INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Liping Yin,Wenhao Duan,Yanai Chen,Danyang Chen,Yong Wang,Shuai Guo,Jianglei Qin
Serious side effects of chemotherapy drugs greatly limited the anticancer performance, while targeted drug delivery could improve the therapeutic effect and reduce side effects. In this work, biodegradable hydrogel was fabricated from pectin hydrazide (pec-H) and oxidized carboxymethyl cellulose (DCMC) for localized Silibinin delivery in lung adenocarcinoma treatment. The self-healing pec-H/DCMC hydrogel showed blood compatibility and cell compatibility both in vitro and in vivo , and could be degraded by enzymes. The hydrogel also formed fast fit for injectable applications and showed sustained drug release characteristic sensitive to pH based on acylhydrzone bond cross-linked networks. The Silibinin, as a specific lung cancer inhibiting drug targets TMEM16A ion channel, was loaded into the pec-H/DCMC hydrogel to treat the lung cancer in mice model. The results showed that the hydrogel loaded Silibinin significantly enhanced the anti-tumor efficiency in vivo and greatly reduced the toxicity of the Silibinin. Based on the dual effect of improving efficacy and reducing side effects, the pec-H/DCMC hydrogel with Silibinin loading have broad application prospects to inhibit lung tumor growth in clinic.
研究领域:
药学
·
材料科学
·
肿瘤学
·
生物医学工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Meigui Huang,Lixia Cong,Ruifeng Ying,Mehraj Ahmad,Gang Hao,Khizar Hayat,Ahmad Mohammad Salamatullah
The intense bitterness of quercetin poses a challenge to its utilization in the food industry. To address this issue, three anionic polysaccharides (carrageenan, pectin, and trehalose) were individually incorporated to fabricate polysaccharide-coated liposome nanocarriers. Electronic tongue analysis revealed a significant decreasing bitterness value (10.34 ± 0.07 mV, sensory score 1.8 ± 0.2, taste weak bitter) in quercetin-loaded nanoliposomes , compared with the bitterness value of quercetin aqueous solution (14 ± 0.01 mV, sensory score 7.3 ± 0.3, taste strong bitter). Furthermore, the polysaccharide-coated nanoliposomes exhibited an even greater capacity to mask the bitterness of quercetin, with carrageenan coated nanoliposomes demonstrating the most pronounced effect. The superior bitter masking ability of carrageenan coated nanoliposomes can be attributed to its high charge and viscosity. In sensory evaluations, gummy incorporated with carrageenan-coated nanoliposomes received the highest ratings, exhibiting enhanced overall palatability and antioxidant activity . This study offers insights into expanding the use of bitter nutrients in food applications and paves the way for more appealing and healthful food products.
研究领域:
食品科学
·
纳米技术
·
药剂学
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产品关联
DOI
PubMed
高影响因子
Separations
·
2024
·Vol. 11
·期 4
·95
·
IF 2.5
Chenyang Yao,Yachao Li,Peng Li,Xiaokui Che,Guosheng Li,Fanfan Zhang,Weijun Peng,Bozeng Wu,Guixia Fan
This paper presents the development of an environmentally friendly, small molecular depressant citrus pectin for improving the recovery of cassiterite resources. Citrus pectin extracted from citrus peel was utilized as the depressant, and it demonstrated significant potential in separating calcite from cassiterite in micro-flotation tests. The molecular weight of the citrus pectin extracted in this paper decreased from 11,485,412 Da to 32,959 Da compared to commercial pectin, resulting in the depressant efficiency of the reagent. The results of a zeta potential and adsorption test indicated that citrus pectin had less and weaker adsorption on the cassiterite surface and could be replaced with NaOL. The chemical adsorption process of citrus pectin on the surface of calcite was determined through FTIR spectroscopy analysis. XPS analysis results indicated that the interaction between the carboxyl groups of citrus pectin and calcium atoms enables adsorption to occur. The AFM revealed that citrus pectin displayed a uniform and dense pattern of point-like adsorption on the surface of calcite. Micro-flotation experiments showed that cassiterite recovery of 80% can be obtained at a citrus pectin dosage of 10 mg/L. Citrus pectin has the advantages of being low-cost, highly selective, and environmentally suitable, making it a promising alternative to conventional reagents.
