INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jin Chen,Zhuangwei Zhang,Huihui Li,Mengchu Sun,Hongjin Tang
The low water solubility and inadequate bioavailability of curcumin significantly hinder its broad biological applications in the realms of food and medicine. There is limited information currently available regarding the particle characteristics and functional capabilities of zein-lysozyme-based nanomaterials . Thereby, the primary goal of the current work is to effectively develop innovative zein-lysozyme- κ -carrageenan complex nanocomposites (ZLKC) as a reliable carrier for curcumin encapsulation. As a result, ZLKC nanoparticles showed a smooth spherical nanostructure with improved encapsulation efficiency. Fourier-transform infrared, fluorescence spectroscopy, dissociation assay, and circular dichroism analysis revealed that hydrophobic and electrostatic interactions and hydrogen bonding were pivotal in the construction and durability of these composites. X-ray diffraction examination affirmed the lack of crystallinity in curcumin encapsulated within nanoparticles . The incorporation of κ -carrageenan significantly improved the physicochemical stability of ZLKC nanoparticles in diverse environmental settings. Additionally, ZLKC nanocomposites demonstrated enhanced antioxidant and antimicrobial properties, as well as sustained release characteristics. Therefore, these findings demonstrate the potential application of ZLKC nanocomposites as delivery materials for encapsulating bioactive substances.
研究领域:
纳米技术
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食品科学
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药学
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材料科学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Pan Yu,Runpeng Liao,Shuming Wen,Shaojun Bai
The direct flotation is highly effective in enhancing the quality of concentrate products and removing the content of magnesium for the beneficiation of middle and low grade phosphate ore. This study introduces carrageenan (CG) as an innovative dolomite inhibitor and assesses its effectiveness through micro-flotation tests with sodium oleate (NaOL) as a collector. At pH 10, the combination of 40 mg/L CG and 4 × 10 −4 M NaOL successfully separated dolomite from apatite, the artificially mixed ore tests produced a concentrate assaying 32.23 % P 2 O 5 with 76.44 % P 2 O 5 recovery. Results demonstrate CG's strong inhibition of dolomite while minimally affecting apatite. The interaction mechanisms of CG with apatite and dolomite were investigated through various analyses including ICP-OES tests, zeta potential measurements, FTIR tests, contact angle measurements, XPS analysis, AFM tests, and ToF-SIMS analysis. Findings suggest that CG adsorbs strongly to dolomite surfaces by chemisorption between carboxyl groups and Ca sites, whereas it adsorbs weakly to apatite surfaces by hydrogen bonds between carboxyl and hydroxyl groups with F sites. Thus, CG shows promise as an innovative bio-based inhibitor for separating apatite from dolomite using direct flotation.
研究领域:
矿物加工工程
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生物材料科学
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DOI
高影响因子
Materials Today Communications
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2024
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IF 3.7
Chuanyi Ma,Zhanguo Li,Yi Wang
Hydrogel is an effective surface radioactive decontamination technology. However, traditional colloid decontaminants face long curing duration and low decontamination rate issues. A peelable hydrogel coating composed of carrageenan, konjac glucan, and graphene oxide (GO) with excellent film-forming performance and decontamination efficiency was explored in this study. The results showed that the GO was effectively dispersed inside the hydrogel, improving the crosslink density and thermal stability of the hydrogel by forming hydrogen bonds with polysaccharide molecules. The GO can effectively enhance the decontamination performance of the hydrogel. For stainless steel, ceramic, glass, and rubber surfaces, the decontamination rates of the hydrogel for 30 min were 96.95 %, 87.6 %, 96.27 %, and 74.5 %, respectively. Furthermore, the decontamination effect was stable to temperature. For cement surfaces, the hydrogel could reach a maximum decontamination rate of 70.68 % after 24 h. The decontamination efficiency of hydrogel was affected by porosity, surface roughness, and GO addition. Moreover, the characterization results of XPS, FT-IR, and SEM/EDS showed that the decontamination process of the composite hydrogel may involve surface wetting, ion diffusion, electrostatic attraction, and physical entanglement. In conclusion, the as-prepared hydrogel has been demonstrated as a green, cost-effective surface decontaminant, which has great potential in the field of nuclear industry fields and environmental remediation.
