ONCOLOGY REPORTS
·
2025
·Vol. 53
·期 3
·1-14
·
IF 3.9
Dongsheng Lv,Xu Han,Liang Hao,Zhimin Sun,Aobo Zhang,Jing Liu,Liang Liu,Liqiang Liu
Cysteine‑ and glycine‑rich protein 2 (CSRP2) are closely associated with tumor invasion and metastasis. CSRP2 is significantly upregulated in glioma tissues and is associated with the clinical stage of the tumor. Overexpression of CSRP2 in glioma cells promotes the proliferation and metastasis of cancer cells, whereas CSRP2 knockdown inhibits the biological functions of tumor cells. Transcriptome sequencing of CSRP2‑knockdown U251M cells revealed that silencing of CSRP2 inhibited the JAK‑STAT1 signaling pathway, and differentially expressed genes were significantly enriched in cell processes related to necroptosis. Experiments on necroptosis in glioma cells using flow cytometry, Hoechst 33342/PI dual staining and transmission electron microscopy indicated that CSRP2 overexpression inhibited necroptosis in glioma cells. Western blotting results showed that overexpression of CSRP2 activated the JAK‑STAT1 signaling pathway, while the addition of the pathway inhibitor ruxolitinib promoted the phosphorylation of necroptosis proteins RIPK1, RIPK3 and MLKL. Therefore, it was hypothesized that CSRP2 maintains JAK‑STAT1 activation by inhibiting the protein inhibitor of activated STAT1, which then inhibits the necrotizing apoptosis of glioma cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2025
·Vol. 39
·期 2
·e6074
·
IF 1.7
Qinghai Dong,Fei Shi,Fang Lin,Yaqi Wang,Yang An,Hongliu Xie,Jihua Liu
Previous studies have suggested that ginsenoside Rg 2 glycine ester derivative (RG) exhibits therapeutic potential in mitigating hypoxia. This study aimed to elucidate the potential mechanism of RG in hypoxia injury through a combined approach of metabolomics and network pharmacology. Initially, a CoCl 2 -induced cell hypoxia model was established, and the therapeutic impact of RG on biochemical indices was evaluated. Subsequently, metabolomics analysis of cell samples was conducted to identify biomarkers, and network pharmacology was employed to identify potential targets of RG for hypoxia treatment. Finally, the key target and pathway were verified. The study revealed that RG could reverse CoCl 2 -induced abnormalities in biochemical indicators. Metabolomics analysis identified 13 biomarkers and seven metabolic pathways associated with RG treatment. Utilizing network pharmacology, five key targets and five metabolic pathways were identified, partially aligning with the metabolomics results. Molecular docking results demonstrated the effective binding of RG to the key targets. Enzyme linked immunosorbent assay verified that RG could exert antihypoxia effect by activated PI3K/Akt pathway. In conclusion, this integrated strategy, combining metabolomics with network pharmacology, sheds light on the protective mechanism of RG against hypoxia-induced cellular damage. The findings offer valuable insights for future research and potential applications of RG in the field.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2017
·
IF 3.091
Cheng Sun,Shujing Wen,Jingkai Zhao,Chongjian Zhao,Wei Li,Sujing Li,Dongxiao Zhang
In this work, the blends of 1-hydroxyethyl-3-methylimidazolium glycine ([C2OHmim][Gly]) synthesized by our laboratory and N-methyldiethanolamine (MDEA) in aqueous solution were prepared for CO2 capture, and the maximum absorption performance of the blends was obtained at the mole ratio of 8:2 of MDEA/[C2OHmim][Gly] with a total concentration of 1.0 mol L–1. CO2 loading of the blended absorbent was less adversely influenced by the temperature and O2 concentration than that of MDEA aqueous, and it had a good performance in regeneration ability. The reaction mechanism of the CO2 absorption in MDEA/[C2OHmim][Gly] was investigated by 13C nuclear magnetic resonance. CO2 first reacted with [C2OHmim][Gly] to form carbamate, and then carbamate promoted the reaction between CO2 and MDEA, which could be described as a shuttle mechanism. The kinetics of CO2 absorption was investigated in a double stirred-cell absorber at different temperatures, and some important kinetic parameters were obtained, such as the reaction rate constant (k2) and the overall rate constant (kov). Experimental results indicated that the addition of [C2OHmim][Gly] enhanced CO2 absorption of MDEA under low CO2 partial pressure, which could improve the application of MDEA in industry.