研究领域:
矿物加工工程
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环境科学
·
生物化学
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产品关联
DOI
高影响因子
JOURNAL OF CULTURAL HERITAGE
·
2025
·
IF 3.3
Kuiju Li,Kezhu Han,Xin Liu,Yuyao Ruan,Xunwei Li,Guangtao Zhao,Yuhu Li,Yujia Luo
Wooden historical architecture is susceptible to wormhole damage due to prolonged exposure to biological factors, compromising the structural integrity and esthetic appearance. To address this issue, this study proposes a pectin-wood shaving composite with boron sodium oxide tetrahydrate (BSOT) and waterborne polyurethane (WP) as the filling material for the restoration of wormholes in wooden components. Accelerated hygrothermal degradation tests were performed under fluctuating temperature and relative humidity conditions, and the shrinkage rate, compressive strength, shear strength, bonding strength, color difference, and morphological characteristics were evaluated using scanning electron microscopy (SEM) and laser confocal microscopy (LCM). The experimental results indicated that the optimal composition of the filling material was 54 % wood shavings, 34 % pectin, 5 % WP, and 5 % BSOT. This composite material exhibited good dimensional stability, improved mechanical performance, weather resistance, antifungal properties, and compatibility with wood. The application of the pectin-wood shaving composite provides a novel approach to the restoration and preservation of similar structural damages in historic wooden architecture.
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 17
·8341
·
IF 4.9
Bo Yu,Liwen Huang,Yuhan Ding,Ning Zhang,Kexin Li,Yuanbao Jin,Zhihua Wu
Naringin and pectin were innovatively and sequentially extracted from naturally dropped fruit of pomelo (NDFP), optimizing yields via response surface methodology (RSM). Under optimized conditions, naringin was extracted first with 70% ethanol (70 °C, 110 min, SSR 15:1v/w), followed by pectin extraction from the residue using pH 1.50 acetic acid (80 °C, 160 min, ratio 40:1v/w) naringin yield reached 42.77% with 97.6% ± 0.31% HPLC purity, while pectin yield was 14.32%. Critically, the recovered pectin was identified as low-ester and exhibited significantly superior antioxidant activity compared to commercial pectin. This work establishes an efficient sequential extraction process valorizing waste pomelo drop, yielding high-purity naringin and antioxidant-rich, low-ester pectin.
研究领域:
食品科学
·
化学工程
·
天然产物提取
·
生物化学
·
废弃物管理
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinyu Zhang,Jiaqi Ma,Bowen Zheng,Zixuan Du,Yong Zhang,Guanghua Zhao,Lei Zhang,Jiachen Zang
Pectin has garnered increased attention in tissue engineering, while the high-methoxylated pectin requires harsh gelling conditions and lacks endogenous cell adhesion. High-methoxylated pectin was first thiolated by conjugating L-cysteine onto the pectin backbone through amide bonds. Glutenin is rich in disulfide bonds and cytocompatible. Here, thiolated pectin then compounded with the reduced glutenin, resulting in hydrogels formed through disulfide crosslinking. The storage modulus increased to 2.24 times and the compressive strength is increased to 2.68 times with the addition of glutenin. The disulfide cross-linked hydrogels present cytocompatibility, reversibility, advanced toughness, permitting cell encapsulation of NIH-3T3 and GES-1 cells with uniform distribution. Above all, the disulfide-based hydrogels satisfy the requirements for cell culture.
