COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 8
·2291-2300
·
IF 1.865
Zhou Qing-Han,Lin Juan,Li Li-Dong,Shang Le
Biodegradable micelles based on disulfide-linked monomethoxy poly(ethylene glycol)- b -poly(methyl methacrylate) 2 (mPEG-SS-PMMA 2 ) miktoarm star block copolymers were synthesized through atom transfer radical polymerization procedure and applied to solubilization and delivery of methotrexate (MTX). The synthesized miktoarm star block copolymers were characterized by 1 H nuclear magnetic resonance, Fourier transform infrared spectra, and gel permeation chromatography. The block copolymers were able to self-assemble into spherical micelles in water with an average diameter up to 130 nm by transmission electron microscopy observation and dynamic light scattering measurements and have a critical micelle concentration of 0.91 mg/L. When MTX was incorporated into obtained micelles, high drug loading capacity was found attributed to the designed miktoarm star-shaped nanostructure. Interestingly, in presence of dithiothreitol, the micelles could be degraded into polymer chains by cleavage of the disulfide linkages. The in vitro release studies revealed that these micelles released over 95 % of MTX within 48 h under a reductive environment analogous to that of the cell comparing to minimal drug release (<22 %) under nonreductive conditions. Cell cytoxicity experiments showed that the obtained micelles exhibited nontoxic, and the drug-loaded micelles exhibited high anticancer efficacy and better biocompatibility as compared to free MTX. All of these results showed that mPEG-SS-PMMA 2 micelles are promising carriers for delivery of hydrophobic antitumor drugs.
研究领域:
药学
·
高分子科学
·
纳米技术
·
药物传递
·
生物化学
·
材料科学
✓ 已验证
DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Liang Xiang,Min Qiu,Minjing Shang,Yuanhai Su
With the RAFT arm-first method, butyl acrylate and 4-acryloylmorpholine were used as monomers to form linear arms, which subsequently reacted with the cross-linker 1,6-hexanediol diacrylate to form star-shaped macromolecules in cascade microreactor systems. After studying polymerization kinetics in each step, homoarm and miktoarm star products with various arm compositions were steadily prepared by optimizing the reaction flowsheet and adjusting the reactant formula. Such continuous-flow processing avoided tedious intermediate purification procedures and prepared polymer products with considerable star yield (>70%), molecular weights ( M w,LS > 100 kg/mol) and arm numbers (>30). Multiple emulsions (including two types, i.e., oil-in-water and water-in-oil) were formed utilizing star products with different amphiphilic architectures as emulsifiers . This study demonstrated that in this continuous-flow mode, through regulating the residence time and flow rate ratio in each step, the arm and core structures of star polymers were tailored to possess remarkable functional applications.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2017
·
IF 3.531
Haohui Huo,Xiaoyan Ma,YeQing Dong,Fengjin Qu
A novel light- and temperature-responsive amphiphilic ABC miktoarm star terpolymer consisting of hydrophilic poly(ethylene glycol) (PEG), light-responsive poly(2-nitrobenzyl methacrylate) (PNBM), and temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) arms, PEG(- b -PNBM)- b -PNIPAM, was synthesized via a combination of atom transfer radical polymerization (ATRP) and click reaction. In aqueous solution, the obtained miktoarm star terpolymer self-assembled into spherical micelles with PNBM cores and hybrid PEG/PNIPAM coronas. When heating above the phase transition temperature of PNIPAM, larger aggregates with mixed PNBM/PNIPAM cores and PEG coronas were formed. Upon UV light irradiation, the initial micelles were disrupted and reassembled into some large micelle complexes. Fluorescence emission measurements showed that Nile red encapsulated in the polymeric micelles could be released by stimuli of UV light or temperature change. More interestingly, the UV triggered release could be strengthened in basic conditions but weakened in acidic conditions. The prepared light- and temperature-responsive polymeric micelles may have great potential in applications such as nanocarriers and biotechnology for controlled drug and bioagent delivery.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 107
·88382-88391
·
IF 3.84
Chunhua Wang,Feng Hu,Kejian Yang,Tianhui Hu,Wenzhi Wang,Rusheng Deng,Qibin Jiang,Hailiang Zhang
A novel star-branched nylon 6 with hexafunctional cyclotriphosphazene core was synthesized using hexa(4-carboxylphenoxy)cyclotriphosphazene (HCPCP) with six carboxyl groups as multifunctional agent in the hydrolytic ring-opening polymerization of ε-caprolactam, and then used for the investigation of mechanical properties, crystallization and rheology behaviors. Star-branching structure and molecular weight have great effects on its properties. Compared with linear nylon 6, star-branched nylon 6 has lower relative viscosity and higher melt flow rate while its mechanical properties can be almost retained by the use of star-branching and an appropriate molecular weight. Research on crystallization behavior indicates that the degree of crystallinity (Xc) of star-branched nylon 6 decreases slightly, but its crystal structure still