APPLIED OPTICS
·
2019
·Vol. 58
·期 25
·6942-6948
·
IF 1.973
Shuang Liang,Chen Cai,Ran Gao,Mengying Zhang,Ning Xue,Zhi-mei Qi
A colorful surface plasmon resonance imaging (SPRi) sensor with the hue-based enhanced sensitivity has been developed by using sputtered AuAg alloy thin film as the sensing layer. The condition for optimizing the hue-based sensitivity of the SPRi sensor was achieved, that is, the initial resonance wavelength is in the range from 595 to 610 nm. Under this condition, the hue-based refractive index sensitivity of the SPRi sensor was measured as high as Δhue/Δnc=29879/RIU. This sensitivity is 8 times higher than that obtained with a gold-layer SPRi sensor (Δhue/Δnc=3658/RIU) and 7.7 times as high in magnitude as the spectral sensitivity of the same sensor (ΔλR/Δnc=3897.6 nm/RIU). After functionalization of the AuAg alloy film with the monoclonal antibody, the sensor was used for quantitative immunodetection of highly carcinogenic benzo[a]pyrene (BaP) in water. According to the experimental results, the average hue of the SPR color image (300 pixels×300 pixels) experiences an initial rapid increase and then stabilizes 15 min after exposure of the functionalized AuAg alloy film to an aqueous BaP solution sample. The variation of average hue obtained at the equilibrium of surface immunoreaction is a linear function of BaP concentration with the slope being Δhue/Δc=132.2/(μg·L−1). A cooled CCD camera is able to distinguish a change of Δhue=1, offering the colorful SPRi sensor the BaP detection limit of 0.01 μg·L−1. The comparative measurements of the sensor’s responses indicate that the hue variation obtained with 0.1 μg·L−1 of BaP is equal to that obtained either with 5 μg·L−1 of benzanthracene or with 5 μg·L−1 of benzofluoranthene, revealing the sensor’s excellent specificity to BaP. The work demonstrated that the AuAg alloy film-based colorful SPRi sensor can be used not only for visualized analysis of molecular interaction at the surface but also for quantitative trace detection of small-molecule analytes.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Nano Today
·
2025
·
IF 10.9
Yangyang Zhou,Jingyao Wu,Wenbo Cui,Yindian Wang,Hezhen Liu,Kwangnak Koh,Hongxia Chen
The precise measurement of trace levels of small molecules in complex environments faces great challenges. The inherent limitation of the limited sensible range of surface plasmon resonance (SPR) is ingeniously leveraged in this work. Zeolite imidazolate frameworks-8 (ZIF8) as a sieve-induced antifouling layer, with gold nanobipyramids (AuNBPs) encapsulated within ZIF8 serving as the sensitizing material for simultaneous antifouling and sensitization. The electromagnetic field at the interface is modeled and simulated using the finite-difference time-domain (FDTD) method to ensure the proper match between the perceptible range and the shell layer thickness. The kinetic size of the molecules is calculated using multifunctional wavefunction analysis to ensure the pore size of ZIF8 is matched to the size of the target substance. The Grand Canonical Monte Carlo (GCMC) method simulated the adsorption of molecules with different properties in ZIF8, ensuring that the target molecule would pass through the pores into the effective sensing range, while impurities would be sieved out for sensitive and specific detection. This theoretical simulation and experimental design strategy, based on AuNBPs@ZIF8-modified integrated sensors, shows significant potential for application.
研究领域:
分析化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LIGHTWAVE TECHNOLOGY
·
2024
·Vol. 42
·期 16
·5768-5774
·
IF 4.1
Xuegang Li,Huiying Sun,Yanan Zhang,Yong Zhao,Xue Zhou
In this paper, a groundbreaking probe-type fiber optic biosensor, harnessing the surface plasmon resonance (SPR) effect enhanced by barium titanate glass microspheres, is unveiled for virus RNA detection. The multi-physics simulation was used to verify the sensitivity improvement achieved by introducing barium titanate microspheres on the surface of the optical fiber microspheres probe. Experiments confirmed this, pushing the sensor's limit to an impressive 6802 nm/RIU. Biomarker capture on the microsphere surface subtly alters the local refractive index, triggering a detectable SPR spectral shift. To showcase its prowess, the sensor tackled the reverse-transcribed complementary DNA (cDNA) of COVID-19 RNA. Chemical modification of the gold film and DNA hybridization technology ensured specific cDNA detection. The limit of detection for this target reached a remarkable 1.58 nmol/L. This sensor not only excels in virus RNA detection but also holds immense potential for diagnosing major diseases by pinpointing the concentrations of key biomarkers.
