JOURNAL OF POWER SOURCES
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2022
·
IF 9.794
Tao Huang,Rongrong Zheng,Haiyang Chang,Di Ma,Haijun Niu
Organic electrode material can be obtained from biomass through green process, so it is a sustainable green electrode material. However, the capacity attenuation problem of organic electrode seriously affects its application in the field of batteries . Desodiation state and sodiation state are the two corresponding states of electrode materials in redox reaction . The reason for this problem is that the reported desodiation state or sodiation state of organic electrode active unit cannot exist stably in aprotic electrolyte. Here, we report a new organic active unit sodium tert-butoxide (STB), which can exist stably in aprotic electrolyte to obtain high cycle stability. As the electrode of rechargeable batteries, the STB exhibits a capacity of 206 mAhg −1 at 35 mAg −1 , 2.4 V. The battery runs more than 5000 cycles at 210 mAg −1 , 135 mAhg −1 , no capacity attenuation. The other two battery samples run more than 6500 cycles and 10000 cycles at 600 mAg −1 , with the capacity retention 99% and 98%, respectively. STB provides a design basis for the development of organic electrode materials with high energy density and high cycle stability.
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高影响因子
POLYMER
·
2024
·
IF 4.1
Jie Li,Nafeesa Mushtaq,Xingzhong Fang,Guofei Chen
In order to prepare thermoplastic polyimide (PI) resins with good comprehensive performances, the modification of thermoplastic polyetherimides (PEIs) by 1,4-bis(2,3-dicarboxyphenoxy)-2- tert -butylbenzene dianhydride (3,3′-TBHQDA) was systematically investigated. The PEI-a-x and PEI-b-x series of polyetherimides were synthesized by chemical imidization of the diamine monomer m -phenylenediamine ( m -PDA) with different contents of 1,4-bis(3,4-dicarboxyphenoxy)-2- tert -butylbenzene dianhydride (4,4′-TBHQDA) and 3,3′-TBHQDA or 4,4′-(4,4′-isopropylidenediphenoxy) bis(phthalic anhydride) (4,4′-BPADA) and 3,3′-TBHQDA. These PEIs had glass transition temperatures ( T g s) in the range of 217–264 °C, low melt viscosities of 79–2367 Pa s, good transmittances of 87–88 % at 450 nm, and displayed good mechanical properties with tensile modulus of 2.8–3.2 GPa, tensile strengths of 89.6–118.4 MPa, and elongations at break of 3.9–6.4 %. The introduction of 3,3′-TBHQDA successfully improved thermal properties and melt processability of the PEIs. Among them, PEI-a-50 and PEI-b-50 displayed better comprehensive performances in PEI-a-x and PEI-b-x series, respectively, with moderate T g s (256 and 249 °C, respectively), extremely low melt viscosities (161 and 297 Pa s at 400 °C, respectively), high transmittances at 450 nm (87 %), and good mechanical properties (tensile modulus of 3.1 and 2.8 GPa, tensile strengths of 105.6 and 106.3 MPa, respectively).
研究领域:
材料科学
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化学工程
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高影响因子
Oxidative Medicine and Cellular Longevity
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2015
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IF 3.516
Dan Lu,Anding Xu,Hongcheng Mai,Jiayi Zhao,Chanjuan Zhang,Renbin Qi,Huadong Wang,Daxiang Lu,Lihong Zhu
Neural stem cells (NSCs) transplanted is one of the hottest research to treat Alzheimer’s disease (AD), but cholinergic neurons from stem cells were also susceptible to cell death which Heat shock protein 70 (HSP70) was affirmed to reverse. Related to cognitive impairment, cholinergic nervous cells should be investigated and ginsenoside Rg1 (G-Rg1) was considered to increase them. We chose tert-butyl hydroperoxide (t-BHP) damage model to study in vitro. Functional properties of our recombination plasmid pEGFP-C2-HSP70 were affirmed by SH-SY5Y cells. To opposite the transitory appearance of HSP70, NSCs used as the vectors of HSP70 gene overexpressed HSP70 for at least 7 days in vitro. After transfection for 3 days, G-Rg1 pretreatment for 4 hours, and coculture for 3 days, the expression of acetylcholinesterase (ChAT), synaptophysin, and the ratio of NeuN and GFAP were assessed by western blot; Morphological properties were detected by 3D reconstruction and immunofluorescence. ChAT was markedly improved in the groups contained G-Rg1. In coculture system, the ratio of neurons/astrocytes and the filaments of neurons were increased; apoptosis cells were decreased, compared to monotherapy (). In conclusion, we demonstrated that, as a safe cotreatment affirmed in vitro, overexpression of HSP70 in NSCs plus G-Rg1 promoted nervous cells regeneration from chronic oxidative damage.