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2020
·
IF 8.821
Jia-Jun Cai,Qing-Yan Zhou,Xiao-Fei Gong,Bing Liu,Yun-Long Zhang,Yun-Kun Dai,Da-Ming Gu,Lei Zhao,Xu-Lei Sui,Zhen-Bo Wang
Development of high-efficiency non-noble metal materials to substitute Pt-based catalysts for oxygen reduction reactions is crucial in the commercial viability of Zn-air batteries technology. Nitrogen doped carbons (NDCs) are highly appealing as promising candidates. This study reports a facile molten salt (MS) method to synthesize aerogel-like nitrogen doped carbon (NDC-MS). The eutectic mixture acting as combined solvent and porogen leads to the obtained porous materials with extremely large surface area (1548.6 m 2 g −1 ) and relatively high pore volume . The unique aerogel-like structure with hierarchical structure, increased catalytic active sits, extended surface area and large pore volume is beneficial for enhancing oxygen reduction reaction (ORR) performance. The resultant NDC-MS displays a superb ORR catalytic activity with high half-wave potential of 0.88 V, which is one of the most effective figures in previous literature of metal-free catalysts. The superb ORR performance can also be evaluated by Zn–air batteries with satisfactory power density and long-term operation stability. Therefore, such an efficient and green synthetic strategy can open up a new avenue for a wide range of commercial application of heteroatom doped carbon materials in advanced energy technologies.
✓ 已验证
DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2022
·Vol. 39
·期 11
·3039-3047
·
IF 3.146
Zhang Pan,Zhao Yuetong,Tian Xiangfeng,Ji Yanxi,Shu Yuxuan,Fu Kun,Fu Dong,Wang Lemeng
Tetramethylammonium glycine ([N 1111 ][Gly]) can be completely ionized into cation [N 1111 ] + and anion [Gly] - in aqueous solution. The anion contains an amino -NH 2 and a carboxyl -COO - , both of which can react with hydrogen sulfide (H 2 S). Therefore, [N 1111 ][Gly] was used to promote the selective absorption of H 2 S in coke oven gas (COG) by N-methyldiethanolamine (MDEA). The absorption performance and selectivity of H 2 S in the aqueous solution of MDEA-[N 1111 ][Gly] were investigated. The effects of MDEA mass fraction, [N 1111 ][Gly] mass fraction, temperature, H 2 S partial pressure and CO 2 partial pressure on the absorption capacity and selectivity were clarified. The results showed that an aqueous solution of MDEA-[N 1111 ][Gly] has good selectivity for H 2 S in COG. The absorption capacity was large and the mass fraction of the solute in the absorbent reached more than 0.55, thereby having outstanding advantages in the aspects of saving energy consumption and operating cost and having a good application potential.
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Haodong Wang,Yangping Sun,Qi Liu,Mengci Ma,Long Hu,Gehong Wei,Chun Chen
BACKGROUND Soybean production is severely affected by the soil-borne phytopathogenic, Fusarium oxysporum , which causes root rot disease. Artificial nanoplatforms have attracted attention as a sustainable strategy to promote crop growth and protection. RESULTS In this study, mesoporous silica nanoparticles (MSNs) loaded with lipopeptide (Lip), referred to as Lip@MSNs, were synthesized with a diameter of approximately 50 nm and a Lip loading capacity of 22.40 wt%. Lip@MSNs demonstrated potent antifungal activity against F. oxysporum , inducing cell membrane disruption, permeability alterations, nuclear damage, and subsequent cell death. Pot experiment showed that Lip@MSNs significantly reduced the severity of soybean root rot disease by 43.10% while enhancing plant growth and root development. Metabolomic analysis revealed that Lip@MSNs modulated critical metabolic pathways, including zeatin and pyrimidine metabolic pathways in roots. Furthermore, Lip@MSNs recruited beneficial endophytic bacteria, such as antagonistic genera ( Sphingomonas , Variovorax , and Streptomyces ) and growth-promoting genera ( Rhizobium , Ensifer , and Nocardioides ). Correlation analysis highlighted the role of these bacteria in nitrogen fixation and phytohormone production (e.g., trans -zeatin), contributing to reduced root rot disease severity and improved plant health. CONCLUSION These findings demonstrate that the silicon-based delivery system could serve as an effectively tool to control soil-borne phytopathogenic diseases and promote the development of sustainable agriculture. © 2025 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Yuhan Yan,Xiaotian Huang,Xinshuo Wang,Yilin Zhang,Heping Cui,Jingyang Yu,Shuqin Xia,Hanjiang Zhu
