BIOMATERIALS
·
2016
·
IF 8.387
Juan Li,Yuchen Tian,Dingying Shan,An Gong,Leyong Zeng,Wenzhi Ren,Lingchao Xiang,Ethan Gerhard,Jinshun Zhao,Jian Yang,Aiguo Wu
Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C 6 F 14 ) within biodegradable photoluminescent polymers (BPLPs) through an emulsion-evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y 1 receptors overexpressed in breast tumors. The developed PNBL-NPY modified NBs were uniform in size with good dispersibility and photostability, presenting good ultrasound enhancement. Further, in vitro and in vivo results indicated that the fabricated NBs exhibit high affinity and specificity to Y 1 receptor-overexpressing breast cancer cells and tumors with minimal toxicity and damage to organs. Our developed PNBL-NPY-modified NBs are novel targeted UCAs for safe, efficient and specific targeted breast cancer imaging, and may provide a new nanoplatform for early cancer diagnosis and treatment in the future.
研究领域:
医学影像
·
癌症诊断
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 74
·70243-70250
·
IF 3.289
Xiaohui Fu,Yinan Ma,Jing Sun,Zhibo Li
A series of poly(L-glutamate) bearing Y-shaped oligo(ethylene glycol)x (OEGx) side-chains (PPLG-g-EGx, x = 2, 3 and 4) were synthesized via a combination of ring opening polymerization (ROP) of γ-propargyl-L-glutamate N-carboxyanhydride (PLG-NCA) with thiol–yne photoaddition. The solubility of the polypeptides in water was firstly investigated. PPLG-g-EG3 and PPLG-g-EG4 were soluble in water and displayed fully reversible thermal-responsive behaviors. Additionally, the polypeptides showed redox-responsive properties along with the conformation associated water solubility due to the presence of thioether groups in the side-chains. In particular, the clouding points (CPs) of the polypeptides are highly tunable depending on the degree of polymerization (DP), the side-chain length, the polymer/salt concentration, and the degree of oxidation/reduction. The key feature of our design is the simultaneous incorporation of thermal-responsive OEG units and redox-responsive thioether linkages by one-step thiol–yne photoaddition, which allows for precisely tuning the phase transition temperature by both stimuli. This synthetic approach offers a facile and efficient way to prepare polypeptide-based biomaterials with highly tunable properties.
研究领域:
生物材料
·
高分子化学
·
生物医药
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
·
2023
·
IF 2.9
Bingyue Yan,Wei Yang,Yuyao Zhong,Qijun Duan,Jun Xie
With the development of alternate electrical power system and the improvement of voltage level, the operation conditions faced by epoxy resin (ER) insulation materials are becoming more and more complex. The traditional ER materials have been difficult to meet the increasingly stringent requirements. In this paper, the thermal and mechanical properties of DGEBA/TDE-85/MTHPA blend system were studied by molecular dynamics (MD) simulation and experiment. The results show that the addition of TDE-85 can significantly improve the thermal and mechanical properties, and the comprehensive improvement effect is the best when the molar ratio of DGEBA and TDE-85 is about 8:2. The experimental results are consistent with the simulation results. Further analysis of the micro-parameters of the monomer and the cross-linking network found that the torsional energy barrier of TDE-85 is higher than DGEBA. And the compatibility of the two ER is better when the ratio is 8:2. In addition, TDE-85 can introduce high-stability Y-nodes into the system, making the cross-linked network more stable, which has a significant effect on improving the thermal and mechanical properties. The research provide a reference for the blending modification of high-performance ER for high-voltage insulation.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Qiuyan Ding,Hengyu Shen,Zongliang Kou,Hong Li,Xiaolei Fan,Xiaoxia Ou,Yilai Jiao,Xin Gao
Rational design of catalytic packing is crucial in developing reactive distillation (RD) processes as efficient in-situ coupling of reaction and separation is required. Structured catalytic packings are advantageous than the conventional packings (e.g., inert packing + catalyst ‘tea bags’), due to the integration of the catalysis and separation function in one unit, mitigating mass/heat transfer limits. Herein, we present one of the latest developments in the field of structured catalytic packings, which was applied to a pilot-scale RD process of ethyl lactate (EL) synthesis via acid-catalyzed esterification and showed the advantages. The tungstophosphoric acid and hierarchical Y zeolite were uniformly decorated on corrugated silicon carbide (SiC) foam sheets via new preparation method (of ultrasound-assisted impregnation and microwave-assisted drying). The activity of the resulting materials was first assessed in a batch reactor, then the best candidate was employed by the pilot process. Findings from the pilot-scale RD experiments show that the developed structured SiC foam catalytic packing (SSFCP) exhibited an excellent performance (with the normalized conversion of 0.155 mol/g catalyst ), outperforming the conventional seepage catalytic packing internal (0.002 mol/g catalyst ). The influence of various variables (including molar feed ratio, feed position and reflux ratio) on the process performance of the pilot RD rig was also investigated and optimized, achieving a lactic acid conversion of 46.9 % and EL purity of 44.9 % (bottom). The good performance was attributed to the improved mass transfer thanks to SiC foam corrugated sheet (which encourage the vortex formation), thereby enabling more efficient coupling with the reaction. The SSFCP demonstrated reasonable stability, making it a promising candidate for relevant practical RD applications.