研究领域:
神经科学
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药理学
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细胞生物学
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分子生物学
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干细胞研究
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PubMed
高影响因子
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
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2020
·Vol. 97
·期 8
·879-888
·
IF 1.659
Qin Ye,Chaosheng Xia,Xiaohua Nie,Xianghe Meng
2- tert -Butyl-1,4-benzoquinone (TBBQ), the main oxidation product of tert -butyl-hydroquinone (TBHQ) during frying, is cytotoxic and its residual levels in frying oils and foods are unknown. In this study, TBBQ residues have been evaluated during the preparation of french fries. Results showed that frying at 140 °C resulted in the highest TBBQ peak concentration (48.42 mg kg −1 ) compared with frying at 190 or 170 °C. This unexpected finding can be attributed to more extensive hydrolytic reaction when frying at the lower temperature, generating more peroxyl radicals. TBBQ concentrations proved to be independent of the oil type among various unsaturated oils. However, higher TBBQ levels were observed in saturated palm oil and crude soybean oil than in unsaturated oil or refined oil. Continuous frying leads to the accumulation of a large amount of TBBQ in fried food. After frying 1–5 batches, TBBQ levels in both the frying oil and fries were above 10 mg kg −1 , exceeding its critical cytotoxic concentration (IC 50 value of 10.71 mg kg −1 for RAW 246.7 cells in our previous study), warranting concern with respect to the safety of fried food. FTIR has been utilized as an effective tool for visually monitoring the degree of oxidation in the frying medium with respect to its hydrogen peroxide level, which contributes to the increased level of TBBQ derived from TBHQ therein.
研究领域:
食品安全
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毒理学
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食品化学
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高影响因子
ELECTRONIC JOURNAL OF BIOTECHNOLOGY
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2020
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IF 2.894
Longxing Wang,Wenjun Zhu,Zhen Gao,Hua Zhou,Fei Cao,Min Jiang,Yan Li,Honghua Jia,Ping Wei
Background L- tert -Leucine has been widely used in pharmaceutical, chemical, and other industries as a vital chiral intermediate. Compared with chemical methods, enzymatic methods to produce L- tert -leucine have unparalleled advantages. Previously, we found a novel leucine dehydrogenase from the halophilic thermophile Laceyella sacchari ( Ls LeuDH) that showed good thermostability and great potential for the synthesis of L- tert -leucine in the preliminary study. Hence, we manage to use the Ls LeuDH coupling with a formate dehydrogenase from Candida boidinii ( Cb FDH) in the biosynthesis of L- tert -leucine through reductive amination in the present study. Result The double-plasmid recombinant strain exhibited higher conversion than the single-plasmid recombinant strain when resting cells cultivated in shake flask for 22 h were used. Under the optimized conditions, the double-plasmid recombinant E. coli BL21 (pETDute-FDH-LDH, pACYCDute-FDH) transformed 1 mol·L -1 trimethylpyruvate (TMP) completely into L- tert -leucine with greater than 99.9% ee within 8 h. Conclusions The Ls LeuDH showed great ability to biosynthesize L- tert -leucine. In addition, it provided a new option for the biosynthesis of L- tert -leucine. How to cite Wang L, Zhu W, Gao Z, et al. Biosynthetic L- tert -leucine using Escherichia coli co-expressing a novel NADH-dependent leucine dehydrogenase and a formate dehydrogenase. Electron J Biotechnol 2020;47. https://doi.org/10.1016/j.ejbt.2020.07.001
研究领域:
生物技术
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微生物学
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酶学
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
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IF 5.2
Guoyong Liu,Yanrui Xie,Yanzhen Cao,Yingying Jing
Under the catalysis of MnO 2 , TBHQ can react with Cys to generate fluorescent CDs. • A fluorescence turn-on sensor for detection of TBHQ is proposed based on in-situ formation of fluorescent CDs. • This sensor is capable of quantitatively measuring the concentration of TBHQ in edible oils. Excessive intake of the food additive tert -butylhydroquinone (TBHQ) causes potential hazards to the human body. Designing an easy-to-fabricate and efficient TBHQ sensor is of great research significance. We found that in the presence of MnO 2 , TBHQ can react with cysteine (Cys) to generate fluorescent carbon dots (CDs). Inspired by this simple fluorogenic reaction, a turn-on sensor for TBHQ detection is proposed based on in-situ formation of fluorescent CDs. The sensor offers a linear range of 1–200 μM and a detection limit as low as 0.06 μM. Due to its simple reaction precursors and unambiguous reaction mechanism, this sensor demonstrates good practicability for TBHQ measurement in edible oils. This fluorescence turn-on in-situ sensor, which does not require pre-synthesized materials, offers considerable potential for on-site detection of TBHQ. Download: Download high-res image (122KB) Download: Download full-size image
