SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Ning Xia,Dehua Deng,Xiangsheng Mu,Ang Liu,Jiaxun Xie,Dandan Zhou,Ping Yang,Yun Xing,Lin Liu
This work reported a novel redox cycling in which pyrroloquinoline quinone (PQQ) promoted the reduction of Fe(III)-ferrozine by tris(2-carboxyethyl)phosphine (TCEP). Specifically, PQQ was reduced into pyrroloquinoline quinol (PQQH 2 ) by TCEP, and then the produced PQQH 2 reduced colorless Fe(III)-ferrozine into dull red Fe(II)-ferrozine. The redox cycling was employed for development of colorimetric immunosensors through the generation of colorful Fe(II)-ferrozine. Mesoporous silica nanoparticle (MSN) was used as the carrier for both PQQ and recognition antibody through electrostatic interactions. Magnetic bead (MB) was used as the support for the immobilization of capture antibody. After the sandwich-type immunoreactions and magnetic separation, the MSN-PQQ nanolabels on the MB surface triggered the production of Fe(II)-ferrozine. The limit of detection was found to be 1 pg/mL with prostate specific antigen (PSA) as the model target. The result for the analysis of serum sample is in agreement with that achieved by the commercial enzyme-linked immunosorbent assay kits. The proposed immunosensor obviated the use of enzyme molecules for signal amplification and did not require expensive instruments for signal readout. This work should be valuable for the design of novel nanolabels and the proposed sensing strategy by the redox cycling could be applied to develop more sensitive biosensors.
研究领域:
分析化学
·
纳米技术
·
生物传感器
·
免疫学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Xiaochen Zhao,Xudong Wang,Yonghao Dong,Hongmin Zhang,Wei Zhao,Jin Wang,Lei Wang
Graphitic carbon nitride nanosheets can be assembled into two-dimensional layered separation membranes due to their unique structure; however, the narrow interlayer channels (0.32 nm) cause strong transmembrane mass transfer resistance. In this study, we expanded the interlayer spacing by intercalating tris(hydroxymethyl) aminomethane (Tris) molecules as supports while introducing high-affinity and adhesive tannic acid (TA) molecules to suppress the disordered stacking of Tris molecules. The two were stably anchored between the layers through hydrogen bonding to form an interlayer channel of 0.83 nm. While maintaining the high rejection performance (>99%) for EB dyes, the improved composite membrane possessed an ultrahigh water flux (170 ± 6 L h −1 m −2 bar −1 ) that was more than ten times higher than that of the pristine g-C 3 N 4 membrane. We also studied the acid-base resistance, organic solvent resistance and mechanical stability of the composite membrane.
研究领域:
材料科学
·
分离技术
·
纳米材料
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产品关联
DOI
高影响因子
DESALINATION
·
2022
·
IF 11.211
Zitian Liu,Xuesong Deng,Ligang Lin,Rongrong Qiang,Qiying Wang,Qi Cheng,Jing Yang,Xu Yang,Wensong Ma,Xinyang Li,Meina Xu,Chunhong Wang,Qingping Xin,Kongyin Zhao
Efficient separation of dyes and salts from textile wastewater is still a great difficulty. Herein, a tris(hydroxymethyl) aminomethane (Tris)-modified polyimide (PI) membrane was developed, which was effective, easy-to-fabricate, and versatile with high-separation-selective performance. With the introduction of Tris, the roughness, hydrophilicity and negative zeta potential of the membranes were increased, and the pore size was reduced. At 3 bar, the representative membrane exhibited high permeate flux (176–206 L·m −2 ·h −1 ) and high rejection (>97 %) to four common dyes and excellent solvent resistance to seven organic solvents, indicating that PI/Tris membrane had potential for application in dye wastewater containing complex organic solvents. Furthermore, the PI/Tris-modified membrane could selectively separate dyes and salts, and presented high dye rejection (>99 %) and low salt rejection (≈7 %) as well as high selectivity (separation factor = 103) for Direct Black 38/NaCl mixture. In particular, the PI/Tris-modified membranes outperformed many contemporary separation membranes in terms of separation efficiency of dye/salt mixtures. In summary, this PI/Tris membrane developed in this study has a promising future in the field of industrial dye wastewater treatment .