研究领域:
化学工程
·
催化材料
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2018
·
IF 0
Fuhai Li,Dairong Hu,Yahui Yuan,Binbin Luo,Yibing Song,Songtao Xiao,Guanghui Chen,Yiwen Fang,Fushen Lu
To mimic biological enzyme in catalysis, metal-imidazole-salen complexes were proposed (via DFT calculation) and synthesized in situ within the cavities of Y zeolite. Among the synthesized zeozymes, the Cu-salenIIY exhibited a prominent catalytic efficiency for the selective oxidation of benzyl alcohol. Specifically, the activity and selectivity of the encapsulated catalyst were comparable to those of the free Cu-salenII complex in solution. Furthermore, the high activity and selectivity were preserved during the repeated cycles. The similarity in the initial activity implies that the Cu-salenII complex just resides in the cavity of the zeolite Y, and its intrinsic properties responsible for the catalytic activity keep intact after encapsulation. The confinement of zeolite nanocavities effectively inhibited the dimerization or aggregation of the Cu-salenII complex and prevented the active species from escaping into reaction solution, thus resulting in a remarkably improved in the catalytic reusability and durability.
研究领域:
催化
·
材料科学
·
化学工程
·
无机化学
✓ 已验证
产品关联
DOI
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-9
·
IF 5.479
Zhang Kai,Cao Jinxuan,Wu Yongxiang,Hu Futao,Li Tianhua,Wang Ying,Gan Ning
A simple and highly sensitive fluorometric method is described for the determination of the antibiotic kanamycin (Kana) in food. Dual signal amplification is accomplished by making use of double Y-shaped aptamer DNA probes acting as a capture probes and signal amplification probes. The DNA probes were immobilized on a gold bar and on a magnetic bar, respectively. On addition of Kana, the Y-shaped aptamer probe captures Kana and then is disassembled to release two single-stranded DNAs. These trigger target recycling and HCR between the two bars simultaneously. As a result, many long duplex DNA chains are formed in the supernatant. After pulling out the bars and adding the fluorescent intercalating probe SYBR Green I, strong fluorescence (with excitation/emission peaks at 497/525 nm) is induced. The use of such double Y-shaped DNA probes obviously overcomes the unspecific signal amplification by HCR which increases selectivity and sensitivity. This is due to the fact that the hairpin of HCR is separated in being present in different arms of the Y-shaped probe. Under the optimal conditions, the assay has a limit of 0.45 pg·mL −1 for Kana. It was applied to analyze spiked milk, fish and pork samples.
The scheme represents a sensitive fluorometric aptamer-based method to detect kanamycin (Kana). It is making use of a double stirring bar-assisted dual amplification strategy with zero background. Abbreviations: apt: aptamer, AuNPs: gold nanoparticles, HCR: hybridization chain reaction.