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Ningxiang Yu,Yunling Lai,Kaili Gao,Yijue Wang,Yuanchao Lu,Chengyu Jin,Xiaohua Nie,Qin Ye,Xianghe Meng
Lys and Arg showed markedly higher TBBQ-eliminating and adduct-forming capacities. • Adducts were likely formed via a 1,4-addition and subsequent oxidation. • The elimination products of Lys-TBBQ-1 and Arg-TBBQ were verified in fried tofu. • The adducts displayed much lower cytotoxicity than TBBQ in Caco-2 cells. 2- tert -Butyl-1,4-benzoquinone (TBBQ), as a potential threat to food safety, is believed to be eliminated by amino acids. This study investigated the potential reaction mechanism between TBBQ and amino acids, and evaluated the cytotoxicity of the l -lysine-TBBQ and L-arginine-TBBQ adducts. The results indicated that the rates of TBBQ elimination and adduct formation would be promoted under alkaline conditions, and with the increase of amino acid concentrations, temperatures. Meanwhile, l -lysine and L-arginine exhibited significantly higher TBBQ-eliminating and adduct-forming capacities. Structural characterization of the l -lysine-TBBQ and L-arginine-TBBQ adducts confirmed 1,4-addition as the primary reaction pathway, validated in real food systems. Furthermore, the cytotoxicity toward Caco-2 cells was reduced with approximately 100% cell viability under 100 μM l -lysine-TBBQ and L-arginine-TBBQ adducts, probably originating from the dramatic decrease in reactive oxygen species production and apoptosis. These findings provided the theoretical support for assessing dietary risk and developing detoxification strategies for TBBQ.
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PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2024
·Vol. 38
·期 8
·e7600
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IF 3.7
Junhui Feng,Hongyu Wang,Yangyu Liu,Wannaiyi Liu,Xiaoyun Lin
In this paper, a porous zirconium-based metal–organic framework (NH 2 -UiO-66) and functionalized carbon black (FCB) composite was prepared through a one-pot hydrothermal method, and a novel electrochemical sensor based on NH 2 -UiO-66@FCB modified glassy carbon electrode (NH 2 -UIO-66@FCB/GCE) was developed for the simultaneous sensoring of butylhydroxyanisole (BHA) and tert-butylhydroquinone (TBHQ). The morphology and structure of NH 2 -UiO-66@FCB were characterized through scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectrum. The electrochemical behaviors of the NH 2 -UiO-66@FCB/GCE were investigated using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Under optimized experimental conditions, the linear ranges for TBHQ and BHA detection were determined to be 0.12–460 μM and 0.7–420 μM, respectively, with their corresponding detection limits of 0.072 μM and 0.29 μM. Furthermore, the sensor exhibited excellent selectivity, repeatability and stability, and successfully used for the simultaneous detection of TBHQ and BHA in food samples.
研究领域:
分析化学
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材料科学
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食品科学
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高影响因子
ENVIRONMENTAL RESEARCH
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2026
·
IF 8.2
Xiao-Min Ren,Yuwei Ma,Xinxin Liu,Xiaochi Zhang,Huan He,Zhixiang Xu,Gui Yang,Bin Huang,Xuejun Pan
Di -tert- butylphenol derivatives, including 2,4-di -tert- butylphenol (2,4-DTBP) and its analogs, are commonly used synthetic phenolic antioxidants and have been widely detected in food, environmental matrices, and human samples. In this study, we systematically investigated the disruptive effects of 2,4-DTBP and its analogs on the thyroid hormone (TH) system using molecular, cellular, and in vivo approaches, and elucidated their underlying mechanisms of action. At the molecular level, luciferase reporter assays, coactivator recruitment experiments, and molecular docking analyses demonstrated that 2,4-DTBP, 1,3,5-tri -tert- butylbenzene (1,3,5-TTBB), and 2,4,6-tri -tert- butylbenzene (2,4,6-TTBP) act as agonists of retinoid X receptor α (RXRα). At the cellular level, proliferation assays in rat pituitary GH3 cells showed that these compounds interfere with the TR/RXRα heterodimer signaling pathway by activating RXRα rather than directly targeting the thyroid hormone receptor (TR). At the in vivo level, zebrafish embryo exposure experiments demonstrated that 2,4,6-TTBP disrupts TH levels and the expression of TH-related genes, and transcriptomic analysis further revealed perturbations in multiple key biological processes. Collectively, these findings identify TH-disrupting effects of 2,4-DTBP and its analogs and reveal a novel mechanism mediated through RXRα rather than TR. Furthermore, potential health risks of 2,4-DTBP and 2,4,6-TTBP were evaluated using the hazard quotient approach, indicating that both compounds may pose TH-disrupting risks at current human exposure levels. This study provides mechanistic insights and toxicological evidence supporting the environmental risk assessment of 2,4-DTBP and its analogs.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2013