研究领域:
生物医学工程
·
光学传感
·
分子诊断
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yuye Xuan,Yong Wei,Songquan Li,Chunlan Liu,Qian Yang,Zhihai Liu
To detect the degree of interaction between coptisine and different DNA G-quadruplexes (G4s) and screen its anti-cancer targets, this paper developed a highly sensitive fiber surface plasmon resonance (SPR) sensor using zirconium-based metal organic framework (MOF-808) nanomaterials and plastic coated multimode optical fiber, which solves the problems of background interference and low sensitivity in traditional fluorescence detection method. MOF-808 has the characteristic of high electron mobility, which increases the sensitivity of the sensor to 4869.03 nm/RIU and improves the performance by 107%. Meanwhile, thanks to the ultra-high specific surface area of MOF-808, coptisine is enriched on the sensor surface, providing more G4s binding sites, the detection limit for c-MYC Pu22 G4 is 11.15 nM. Three types of G4s were detected using the sensor, and the sensor showed a significant response to c-MYC Pu22 G4, indicating that coptisine has a strong targeting effect on Pu22 G4, which is consistent with the results of molecular docking simulation, confirming the effectiveness of the sensor as a drug target screening validation tool. This sensor exhibits good specificity, with no significant response to other substances such as double stranded DNA except for the substance being tested, and maintains excellent stability after long-term storage. This work provides a concept validation optical sensing platform for drug target screening.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LIGHTWAVE TECHNOLOGY
·
2025
·
IF 4.8
Mingshi Song,Xili Jing,Zhiyong Yin,Shuguang Li
This paper designed a based on surface plasmon resonance (SPR) optical fiber type low crosstalk pH value and temperature sensor. The sensor has the ability to detect pH value and temperature simultaneously, and can overcome the error factor caused by temperature changes in the pH value detection process of optical fiber sensors. Sensor is based on a multimode fiber (MMF) fused with a coreless fiber (NCF) to build the sensing substrate. Ag was used as SPR excitation material and polyacrylic acid (PAA)/ chitosan (CS) composite membrane was used for pH detection. Compared with previous research on temperature compensation, the SPR cascade sensing method treated by TiO2/PDMS composite membrane significantly improved the temperature sensitivity of SPR signals and reduced crosstalk. This ensures that the SPR signal has a sufficient working range. In the range of -10°C ∼ 100°C, the maximum temperature sensitivity can reach -4.1301 nm/°C, and the detection limit (DL) is 0.1542°C. In the pH range of 4.08 ∼ 9.85, the sensor's pH sensitivity can reach up to -17.9359 nm/pH, and the resolution is 0.1272pH. Excellent sensing performance. The sensor is important for advancing future applications of high-precision temperature compensation detection, high-sensitivity pH biodetection, and SPR modulation technology.
研究领域:
传感技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2016
·Vol. 4
·期 13
·2614-2620
·
IF 5.066
Zihua Wu,Qiang Zeng,Haishui Wang
The pursuit of desirable longitudinal surface plasmon resonance (LSPR) of gold nanorods (AuNRs) and a suitable silica coating structure are two important aspects concerning mesoporous silica-coated gold nanorods (AuNR@mSiO2). This paper reports a simple approach to not only tailor the LSPR of AuNRs but also simultaneously control the structure and thickness of the silica shell after the silica coating process. Under acidic conditions, the use of O2 for end-selective etching of internal AuNRs shows good control over the aspect ratio of the AuNRs, thus enabling controllable tuning of the LSPR of AuNR@mSiO2. Compared to other strong oxidants such as aqua regia, O2 provides a milder and more gentle etching atmosphere, which gives the etched AuNRs good uniformity and regularity. Results showed that the thermal treatment of AuNR@mSiO2 solution before the initiation of the etching reaction had important impacts on the silica shell structure. Thermal treatment in ethanol solution gave rise to an empty and open mesoporous shell, and the use of ethanol–water as the solvent caused thinning of the shell thickness, while the internal AuNRs were basically unaffected in both cases. Both the opening and reduced thickness of the mesoporous silica shell facilitate the etching of the AuNRs. In addition, the rigid-type of mesoporous silica framework exposed in ethanol solution led to generation of cavity-possessing, rattle-type and hollow AuNR@mSiO2 as etching proceeded; however, in ethanol–water solution, the silica shell gained a certain extent of fluidity, resulting in movement of silica to fill the cavities created by end-etching of the internal AuNR.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 16
