cellular association in human breast cancer cells (MCF-7). Furthermore, F3-NP-PTX showed a prominent anti-tumor efficacy compared with non-targeting nanoparticles (NP-PTX) both in vitro and in vivo, and showed great potential as an efficacious targeting drug delivery system for breast cancer treatment.
研究领域:
药学
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纳米技术
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癌症研究
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2020
·Vol. 21
·期 5
·1856
·
IF 4.556
Qi Shuai,Yue Cai,Guangkuo Zhao,Xuanrong Sun
On account of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, amphiphilic block copolymer-based micelles have been widely utilized for chemotherapy drug delivery. In order to further improve the antitumor ability and to also reduce undesired side effects of drugs, cell-penetrating peptides have been used to functionalize the surface of polymer micelles endowed with the ability to target tumor tissues. Herein, we first synthesized functional polyethylene glycol-polylactic acid (PEG-PLA) tethered with maleimide at the PEG section of the block polymer, which was further conjugated with a specific peptide, the transactivating transcriptional activator (TAT), with an approved capacity of aiding translocation across the plasma membrane. Then, TAT-conjugated, paclitaxel-loaded nanoparticles were self-assembled into stable nanoparticles with a favorable size of 20 nm, and displayed a significantly increased cytotoxicity, due to their enhanced accumulation via peptide-mediated cellular association in human breast cancer cells (MCF-7)in vitro. But when further usedin vivo, TAT-NP-PTX showed an acceleration of the drug’s plasma clearance rate compared with NP-PTX, and therefore weakened its antitumor activities in the mice model, because of its positive charge, its elimination by the endoplasmic reticulum system more quickly, and its targeting effect on normal cells leading towards being more toxic. So further modification of TAT-NP-PTX to shield TAT peptide’s positive charges may be a hot topic to overcome the present dilemma.Keywords:cell-penetrating peptide;nanoparticles;active tumor targeting;PEG-PLA
研究领域:
药学
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纳米技术
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癌症研究
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药物递送系统
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DOI
PubMed
高影响因子
Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
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2018
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IF 2.129
Chongxing Huang,Yuan Zhao,Hongxia Su,Ronghua Bei
As novel materials for food contact packaging, inorganic silicon oxide (SiOx) films are high barrier property materials that have been developed rapidly and have attracted the attention of many manufacturers. For the safe use of SiOx films for food packaging it is vital to study the interaction between SiOx layers and food contaminants, as well as the function of a SiOx barrier layer in antioxidant migration resistance. In this study, we deposited a SiOx layer on polylactic acid (PLA)-based films to prepare SiOx/PLA coated films by plasma-enhanced chemical vapour deposition. Additionally, we compared PLA-based films and SiOx/PLA coated films in terms of the migration of different antioxidants (e.g. t-butylhydroquinone [TBHQ], butylated hydroxyanisole [BHA], and butylated hydroxytoluene [BHT]) via specific migration experiments and then investigated the effects of a SiOx layer on antioxidant migration under different conditions. The results indicate that antioxidant migration from SiOx/PLA coated films is similar to that for PLA-based films: with increase of temperature, decrease of food simulant polarity, and increase of single-sided contact time, the antioxidant migration rate and amount in SiOx/PLA coated films increase. The SiOx barrier layer significantly reduced the amount of migration of antioxidants with small and similar molecular weights and similar physical and chemical properties, while the degree of migration blocking was not significantly different among the studied antioxidants. However, the migration was affected by temperature and food simulant. Depending on the food simulants considered, the migration amount in SiOx/PLA coated films was reduced compared with that in PLA-based films by 42–46%, 44–47%, and 44–46% for TBHQ, BHA, and BHT, respectively.
研究领域:
材料科学
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食品安全
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包装工程
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DOI
高影响因子
Materials Today Communications
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2025
·
IF 4.5
Zhicheng Ye,Lan Zhang,Pengliang Hou
Polylactic acid (PLA) is an excellent smart material with favorable mechanical properties and shape memory behavior, along with low cost and broad applicability. However, its relatively high deformation temperature and poor toughness limit its application in implantable medical devices. The PLA/TPU/HA blend was prepared via physical blending to reduce the glass transition temperature ( T g ) of PLA and to enhance its shape memory performance and mechanical properties. Experimental results revealed that the addition of thermoplastic polyurethane (TPU) and hydroxyapatite (HA) reduced the T g by 7.16 ℃, improved the tensile strength by 15 MPa, and achieved a shape recovery rate of 94.1%, representing an improvement of over 10% compared to neat PLA. Furthermore, by adjusting the mixing ratios, the blends exhibited controllable deformation behavior, thus expanding their potential for biomedical applications.