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Ning Gao,Lanpeng Yang,Xueqiang Lu,Lin Zhu,Jianfeng Feng
Micro(nano)plastics (MNPs) inevitably interact with coexisting contaminants and can act as vectors to affect their fate in organisms. However, the quantitative contribution of MNPs in the in vivo bioaccumulation and distribution of their coexisting contaminants remains unclear. Here, by selecting tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) as the typical coexisting contaminant, we quantified the contribution of MNPs to bioaccumulation and distribution of TDCIPP with toxicokinetic models. Results indicated that MNPs differentially facilitated TDCIPP bioaccumulation and distribution, and NPs slowed down TDCIPP depuration more significantly than MPs. Model analysis further revealed increasing contributions of MNPs to whole-fish TDCIPP bioaccumulation over time, with NPs (33–42%) contributing more than MPs (12–32%) at 48 h exposure. NPs contributed more than MPs to TDCIPP distribution in the liver (13–19% for MPs; 36–52% for NPs) and carcass (24–45% for MPs; 57–71% for NPs). The size-dependent vector effect might be attributed to the fact that MNPs promote contaminant transfer by damaging biofilm structure and increasing tissue membrane permeability, with NPs exerting stronger effects. This work demonstrated the effectiveness of using modeling tools to understand the relative importance of MNPs as contaminant vectors in the TK process and highlighted the higher contaminant transfer potential of NPs under combined exposure scenarios.
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Chenyu Yang,Qian Yao,Liangzhong Li,Xian Xiao,Lun Lu,Chang Liu,Chunyou Zhu,Sihui Zhan,Haoran Yuan
The biochar with single Ca atom (1.7 wt%) loaded nanoscale zero-valent iron composites (Fe@Ca-N-C) were prepared and effectively degraded tris(2-chloroethyl) phosphate (TCEP) via Fenton-like oxidation. Systematic experiments and theoretical calculations indicated that the enhanced removal of TCEP was attributed to the synergistic effect of adsorption (Ca-N x sites) and degradation (Fe sites). Remarkably, the optimal system of 0.1 g L −1 Fe@Ca-N-C, 1 mM peroxydisulfate (PDS) achieved 99.5 % TCEP degradation (2 mg L −1 ) in 30 min and maintained 100 % TCEP removal for 72 h in continuous-flow reaction column. The Ca-N x sites exhibited high adsorption energy for TCEP (especially the Ca-N 1 sites), and the Fe sites (Fe(0) and Fe(Ⅱ)) activated PDS into HO•, which quickly degrades the adsorbed TCEP through C-O bond breaking and C-Cl bond hydroxylation. This study provided insights into single Ca atom utilization and TCEP pollution remediation.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Nanoscale
·
2024
·
IF 5.8
Guo He,Dezhi Yang,Sizhe Tao,Liqing Yang,Dechao Guo,Jingbo Zheng,Ji Li,Jiangshan Chen,Dongge Ma
Perovskite photodetectors (PPDs) offer a promising solution with low cost and high responsivity, addressing the limitations of traditional inorganic photodetectors. However, there’s still room for improvement in terms of dark current and stability of air-processed PPDs. In this study, 4',4"-Tris(carbazl-9-yl)-triphenylamine (TCTA) is utilized as nucleation agent to enhance the quality of perovskite film. The synergistic effect of TCTA and moisture promotes rapid nucleation of PbI2-PbCl2, resulting in an increased nucleation rate and the elimination of pinholes in the film. By employing additive engineering, we obtain a PbI2-PbCl2 layer with high coverage, leading to a lower density of traps in the corresponding perovskite film. Consequently, the modified PPD exhibits a remarkable reduction in dark current density by over one order of magnitude, reaching 2.4×10-10 A cm-2 at -10 mV, along with a large linear dynamic range (LDR) of 183 dB. Furthermore, the resulting PPD demonstrates remarkable stability, retaining 90% of the initial external quantum efficiency (EQE) value even after continuous operation for over 3200 hours. Due to a fast response time in nanosecond range, the PPD can convert modulated light signals into electrical signals at a speed of 588 Kbit s-1, highlighting great potential in the field of optical communication.
研究领域:
材料科学
·
光电技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
·
2015
·Vol. 19
·期 1
·129-135
·
IF 1.685
Li Xu,Xing Fenglan,Xu Qun,Sun Xiaolong,Wang Yuping,Wang Liyan,Wang Pinglang
A novel homologous series of trimeric anionic surfactants, 3C
n
TE3CNa (where n is a fatty acid chain length of 7, 10, or 12), with three hydrocarbon chains and three carboxylate heads connected via tri-etheric bonds were synthesized from long-chain α-bromo fatty acids and a triol, 1,1,1-tris(hydroxymethyl)ethane. The obtained trimeric carboxylic acids were esterified and purified by silica gel column chromatography, then hydrolyzed with dilute sodium hydroxide solution to form a series of trimeric carboxylate surfactant products. All prepared compounds were analyzed by IR, 1 H NMR, and 13 C NMR spectroscopy to confirm their chemical structures. Their surface-active properties were investigated. The critical micelle concentrations (cmc) of 3C
n
TE3CNa were in the range of 0.12–0.71 mmol/L, and the surface tensions at the cmc ( γ
cmc ) were 29.3–34.8 mN/m.
