ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Ting Li,Anjun Hu,Yuanjian Li,Borui Yang,Kun Li,Kai Chen,Jingyun Jiang,Fei Li,Zhi Wei Seh,Jian Wang,Jianping Long
Lithium metal is environmentally sensitive and highly reactive, especially when coupled with flammable organic electrolytes, which pose critical safety challenges for lithium metal batteries under harsh operational conditions. This study tackles this challenge by constructing an integrated strategy for encapsulating lithium metal with a multifunctional polyfluoride ionogel (PFIGE) through in situ thermal polymerization. Based on the cross-linking network design of hexafluorobutyl methacrylate monomer and 1-butyl-3-lithium bis(trifluoromethylsulfonyl)imide ionic liquid plasticizer, C−F group and TFSI − anion cooperate to confer excellent water/oxygen barrier properties of the PFIGE. Meanwhile, the fluorinated skeleton optimizes the Li + flux by regulating anion migration, thereby promoting the formation of stable inorganic-rich interphases and achieving homogeneous lithium deposition. Additionally, the C−F group forms ion−dipole interactions with imidazole cations to achieve dynamic self-healing capabilities, while the condensed-phase physical barrier and gas-phase radical scavenging effect of the pyrolyzed PFIGE synergistically contribute to the battery safety. As a proof-of-concept, PFIGE-integrated Li||LiNi 0.5 Co 0.2 Mn 0.3 O 2 cells demonstrate extended cycling stability at high voltage (4.6 V) and high temperature (80 °C), and a 0.4 Ah-level pouch cell exhibits exceptional resistance to thermal runaway under mechanical/electrical/thermal abuse conditions. This design philosophy presents a paradigm-shifting electrolyte system that significantly enhances the cycle life and safety of lithium metal batteries.
研究领域:
材料科学
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电化学
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能源存储
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产品关联
DOI
高影响因子
Matter
·
2022
·Vol. 5
·期 7
·2225-2237
·
IF 19.967
Cheng Ma,Xuyan Ni,Youquan Zhang,Qingbing Xia,Liangjun Zhou,Libao Chen,Yanqing Lai,Xiaobo Ji,Chenglin Yan,Weifeng Wei
Ion electrokinetic regulation in electrolyte is of great significance to alleviating polysulfide shuttling and dendritic growth in lithium-sulfur (Li-S) batteries. Inspired by the tunable solute-polymer interactions of ion exchange membrane, herein we implant an ion-selective “skin” constructed by isocyanoethyl methacrylate grafted polyethylenimine (PEI-IEM) in electrolyte via in situ gelation. This tailored skin endows the PEI-IEM-based gel polymer electrolyte (GPE) with a hyper-branched network with abundant polar groups, thus upgrading the electrolyte flame resistance, realizing obstruction on polysulfide migration, and facilitating Li + transport against uneven deposition. Consequently, the PEI-IEM-based GPE empowers enhanced S electrochemical reversibility and high security, as evidenced by a 10 Ah Li-S pouch cell with a low electrolyte/S ratio of 2.6 and 1.4× excess Li anode that delivers an energy density of 412.7 Wh kg −1 . This proof-of-concept study provides new insights for tailoring the ionic behaviors of electrolyte to achieve high-energy and safe Li-S batteries.
研究领域:
储能
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电化学
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材料科学
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电池技术
✓ 已验证
DOI
高影响因子
Exploration
·
2025
·
IF 22.5
Galong Li,Xin Qiao,Yu Zhao,Dongyan Li,Guigen Zhang,Xiaoli Liu,Fulin Chen,Huaning Wang,Hongbing Lu,Jin Zhou,Changyong Wang,Haiming Fan
Magnetothermal neuromodulation is a minimally invasive, deep-brain accessible, and tether-free technique. The precisely timed activation of thermosensitive ion channels, such as TRPV1, with local heat generated using magnetic nanoparticles is crucial for efficient neuromodulation. Nevertheless, this technique is greatly hindered by its long stimulus-response time and high safety risks due to the poor heat-generating performance of the nanomediators. Herein, we report the establishment of a ferrimagnetic vortex iron oxide nanoring (FVIO)-mediated magnetothermal neurostimulation technique that is efficient and safe. Compared with widely used superparamagnetic iron oxide nanomediators (SPIOs), the FVIOs triggered Ca 2+ influx into HEK293T cells and cortical neurons at an Fe concentration of 51 µg mL −1 , which is 20.27-fold lower than that needed for SPIOs. In vivo magnetothermal stimulation in the central nucleus of the amygdala of mice further demonstrated that FVIOs with the optimal dose of 0.05 µg evoked fear behaviors with an average latency of 2.51 s, which was 2.3-fold faster than that in the SPIO (0.80 µg)-treated group. More importantly, FVIOs-mediated stimulation not only exhibited negligible histopathological alterations and proinflammatory cytokine expression but also successfully elicited fear behaviors in transgene-free mice. The FVIO-mediated efficient and safe neuromodulation has the potential for future neuroscience exploitation and neurological disease treatment.