belongs to α form. The peak crystallization temperature (Tc) and crystallization rate (1/t1/2) of star-branched nylon 6 are significantly higher than that of linear nylon 6 because of heterogeneous nucleation induced by HCPCP core, which is beneficial for the use of rapid molding process. As the molecular weight increases, the Tc and 1/t1/2 of star-branched nylon 6 first increase and then decrease. Capillary rheometer measurement exhibits that the shear viscosity of star-branched nylon 6 decreases with decreasing molecular weight, and the shear viscosity of star-branched nylon 6 with an appropriate molecular weight shows a low value and little or no sensitivity to shear rate and temperature. Such rheology behavior allows for processing at low temperature and low pressure and reduces system cost.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2015
·Vol. 11
·期 15
·2945-2951
·
IF 4.029
Yong Shen,Shusheng Zhang,Yaoming Wan,Wenxin Fu,Zhibo Li
A second or fourth generation dendrimer with primary amine as the peripheral terminal group was first synthesized via Michael addition and thiol–yne addition. A series of star-shaped polypeptides was synthesized by ring opening polymerization (ROP) of γ-(2-(2-methoxyethoxy)ethyl) L-glutamate (L-EG2Glu) N-carboxyanhydride (NCA) using the amine group terminated dendrimer as the initiator. Taking advantage of the well-defined dendrimer and ROP, the arm number and arm length can be easily controlled. These star-shaped poly(L-EG2Glu) can spontaneously form hydrogels instead of micelles in water at low concentration. The critical gelation concentration (CGC) and hydrogel strength displayed a stronger dependence on arm numbers than the arm length under similar conditions. These properties can be easily modulated by varying the poly(L-EG2Glu) arm length and arm number. The hydrogels showed shear thinning and rapid recovery properties. TEM and AFM characterization revealed that the hydrogel networks were constituted by entangled and branched fibrils.
研究领域:
生物材料学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2015
·
IF 2.515
Li-Ping Wang,Ke-Yang Yin,Guang Li,Qian Liu,Ai-Xia Deng,Hui-Yan Ma
Two types of star polystyrene (SPS) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization: three-arm star polystyrene (TSPS) and five-arm star polystyrene (FSPS). Honeycomb-structured porous films were fabricated by drop-casting of the SPS solutions on glass substrates . The regular honeycomb-patterned porous films were successfully constructed from the SPS solution casting process , and the pore diameter increased with the molecular weight of the SPS enhanced at appropriate molecular weight range. Furthermore, rhodamine B (RhB) was loaded into SPS to endow the microporous film with fluorescence. The RhB-loaded SPS film exhibits a strong and uniform red emission image.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 8
·3121-3128
·
IF 4.705
He Jing,Yu Tao,Yang Weidong,Li Yan
Biodegradable four-arm star-shaped poly(lactic acid) (4sPLA) was synthesized from l -Lactic acid ( l -LA) and pentaerythritol (PENTA), and the polymerization kinetics was studied. The effects of reaction time, reaction temperature and molar ratio on the polymerization of 4sPLA were discussed. The molecular structure of 4sPLA was characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance spectra ( 1 H-NMR). The results showed that the optimum reaction conditions were as follows: the molar ratio of l -LA to PENTA was 12:1, and the polymerization reaction occurred at 160 ℃ for 5 h. Gel permeation chromatography method was used to determine the polymerization kinetics of 4sPLA consistent with the first-order reaction kinetics.
研究领域:
材料科学
·
化学工程
·
生物医学材料
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Ze-Zhong Lin,Yan Wang,Xiao-Bo Yang,Shang-Rong Yan,Yu Chen,Hai-Chao Li,Gang Wang
Besides the good flexibility and extensibility, plasticized soft poly(vinyl chloride) (PVC) possessing the extra characteristics of high modulus, tensile strength and toughness are desired for wider applications. Herein, a series of three-arm star copolymers possessing the hard polylactide (PLA)-rich core and the soft poly(ε-caprolactone)-rich (PCL) shell (S 3 -PLA-PCL) were prepared, which were used as the plasticizers for the preparation of soft PVCs. The monomer ratio of ε-caprolactone to lactide (LA), the average polymerization degree of LA and the type of LA (racemic or L type) were optimized to achieve the best mechanical performance of soft PVCs. With the similar elongation at break, S 3 -PLA-PCL plasticized PVC exhibited higher modulus, strength and toughness than PVCs plasticized by the corresponding linear PLA-PCL and other traditional low molar-mass and polymeric plasticizers without hard core. This pointed out the importance of the star topology and the hard PLA-rich core of S 3 -PLA-PCL in strengthening soft PVCs. The transparency of PVC plasticized by S 3 -PLA-PCL was similar to the neat PVC and PVCs plasticized by the traditional plasticizers. Migration stability tests demonstrated that S 3 -PLA-PCL had excellent migration resistance in PVC matrix. Moreover, both PLA and PCL are sustainable, biocompatible and biodegradable, hence, the as-prepared S 3 -PLA-PCLs can be called as high-performance, green polymeric plasticizers for PVC plastics.