研究领域:
化学
·
材料科学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2020
·
IF 7.864
Chen Wang,Haibo Chen,Hui Li,Yunchao Zhang,Luyao Ren,Chao Chen,Xiaoli Wang,Jun Yu,Zongrui Li,Yongdi Liu
Tris(1,3-dichloro-2-propyl)phosphate (TDCPP) is an environmental contaminant that has attracted increasing concern due to its presence in environmental media and biological samples. Our previous study demonstrated that exposure to TDCPP reduced the lifespan of Caenorhabditis elegans, but the mechanisms, including the relevant signaling pathways, are unclear. The current study found that TDCPP exposure triggers an unconventional insulin/insulin-like growth factor signaling (IIS) pathway, not by disrupting the insulin-like growth factor-1 receptor DAF-2/IGF1R but by inhibiting the downstream tumor-suppressor factor DAF-18/PTEN. This inhibition reduces PI(3,4,5)P3 (PIP3) dephosphorylation, causing buildup that increases the activation of the Akt/Protein Kinase B (PKB) family of serine/threonine kinases. This activation induces DAF-16/FoxO phosphorylation and promotes the sequestration of DAF-16/FoxO in the cytoplasm, reducing the lifespan of nematodes. Our results have important diagnostic and therapeutic implications for controlling TDCPP-related diseases, especially those originating with IIS pathway components.
研究领域:
环境毒理学
·
分子生物学
·
细胞信号传导
·
衰老研究
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DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Guangcai Ma,Kan Ma,Jing Zhang,Xianglong Zhao,Qiuyi Wang,Yewen Chen,Jiayu Lu,Xiaoxuan Wei,Xueyu Wang,Haiying Yu
The escalating focus on the environmental occurrence and toxicology of emerging pollutants underscores the imperative need for a profound exploration of their metabolic transformations mediated by human CYP450 enzymes. Such investigations have the potential to unravel the intricate metabolite profiles, substantially altering the toxicological outcomes. In this study, we integrated the computational simulations with in vitro metabolism experiments to investigate the metabolic activity and mechanism of an emerging pollutant, 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione (TDBP-TAZTO), catalyzed by human CYP450s. The results highlight the important contributions of CYP2E1, 3A4 and 2C9 to the biotransformation of TDBP-TAZTO, leading to the identification of four distinct metabolites. The effective binding conformations governing biotransformation reactions of TDBP-TAZTO within active CYP450s are unveiled. Structural instability of primary hydroxyTDBP-TAZTO products suggests three potential outcomes: (1) generation of an alcohol metabolite through successive debromination and reduction reactions, (2) formation of a dihydroxylated metabolite through secondary hydroxylation by CYP450, and (3) production of an N-dealkylated metabolite via decomposition and isomerization reactions in the aqueous environment. The formation of a desaturated debrominated metabolite may arise from H-abstraction and barrier-free Br release during the primary oxidation, potentially competing with the generation of hydroxyTDBP-TAZTO. These findings provide detailed mechanistic insight into TDBP-TAZTO biotransformation by CYP450s, which can enrich our understanding of the metabolic fate and associated health risk of this chemical.
研究领域:
环境科学
·
毒理学
·
计算生物学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Caixia Huang,Lucheng Li,Peng Yang,Jun Chen
Although many researchers continue to pursue improved battery capacity, battery safety remains a major concern. The main cause of battery fires is the flammability of the currently available commercial organic liquid electrolytes, which are mainly composed of 1 M lithium hexafluorophosphate (LiPF6) and EC-containing carbonate solvents. Herein, a flame-retardant co-solvent tris(2,2,2-trifluoroethyl) phosphite (TTFP) was applied to improve the flame retardancy of a battery. It could improve the battery's discharging capacities at both 4.2 V and high cut-off voltage (4.5 V). Specifically, at a common voltage of 4.2 V, the cells’ 100th discharge capacity without TTFP was 130 mA h g−1 by 0.2C with a capacity retention (CR) of 69%. In comparison, under the same conditions, the capacity of the 10% TTFP-containing cell was 162.3 mA h g−1 with a CR of 73.9%. This increase in the electrochemical properties of the cell is clearly due to the addition of TTFP. When charging and discharging at 2.75–4.5 V, the capacity of the battery with STD after 100 cycles at 0.2C was 118.7 mA h g−1, and the corresponding CR was 60.93%. Meanwhile, the discharged capacity of the battery containing 10% TTFP was 150.0 mA h g−1 with a corresponding CR of 65.39%. Through combustion test with and without the TTFP electrolyte, it can be concluded that the TTFP-containing electrolyte is difficult to ignite. This result indicates that TTFP can efficiently enhance the safety performance of the battery. Thus, the incorporation of TTFP can be beneficial to improve the flame retardancy of the electrolyte. Moreover, TTFP does not affect the electrochemical stability of batteries. Thus, the present work may provide a good direction for the next generation of high-performance and high-safety lithium-ion batteries.