研究领域:
神经科学
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纳米医学
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生物医学工程
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磁热疗
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神经调控
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 33
·期 33
·2100895
·
IF 30.849
Min Hao,Zixian Zhang,Chao Liu,Yue Tian,Jiazhi Duan,Jianlong He,Zhaoyang Sun,He Xia,Shan Zhang,Shuhua Wang,Yuanhua Sang,Guogang Xing,Hong Liu
Neural stem cell (NSC) transplantation is one of the most promising therapeutic strategies for neurodegenerative diseases. However, the slow spontaneous differentiation of NSCs often hampers their application in neural repair. Although some biological growth factors accelerate the differentiation of NSCs, their high cost, short half-life, and unpredictable behavior in vivo, as well as the complexity of the operation, hinder their clinical use. In this study, it is demonstrated that hydroxyapatite (HAp), the main component of bone, in the form of nanorods, can regulate the neural differentiation of NSCs and maturation of the newly differentiated cells. Culturing NSCs with HAp nanorods leads to the differentiation of NSCs into mature neurons that exhibit well-defined electrophysiological behavior within 5 days. The state of these neurons is much better than when culturing the cells without HAp nanorods, which undergo a 2-week differentiation process. Furthermore, RNA-sequencing data reveal that the neuroactive ligand–receptor interaction pathway is dominant in the enriched differentiated neuronal population. Hence, inorganic growth factors like HAp act as a feasible, effective, safe, and practical tool for regulating the differentiation of NSCs and can potentially be used in the treatment of neurodegenerative diseases.
研究领域:
神经科学
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生物材料
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干细胞生物学
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ChemMedChem
·
2025
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IF 3.4
Xinlin Zhu,Qin Li,Junhui Wu,Zhiran Ju
Graphical In recent years, the development of COX-2 inhibitors has shifted from a focus on highly selective inhibition to emphasizes more moderate selectivity. This study presents a potent balanced COX-2 inhibitor, compound 21d, which effectively alleviates histological damage and provides protection against DSS-induced colitis. The severe adverse effects associated with imbalanced cyclooxygenase-2 (COX-2) inhibition continue to pose significant challenges in the development of contemporary anti-inflammatory drugs. In recent years, the approach to COX-2 inhibitor drug development has shifted from a focus on highly selective inhibition of COX-2 to a strategy that emphasizes more moderate selectivity. The amino acid sequence and structural similarities between inducible COX-2 and constitutive cyclooxygenase-1 (COX-1) isoforms present both substantial opportunities and challenges for the design of next generation of balanced COX-2 inhibitors. As part of our ongoing research into the discovering novel and safer COX-2 inhibitors, we reported herein a highly potent and balanced COX-2 inhibitor 21 d (IC 50 value=1.35 μM, selectivity profile (IC 50 (COX-1)/IC 50 (COX-2)=22.34)). In vivo assays demonstrated that 21 d significantly alleviated histological damage and provided robust protection against dextran sulfate sodium (DSS)-induced acute colitis.
研究领域:
药理学
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分子生物学
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药物开发
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 45
·2406764
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IF 18.5
Chunlei Zhu,Daxiong Wu,Chuan Wang,Jianmin Ma
Sodium metal batteries (SMBs) remain greatly challenging in safety and stability. Herein, a flame-retardant s designed, self-purging high-voltage electrolyte is designed to stabilize SMBs with the use of ethoxy (pentafluoro) cyclotriphosphazene (PFPN) as the electrolyte additive. PFPN can participate in the shell structure of PF 6 − ${\mathrm{PF}}_6^ - $ solvation through stronger van der Waals force to form Na 3 N, NaF-rich solid/cathode electrolyte interphase (SEI/CEI) with electronic insulation and fast ion transport. Moreover, harmful impurity (PF 5 ) also can be scavenged by van der Waals force to avoid HF production, which helps to stabilize the electrode interface. Additionally, combustion radicals (H, HO) can be cleared by van der Waals force between radical (RPO) formed by breaking with PFPN and combustion radicals for flame-retardation purpose. As expected, the high-voltage Na||Na 3 V 2 (PO 4 ) 2 O 2 F battery with modified electrolyte can deliver reservation of 92.4%, CE of 99.71% after 2000 cycles, and simultaneously possess excellent high-rate and fast charging/slow discharging performance.