研究领域:
材料科学
·
高分子化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2025
·
IF 3.9
Xuehui Liu,Qian Li,Ranran Gao,Qu Wang,Li Wang,Wantai Yang
Macromolecular architecture control of fluorescent polymers presents an important approach to diverse self-assembled nanostructures and tailored functions. Herein, tetraphenylethylene (TPE) derivatives with different bromopropionate and hydroxyl functionalities were synthesized efficiently. Based on the single electron transfer living radical polymerization (SET-LRP) of oligo(ethylene glycol) methyl ether acrylate (OEGA) and the mechanistic transition to reversible addition−fragmentation chain transfer (RAFT) dispersion polymerization of benzyl methacrylate (BzMA), well-defined aggregation-induced emission (AIE)-active miktoarm star TPE-(POEGA)n-(PBzMA)4-n (n = 1−3) nanoassemblies were synthesized for the first time. The nanoassemblies were utilized as an ideal platform to probe the intricate interplay between macromolecular architecture, self-assembly behavior, and fluorescence properties. Results showed that the arm engineering (changing the respective arm numbers) of miktoarm star polymers can bring about drastic alterations in the self-assembled morphology and photoluminescence characteristics. This arises from the influences of macromolecular structure on molecular packing, intermolecular interactions and intramolecular motions. This work highlights the unique advantage of miktoarm star architecture design and has far-reaching implications for the rational design of high-performance intelligent fluorescence systems.
研究领域:
高分子化学
·
材料科学
·
纳米技术
·
荧光材料
·
自组装
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2019
·
IF 13.903
Xuexiang Han,Ying Xu,Yiye Li,Xiao Zhao,Yinlong Zhang,Huan Min,Yingqiu Qi,Gregory J. Anderson,Linhao You,Yuliang Zhao,Guangjun Nie
Combining informative imaging methodologies with effective treatments to destroy tumors is of great importance for oncotherapy. Versatile nanotheranostic agents that inherently possess both diagnostic imaging and therapeutic capabilities are highly desirable to meet these requirements. Here, a simple but powerful nanoplatform based on polydopamine-coated gold nanostar (GNS@PDA), which can be easily diversified to achieve various function extensions, is designed to realize functional and anatomical imaging-guided photothermal oncotherapy. This nanoplatform intrinsically enables computed tomography/photoacoustic/two-photon luminescence/infrared thermal tetramodal imaging and can further incorporate fibroblast activation protein (FAP, a protease highly expressed in most of tumors) activatable near-infrared fluorescence imaging and Fe3+-based magnetic resonance imaging for comprehensive diagnosis. Moreover, GNS@PDA exhibits excellent photothermal performance and efficient tumor accumulation. Under the precise guidance of multimodal imaging, GNS@PDA conducts homogeneous photothermal ablation of bulky solid tumors (∼200 mm3) in a xenograft mouse model. These results suggest great promise of this extendable nanoplatform for cancer theranostics.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
医学成像
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2016
·
IF 2.437
Xinyu Peng,Yixin Zhang,Ying Chen,Sai Li,Bin He
A well-defined miktoarm star copolymer (μ-PEG-PCL-PLLA) was synthesized and the crystallization behavior of the copolymers was investigated. The structure of copolymer was confirmed by 1 H NMR, the molecular weight and molecular weight distribution were studied by GPC . XRD and POM were used to study the crystallization behavior of the miktoarm star copolymers. The XRD spectra showed that the miktoarm star copolymer showed low crystallinity for the joint of terminal, which limited the mobility of polymeric chains. The POM photographs revealed that PCL segments formed spherulites with PLLA crystalline grains as nucleus due to the good compatibility between PCL and PLLA.
研究领域:
材料科学
·
高分子化学
·
生物医学材料
✓ 已验证
DOI
高影响因子
Advances in Materials Science and Engineering
·
2018
·Vol. 2018
·期 1
·8191095
·
IF 1.372
Xue-Yu Tao,Jie Ma,Rui-Lin Hou,Xiang-Zhu Song,Lin Guo,Shi-Xiang Zhou,Li-Tong Guo,Zhang-Sheng Liu,He-Liang Fan,Ya-Bo Zhu
Star-like nano-ZrO 2 has been synthesized using Zr(NO 3 ) 4 ·5H 2 O as zirconium source by a hydrothermal process without any template and surfactant. The structure of the as-prepared ZrO 2 powder was investigated by multiple advanced analytical methods. The results showed that CH 3 COO − and NO 3 − had great effects on the formation of star-like ZrO 2 nanostructures. The as-prepared ZrO 2 had a superior catalytic activity, and the reason for it was analyzed by UV-Vis diffuse reflectance spectroscopy. The effect of raw material ratios on the photocatalytic property of ZrO 2 was studied. The synthesized ZrO 2 showed a narrow bandgap (3.50–3.85 eV) and an excellent photocatalytic activity, and the degradation of RhB was up to nearly 100% in 30 min with this photocatalyst.
研究领域:
材料科学
·
纳米科技
·
光催化
·
无机化学
·
环境功能材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）