JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Tang Linghui,Huang Yufeng,Wang Yue,Zhao Hongbin
The development of a selective, sensitive, and effective electrochemical sensor for the simultaneous analysis of multiple drugs presents a significant and urgent challenge. In this work, an electrochemical sensor capable of separating and detecting paracetamol (PAR) and diclofenac sodium hydrochloride (DIC) was constructed through the synthesis of a carbon nanotube (CNT)-doped hydrogel. Because of the hydrophilic functional groups on CNTs, they can be uniformly dispersed in organic precursor solution to form a homogeneous conductive hydrogel. The structure and morphology of the CNT-doped hydrogel was studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The operating conditions of the sensor were optimized, including the hydrogel volume, electrolyte pH, electrochemical deposition potential, and deposition time. Under optimal working conditions, the linear ranges for PAR and DIC detection were 10–80 μM and 10–80 μM, with detection limits of 3.5 and 3.6 μM, respectively. In addition, the hydrogel sensor demonstrated good reproducibility, long-term stability, excellent flexibility in bending and twisting, and favorable mechanical properties, with a maximum strain rate of 478% and tensile strength of 0.102 MPa. This research provides a new flexible material for drug separation sensors, and opens up a new research platform for hydrogels.
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高影响因子
DIAMOND AND RELATED MATERIALS
·
2026
·
IF 5.2
Rafi Ullah,Raza Ullah,Pervaiz Ahmad,Adeel Ahmed,Rizwan Ahmed Malik,Awais Khalid
The creation of efficient and resilient catalysts for advanced oxidation processes (AOPs) is crucial for the effective elimination of persistent pharmaceutical contaminants from wastewater. Cobalt metal–organic framework ( Co -MOF) was effectively incorporated into polyacrylonitrile (PAN) nanofibers using electrospinning and subsequently carbonized to produce cobalt nanoparticles supported on carbon nanorods (Co/CNRs). The customized catalyst, Co/CNR-2, demonstrated evenly dispersed cobalt nanoparticles, an increased surface area, and improved electrical conductivity, which collectively enabled rapid activation of peroxymonosulfate (PMS). The catalyst Co/CNR-2 exhibited remarkable catalytic effectiveness in the degradation of diclofenac (DCF), achieving almost 99% removal after 20 min using 0.5 g/L dose of catalyst, 1.0 mM PMS, and at pH 6.0, adhering to pseudo-first-order kinetics with a rate constant of 0.194 min −1 . Radical quenching and electron paramagnetic resonance (EPR) studies confirmed that sulfate radicals (SO 4 •- ), hydroxyl radicals (OH • ), and singlet oxygen ( 1 O₂) were the primary reactive species engaged in DCF breakdown. The catalyst demonstrated exceptional structural stability and reusability over five consecutive cycles, with negligible cobalt leaching. Furthermore, Co/CNR-2 has demonstrated considerable degradation efficiency for several drugs, highlighting its broad applicability. This study presents innovative insights into the rational design of MOF-derived carbon-based catalysts and recognizes Co/CNRs as a feasible and sustainable platform for the PMS-mediated degradation of emerging organic contaminants.
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Journal of Cleaner Production
·
2025
·
IF 10
Duo Xu,Bowen Du,Xuan Jiang,Jiaxin Ling,Shengwei Xiao,Huimin Sun,Xianqiang Yin
Diclofenac sodium (DCF) and venlafaxine (VLF), as widely used and environmentally persistent pharmaceutical pollutants, are frequently detected in water bodies and exhibit bioaccumulation and ecotoxicity, which may threaten the stability of ecosystems by disrupting the endocrine systems of aquatic organisms and neural signaling. The combination of these pollutants with microplastics (MPs) not only enhances the migration of the pollutants, but also amplifies the risk of exposure to high trophic level organisms via the food chain, which is an important warning significance for the study of the safety of the aquatic environment and the mechanism of pollutant coupling in the global “plastic circle”. This study delved into the sorption behavior and mechanisms of DCF and VLF on two different MPs ( i.e. , polystyrene (PSMPs) and polylactic acid (PLAMPs)). Batch sorption experiments were used to quantify sorption capacity under controlled solution chemistry conditions, examining sorption kinetics, isotherms, and thermodynamics. The maximum sorption capacity of PLAMPs and PSMPs for DCF was 2.994 and 3.296 mg g −1 , respectively, while that of PLAMPs and PSMPs for VLF was 5.864 and 6.234 mg g −1 , respectively. The sorption of DCF and VLF on both MPs mainly depended on physical interactions, with the kinetic model in agreement with the pseudo-first-order model, the isotherms were consistent with the Langmuir model. Fourier infrared spectroscopy and X-ray photoelectron spectroscopy demonstrated variations regarding surface functional groups upon MPs before and after sorption. Both MPs showed a significant increase in oxygen and nitrogen-based functional groups after sorption of DCF and VLF, with the most obvious variations being the increase in C-O and C=O. Density-functional theory was used to detect the main sorption mechanisms and the binding energies between PhACs and MPs. In summary, our study found the sorption of DCF and VLF on MPs is controlled by electrostatic interactions, followed by some weaker interactions ( i.e. , van der Waals forces, hydrogen bonding, and hydrophobic interactions). This study provides new insights into the mechanisms of effective separation and interaction between complex pollutants.