研究领域:
环境科学
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材料科学
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核工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Xinlong Liu,Longmeng Du,Yong Ma,Tingxi Li,Song Chen,Jia Yang,Zhenzhen Ran,Longbao Zhou,Qi Dong,Wenhui Zheng,Zaixing Jiang
Conductive hydrogels with excellent mechanical properties, a broad detection range, and stability in complex environments have remained a significant challenge for the development of flexible sensors. In this study, a straightforward freeze-thaw cycles strategy was developed to fabricate a polyvinyl alcohol (PVA)/carrageenan (CA)/calcium chloride (CaCl 2 )/MXene-based double network organohydrogel (PCCME) for highly flexible and responsive strain detection across a broad temperature spectrum. The PCCME organohydrogel features multiple interactive forces including hydrogen bonding, ionic interactions, and microphase crystallization, which contribute to the organohydrogel's exceptional mechanical and electrical performance. The PCCME organohydrogel exhibited excellent performance in a load-unload test repeated 100 times after being maintained at room temperature for 7 days, with a minimal mechanical decay of only 2.6%. Furthermore, the repaired PCCME organohydrogel retained its robust stability after storage at low temperatures followed by placement at room temperature. The organohydrogel sensor not only detects various movement amplitudes of the human body but also recognizes arrays of pressure signals and converts these into digital images, highlighting its significant potential for applications in rehabilitation monitoring, pressure sensing, and human-computer interaction.
研究领域:
材料科学
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生物医学工程
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DOI
PubMed
高影响因子
FOOD CONTROL
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2025
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IF 6.3
Mingrui Zhou,Mengqi Chen,Youwei Ai,Wenfu Hou,Yang Yi,Hongxun Wang,Yahong Han
Petroleum-based packaging materials raise serious environmental and food safety concerns, driving the development of sustainable smart packaging derived from natural polymers. In this study, natural pigment-zein-chondroitin sulfate-epigallocatechin gallate-ι-carrageenan (NZCEC) nanoparticles were fabricated and incorporated into κ-carrageenan-based films to enhance their functional properties. The effects of NZCEC addition on the films' physicochemical stability, intermolecular interactions, antioxidant activity, and responsiveness to ammonia and acetic acid vapors were systematically evaluated, along with their application in preserving mandarin fish ( Siniperca chuatsi ). Scanning electron microscopy revealed good compatibility between κ-carrageenan and moderately loaded NZCEC nanoparticles. Incorporation of NZCEC significantly improved the film's optical properties (opacity increased from 4.10 to 23.32 A mm −1 ) and reduced its water vapor permeability (from 8.23 × 10 −9 to 6.93 × 10 −9 g m −1 s −1 Pa −1 ). Moreover, the antioxidant activity was markedly enhanced (from 1.75 % to 77.65 %), along with notable responsiveness to ammonia and acetic acid. Storage trials with mandarin fish demonstrated that the smart film effectively delayed fish spoilage. Additionally, the film displayed distinct chromatic variations in response to freshness, allowing continuous assessment of food quality. These results establish NZCEC nanoparticle-reinforced κ-carrageenan films as a promising intelligent packaging material with improved stability, responsiveness, and food preservation performance.
研究领域:
食品科学与技术
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高分子科学
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纳米技术
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智能包装
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食品保鲜
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材料表征
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2022
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IF 5.546
Junhua Li,Qian Zhang,Cuihua Chang,Luping Gu,Yujie Su,Yanjun Yang,Qi Han
Composite hydrogels are known for their potential applications in drug delivery fields. Pure κ-carrageenan (KC) hydrogels have a drug burst release behavior, which greatly limit their applications. In this study, konjac glucomannan (KGM) was used to further improve the properties of soy protein isolate (SPI)/KC composite hydrogels. The results showed that the viscoelasticity of the composite hydrogels increased at KC/KGM ratio 9:1 due to the increase of hydrogen bond interaction. Excessive addition of KGM in composite hydrogels led to the increase in frequency dependence and gel network cavity as well as the decrease in gel cohesiveness. In vitro study on glucose release behavior of composite hydrogels showed that the glucose slow release behavior was enhanced by a small amount of KGM incorporation and had highly positive correlation with the gel viscoelasticity. These results suggested that KGM had the potential to enhance the properties and drug release characteristics of composite hydrogels.
