MATERIALS & DESIGN
·
2021
·
IF 7.991
Di Chuan,Min Mu,Huan Hou,Na Zhao,Jinglun Li,Aiping Tong,Bingwen Zou,Haifeng Chen,Bo Han,Gang Guo
Epigallocatechin Gallate (EGCG) is the main component of green tea which can strongly bind to proteins, small molecular drugs, and DNA. Therefore, EGCG can be used to deliver biomacromolecules and drugs. In this study, a doxorubicin (DOX) delivery system (FPE/DOX NPs) based on the folic acid-functionalized EGCG was developed for the targeting therapy of ovarian cancer. Cellular uptake studies showed that FPE/DOX NPs enhanced DOX uptake by SKOV3 cells compared with PE/DOX NPs that without folic acid modification. In vitro , the toxicity of FPE/DOX NPs to SKOV3 cells was stronger than nanoparticles without folic acid modification. In vivo , the SKOV3 tumor growth inhibition effect of FPE/DOX NPs was substantially more effective than other groups. Together, the results of this study suggested that FPE/DOX NPs may have promising applications in ovarian cancer therapy.
研究领域:
药学
·
癌症研究
·
纳米技术
·
药物递送系统
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Zhongyi Fang,Jie Zhao,Yuan Li,Yu Wang,Tian Qiu,Yanlin Wu,Wenbo Dong,Gilles Mailhot
Fenton-like system had long been modified to promote its adaptability and efficiency by adding extra components like metal chelators or reducers. Nonetheless, chelator such as ethylene diamine tetraacetic acid (EDTA) was harmful in high dosage. While strong reducers could efficiently promote the generation speed of hydroxyl radicals (HO ), they could also get oxidized easily during storage time, for which further application was costly. In this study, (+)-catechin (CAT), an environmental- friendly component, was proved to be an efficient promoter of Fenton-like system on Bisphenol A (BPA) degradation. The modified system achieved 92% of BPA removal in one hour. The mechanism was studied, and the reaction procedure between CAT and Fe(III) together with the degradation pathways of CAT were identified. Fe(III) got chelated first by CAT and quickly reduced to Fe(II) via a single inner-compound electron transfer. The intermediates of CAT could further reduce one and a half more potion of Fe(III) on average. Consequently, massive amount of Fe(II) turned Fenton-like procedure to Fenton reaction and thus promoted the generation of HO . The main radicals contributed on BPA degradation was HO . BPA could be efficiently degraded at pH 6.5 or acidic pH range, but the degradation was completely inhibited with the pH higher than 8.0. The optimal mole ratio between Fe(III) and CAT was 6:1 and the degradation pathway of BPA was deduced.
研究领域:
环境化学
·
水处理
·
污染物降解
·
绿色化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Yuantong Qi,Jingru Li,Qiang Nie,Mingjie Gao,Qinghua Yang,Zimeng Li,Qi Li,Songling Han,Jun Ding,Yongqin Li,Jianxiang Zhang
It remains a great challenge for targeted therapy of heart diseases. To achieve desirable heart targeting, we developed a polyphenol-assisted nanoprecipitation/self-assembly approach for facile engineering of functional nanoparticles . Three different materials were employed as representative carriers, while gallic acid , catechin , epigallocatechin gallate , and tannic acid (TA) served as typical polyphenols with varied numbers of phenolic hydroxyl groups. By optimizing different parameters, such as polyphenol types and the weight ratio of carrier materials and polyphenols, well-defined nanoparticles with excellent physicochemical properties can be easily prepared. Regardless of various carrier materials, TA-derived nanoparticles showed potent reactive oxygen species-scavenging activity, especially nanoparticles produced from a cyclodextrin-derived bioactive material (TPCD). By internalization into cardiomyocytes , TPCD/TA nanoparticles (defined as TPTN) effectively protected cells from hypoxic-ischemic injury. After intravenous injection, TPTN considerably accumulated in the injured heart in two murine models of ventricular fibrillation cardiac arrest in rats and myocardial hypertrophy in mice. Correspondingly, intravenously delivered TPTN afforded excellent therapeutic effects in both heart diseases. Preliminary experiments also revealed good safety of TPTN. These results substantiated that TPTN is a promising nanotherapy for targeted treatment of heart diseases, while polyphenol-assisted self-assembly is a facile but robust strategy to develop heart-targeting delivery systems.
