Science of Advanced Materials
·
2017
·
IF 1.671
Li Tingting,Li Yuebin,Xu Gai,Du Guihuan,Wang Fei,Han Junbo,Zhang Junpei,Ma Zongwei,Liu Zuli,Yao Kailun
ZnSe:Mn/ZnS core–shell nanocrytals were successfully synthesized via a nucleation-doping strategy assisted with a low-toxicity, high-reactivity, and organic soluble selenium precursor in oleyamine. The as-prepared ZnSe:Mn/ZnS nanocrytals were then investigated by transmission
electron microscopy (TEM), X-ray powder diffraction (XRD), ultraviolet-visible (UV-Vis) absorption spectroscopy, and photoluminescence (PL) spectroscopy. All the results showed that the ZnSe:Mn/ZnS nanocrystals have good monodispersibility and high photoluminescence. Further systematic research
found that injection temperature of 250 °C, three ZnS layers, and Mn doping concentration of 2% are the optimal parameters for the synthesis of high luminescence ZnSe:Mn/ZnS nanocrystals. Additionally, these ZnSe:Mn nanocrystals exhibit temperature- and magnetic field-dependent optical
properties, which show great potential in the application of temperature and magnetic field sensing.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2013
·Vol. 5
·期 8
·1024-1031
·
IF 2.509
Xiong Jinyan,Cheng Gang,Wang Runming,Yang Hao,Xiao Shengqiang,Chen Rong
Different bismuth oxychloride (BiOCl) nanosheets were successfully synthesized via a facile solvothermal process in different solvents. The products were characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and UV–vis diffuse reflection spectroscopy
(DRS) and nitrogen adsorption. The prepared sheet-like BiOCl products showed different optical properties, BET surface areas and photocatalytic activities on the degradation of Rhodamine B (RhB) under visible light irradiation (> 400 nm). More importantly, the as-synthesized BiOCl
nanosheets exhibited superior photocatalytic activities compared with commercial BiOCl and TiO2 under visible light irradiation. The visible-light-induced degradation of RhB over the as-synthesized BiOCl photocatalysts was mainly ascribed to the photosensitization process and their
layered structures.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 4
·624-631
·
IF 1.474
Lin Jianyao,Chen Yu,Ye Yun,Xu Sheng,Guo Tailiang,Chen Enguo
We present a ligand-exchange-free photo-patternable quantum-dot photoresist (QDPR) with high photolithographic uniformity. The dispersion mechanism between the QD’s surface ligands and the functional groups of photoresist polymers are studied. Results show that the dispersibility
and photoluminescent intensity of this QDPR can be both improved by controlling dispersant and antioxidant. For device demonstration, multi-colored quantum dot color conversion films (QDCCF) were prepared and patterned by a photolithography process. High QD dispersibility and film-forming
uniformity were both achieved with this QDCCF. It is believed that the proposed QDPR has the potential to be extensively used in lighting or display applications.
研究领域:
材料科学
·
光学工程
·
显示技术
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2023
·Vol. 15
·期 6
·754-760
·
IF 0.9
Chen Lin,Zhang Hang,Fouad Hassan,Akhtar M. S.,Wang Zhihong
This study presents a straightforward hydrothermal synthesis technique for modifying the crystal size and shape of MIL-53(Al) via the use of a mixed solvent solution consisting of water and DMF. Without the use of coordination inhibitors or surfactants, a sequence of nanosized MIL-53(Al)
crystals was efficiently synthesized. The lowest crystal size we were able to achieve in this work was 100 nm, but present technologies are not suited to creating nanoscale crystals of this size. Large crystallinity and yield were attained, and the samples’ very large specific surface
areas expanded the usefulness of this MOF material for gas adsorption and storage. X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, nitrogen gas adsorption/desorption, and infrared spectroscopy were all used to characterize the samples. Finally, the effect of moisture
concentration on crystal size and shape was investigated.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2024
·Vol. 16
·期 1
·93-101
·
IF 0.9
Yang Ke,Chen Zheng,Xu Dayong,Peng Fang
This research aimed to analyze the biocompatibility and growth behavior of human immunodeficiency virus (HIV)-associated colorectal cancer (CRC) cells on a polylactic acid/polyglycolic acid (PLA-PCL) composite nanofiber scaffold (CNS) using proteomic analysis. The PLA-PCL CNS was prepared