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Bingrui Yang,Tengfei Fan,Yixuan Mao,Jixi Chen,Botuo Zheng,Yu Sheng,Huagui Zhang
To address the increasing global plastic pollution while the reducing oil supply, the biodegradable and bio-derived poly(lactic acid) (PLA) has been developed and considered to be the most promising substitute of petroleum-based plastics. However, the severe brittleness of PLA has become the obstacle of its broad application. Blending modification with poly(butylene-adipate-co-terephthalate) (PBAT) has been proved to be an potentially feasible strategy to toughen PLA, but conflicted by the poor compatibility between PLA and PBAT. To tackle the problem, a comb-type clay-based Janus nanosheet of poly(methyl methacrylate- kaolinite- poly(butylene-adipate-co-terephthalate) (PMMA-Kaol-PBAT) was prepared by selectively grafting PMMA and PBAT separately on either sides of kaolinite Janus nanosheets (JNS). PBAT was functionalized with quaternary amine via aminolysis before being cation-exchanged onto the siloxane tetrahedral surface (STS) side of kaolinite nanosheets, while PMMA chains were grafted onto the aluminoxyl octahedral surface (AOS) side after a beforehand surface modification with the silane coupling agent KH-570. Introduced in the PLA/PBAT blend system, the PMMA-Kaol-PBAT was found to enrich at the interface, enhancing the phase compatibility with the phase separation and aggregation inhibited during the film coating and annealing process.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
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2020
·
IF 5.289
Dongsheng Yan,Ziyu Wang,Ziyi Guo,Yongming Ma,Chengyu Wang,Haiyan Tan,Yanhua Zhang
Poly(lactic acid) (PLA) and poly(butylene adipate-Co-terephthalate) (PBAT) show high and excellent biocompatibility, which are promising materials used in bone tissue engineering field. In this research, n-HA/PLA/PBAT/MCC composites were prepared by solution blending method. Nano hydroxyapatite (n-HA) was used as nucleation, and microcrystalline cellulose (MCC) was added to improve the degradation performance of the materials. Compared with the composite without n-HA, the crystallinity of the composites with 6% n-HA was increased by 62%. The scanning electron microscopy (SEM) and the transmission electron microscopy (TEM) showed that the n-HA was evenly dispersed in the composites when the addition ration of n-HA was lower than 6%, while obvious agglomeration of n-HA appeared at the addition ratio of 10%. The tensile test demonstrated that the tensile strength of the composites with different addition ratio transcended the needs of bone tissue engineering materials. The introduction of n-HA in obtained composites simulated the composition and structure of native bone, which suggested a potential utility and application prospect in bone tissue engineering.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
AICHE JOURNAL
·
2018
·Vol. 64
·期 10
·3700-3708
·
IF 3.326
Ruizhe Xing,Renliang Huang,Wei Qi,Rongxin Su,Zhimin He
A novel lotus-leaf-inspired superhydrophobic poly(lactic acid) (PLA) porous membrane was fabricated for oil-water separation based on fused deposition modeling three-dimensional printing and subsequent chemical etching and the decoration of polystyrene nanospheres. A superhydrophobic PLA fractal surface with a water contact angle of 151.7° and low water adhesion force of 21.8 μN was achieved. The membrane pore size could be easily adjusted from 40 to 600 μm via a computer-aided design program to optimize separation performance. The maximal oil-water separation efficiency of 99.4% was achieved with a pore size of 250 μm, which also exhibited a high flux of 60 kL m −2 h −1 . © 2018 American Institute of Chemical Engineers AIChE J , 64: 3700–3708, 2018
研究领域:
材料科学
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环境工程
·
生物仿生学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Hui Wang,Xiao Shi,Ailin Gao,Haibo Lin,Yongliang Chen,Yumin Ye,Jidong He,Fu Liu,Gang Deng
In the present work, we report one-step immobilization of nano-heparin coating on PLA membranes via initiated chemical vapor deposition (iCVD) for enhanced hemocompatibility. The nano-coating introduced onto the membrane surface via the crosslinking of P(MAA-EGDA) was confirmed by the FTIR, SEM and weight measurement respectively. The negative carboxyl groups could form the hydration interaction with the protein and platelets and electrostatic interaction with amide groups of thrombin by the mediation of antithrombin, which is similar but different with heparin. The P(MAA-EGDA) coated membranes showed suppressed platelet adhesion and prolonged clotting time (APTTs increased to 59 s, PTs increased to 20.4 s, TTs increased to 17.5 s, and the FIBs declined by 30 mg/dL). Moreover, the complement activation tests demonstrated the formation of C3a and C5a was inhibited. All results demonstrated that the nano-coating of P(MAA-EGDA) via iCVD significantly enhanced the hemocompatibility of PLA membranes, which is also applicable for various membranes.