研究领域:
分析化学
·
食品科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Yue Wang,Ximing Liao,Lei Zhou,Songchao Fu,Qing He,Xinqi Chen,Linxi Xia,Cihui Liu,Feng Liu,Lei Yang
We developed a magnetically responsive Y-shaped hydrogel mitral clip for minimally invasive repair of mitral regurgitation. Fabricated through a multilayer assembly strategy, the clip integrates a polyurethane layer featuring a biomimetic inverse opal architecture to enhance tissue adhesion, a GelMA/Fe 3 O 4 hydrogel for magnetic actuation, a flexible epoxy acrylate scaffold for mechanical compliance, and a biocompatible polydimethylsiloxane interface. The clip exhibits Janus wettability, with a hydrophilic inner surface to promote effective leaflet anchoring and a hydrophobic outer surface to minimize blood fouling, thus optimizing device-tissue and device-fluid interactions. Performance was validated through in vitro, ex vivo, and computational studies, confirming precise magnetic clamping, strong adhesion, and mechanical resilience under simulated physiological conditions. Hemocompatibility evaluations demonstrated favorable outcomes in terms of blood interaction and reduced thrombogenicity when benchmarked against commercial alternatives. This soft, adaptive device supports minimally invasive deployment and reliable leaflet fixation, offering a promising approach for next-generation transcatheter mitral valve repair with enhanced tissue integration and blood compatibility.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Bo Meng,Shenyong Ren,Zhi Li,Suofu Nie,Xinyue Zhang,Weiyu Song,Qiaoxia Guo,Baojian Shen
The direct synthesis of zeolite Y with high SiO 2 /Al 2 O 3 (SAR > 6.0) and small crystal size is a great challenge. The conventional production of high silica Y usually involves organic template into the synthesis system, which takes high cost. Here, zeolite Y with SAR of 6.15 and small crystal size via introducing Co 2+ in a facile one-step hydrothermal method without organic template was achieved. The SAR increased from 5.2 to 6.15 compared to normal NaY, and the crystal size decreased to 50%. The introduction of Co 2+ in synthesis system affects the formation of 5-coordination intermediate ( M-O -Si )* around Co 2+ during crystallization process which is the critical factor to nucleation. The stability of ( Co–O –Si )* is weaker than that of ( Al–O –Si )*, which leads to the increase of SAR around Co 2+ . The microcrystals of Co(OH) 2 provide adhesive surface for the amorphous material and promote nucleation. The zeolite Y shows good performance in the cracking of 1,3,5-triisopropylbenzene because of larger surface area and more active sites being exposed. This is a new strategy for industrial synthesis of high SiO 2 /Al 2 O 3 and small crystal size zeolite Y.
研究领域:
材料科学
·
化学工程
·
催化
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 111
·91206-91212
·
IF 3.84
Wen Long Li,Hong Yan Zou,Jing Lan,Qiang Wang,Yuan Fang Li,Cheng Zhi Huang
Hollow nanostructures have been diversely applied in many fields and efforts have been made to develop their various synthesis methodologies. Herein, homogeneous hollow Cu2−xSeyS1−y/reduced graphene oxide (rGO) nanocomposites were prepared for the first time via a facile and green aqueous chemical approach using H2S gas bubble templates as soft templates at room temperature. It is found that 2D hexagonal Cu2−xSeyS1−y nanosheets assemble around the gas–liquid interface of H2S bubbles to form hollow nanospheres on the rGO sheets, wherein rGO sheets as molecular templates play a critical role in maintaining the structural integrity of single-crystal hollow Cu2−xSeyS1−y nanospheres. Increasing the S content in the precursors, i.e., increasing the amount of H2S bubbles, both the diameter and chalcogen composition (S/Se molar ratio) of hollow Cu2−xSeyS1−y/rGO nanocomposites gradually increase. The near-infrared (NIR) localized surface plasmon resonance (LSPR) in Cu2−xSeyS1−y/rGO nanocomposites, arising from the free carriers (holes) in Cu2−xSeyS1−y, gets red shifts with increasing the S content, due to the higher carrier mass and assembly degree of Cu2−xSeyS1−y.
研究领域:
材料科学
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2019
·
IF 5.657
Xueming Cao,Na Zhu,Li Li,Yuwei Zhang,Yan Chen,Jing Zhang,Jiang Li,Chuanyu Gao
Aims Y-box protein 1 (YB1) is a key regulator of inflammatory mediators . However, the roles of YB1 in oxidized low-density lipoprotein (ox-LDL)-induced macrophage inflammation and lipid uptake remain less understood. Thus, we explored the roles of YB1 in ox-LDL-induced macrophage inflammation and lipid uptake and its underlying molecular mechanisms. Methods An ox-LDL-induced atherosclerosis (AS) model was used in this study. Western blotting , RT-PCR, immunofluorescence, ELISA, dil-ox-LDL staining, a dual-luciferase reporter assay, RNA-binding protein immunoprecipitation (RIP) and in vivo experiments were used to detect each target. Results ox-LDL downregulates YB1 expression in THP-1-derived macrophages and human monocyte-derived macrophages (hMDMs) via the NF-κB pathway. Downregulation of YB1 is facilitated by lipid uptake in macrophages, and CD36 is involved in this process. Furthermore, YB1 suppresses CD36 protein levels by directly binding to the coding sequence of the CD36 gene to promote CD36 mRNA decay but does not affect its mRNA transcription. Additionally, YB1 knockdown enhances the inflammatory response and lipid deposition via the NF-κB pathway in vivo. Conclusion ox-LDL decreases YB1 expression in macrophages, resulting in enhanced inflammatory responses by affecting NF-κB and facilitating lipid uptake by promoting scavenger receptor CD36 mRNA decay.