using a gel extraction phase separation (GEPS) method in a dioxane/ethanol solvent system, and the effects of gel temperature, PLA-PCL mass ratio (MR), solvent-to-polymer MR on the structure and properties of the PLA-PCL CNS were analyzed. Subsequently, Lappaol F (LAF) was incorporated into
the PLA-PCL CNS using electrospinning (ES) technology, and tissue specimens were obtained from HIV-associated CRC patients to investigate the impacts of LAF-PLA-PCL CNS on the growth behavior of HIV-associated CRC cells through mass spectrometry and bioinformatics analysis. Field emission
scanning electron microscopy (FE-SEM) revealed that the CNS could be obtained at gel temperatures between −20 °C and −10 °C, PLA-to-PCL MRs of 1:1, 3:2, 7:3, and ethanol content of 5%–15%. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed
that the PLA-to-PCL MR of 70:30 exhibited compatibility and crystallinity of the PLA-PCL CNS, while the porosity increased with an increase in PCL content. Fourier-transform infrared spectroscopy (FTIR) analysis indicated a good biological activity of the PLA-PCL CNS. The relative cell proliferation
(RCP) and cytotoxicity grades exhibited no marked differences (P >0.05) between the cancer cells cultured with DMEM and those with PLA-PCL scaffold extract over time. Proteomic analysis identified 127 differentially expressed proteins (DEPs) in HIV-associated CRC cells co-cultured
with LAF-PLA-PCL CNS, and Gene Ontology (GO) protein and KEGG pathway enrichment analysis (KEGG analysis) revealed that the LAF-PLA-PCL NCS could affect the cell cycle (CC) of HIV-associated CRC cells. In conclusion, the PLA-PCL NCS exhibited good compatibility, crystallinity, and biological
activity, while the LAF-PLA-PCL NCS showed the potential to inhibit cell proliferation by affecting the CC.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2024
·Vol. 16
·期 2
·271-279
·
IF 0.9
Wang Yan
The application value of titanium dioxide (TiO2)/graphene nanocomposites in photothermal therapy of pancreatic cancer (PC) was explored. Using scale graphite as raw material, graphene was obtained by Hummer oxidation method and hydrazine hydrate reduction method, and then
TiO2/graphene nanocomposites were prepared by ultrasonic heating. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and degraded methyl orange solution were adopted to detect the surface structure, particle size, element morphology, and photocatalytic activity under different
composite ratios, different sonication times, and different heating temperatures. Human normal pancreatic ductal epithelial cell line HPDE6-C7 and human metastatic PC cell AsPC-1 were adopted as research models. The cytotoxicity of TiO2/graphene nanocomposites and the killing effect
of photothermal therapy based on TiO2/graphene nanocomposites were analyzed by water soluble tetrazolium salt colorimetric assay (WST-1) and methyl thiazolyl tetrazolium salt colorimetric assay (MTT). The results suggested that when the ratio of graphene to TiO2 was 50:1,
the ultrasonic time was 100 min, and the heating temperature was 200 °C, TiO2 was better attached to the surface of graphene, the distribution of particles was relatively more uniform, and the concentration of methyl orange was relatively lowest. The XRD pattern showed that
the diffraction peak of the doped TiO2/graphene nanocomposite was basically the same as that of the pure TiO2. When the ultrasonic time was 100 min, the diffraction peak intensity in the XRD pattern was the largest. As for AsPC-1 cells, the cell viability was obviously
lower than 0.1/1/10/100 μm/mL when the concentration of TiO2/graphene nanocomposites was 500 μm/mL (P <0.05). For HPDE6-C7 cells, when the concentration of TiO2/graphene nanocomposites was 100 and 500 μm/mL, the cell viability was
obviously lower than 0.1/1/10 μm/mL (P <0.05), and 500 μm/mL was the lowest. The cell killing rate in group D was clearly higher as against groups A, B, and C (P <0.05). Graphene: The optimal preparation conditions of TiO2/graphene nanocomposites
are 50:1, 100 min of ultrasound time, and 200 μC of composite temperature. The photothermal therapy based on TiO2/graphene nanocomposites can effectively kill PC cells, and has a good potential in the field of hyperthermia for pancreatic tumors.