研究领域:
生物材料
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医学工程
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产品关联
DOI
高影响因子
Sustainability
·
2022
·Vol. 14
·期 19
·12872
·
IF 3.889
Zihan Lang,Lidong Xue
Triclosan (TCS) has been widely employed as active ingredient in household products and has received attention for its hepatotoxicity, endocrine disruption and disturbance on immune function. Polylactic acid (PLA) has been highlighted as an alternative biodegradable microplastic, and the knowledge about the adsorption affinity towards TCS is limited. In this study, the ability to act as carrier of TCS by PLA and non-biodegradable microplastics, including polystyrene (PS), polyvinyl chloride (PVC) and polyethylene (PE) with different particle sizes were explored. The influence factors (e.g., dosage, pH and salinity), adsorption kinetics and isotherms were also investigated. Batch experiment results indicated that the TCS adsorption onto PLA and non-biodegradable microplastics exhibited a pronounced pH-dependent pattern (pH of 4, 7 and 10), and the adsorption capacity decreased gradually as pH increased. Furthermore, the adsorption capacity of TCS on PS, PVC and PE decreased as salinity increased from 0 to 3.5%, while no significant inhibition for the sorption capacity of PLA was observed. The adsorption kinetic data of TCS was best fitted with the pseudo-second order model. The Freundlich model with R2(0.999) was suitable to describe the adsorption isotherms of TCS on PLA, while the isotherms data of TCS on PS, PVC and PE was fitted by linear and Freundlich model. The higher adsorption capacity of PLA (38.6 mg g−1) compares to those of PS, PVC and PE (31.3, 11.4 and 9.64 mg g−1, respectively), illustrated by the fact that the physicochemical properties of microplastics have a noticeable impact on adsorption process, and the biodegradable PLA is a stronger vector than the non-biodegradable microplastics.Keywords:triclosan;polylactic acid;vector;pH-dependent
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Ziran Du,Gaoyan Zhang,Kun Chen,Cheng Zhou,Xiaoshuai Zhu,Yuxiang Zhang,Kang Chen,Hao-Yang Mi,Yaming Wang,Chuntai Liu,Changyu Shen
Proliferation in telecommunications and integrated/intelligent devices entails an intense concern for electromagnetic interference (EMI) shielding and versatility. It remains an activated passion to launch infusive EMI shielding materials integrated with self-powered peculiarities. Herein, a double-layered MXene/polylactic acid (PLA) fabric resonance cavity (D-MPF-RC) comprised of two MXene/PLA fabrics (MPFs) with alternating MXene and PLA structures that are separated by a poly(tetrafluoroethylene) (PTFE) frame is developed. The D-MPF-RC achieved 48.5 and 74.8% improvement in SET and SEA, and 24.6% reduction in SER by introducing the double-layered structure and increasing the resonance cavity (RC) distance without varying the material composition and cost. A high shielding efficiency (SE) of 92.3 dB was obtained at an RC distance of 6 mm owing to the synergetic effects of multiple reflections and destructive EM wave interference. The tribopolarity difference between PLA and MXene and the RC structure made the D-MPF-RC a readily available triboelectric nanogenerator (TENG) that could convert mechanical energy into electricity. The D-MPF-RC TENG demonstrated an open-circuit voltage of 88 V and achieved a peak power density of 35.4 mW m–2 on a 6.6 MΩ external resistor, which made it possible to charge capacitors and serve as a self-powered tactile sensor. This report offers new insights into the design of high-performance EMI shielding shields with a resonance cavity and proposes a feasible pathway to integrate them with energy harvesting capabilities.
研究领域:
材料科学
·
电子工程
·
能源技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）