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
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IF 9.136
Ying Han,Qingjie Lu,Weiwei Li,Yaping Guo,Yue Wu,Hongyuan Liu,Xiaoping Zheng,Yanhong Gao
Diclofenac (DCF) is one kind of pharmaceuticals and personal care products (PPCPs), and it is imperative to develop a green and efficient method to remove it. The removal of DCF with zinc (Zn) in the presence of Cu(II) and Co(II) were investigated on the influence factors, products, and mechanism. The results showed that with the increasing of Cu(II) and Co(II) concentrations, the reactions were accelerated. The removal rate was higher with lower pH value. In all the systems, the DCF removal rate hardly changed when the dissolved oxygen (DO) concentration was 0–8 mg·L −1 and increased at 20 mg·L −1 . Products analysis showed that the products were hydroxylated DCF (DCF 0 ) and an unknown product (DCF u ) in Zn system, monochlorinated DCF (DCF 1 ) in Zn/Cu(II) system, DCF 1 and dechlorinated DCF (DCF 2 ) in Zn/Co(II) system. The order of toxicity from highest to lowest was DCF, DCF 0 , DCF 1 , DCF 2 . The corrosion degree of zinc powder surface increased in the presence of Cu(II) and Co(II). After 48 h, ZnO formed in Zn system. In Zn/Cu(II) system, CuO and Cu 2 O formed in addition to ZnO. In the Zn/Co(II) system, Co 3 O 4 , ZnO and Zn(OH) 2 formed. After adding Cu(II) and Co(II), the corrosion currents increased. In Zn/Cu(II) system, DCF was dechlorinated to DCF 1 by catalytic hydrogenation. In Zn/Co(II) system, DCF was mainly dechlorinated to DCF 1 and DCF 2 by catalytic hydrogenation. This technique provides an alternative method for DCF removal and expands the application field of Zn reduction technology.
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Journal of Water Process Engineering
·
2023
·
IF 7
Jinbing Huang,Xiaoyan Liu,Shiwei Xie
Although electrochemical activation of permanganate ( E -PM) is a green and efficient method to degrade refractory organics by in-situ generated reactive Mn( III ) aq , this process highlights on the presence of promoter and/or stabilizer. Oxalate (OA) is a widespread organic chelate in natural water bodies (with concentrations up to 1 mM), but whose effect on the E -PM process is still unclear. In this study, we found electrolysis and the presence of OA both promote the activation of PM for the degradation of diclofenac (DCF), showing a high synergistic coefficient (3.23) and elevated reaction constant (0.1395 min −1 ). Nevertheless, this process is highly pH-dependent, behaving decreased reactivity as pH value increasing from 3 to 11. Sufficient concentration of OA (≥0.5 mM in this study) is required for stabilizing Mn(III). UV–vis spectra, visual evidence and quenching experiments identified the presence and dominant role of Mn(III)-OA on the degradation of DCF. Using chronoamperometry, we confirmed Mn(III)-OA was primarily generated from the electro-reduction of PM in the presence of OA at pH 5.
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CHEMOSPHERE
·
2023
·
IF 8.8
Jieli Ou,Jiewen Deng,Zhenran Wang,Yongsheng Fu,Yiqing Liu
A Cu(II)/heat coactivated peracetic acid (PAA) system for enhancing diclofenac (DCF) degradation was proposed in this work. The superiority of this synergetic activation strategy for PAA, working reactive species, catalytic mechanism and effects of reaction parameters on DCF elimination in this system were simultaneously investigated. Based on our results, the DCF loss rate in Cu(II)-heat/PAA process at pH 8.0 was about 49.3 and 4.2 times of that in Cu(II)/PAA and heat/PAA processes, respectively. Increasing the reaction temperature to 60 о C not only motivated the conversion of Cu(II) to Cu(I) but also facilitated the one-electron transfer between Cu(I) and PAA, boosting the generation of radicals. Organic radicals (mainly CH 3 C(O)O• and CH 3 C(O)OO•) were evidenced to be the core oxidizing substances dominating in the destruction of DCF while hydroxyl radical (•OH) made a minor contribution in this system by electron paramagnetic resonance (EPR) method together with scavenging experiments. This study broads the eyes into enhanced PAA activation initiated by homogenous Cu(II), providing a simple but efficient tool to degrade micropollutants .