研究领域:
肿瘤学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2024
·Vol. 16
·期 1
·85-92
·
IF 0.9
Zhang Xuhui,Hu Wenjun,Wang Jinghua,Wang Xinlei,Wang Li,Fang Yong
This research was aimed to evaluate extension effect of poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA/PEG) thermosensitive hydrogel-encapsulated bupivacaine (BUP) on neuroblockade in cardiothoracic surgery and explore the potential adoption of this thermosensitive hydrogel
as a drug carrier for postoperative neuroblockade. An animal experimental design was adopted. First, PLGA/PEG thermosensitive hydrogel was prepared and BUP was encapsulated as the drug carrier and evaluated. Then, 40 rats were selected for thoracic surgery and randomly rolled into experimental
group (injection of hydrogel in the cardiothoracic region for neuroblockade after cardiothoracic surgery) and control group (conventional BUP injection). The neuroblockade effects (maximum possible effect (MPE), sensory and motor blockade duration) in the two groups of rats were compared and
analyzed. The Results showed that gel-microsphere (Gel-MS) composite drug delivery system was successfully prepared, which exhibited a complete 3D porous structure and favorable encapsulation effect for BUP. Rheological testing showed favorable hardness (G′) and viscosity (G″)
for Gel-MS/BUP (GMB). The experimental group exhibited a notably prolonged period of 100% MPE with a slower rate of decline versus controls. Sensory blockade and motor blockade durations in the experimental group rats were (22.4±3.8) h and (22.7±3.5) h, respectively, both markedly
longer than those in the control group rats (P <0.05). In Conclusion, Gel/MS-BUP demonstrated a remarkable extension effect on neuroblockade in cardiothoracic surgery, indicating its potential adoption value in prolonging anesthesia duration.
研究领域:
药理学
·
外科手术
·
材料科学
·
麻醉学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2017
·Vol. 9
·期 10
·1713-1723
·
IF 1.671
Li Mengmeng,Chen Yongchao,Yin Li,Wang Haiyan,Cao Yanping,Wei Zhihao,Wang Yanfei,Yuan Qi,Pu Xiaohui,Zong Lanlan,Duan Shaofeng
To manufacture a stable paclitaxel nanosuspension (PTX-CP-Nanos), poly(L-phenyl-alanine)-b-poly(L-aspartic acid) (PPA-PAA), a multifunctional stabilizer, was synthesized via NCA-based ring-opening copolymerization. PTX-CP-Nanos were manufactured by a microprecipitation-high pressure
homogenization method. X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC) results indicated that the PTX in PTX-CP-Nanos existed in amorphous state. Particle size and zeta potential of the PTX-CP-Nanos were 226.8 ± 2.1 nm and –28.4 ± 0.1 mV, respectively,
as indicated by dynamic light scattering method. Transmission electron microscopy (TEM) revealed that the morphology of PTX-CP-Nanos were of rod-like crystals. In addition, it was found that the structure of PTX-CP-Nanos altered to micelles by TEM during dissolution. The dissolution rate of
PTX-CP-Nanos was significantly increased compared with the crude crystals but obviously lower than PTX injection, which could be ascribed to the particle size reduction of PTX nanoparticles and the conversion of PTX-CP-Nanos into micelles in the later stage of the dissolution test. The tests
of storage stability, dilution stability and plasma stability both showed that PTX-CP-Nanos were significantly more stable than PTX-Nanos stabilized by other traditional surfactants and polymers. The acute toxicity tests demonstrated that PTX-CP-Nanos also had a high systemic safety.
研究领域:
药剂学
·
生物材料学
·
药物化学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 10
·1362-1368
·
IF 1.158
Liu Mengna,Wu Jun,Wang Kaili,Yuan Dehao,Wang Yinan,Cheng Haoran,Zhao Feng,Fan Huaying,Xu Hui,Chen Daquan
In this paper, for the sake of improving the bioavailability and tumor targeting ability of curcumin (cur), we reported a nanoplatform self-assembled from Folic acid-Adipic dihydrazide-oligomeric hyaluronic acid (FA-ADH-oHA) as drug carrier, curcumin and β-elemene as loaded
model drug for dual targeting to breast cancer cells. We used pH sensitive Folic acid-Adipic dihydrazide (FA-ADH) as hydrophobic moieties, HA as the target of cancer stem cells CD44 receptor. The structure characteristic of this smart multifunctional dual targeting nano-sized carrier was measured
by 1H-NMR. Cur, an anticancer drug, was successfully loaded into FA-ADH-oHA micelles by self-assembly with a hydrodynamic diameter of 216.4 ± 0.5 nm. Triggered by faintly acidic tumor microenvironment, more encapsulated curcumin and β-elemene could be released
from the FA-ADH-oHA micelles in tumor environment than in the pH 7.3 environment. To sum up, the novel polymeric carrier based on pH sensitive and dual drug-targeting strategies was a prospective delivery platform to enhance therapeutic efficiency and decrease toxic side effect in breast cancer
therapy.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2015
·Vol. 7
·期 9
·1708-1716
·
IF 2.598
Zhou Jing,Wang Xuejiao,Li Luoyuan,Lu Zhigao,Li Kai
To improve the efficacy of therapies and reduce side effects, theranostics integrated imaging and therapy can achieve an optimized therapeutic outcome. Polypyrrole nanorods (PPy) were synthesized using a hydrothermal method and stabilized by both sodium oleate and 6-aminocaproic acid.