研究领域:
生物材料
·
组织工程
·
细胞培养技术
·
高分子水凝胶
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Qianyun Zhao,Yubin Liu,Mingxing Li,Long Zhao,Tiangang Wang,Yaqin Xiao,Shulin Wei,Ke Wu,Jiayue Yang,Yaqiu Wang,Yueshui Zhao,Fukuan Du,Yu Chen,Shuai Deng,Jing Shen,Zhangang Xiao,Zhi Li,Shengpeng Wang,Xu Wu
Hawthorn fruit is rich in pectins; however, the gut microbiota-modulating effects of hawthorn pectin remain unclear. In this study, enzyme-extracted hawthorn pectin ( M w : 126.24 kDa; HG/RG-I ratio: 55.64 %/37.93 %; branching degree: 2.44) was fractionated into two components: D1 (spherical, 345.76 kDa, HG/RG-I 57.48 %/37.25 %, branching degree 2.16) and D2 (flexible, 17.20 kDa, HG/RG-I 78.24 %/21.76 %, branching degree 1.33). Hawthorn pectin directly stimulated Dubosiella newyorkensis and Bifidobacterium bifidum growth in vitro . In hyperlipidemic mice, it alleviated dyslipidemia and enriched Lactobacillus and Dubosiella . Parallel experiments confirmed that D. newyorkensis supplementation similarly reduced dyslipidemia and enhanced Lactobacillus abundance, mediated by bacterial acetate production. Only D1 mimicked the pectin's prebiotic activity, promoting D. newyorkensis and B. bifidum growth. The high-RG-I D1, with elevated branching and larger M w , was identified as the key driver of hawthorn pectin's prebiotic effect. These findings highlight that hawthorn pectin and D1 specifically target probiotic D. newyorkensis to synergize with Lactobacillus against hyperlipidemia.
研究领域:
营养学
·
微生物学
·
代谢疾病研究
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产品关联
DOI
PubMed
高影响因子
BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2026
·
IF 4.3
Li Yanqiong,Xu Peiyang,Li Xinran,Zhao Yanyan,Wang Ting,Shi Yanling,Lu Jike,Zhu Jiaqing
Oligogalacturonic acid demonstrated potent antibacterial efficacy against foodborne pathogens. To obtain oligogalacturonic acids with favorable antibacterial activity, this study established a controlled enzymatic hydrolysis process for citrus peel pectin based on the characterization of three commercial pectinases. Different fractions of the pectin hydrolysates were then obtained via ethanol fractional precipitation. Results showed that the supernatant from 90% ethanol fractionation (F90%-s) exhibited the best antibacterial effects. ESI-MS analysis revealed that pectin hydrolysates with higher degradation degrees displayed better antibacterial activity. Interestingly, oligogalacturonic acid standards (DP ≤ 4) unexpectedly showed no antibacterial activity. FT-IR analysis suggested that hydrophobic groups might contribute to the antibacterial properties of the hydrolysates. It could disrupt cell membranes, leading to leakage of cellular contents and ultimately to bacterial death. These findings established theoretical foundation for developing citrus peel pectin-derived oligosaccharides as next-generation food preservatives, while guiding the value-added utilization and sustainable development of pectin-rich agro-industrial waste. Graphical abstract
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DOI
高影响因子
Materials Research Express
·
2019
·Vol. 6
·期 6
·065405
·
IF 1.449
Qinghong You,Miaomiao Wan,Xiaoxu Fang,Xiulian Yin,Chuping Luo,Xuejuan Zhang
The process of intermittent microwave extraction (IME) pectin from pomelo peels assisted with EDTA was optimized by response surface methodology. Results showed that the optimal process for intermittent microwave extraction of pectin was as follows: 0.25% EDTA, pH 1.0, solid-to-liquid ratio 1:25 g ml−1, extraction time 125 s, microwave power 550 W, the extraction yield of pomelo peels was (38.48 ± 0.28)%. The structure of three kinds of pectin was verified by IR, SEM, XRD, HPLC and the results showed that pectin obtained from IME had a poor solubility but a good emulsifying activity. The IUEP had the highest scavenging rates of DPPH radicals.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Xuan Zhang,Jiawei Lin,Fang Pi,Tao Zhang,Chao Ai,Shujuan Yu