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PubMed
高影响因子
DRUG DELIVERY
·
2016
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IF 4.843
Zichao Luo,Ling Jin,Lu Xu,Zhao Liang Zhang,Jing Yu,Shuai Shi,Xingyi Li,Hao Chen
Development of efficient ocular drug delivery systems was still a challenging task. The objective of this article was to develop a thermosensitive PEG–PCL–PEG (PECE) hydrogel and investigate its potential application for ocular drug delivery of diclofenac sodium (DIC). PECE block polymers were synthesized by coupling MPEG-PCL co-polymer using IPDI reagent, and then its sol–gel transition as a function with temperature was investigated by a rheometer. The results showed that 30% (w/v) PECE aqueous solution exhibited sol–gel transition at approximately 35 °C. In vitro release profiles showed the entrapped DIC was sustained release from PECE hydrogels up to 7 days and the initial drug loading greatly effect on release behavior of DIC from PECE hydrogels. MTT assay results indicated that no matter PECE or 0.1% (w/v) DIC-loaded PECE hydrogels were nontoxic to HCEC and L929 cells after 24 h culturing. In vivo eye irritation test showed that the instillation of either 30% (w/v) PECE hydrogels or 0.1% (w/v) DIC-loaded PECE hydrogels to rabbit eye did not result in eye irritation within 72 h. In vivo results showed that the AUC0–48 h of 0.1% (w/v) DIC-loaded PECE hydrogels exhibited 1.6-fold increment as compared with that of commercial 0.1% (w/v) DIC eye drops, suggesting the better ophthalmic bioavailability could be obtained by the instillation of 0.1% (w/v) DIC-loaded PECE hydrogels.
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 4
·1-16
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IF 3.8
Wang Hongyu,Xie Yi,Xiao Henglin,Li Lu,Zhang Shujia,Wang Bin,Jiang Can,Hu Xiaoling,Zhou Dao,Nan Dongyun
Ecotoxicity of diclofenac sodium (DS) even at low concentrations makes it urgent to remove DS from water. In this work, chitosan microspheres were prepared by one-step reversed-phase emulsion method, and then, polyethyleneimine (PEI) was successfully grafted to form CS/PEI composites. The CS/PEI was characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Effects of different influencing factors like material composition, dosage, pH, co-existing anions, and humic acid were investigated, and adsorption behavior of CS/PEI was explored by model simulation analysis. Results showed that adsorption process fits well with pseudo-second-order kinetic model and Langmuir adsorption isotherm model, indicating homogeneous and monolayer adsorption nature, and maximum Langmuir adsorption capacity was 364.12 mg/g at pH 6. The reusability of CS/PEI was confirmed by cyclic adsorption-desorption experiments, and electrostatic attraction and hydrogen bonding were the main mechanism for DS uptake by CS/PEI. Therefore, CS/PEI microspheres can be regarded as an efficient and convenient adsorbent for DS removal from aqueous media. Graphical Abstract
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
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IF 4.9
Feiyue Wang,Xue Song,Yongde Liu,Jie Zhang,Jihong Zhao,Yue Chen
Diclofenac (DCF), a widely used pharmaceutical ingredient, exhibits long-lasting properties and significant ecotoxicity in aquatic ecosystems. In this study, a new granular adsorbent, GSBE@C H-CTAB , was synthesized to remove DCF by initially granulating powder spent bleaching earth carbon (SBE@C) with polytetrafluoroethylene (PTFE) emulsion as a binding agent, followed by a co-modification process involving H 2 SO 4 and cetyltrimethyl ammonium bromide (CTAB). The adsorption capacity of the prepared adsorbent for DCF under the best conditions was 4.26 mg/g. In a wide pH range, GSBE@C H-CTAB could maintain a high adsorption capacity and show a good reusability. The presence of the three cations inhibited the adsorption of DCF (inhibition effect: Mg 2+ >Al 3+ >Na + ). The adsorption process conformed to the pseudo-second-order kinetic model and Langmuir isotherm model. From the theoretical evaluation results, it could be inferred that DCF molecules were adsorbed on GSBE@C H-CTAB surface in both horizontal and non-horizontal directions at all operating temperatures. The main mechanisms of adsorption included electrostatic interaction, pore filling interaction, π-π interaction and H bond interaction. The granular adsorbent GSBE@C H-CTAB prepared in this study could effectively remove DCF, treat waste with waste, and solve the problem that powder adsorbent was easy to lose and difficult to recover, which was of great significance for the remediation of polluted water.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Fajian Zeng,Gege Cheng,Xing Zhou,Liangyi Yao,Qin Huang,Yan Jiang,Xiuyu Liu