研究领域:
电化学
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能源材料
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纳米材料
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界面化学
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电池安全
✓ 已验证
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2021
·
IF 4.094
Zhongxu Li,Shengzhao Zhang,Zhao Jiang,Dan Cai,Changdong Gu,Jiangping Tu
A novel cheap eutectogel (ETG) membrane based on the deep eutectic solvent (DES) immobilized poly (vinylidene fluoride-hexafluoro propylene) (PVDF-HFP) is proposed as a solid electrolyte for safe lithium metal batteries in this study. The composition of DES is optimized, which is prepared by mixing the N-methylacetamide (NMAC) and the lithium bis [(trifluoromethyl)sulfonyl]imid (LiTFSI) with a molar ratio of 4:1. The eutectogel is formed by incorporating 70 wt% DES into the PVDF-HFP, which is non-flammable and shows excellent mechanical properties. This ETG membrane electrolyte with a thickness about 25 μm possess a high ionic conductivity (3.05 × 10 −4 S cm −1 ) at room temperature and a wide electrochemical stability window (~5 V). The Li//ETG//LiFePO 4 full cells deliver an acceptable discharge capacity of ~133.9 mAh g −1 at 0.1C and room temperature after 100 charge-discharge cycles. The ETG membrane electrolyte can also endow the Li//ETG//LiFePO 4 pouch cell with flexibility and withstanding abuse operations, like nail penetration and cutting. We expect that the flexible and non-flammable eutectogel membrane will have implications for the use of DES based ionic liquids in the synthesis of advanced solid-state electrolytes for safer lithium batteries .
研究领域:
材料科学
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电化学
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能源存储
·
高分子物理
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电池技术
✓ 已验证
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 38
·2203693
·
IF 15.153
Tao Zhu,Dongli Chen,Guoqing Liu,Peng Qi,Xiaoyu Gu,Hongfei Li,Jun Sun,Sheng Zhang
Lithium–sulfur batteries (LSBs) have attracted extensive attention owing to their high energy density and abundant sulfur resources. However, LSBs are still restricted by the unsatisfactory electrochemical performance resulting from the shuttle effect of lithium polysulfide (LiPSs), and the potential fire hazard caused by inflammable ether electrolytes and polyolefin separators. Herein, a facile immobilization strategy for hexachlorocyclotriphosphazene (HCCP) is creatively applied to address the above issues simultaneously. Insoluble HCCP cross-linked microspheres (H-CMP) are firstly obtained at ambient temperature using tannic acid (TA) as a cross-linking agent and then a multifunctional separator coating is constructed based on H-CMP. The released phosphorus-related radicals from H-CMP in wide temperatures effectively prevent the combustion of electrolytes and separators, and hence improve the fire safety of the Li–S pouch cell. Furthermore, H-CMP availably chemisorbs LiPSs to interdict the shuttle effect, thereby dramatically improving the electrochemical performance of LSBs. The effectiveness of this strategy is also verified in high sulfur loading (6.38 mg cm -2 ), high temperature (50 °C), and Li–S pouch cells. More importantly, H-CMP exhibits sufficient stability for Li metal and suppression of Li dendrites. This facile immobilization strategy for multifunctional phosphazenes provides a competitive option for the large-scale fabrication of high-safety and high-performance LSBs.
研究领域:
材料科学
·
能源存储技术
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Shenglong Liu,Yu Zhou,Yan Feng,Qixia Peng,Yurong Li,Cheng He,Zemin Fang,Yazhong Xiao,Wei Fang
Laccase mediators possess advantage of oxidizing substrates with high redox potentials, such as aflatoxin B 1 (AFB 1 ). High costs of chemically synthesized mediators limit laccase industrial application. In this study, thin stillage extract (TSE), a byproduct of corn-based ethanol fermentation was investigated as the potential natural mediator of laccases. Ferulic acid, p -coumaric acid, and vanillic acid were identified as the predominant phenolic compounds of TSE. With the assistance of 0.05 mM TSE, AFB 1 degradation activity of novel laccase Glac1 increased by 17 times. The promoting efficiency of TSE was similar to ferulic acid, but superior to vanillic acid and p- coumaric acid, with 1.2- and 1.3-fold increases, respectively. After Glac1-TSE treatment, two oxidation products were identified. Ames test showed AFB 1 degradation products lost mutagenicity. Meanwhile, TSE also showed 1.3–3.0 times promoting effect on laccase degradation activity in cereal flours. Collectively, a safe and highly efficient natural mediator was obtained for aflatoxin detoxification.