This work aimed to extract gelatinous chicory root pectin (CRP) and evaluated the rheological behavior of the dispersions and gels. CRP was extracted by citric acid (CEP), alkaline (AEP), ammonium oxalate (OEP) and sodium citrate (SEP). The yield, molecular weight (Mw) and the degree of esterification (DE) of pectin samples varied from 8.8 to 14.8% (w/w), 204 to 336 k Da and 4.0 to 47.4%, respectively. AFM studies showed self-organize on mica of CEP, revealing a random coil conformation due to the interaction of multiple branching, whereas, AEP exhibited long linear filamentous structures. The flow behavior study verified the pseudoplastic character of CEP and SEP at 25 °C, while OEP and AEP belonged to dilatant fluid, besides, a closed hysteresis loop was observed when the CEP concentration increased to 1.5%. OEP gel was thermo insensitive and stiff, AEP gel presented most sensitive to calcium ion but more brittle, and SEP was observed a weak syneresis in spite of the poor gelation property. The texture analysis indicated OEP gel had a superior firmness and chewiness. These findings demonstrated that CRP may be attractive as a thickener or gelling agent to modulate textures of sugar-free and calcium content food.
研究领域:
食品科学
·
高分子化学
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产品关联
DOI
PubMed
高影响因子
Foods
·
2021
·Vol. 10
·期 12
·3127
·
IF 4.35
Risi Wang,Ya Li,Xixiang Shuai,Jun Chen,Ruihong Liang,Chengmei Liu
Traditional aerogels lack specific functional groups for the adsorption of Pb2+, which results in a low adsorption capacity and limits the application scope. Novel porous pectin-based aerogels (PPEAs) were prepared by incorporating polyethylenimine (PEI) using ethylene glycol diglycidyl ether (EGDE) as a cross-linker for the removal of Pb2+from water. The cross-linking mechanism, morphology, mechanical strength, thermal stability, adsorption properties, and mechanism of the aerogels were investigated. The aerogels possessed several desirable features, such as a large maximum Pb2+adsorption capacity (373.7 mg/g, tested at pH 5.0), ultralight (as low as 63.4 mg/cm3), high mechanical strength (stress above 0.24 MPa at 50% strain), and easy recyclability. Meanwhile, the equilibrium adsorption data was well described by the Langmuir–Freundlich (Sips) model and the kinetic adsorption process was well fitted using the pseudo-second-order model. The donor groups, such as -NH2, and oxygen-containing functional groups were responsible for the Pb2+adsorption, which was confirmed by the FTIR and XPS analysis. The excellent characteristics mean that PPEAs are highly effective adsorbents in the remediation of lead-containing wastewater.Keywords:pectin;PEI;EGDE;aerogel;Pb2+;adsorption
研究领域:
材料科学
·
环境科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2021
·
IF 3.605
Hao Xu,Shanshan Xiong,Yuan Zhao,Lingjun Zhu,Shurong Wang
Furfural is an important platform chemical that can be produced by dehydration of pentose, which is an important building block of lignocellulosic biomass. In this study, xylose was chosen as the reaction substrate, and a carbon-based solid acid prepared from pectin was used as the catalyst in a mixed solvent consisting of water and γ-valerolactone (GVL). FTIR results showed that the sulfonated catalyst had typical characteristic peaks of sulfonic groups, while the results based on NH3-TPD and elemental analysis showed that the sulfonation temperature changed the surface acid concentration and acid site intensity of the catalyst. A furfural yield of 80.4% and a xylose conversion of 100% were obtained at 170 °C for 60 min. The conversions and product yields were influenced by the reaction temperature, reaction time, solvent composition, and catalyst acidity. Different sulfonation temperatures can change the acidity of the catalyst, which determines the catalytic performance of the catalyst.
研究领域:
生物化学
·
催化化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）