Unexpected browning was observed in sorbitol and amino acid system under high-temperature process and long-term storage. The effect of glycerol on the browning reaction of sorbitol-glycine model system under different heat treatment time was explored. The results confirmed that partial sorbitol was converted to glucose and fructose, which underwent a Maillard reaction with glycine to produce the melanoidins. Glycerol concentration and the heating time were positively correlated with the course of the reaction, which reflected in the increase of browning index, the rise of uncolored intermediate products and fluorescent substance accumulation. Compared with the system without glycerol, the browning index increased by about 100 times and the accumulation of uncolored intermediate products increased by 65 times with the presence of 4 mol/L glycerol. Furthermore, the content of α-dicarbonyl compounds (glyoxal, methylglyoxal and 2, 3-butanedione) in the system was changed by glycerol, which showed a trend of first increasing and then decreasing with the accumulation of melanoidins, and reached a peak value of 190.6 mg/L after heating for 2 h. The glycerol-dependent browning was related to the water activity of the system at a high level (>0.80) and the migration rate of free water to immobilized water ranging from 0.60% to 8.59%. It indicated that glycerol could promote the reaction by influencing the substrate concentration, weakening the inhibition of product and promoting the conversion of sorbitol to reducing sugar.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Qian Hou,Tong Zhou,Xinjing Li,Cuimin Hua,Heping Cui,Foxin Zhang,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The browning degree in light-colored Maillard reaction products (L-MRPs), derived from the glycine-xylose system with cysteine (Cys) addition increased during storage. This secondary browning reaction might compromise their long-term stability. To elucidate the underlying mechanism, accelerated storage and model systems (glycine-xylose Amadori compound (GX-ARP) and GX-ARP/cystine) were employed. The findings demonstrated that cysteine undergoes oxidative conversion to cystine, triggering adverse changes including promoted degradation of GX-ARP and retro-aldolization of deoxyosones (DXs) into glyoxal (GO) and methylglyoxal (MGO), thereby accelerating secondary browning. Storage tests with different Cys levels indicated low concentrations insufficiently inhibited browning, while high levels exacerbated darkening from cystine accumulation, and 2 mmol/L Cys achieved optimal balance between browning inhibition and minimized side reactions. In conclusion, the conversion of Cys to cystine and its interference in the GX-ARP degradation pathway cause the instability of L-MRPs. This finding provides a novel theoretical basis for improving the color stability of L-MRPs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2025
·
IF 17.1
Xiuzi Che,Huiqing Fan,Jiahao Cao,Yongbo Fan,Yuxin Jia,Yidi Duan,Qinghua Guo,Yafei Feng,Weijia Wang
Piezoelectric biomaterials can convert mechanical energy into electricity, which make them attractive for implant applications, such as sensing, energy harvesting, and medical devices. The β-glycine has excellent piezoelectric performance, but their practical use is hindered by instable crystal phase and water solubility. Here, we present a simple method for preparing poly L-lactide (PLLA) composite fibers encapsulating β-glycine nano crystals via coaxial electrospinning. The formation of β-glycine crystals is the synergistic outcome of the ionization of glycine solution under the electric field and the confinement of external PLLA solution, which enhances the piezoelectric performance of the film. The V oc , I sc , and power density of composite film reach 14 V, 0.94 μA, and 0.92 mW/cm 2 , respectively. In addition, PLLA shell stabilizes β-glycine, leading to a stable piezoelectric performance for device applications. The composite film can be ultrasonically driven to generate electric signals, and therefore functions well in promoting cell proliferation and bone tissue repairing in vivo . Moreover, the film can be naturally degraded after long-term implantation. This study provides a strategy to deal with the instability of β-glycine-based biodegradable piezoelectric films, and promotes the implant applications.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 5
·996
·
IF 3.098