研究领域:
食品科学
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材料科学
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生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xiangyan Chen,Guiyuan Zhao,Xiaohan Yang,Fei Liu,Shixin Wang,Xia Zhao
Sexually transmitted diseases (STDs) are usually caused by co-infections of bacteria and viruses. However, there is a lack of products that possess both antibacterial and antiviral activities without using chemical drugs. Here, we developed a carrageenan silver nanoparticle composite hydrogel (IC-AgNPs-Gel) based on the antiviral activity of iota carrageenan (IC) and the antibacterial effect of silver nanoparticles (AgNPs) to prevent STDs. IC-AgNPs-Gel showed excellent biocompatibility, hemostasis , antibacterial and antiviral effects. IC-AgNPs-Gel not only effectively prevented S. aureus , E. coli , P. aeruginosa , and C. albicans without using antibiotics, but also significantly inhibited human papilloma virus (HPV)-16 and HPV-6 without using chemotherapy drugs. Moreover, IC-AgNPs-Gel showed the effects of accelerating infected wound healing and reducing inflammation in a rat wound model infected with S. aureus . Therefore, the multifunctional hydrogel shows great potential application prospect in preventing STDs.
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2023
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IF 8.8
Jia-Nan Yan,Yu-Qiao Wang,Zhu-Jun Zhang,Yi-Nan Du,Hai-Tao Wu
Scallop ( Patinopecten yessoensis ) male gonad hydrolysates (SMGHs)/ κ -carrageenan (KC)/KCl beads with SMGHs :KC ratios (0:10–5:5) were investigated. SMGHs/KC/KCl-Cur bead (5:5) exhibited the most intact spherical morphology and highest Cur loading content of 0.063 mg/0.1 g bead, ascribing to a shortened T 23 from 1607.9 to 966.4 ms, and red and blueshifts of O H, NH, amide I and II bands. The undetected fingerprint region within 7.82°-28.90° of SMGHs/KC/KCl-Cur beads indicated successful Cur entrapment. Moreover, SMGHs/KC/KCl-Cur beads exhibited shrinkage network backbones and larger void pores as SMGHs increased, with vessel percentage area, total number of junctions, total vessel length decreasing from 52.1, 1446.8, 57931.4 to 39.7, 530.5, 34458.4, and lacunarity increasing from 0.048 to 0.111, respectively. Furthermore, Cur showed approximately 50% release contents in colon phase and above 90% retention rate during 30 days of storage at 4 °C. These results suggested that SMGHs/KC/KCl-Cur beads exhibited sustained-release of Cur and promised stable Cur preservation.
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DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2023
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IF 4.1
Yingnan Liu,Fei Tong,Yingran Xu,Yunyun Hu,Wenya Liu,Zan Yang,Zhenyu Yu,Guoyuan Xiong,Yibin Zhou,Yaqing Xiao
BACKGROUND Active and smart food packaging based on natural polymers and pH-sensitive dyes as indicators has attracted widespread attention. In the present study, an antioxidant and amine-response color indicator film was developed by incorporating bilirubin (BIL) into the κ-carrageenan (Carr) matrix. RESULTS It was found that the introduction of BIL had no effect on the crystal/chemical structure, water sensitivity and mechanical performance of the Carr-based films. However, the barrier properties to light and the thermal stability were significantly improved after the addition BIL. The Carr/BIL composite films exhibited excellent 1,1-diphenyl-2-picryl-hydrazyl (i.e. DPPH)/2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (i.e. ABTS) free radical scavenging abilities and color responsiveness to different concentrations of ammonia. The application assay reflected that the Carr/BIL 0.0075 film was effective in delaying the oxidative deterioration of shrimp during storage and realizing the color response of its freshness through the change of b * value. CONCLUSION Active and smart packaging films were successfully prepared by incorporating different contents of BIL into the Carr matrix. The present study helps to further encourage the design and development of a multi-functional packaging material. © 2023 Society of Chemical Industry.