Following modification with PEG and Gd-DTPA, the developed nanorods (PPy-PEG-Gd) were well dispersed in water and demonstrated excellent biocompatibility, high photothermal conversion efficiency (53.5%), and magnetic properties (r
1 = 4.56 mM–1 · s–1).
T
1-weighted MR and photothermal imaging were integrated into the system to visualize the location of the cancer, or for real-time monitoring of photothermal therapy (PTT). Finally, PPy-PEG-Gd were successfully used as an efficient coupling agent for imaging-guided PTT in
vitro and in vivo under NIR laser irradiation. Therefore, PPy-PEG-Gd has great potential for use in T
1-weighted MR and/or infrared thermal imaging-guided PTT of cancer.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 5
·1074-1078
·
IF 1.812
She Boxi,Wan Xuejuan,Tang Jiaoning,Deng Yuanming,Zhou Xiaofeng,Xiao Caihua
Cuprous oxide nanoparticles with diverse morphology and particle size were prepared through reductive solution chemistry routes under alkaline condition. The standard minimal inhibitory concentration (MIC) test against Escherichia coli indicated that both size and morphology
of cuprous oxide nanoparticles played important role in their antibacterial performance. Cuprous oxide nanoparticles with smaller size (∼50 nm) exhibited better antibacterial activity than those with larger size (250∼350 nm); spherical cuprous oxide nanoparticles were found to be superior
to the cubic ones in the bacterial killing process. In addition, the synergistic antibacterial effect of cuprous oxide nanoparticles in the presence of another antibacterial agent, ascorbic acid (AA), was investigated. Experimental results showed that the antibacterial capacity of cuprous
oxide nanoparticles was significantly improved in the presence of ascorbic acid (0.1 wt%). The probable mechanism underlying the synergistic antibacterial activity has been discussed in detail. All the experimental results indicated that the developed low-cost antimicrobial mixture holds promising
application potential.
研究领域:
材料科学
·
微生物学
·
生物医学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2017
·Vol. 9
·期 11
·1895-1904
·
IF 1.671
Song Haixiang,Wang Meng,Wang Yanfei,Zhang Yadong,Umar Ahmad,Guo Zhanhu
In this study, one waterborne polyurethane (WPU) pre-polymer was synthesized by using polypropylene glycol (PPG-2000), 2,2-dimethylolpropionic acid (DMPA) and isophorone di-isocyanate (IPDI) via a step-wise reaction. Then, a series of WPU/graphene oxide (GO) nanocomposites were prepared
by ultra-sonication of GO dispersion and high shear emulsification. The GO and the WPU/GO nanocomposites were characterized by the Fourier transform infrared spectroscopy (FTIR), particle size analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy
(TEM), water contact angles test, atomic force microscopy (AFM), Raman spectroscopy, tensile properties test, thermo-gravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that the WPU/GO emulsions exhibited optimal dispersion stability, the particle size
of WPU/GO increased compared with that of virgin WPU. While the GO amount in the WPU/GO nanocomposites was 0.25–0.50 wt% (based on the weight of WPU resin), the GO could be dispersed homogeneously, yet the water contact angle values for the WPU/GO films were higher than that of pure
WPU, an increase from 58.83 for pure WPU to 61.38 for the GO content of 0.25%, and 62.32 for the GO content of 0.50%, respectively, showing an improvement in the hydrophobic properties. Furthermore, with the GO content increased from 0.00 (WPU0) to 0.25% (WPU1), the tensile strength of the
film got 60.69% improvement from 2.90 to 4.66 MPa, whereas the GO content increased from 0.25 (WPU1) to 0.50% (WPU2), the tensile strength of the films decreased from 4.66 to 4.31 MPa, with further increasing GO content, the elongation at break of the WPU/GO films decreased correspondingly.
Finally, better synergy interactions between WPU and GO were observed, and the micro-phase separation was reduced.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）