Wenchao Li,Jingjian Liu,Minghua Fan,Zhongtang Li,Yin Chen,Guisen Zhang,Zhuo Huang,Liangren Zhang
GLYX-13, a NMDAR glycine-site partial agonist, was discovered as a promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and the use of unfriendly reagents. Here, we report a scaled-up synthesis of GLYX-13 with an overall yield of 30% on the hectogram scale with a column chromatography-free strategy, where the coupling and deprotection reaction conditions were systematically optimized. Meanwhile, the absolute configuration of precursor compound of GLYX-13 was identified by X-ray single crystal diffraction. Finally, the activity of GLYX-13 was verified in the cortical neurons of mice through whole-cell voltage-clamp technique.Keywords:GLYX-13;NMDA receptor;chromatography-free synthesis;crystal structure;whole-cell voltage-clamp
✓ 已验证
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Yi He,Shulin He,Xuemei Fan,Lin Gan,Ishak Ahmad,Wan Hafizi Wan Ishak,Chaojiu Long,Kun Qian,Jin Huang,Yongqiang Zhang
Engineered a TP/GB-assisted polysaccharide quaternary preservation coating. • Extended mango shelf life over 11 days via physiology and antibacterial action. • Identified C. siamense via morphology and Koch's postulates. • Revealed TP-enhanced binding of polysaccharide-CSH by molecular docking. • Confirmed ecological safety after washing using soil and aquatic bioassays. Climacteric mangoes suffer a short shelf life due to rapid postharvest nutrient loss and pathogen invasion. Herein, a strategy of quaternized chitosan (QCS)/cellulose nanocrystal (CNC) coating incorporating complementary glycine betaine (GB) and tea polyphenols (TP) functionalities was developed through integrated metabolic regulation and antifungal-antioxidant functionalities. The prepared QCS/CNC/TP/GB-10 coating exhibited water vapor permeability (WVP) of 0.41 × 10 −3 g m −1 ·kPa −1 ·h −1 and oxygen permeability (OP) of 0.10 cm 3 μm·m −2 ·d −1 ·kPa −1 , respectively, with improvements of 38.1% and 61.5% over QCS. The 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging rate reached 91.93 ± 1.49%, 75.29% higher than QCS. Mangoes treated with QCS/CNC/TP/GB-10 extended shelf life by 11 days, with weight loss of 23.22 ± 0.83% and firmness loss of 32.69 ± 2.20%, respectively. The titratable acidity (TA) was maintained at 0.20%, significantly higher than controls (<0.07%). Colletotrichum siamense ( C. siamense ) was identified as the causal agent, and the QCS/CNC/TP/GB-10 coating achieved 67.02 ± 2.35% inhibition, 2.23-fold higher than QCS. Molecular docking suggested TP-assisted binding enhancement between QCS/CNC and the CSH protein of C. siamense , with GB showing limited contribution. Soil and aquatic organism models demonstrated no ecological risks of the coating solution. This study provides a design paradigm for developing promising polysaccharide-based coatings for climacteric fruit preservation.
✓ 已验证
DOI
高影响因子
CURRENT PHARMACEUTICAL DESIGN
·
2023
·
IF 3.1
Yi Shi,Qian Wu,Yi Lu,Ling-Peng Meng,Xiao-Ling Xu,Xiao-Juan Wang,Wei Chen
Aim We aimed to design RGD-anchored liposomes encapsulating an antipyroptosis drug that could efficiently target macrophages and relieve the rate of cytokine release syndrome, providing a new strategy for sepsis treatment, especially sepsis-induced acute renal injury. Background Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by host response disorders due to infection. Sepsis has a high incidence and remains one of the leading causes of death worldwide. Objective Macrophage-mediated pyroptosis plays an important role in the occurrence and development of cytokine release syndrome and organ injury caused by sepsis. Curcumin can inhibit inflammasome assembly and slow the progression of pyroptosis by scavenging intracellular reactive oxygen species, but it has poor water solubility and low bioavailability. The emergence of drug-delivery nanosystems has overcome this problem, but there is still a lack of research on how to accurately deliver antipyroptotic drugs to innate immune cells and subsequently hinder pyroptosis. Methods We constructed a curcumin-loaded RGD-modified liposome (RGD-lipo/Cur) and demonstrated that RGD-lipo/Cur could effectively target macrophages. Results In vitro , RGD-lipo/Cur reduced the upregulation of caspase-1, caspase-3, NLRP3, IL-1β and GSDMD, inhibiting pyroptosis, reducing oxidative stress, and attenuating the proinflammatory cytokine cascade. Conclusion RGD-lipo/Cur was considered to have great potential for sepsis treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）