研究领域:
食品安全
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生物化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Sustainable Materials and Technologies
·
2024
·
IF 8.6
Han Li,Zhi Li,Jia-Wei Du,Ao-Yun Zhou,Fei-Yang Zhang,Song Tian,Zhi Hu,De-Yi Wang
A balanced enhancement of anti-flammability, smoke suppression and mechanical property of thermosetting epoxy merely via a phosphorus/nitrogen-free catalytic mode was a vigorous challenge. To attain this goal, we put forward a simultaneous optimizing strategy via integrating the vapor/condensed-phase sensitive dual-effect iron-catalytic structures into polymeric supermolecule. A radical co -polymerization was executed on specific host-guest vinyl cyclodextrin/ferrocene (VCD@Ferr) and co-monomer acrylic acid, followed by a complexation with Fe 3+ to synthesize a bio-based iron-derived supermolecule (VCD@Ferr-AA-Fe). Various characterizations verified the target structure. An incorporation of merely 2 wt% VCD@Ferr-AA-Fe4:1 (iron loading 0.085 wt%) resulted in a UL-94 V-1 and a LOI of 27.9 % with total smoke production and peak smoke production rate decreased by 31.3 % and 33.6 %, respectively. A series of experiments evidenced a presence of intra-molecular synergistic effect between VCD@Ferr and AA-Fe component. In a proposed mechanism, iron ions of VCD@Ferr-AA-Fe4:1 coordinated with degraded products of epoxy to increase the melt viscosity, followed by a combined catalytic charring behavior. Additionally, the released ferrocene participated into the vapor-phase flame inhibition and smoke suppression. Besides, flexural and unnotched impact strength were respectively increased by 37.3 % and 39.5 % without a loss of tensile strength. Prospectively, a bio-based dual-effect structure exploited a P/N-free highly efficient route towards fire-safe polymers.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Food Analytical Methods
·
2018
·Vol. 11
·期 6
·1677-1689
·
IF 2.245
Liu Ye,He Congcong,Song HuanLu
The aim of the study was to compare the extraction efficiency of headspace and solvent extraction methods on watermelon juice flavor. Solid-phase microextraction (SPME) and solvent-assisted flavor evaporation (SAFE) techniques were employed to extract the volatiles from watermelon juice. Aroma compounds were separated and analyzed through gas chromatography-olfactometry-mass spectrometry (GC-MS/O) equipped with DB-5 and DB-Wax capillary columns. Forty-seven compounds were identified by SPME (30) and SAFE (28). These compounds included 7 aldehydes, 10 olefinic aldehydes, 14 alcohols, 7 sulfur compounds, 5 ketones, and 4 miscellaneous compounds. SPME extracted the saturated aldehydes, olefinic aldehydes, alcohols, and ketones effectively, whereas SAFE exerted better efficiency to extract sulfur compounds. ( Z,Z )-3,6-Nonadienal, ( Z )-6-nonen-1-ol, ( E )-2-hexenal, ( E )-2-nonenal, hexanal, nonanal, ( Z )-3-nonen-1-ol, and ( E )-2-octenal were identified as the key aroma compounds through odor activity value (OAV) and aroma extract dilution analysis (AEDA). Also, the aroma compounds can be extracted comprehensively by the combination of both SPME and SAFE techniques.
研究领域:
食品科学
·
分析化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Jiahang Chen,Huijun Yang,Xuan Zhang,Jingyu Lei,Huiming Zhang,Huanhuan Yuan,Jun Yang,Yanna Nuli,Jiulin Wang
Rechargeable lithium-metal batteries have gained significant attention as potential candidates of energy storage systems; however, severe safety issues including flammable electrolyte and dendritic lithium formation hinder their further practical application. In this work, we develop a novel intrinsic flame-retardant electrolyte, which enables a stable and dendrite-free cycling with lithium plating/stripping Coulombic efficiency of up to 99.1% over 500 cycles. Raman spectra indicate that no free molecular solvent exists, and X-ray photoelectron spectroscopy reveals the LiF-rich interphase on the Li-metal anode. When coupled with sulfurized pyrolyzed poly(acrylonitrile) cathode, it shows a benign electrochemical reversibility with the areal capacity of up to 3.41 mAh cm–2 after 70 cycles. To further check its compatibility with sulfur cathode, a higher sulfur content (51.6%) is examined with the areal capacity of 3.92 mAh cm–2 and sulfur utilization of 81.7%. This work provides an alternative for safe and high-performance Li–S batteries via a novel electrolyte strategy.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）