·5074-5086
·
IF 4.174
Hua Jiang,Shuaiqi Gong,Shu Xu,Penghui Shi,Jinchen Fan,Volkan Cecen,QunJie Xu,YuLin Min
A major challenge in the field of photocatalytic carbon dioxide (CO2) reduction is to design catalyst systems featuring high selectivity for CO production, long-term stability and a composition of Earth-abundant elements. Here, we present a metal–organic framework (MOF) based catalyst to mitigate the technical problems associated with the above-mentioned features. We report a carbon-coated CuNi alloy nanocatalyst obtained by high temperature vacuum treatment of a MOF material (CuNiBTC). The resulting carbon encapsulated CuNi (denoted as CuNi/C) nanoparticles possess a well-designed core–shell composite structure with graphene shells. Meanwhile, we investigated the reaction mechanism of CO2 on the surface of the CuNi/C photocatalyst in an aqueous solution containing triethanolamine. The experimental results show that the activity and catalytic yield of CuNi/C are much higher than those of Cu/C and Ni/C alone. At the same time, the catalytic activity of CuNi/C is also affected by changing the reaction temperature in the preparation process. As a result, the CuNi/C samples can achieve nearly 90% selectivity for NIR-light-driven CO2 reduction to CO. Our approach demonstrates the potential of non-semiconductor materials as catalysts for efficient and selective reduction of CO2 to CO.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2020
·
IF 1.418
Li-Ye Niu,Qi Wang,Wan-Ming Zhao,Jian-Ying Jing
A D-type optical fiber surface plasmon resonance (SPR) sensor based on gold film and Au nanoshells is described. The sensor has a smaller full width at half maximum (FWHM) and a higher quality factor. The influence of the coupling effect between the Au nanoshells and gold film with different internal and external diameter ratios on the sensor was investigated by the finite element method. The simulation results show that the coupling effect between the SPR of the gold film and the localized surface plasmon resonance (LSPR) of the Au nanoshells effectively improved the electric field strength of the sensing region. The refractive index measurements show that the sensitivity of the D-type fiber/gold film/Au nanoshell (50/40 AuNS) SPR sensor is 3064 nm/RIU, which is 993 nm/RIU higher than for the D-type fiber/gold film SPR sensor. The D-type fiber/gold film/Au nanoshell (50/40 AuNS) SPR sensor also provides good linearity with a value of 99.4%. The sensor reported in this paper can be used for reference in the development of high performance biosensors.
研究领域:
传感器技术
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Huanxian Shi,Wei Wang,Lihua Zhang,Zhishu Tang,Jun Fan
Here, a novel Ag quantum dots (Ag QDs) with diameter 3.1–10 nm modified Bi 4 O 5 Br 2 composite system was firstly fabricated via the facile mechanical agitation method and the photocatalytic ability of Ag QDs/Bi 4 O 5 Br 2 was evaluated by disinfection towards Escherichia coli ( E.coli ) under visible light stimulation (λ > 420 nm). The Ag QDs/Bi 4 O 5 Br 2 composites displayed the superior photocatalytic disinfection ability to the pure Bi 4 O 5 Br 2 . Especially, the 1000 Ag QDs/Bi 4 O 5 Br 2 composite exhibited the strongest photocatalytic ability with disinfecting all bacteria (1 × 10 7 cfu/mL) after 180 min visible light irradiation. The promoted photocatalytic ability of 1000 Ag QDs/Bi 4 O 5 Br 2 mainly be attributed to the synergistic effect of SPR produced by Ag and the formation of Schottky barrier which facilitate the separation efficiency of charge carrier and light utilization. The mechanism of photocatalytic disinfection over the Ag QDs/Bi 4 O 5 Br 2 composite was that the generated active species h + (hole) and · O 2 − (superoxide radical) disrupted the cell envelop to induce the leakage and decomposition of the cellular substances (e.g. protein, deoxyribonucleic acid (DNA) and potassium ion (K + )) as validated with the multiple techniques. This work open a new horizon to develop high-efficient Bi m O y X n -based photocatalytic disinfection materials.