研究领域:
免疫学
·
心血管疾病
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 20
·2830-2842
·
IF 4.927
Mo Zhu,Nairong Hao,Jinxian Yang,Lianwei Li
V-type (B∼∼A∼∼B) and Y-type (A∼∼∼∼B2) macromonomer approaches are two of the most widely adopted synthetic methodologies for the preparation of long-subchain hyperbranched polymers (LHPs) with a controlled subchain length. However, little attention has been paid to the difference of the structural regularity of hyperbranched polymers prepared via the two approaches in previous related studies. This work aims to elucidate how these two synthetic approaches quantitatively influence the polymerization, branching pattern and solution properties of the prepared hyperbranched polymers. First, two sets of model hyperbranched polystyrenes (HPSV and HPSY) were prepared from V-type and Y-type macromonomers by a combination of atom transfer radical polymerization (ATRP) and azide–alkyne cycloaddition coupling reaction, respectively. The intrachain cyclization study indicated that the macromonomer self-cyclization during the interchain coupling process was strongly affected by the chain length and the structure of the used macromonomer as well as the reaction concentration. The V-type macromonomer was found to be less inclined to undergo interchain coupling due to the stronger steric hindrance effect. Furthermore, via triple-detection size exclusion chromatography (TD-SEC) characterization, the intrinsic viscosity ([η]) and the radius of gyration (Rg) were found to be scaled to the molar mass of the macromonomer (Mm) and the molar mass of the entire chain (Mt) as [η] = KηMtνMmμ (μ ≃ 0.25 and ν ≃ 0.40) and Rg = HRMtαMmβ (α ≃ 0.47 and β ≃ 0.083) for both HPSV and HPSY samples. These scaling relationships evidenced that both HPSV and HPSY hyperbranched structures hold a similar statistically fractal feature. More importantly, the determined values of ratios Kη,Y/Kη,V (∼1.5) and HR,Y/HR,V (∼1.2) demonstrated, for the first time, that the average equivalent length of the branching subchain (Ls) for HPSY is much longer than the initial macromonomer chain length (Lm), i.e. Ls = 2.5Lm while Ls is exactly equal to 1/2Lm for HPSV. This finding clearly clarified the difference between Ls and Lm, and thus the terms of Ls and Lm should not be misused in the future structure–property study. Finally, the value of the Rg/Rη ratio is determined to be ∼1.05 and ∼1.15 for HPSV and HPSY samples (Rη: viscometric radius), respectively, which are much smaller than the typical values for linear chains in good solvents (1.20–1.40), revealing the less draining nature of these hyperbranched structures.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Hao Li,Min Long,Huiyu Su,Lei Tan,Xiaowen Shi,Yumin Du,Yan Luo,Hongbing Deng
Immunoglobulin Y (IgY) proves advantageous to IgG in prophylaxis and diagnosis. Quantification of IgY is therefore becoming a topic of interest. Here, we demonstrate a piezoelectric biosensor with carboxymethyl chitosan (CMCS) as the immobilization matrix. Gelation and hydrophilic nature of CMCS are favored to form a crosslinked matrix for antibody immobilization, and a comparison was made between carboxymethyl cellulose (CMC) and CMCS to investigate the benefits of such substitution. Calibration from 500 ng/mL to 200 μg/mL was established in buffer with the detection limit (LOD) down to 270 ng/mL, confirming its feasibility. As-prepared biosensor effectively prevents non-specific binding of bovine serum albumin (BSA) and lysozyme . Each real-time assay took 15 min including sensor regeneration, which can be further reduced to 4 min for signal readout only, ready for both repeated measurements after regeneration and disposable devices. Thus, as-prepared biosensor offers a rapid, label-free and cost-effective approach for IgY quantification.
研究领域:
生物传感器
·
分析化学
·
免疫学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）