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高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
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2019
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IF 2.442
Guowen Qian,Xingmei Li,Fupo He,Jiandong Ye
Anti-washout calcium phosphate cement (CPC) was prepared by dissolving water-soluble konjac glucomannan (KGM) and κ-carrageenan (KC) blend in the cement liquid. The anti-washout property, setting time, compressive strength and in vitro cytocompatibility of the CPC modified with KGM/KC blend were evaluated. The results indicated that the CPC pastes modified with KGM/KC blend exhibited excellent anti-washout property. The addition of KGM/KC blend shortened the setting time and increased the injectability of CPC. Although the introduction of KGM/KC blend reduced the compressive strength of CPC, the compressive strength still surpassed that of human cancellous bone. The optimal KGM/KC mass ratio was 2:8, with which the modified cement exhibited the most efficient washout resistance and the highest compressive strength. The introduction of KGM/KC blend obviously promoted the proliferation of mouse bone marrow mesenchymal stem cells. This anti-washout CPC modified by KGM/KC blend with excellent in vitro cytocompatibility will have good prospects for application in bone defect repair.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Xiaoxiao Sun,Chao Liu,A.M. Omer,Li-Ye Yang,Xiao-kun Ouyang
A new pH-sensitive drug carrier based on alginate (Alg), chitosan (Cs), and kappa-carrageenan (kC) marine biopolymers was developed, comprising a dual-layered polyelectrolyte complexes microbead structure. Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) were used to investigate the structures, thermal stability , and morphological changes, respectively, of the microcapsules we developed. In the intestinal environment (pH 7.4), the stability and swelling of Alg microbeads were enhanced after generation of the dual-layered polyelectrolyte complexes. The in vitro release profiles of 5-fluorouracil under simulated GI conditions were also examined. At gastric pH (1.2), the cumulative 5-FU release percentage was decreased by introduction of the additional kC layer from 14% in Alg/Cs microbeads to 7% in the dual-layered Alg/Cs/kC microbeads. Additionally, the release profiles were greatly improved under simulated intestinal and colon conditions. Finally, the microbeads were all biodegradable and showed no cytotoxicity in Chang liver cells. Our results clearly indicate that the dual-layer pH-sensitive Alg/Cs/kC microbeads could be used effectively for the targeted delivery of anticancer drugs to the colon.
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PubMed
高影响因子
BIOMACROMOLECULES
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2018
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IF 5.738
Xichao Liang,Xiaolan Wang,Qi Xu,Yao Lu,Yu Zhang,Hong Xia,Ang Lu,Lina Zhang
In the present work, the bulk and homogeneous composite hydrogels were successfully constructed from positively charged chitosan (CS) and negatively charged carrageenan (CG) in alkali/urea aqueous solution via a simple one-step approach for the first time. An electroneutral CS solution was achieved in alkali/urea, leading to a homogeneous solution blended by CS and CG, which could not be realized in acidic medium because of the agglomeration caused by polycation and polyanion. Subsequently, the CS/CG composite hydrogels with multiple cross-linked networks were prepared from blend solution by using epichlorohydrin (ECH) as the cross-linking agent. The composite hydrogels exhibited hierarchically porous architecture, excellent mechanical properties as well as pH- and salt-responsiveness. Importantly, the composite hydrogels were successfully applied for spreading ATDC5 cells, showing high attachment and proliferation of cells. The results of fluorescent micrographs and scanning electronic microscope images revealed that the CS/CG composite hydrogels enhanced the adhesion and viability of ATDC5 cells. The alcian blue staining, glycosaminoglycan quantification, and real-time PCR analysis proved that the CS/CG composite hydrogels could induce chondrogenic differentiation of ATDC5 cells in vitro, exhibiting great potential for application in cartilage repair. This work provides a facile and fast fabrication pathway for the construction of ampholytic hydrogel from polycation and polyanion in an electroneutrality system.
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高影响因子
危险品化学品经营许可证（带存储）