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IF 4.093
Guang Lu Han,Ke Zhou,Ao Nan Lai,Qiu Gen Zhang,Ai Mei Zhu,Qing Lin Liu
As a new type of filler for mixed matrix membranes (MMMs), metal–organic frameworks (MOFs) have received increasing attention. As a kind of MOFs, [Cu 2 (bdc) 2 (bpy)] n is successfully synthesized in this work and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), wide angle X-ray diffraction (WAXRD), thermogravimetric analysis (TGA) and adsorption isotherms . [Cu 2 (bdc) 2 (bpy)] n is found to preferentially adsorb methanol (MeOH) over methyl tert -butyl ether (MTBE). For this reason, the [Cu 2 (bdc) 2 (bpy)] n is incorporated into sulfonated polyarylethersulfone with cardo (SPES-C) to form [Cu 2 (bdc) 2 (bpy)] n /SPES-C MMMs for the separation of MeOH/MTBE mixtures. Both the sorption selectivity and the diffusion selectivity are found to increase with the addition of [Cu 2 (bdc) 2 (bpy)] n leading to an increase in the separation factor. With increasing [Cu 2 (bdc) 2 (bpy)] n loading from 5 to 20 wt%, the flux increased up to 0.288 kg m −2 h −1 at 20 wt% loading. A threshold of [Cu 2 (bdc) 2 (bpy)] n loading is approximately 20 wt% where the flux remains almost constant regardless of further increasing the [Cu 2 (bdc) 2 (bpy)] n content. This work demonstrates an improved performance of the [Cu 2 (bdc) 2 (bpy)] n /SPES-C MMMs for the separation of MeOH/MTBE mixtures.
研究领域:
材料科学
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化学工程
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2019
·Vol. 84
·期 8
·2042-2049
·
IF 2.081
Lipeng Han,Qingna Lin,Guoqin Liu,Dongxue Han,Li Niu,Dongxiao Su
It is important to inhibit the food-derived, potentially hazardous chemical glycated lipids by natural products. A model system was established and the products are identified to study the inhibitory mechanism of four types of catechin, resveratrol (RES), and the synthetic antioxidants butylated hydroxylanisole (BHA) and tert-butylhydroquinone (TBHQ) on the formation of carboxymethyl 1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (CM-DPPE) by determining hydroxyl radical (OH·), Amadori-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (Amadori-DPPE) and glyoxal (GO). The results show that the inhibitory rates of catechin and RES on the content of CM-DPPE in the model system are higher than those of BHA and TBHQ. There are at least two inhibitory mechanisms of antioxidants on CM-DPPE. (1) Antioxidants scavenge OH·, which blocks the process of Amadori-DPPE oxidation to form CM-DPPE. (2) Antioxidants trap GO, which blocks the reaction between GO and DPPE to form CM-DPPE. This research will reveal the inhibitory mechanisms of natural antioxidants on glycated lipids from the aspect of scavenging OH· and trapping GO. Practical Application Food manufacturers should pay attention on the production of glycated lipids in food processing. This study will provide the theoretical basis for the use of natural products to inhibit the formation of food-derived glycated lipids. Natural products, such as catechin and resveratrol, can substitute chemical synthesis antioxidants, such as butylated hydroxylanisole and tert-butylhydroquinone, in food processing, which inhibit the formation of glycated lipids.
研究领域:
食品科学
·
生物化学
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DOI
PubMed
高影响因子
CATALYSIS COMMUNICATIONS
·
2019
·
IF 3.674
Lei Wang,Guoliang Wang,Lu Wang,Shasha Feng,Deren Fang,Wenyou Xu,Haisheng Wei,Lv Qi,Wanzhong Ren
Co 6 Fe 4 Mo 12 Bi 1.5 O x phase has been successfully synthesized via a novel urea-assisted hydrothermal process, wherein urea as an assistant reagent plays an important role on the homogeneous dispersion of the metal elements in the obtained mixed solution. The resulted catalyst was characterized by powder X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectrometer. These results suggest that the catalyst is mainly a single phase. Compared with the common multiphase metal oxides, the single Co 6 Fe 4 Mo 12 Bi 1.5 O x phase exhibits remarkable activity in selective oxidation of tert-butyl alcohol to methacrolein by synergistic effects of two active sites at a nano level in the single phase system.
研究领域:
催化化学
·
材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）