Composite aerogels (CPA) constructed based on lignocellulose nanofibers (LCNF) with anisotropic and honeycomb-like three-dimensional network structures are excellent adsorbent materials. LCNF, as a core constituent of CPA, combines the advantages of cellulose nanofibers and lignin, which endows excellent adsorbent properties to the aerogels and shows great potential in the adsorption of aromatic pollutant diclofenac sodium (DS). Herein, a deep eutectic solvent (DES) and high-pressure homogenization strategy was employed to prepare cationized lignocellulose nanofibers (CLCNF) from industrial and agricultural waste bagasse, and cationized lignocellulose-based composite aerogels were prepared with polyvinyl alcohol (PVA) as crosslinking agent combined with directional freezing technique to efficiently remove DS from water bodies. The prepared CPA had a uniformly distributed honeycomb-like pore structure (porosity ≈ 98 %) and excellent mechanical properties (compressive strength up to 183.93 KPa). In addition, the CPA had a rapid adsorption response to DS with a theoretical maximum adsorption capacity of up to 298.51 mg/g. Its adsorption behavior was in accordance with the pseudo-second order kinetic and Langmuir isotherm model, which demonstrated that it was dominated via the monolayer chemical adsorption, and the main mechanism of the adsorption were electrostatic interactions and intermolecular interactions. Importantly, the CPA still had good stability and reusability after four cycles of use. Therefore, the CPA prepared in this study can be used as a desirable adsorbent for water remediation to achieve the effect of "treating pollution with waste".
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Biochar
·
2022
·Vol. 4
·期 1
·1-19
·
IF 11.452
Han Yu,Gan Lu,Gong Han,Han Jiangang,Qiao Weichuan,Xu Lijie
Metal-free photocatalysts have attracted growing concern recently. Herein, the composites combining g-C 3 N 4 with wood pulp cellulose biochar (WPBC/g-C 3 N 4 ) were synthesized to effectively activate peroxymonosulfate (PMS) under visible light for the degradation of diclofenac (DCF). The incorporation of WPBC endowed g-C 3 N 4 with enhanced visible light absorption, improved charge separation capability, reduced electrical conductivity, and increased photocatalytic and PMS activation capability. Based on quenching tests, electron paramagnetic resonance (EPR), electrochemical analysis and solvent exchange experiments, both radical and nonradical mechanisms were proposed. Radical species including ·OH, h + , ·O 2 – were identified to contribute to DCF degradation. The 1 O 2 and electron transfer were the dominant nonradical pathways for DCF degradation. Moreover, the common influencing factors were examined, and DCF concentration was the most influential factor based on principal component analysis. Generally, the composites exhibited good reusability during consecutive runs. Based on HPLC/MS analysis, four intermediates were detected and the possible DCF degradation pathway was proposed. This work provided a potential strategy based on metal-free WPBC/g-C 3 N 4 for the photocatalytic activation of PMS to effectively degrade emerging contaminants in wastewater. Graphical abstract
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Yongfei Zhou,Ning Li,Xinhua Zhou,Li Ming,Hongyan Zhang,Xiaobo Zou,Can Zhang
In this study, we proposed a novel dual-mode paper-based sensor that synergistically combines colorimetric and fluorescence detection for the rapid and sensitive quantification of diclofenac sodium (DFS) in fresh milk, beef, and water matrices. By integrating copper sulfide nanoflowers (CuS) with molecularly imprinted polymers (MIPs), the sensor achieves high specificity and catalytic efficiency, while europium nitrate polymer (EuPMs) enhance sensitivity through fluorescence quenching. The smartphone-enabled analytical platform provides rapid on-site quantification with simplified sample pretreatment, achieving detection limit of 0.007 μM and recovery rates of 95.3 %–114.4 % in real matrices. This innovative approach not only addresses the limitations of traditional methods but also provides a portable, cost-effective solution for monitoring drug residues in agri-food supply chain and agri-environment, bridging the gap between conventional laboratory analysis and field deployable testing.
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