研究领域:
材料科学
·
环境科学
·
纳米技术
·
光催化
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2025
·
IF 5
Zhuo-Yu Jin,Chu Cao,Nuerguli Kari,Dian-Yun Zhang,Qi Wang
Surface plasmon resonance (SPR) sensors are currently applied in various fields, driving the development of precise detection technologies. However, few designs effectively balance ease of fabrication, high detection performance, and structural stability. To address this challenge, we developed an SPR sensor with a sapphire prism-Au/Gallium Nitride (GaN)/Au composite film structure. The GaN thin film enhances sensitivity, while the coupling between the dual Au layers and sapphire reduces the full width at half maximum (FWHM) and improves sensor stability. Simulation results indicate a significant increase in the electric field intensity at the sensor surface. Experimental results demonstrate that the structure exhibits excellent long-term stability. Compared with conventional Au film sapphire prism SPR sensors, this design achieves a 3.14-fold increase in sensitivity and a 5.43-fold improvement in the figure of merit (FOM). This study presents a novel approach to further enhancing SPR sensor performance and highlights the potential applications of this structure in detection technologies.
研究领域:
光学传感
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Lixia Li,Minglong He,Yurui Huang,Jiabin Zhao,Yufang Liu
Developed a deep learning-assisted dual-modal SPR/digital SERS optical fiber sensor. • Enabled highly selective measurement of mercury ions. • Adopted a silver (Ag)/Ti 3 C 2 T x MXene/gold nanoparticle (AuNP) hybrid composite structure. • Achieved Hg 2+ detection limits as low as 10 pM. A deep learning-assisted dual-mode optical fiber sensor integrating surface plasmon resonance (SPR) and digital surface-enhanced Raman scattering (SERS) is developed for ultra-trace Hg 2+ detection. The sensor employs a silver (Ag)/Ti 3 C 2 T x MXene/Gold nanoparticle (AuNP) hybrid interface, where synergistic LSPR–SPR coupling amplifies electromagnetic fields for sensitive sensing. Upon Hg 2+ exposure, thymine (T)-rich DNA immobilized on the sensing surface and 4-mercaptopyridine-functionalized gold nanoparticle (AuNP@4-MPY) can selectively bind Hg 2+ , forming stable T–Hg 2+ –4-MPY complexes. This process anchors AuNP@4-MPY onto the sensing surface to form AuNP dimers, inducing a distinct SPR redshift and a prominent digital SERS enhancement. The sensor achieves detection limits of 10 pM (SPR) and 1 pM (digital SERS). The 18-layer Residual Network-Squeeze-and-Excitation (ResNet18-SE) regression model is utilized in this study to precisely predict Hg 2+ concentrations, yielding coefficient of determination ( R 2 ) values of 0.9997 and 0.9991 for SPR and digital SERS modes, respectively. Spike-and-recovery experiments performed in tap water and river water produced recoveries in the range of 95.4%–106.4% for both detection modes. This work provides an effective strategy for ultra-trace Hg 2+ detection and offers new perspectives on dual-mode optical sensing. Download: Download high-res image (269KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Jiale Wang,Minghua Deng,Chuanquan Wang,Kunpeng Niu,Ning Wang,Jinhua Li,Binyun Xia,Liyun Ding,Huan Yang,Xiaohan Chen,Jiayi Zhu
Background Efficient and rapid identification of trace amounts of microRNA-21 (miRNA-21), an oncogenic miRNA, is conducive to the early diagnosis of prostate cancer. Despite extensive research efforts, the development of biosensors capable of achieving clinically relevant sensitivity and limits of detection (LOD) remains challenging, primarily due to the ultralow physiological concentrations of cancer biomarkers in human biological systems. Beyond that, the suboptimal probe designs such as complex sensing structures and unstable sensing materials collectively lead to inadequate repeatability and stability for clinical application. Results Hence, in this work, a label-free and highly sensitive optical fiber Surface Plasmon Resonance (SPR) biosensor with ultralow LOD was developed for detecting miRNA-21, which was fabricated simply by coating a layer of Au film and gold nanoparticles (AuNPs) onto a multimode-single-mode-multimode (MSM) optical fiber, and then biofunctionalized with optimized single-stranded DNA (ssDNA) enabling the quantification of miRNA-21. Excitingly, the biosensors, which have a simple composition and demonstrated with excellent linearity, specificity and stability, were experimentally verified to reach an ultra-low LOD of 1.86 × 10 –19 M that significantly lower than current detection method and high sensitivity of 3021.48 RIU/nm. And detection of trace miRNA-21 was enabled without RNA amplification. The sensor's capability to effectively differentiate prostate cancer patients from healthy controls was demonstrated by testing clinical serum samples and the sensor achieved higher detection accuracy compared to the commonly used clinical prostate-specific antigen (PSA) quantification. Significance The proposed sensing platform processes the merits of simple configuration as well as low cost and has potential to auxiliary early-stage diagnosis of various cancers by detecting associated biomarkers.
研究领域:
生物医学工程
·
生物传感器
·
肿瘤学
·
纳米技术
·
即时检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）