研究领域:
材料科学
·
能源科学
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产品关联
DOI
高影响因子
Agronomy-Basel
·
2025
·Vol. 15
·期 11
·2483
·
IF 3.4
Meijun Liu,Liangzhu Gong,An Yan,Wenjing Liu,Haojie Li,Peiyi Guo
Tris(2-chloroethyl) phosphate (TCEP), as an organophosphate contaminant, poses a significant threat to the growth and development of plants, especially roots. This study aimed to clarify the mechanisms of TCEP’s toxicity and damage to root systems, as well as the mechanisms of its damage to the respiration and energy metabolism of alfalfa root cells. The results showed that TCEP obviously affected the root length, root surface area, root volume, and root diameter of alfalfa. With increasing stress intensity, the total mitochondrial respiration rate and Cytochrome C Oxidase (COX) pathway respiration rate progressively declined, while the Alternative Oxidase (AOX) pathway respiration rate and its proportion of total respiration gradually rose. In addition, adenosine triphosphate (ATP) content and root vigor were significantly reduced. Moreover, with an increase in TCEP concentration, root superoxide anion radical content in alfalfa root cells was significantly elevated, while superoxide dismutase (SOD) and catalase (CAT) activities were significantly lowered, and ascorbate peroxidase (APX) and peroxidase (POD) activities were significantly enhanced. The present study indicated that respiration was disrupted, causing a lack of ATP in root cells under TCEP. Both the overproduction of reactive oxygen species (ROS) from the mitochondrial respiratory electron transport chain (mECT) and the deficiency of ROS-scavenging enzymes caused ROS accumulation, which led to the destruction of the cell membrane structure and exacerbated the disruption of the respiratory metabolism. The disruption of the conversion and reuse of energy by TCEP affected root growth and development.
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2022
·
IF 10.633
Longyi Nan,Jie Liu,Chao Liu,Peng Quan,Jianpeng Guo,Liang Fang
Pressure-sensitive adhesives are critical to the product's safety, efficacy, and quality in transdermal drug delivery systems. However, many defects of transdermal patches ( e.g. , insufficient adhesion, patch displacement, and “dark ring” phenomenon) remain. Herein, the N -[tris(hydroxymethyl)methyl]acrylamide (NAT)-modified acrylic pressure-sensitive adhesive coordinated with Fe(III) (AA-NAT/Fe 3+ ) was creatively proposed. Results demonstrated that the adhesiveness and cohesiveness of the optimized AA-NAT/Fe 3+ were higher by 1.8- and 9.7-fold, respectively, than those of commercially available DURO-TAK® 87-4098 due to the hydrogen bonding interaction of NAT-skin interface and coordination of NAT-Fe 3+ . Moreover, compared with that of DURO-TAK® 87-4098, the adhesion time of AA-NAT/Fe 3+ on the human forearm was remarkably prolonged, and no “dark ring” phenomenon was observed for AA-NAT/Fe 3+ after removal. After clonidine (CLO) was loaded into AA-NAT/Fe 3+ , controlled drug release and a drug transdermal behavior were endowed for CLO@AA-NAT/Fe 3+ in vitro and in vivo . AA-NAT/Fe 3+ still maintained superiority in adhesion and cohesion properties after CLO loading. These observations would contribute to the development of pressure-sensitive adhesives with outstanding adhesion and cohesion for transdermal patches. Statement of significance This N -[tris(hydroxymethyl)methyl]acrylamide-modified acrylic pressure-sensitive adhesive coordinated with Fe(III) has enhanced adhesion and cohesion properties, which provide a simple but effective strategy to solve the problems ( e.g. , insufficient adhesion, patch displacement, and “dark ring” phenomenon) in existing transdermal patches.
研究领域:
材料科学
·
药剂学
·
生物医学工程
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DOI
PubMed
高影响因子
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