研究领域:
药学
·
纳米技术
·
心脏病学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Fangfang Zhou,Jianquan Luo,Siqing Song,Yinhua Wan
Catechol–amine codeposition can improve the stability of a mussel-inspired coating layer (e.g., dopamine, tannic acid, gallic acid) but its superior performance on enzyme immobilization has not been studied yet. For the first time, a tannic acid-3-aminopropyltriethoxysilane (TA–APTES) coating was investigated for carrier activation and subsequent enzyme loading via covalent bonding. During the coating process, nanoparticles were generated by the reaction between APTES and TA, and then in situ assembled and adhered to the carrier surface, resulting in a hierarchical nanostructure. The TA/APTES ratio and coating time greatly affected enzyme loading and specific activity by changing the nanoparticles’ amount/size and available quinone groups of oxidized TA. The nanoparticles offered more area (i.e., specific surface area) for enzyme loading and reaction, while the quinone groups were responsible for covalently binding the enzyme. The TA–APTES coating showed much better performance in enzyme immobilization than glutaraldehyde, genipin, and polydopamine activation strategies, thanks to its special surface nanostructure and abundant quinone groups. Secondary grafting branched polymer γ-polyglutamic acid (γ-PGA) on the TA–APTES coating layer further increased enzyme loading (3.5–4.5 times). Finally, the universality of the TA/APTES coating was demonstrated by applying it on various materials for immobilizing different enzymes and removing five micropollutants (i.e., bisphenol A, 2,4,6-trichlorophenol, aflatoxin B1 (AFB1), deoxynivalenol (DON), and tetracycline (TC)). This work not only established a novel platform for facile and efficient enzyme immobilization but also clarified the effect of surface chemistry and morphology on enzyme immobilization and micropollutant removal.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Shu Xu,Dongwei Lu,Panpan Wang,Yumeng Zhao,Yan Sun,Jingyao Qi,Jun Ma
A dual-charged composite membrane was engineered for efficient separation of both cationic and anionic molecules. Alternately charged functional layer with sandwich structure was assembled onto porous membrane via chemical-mediated polyphenol surface engineering. The surface morphology , element variation and surface charge properties of the functional layer were respectively analysed using SEM, FTIR and streaming zeta potential measurements. The as-prepared “sandwich”-type composite membrane showed preferable rejection to multiple charged dyes (99.6% Alcian blue, 99.3% Brilliant blue, 92.21% Methyl blue, 89.91% Rhodanile blue). Both Donnan repulsion by dual-charged functional layer and entrapment effect by micro electric fields contributed to the outstanding separation performance. Compared with generally needed high pressure of 4–8 bar for the current nanofiltration separation, the developed composite membrane achieved desirable rejection under a low operating pressure of 1.5 bar, as well as favorable recycling performance for long-term use. This study provides an energy-efficient membrane candidate for comprehensive separation of charged molecules in practical applications such as dye wastewater treatment .
研究领域:
材料科学
·
环境工程
·
化学工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Renjie Li,Hangxu Fan,Liguo Shen,Linhua Rao,Jiayi Tang,Sufei Hu,Hongjun Lin
While polyphenol-based coating has been regarded as a promising alternative to functionalize membrane surface, it usually suffers from problems of low-efficient procedure and low utilization rate of the polyphenolic compounds, hindering its large-scale implementations. To solve these problems, this study provided a first report on inkjet printing of polyphenols (catechol (CA) or tannic acid (TA)) and sodium periodate (SP) on a polyvinylidene fluoride (PVDF) membrane to improve membrane performance. A series of analyses showed the efficient formation of homogenous films on the PVDF membrane surface and the improvement of hydrophilicity by the inkjet printing technique. The PVDF membranes decorated with the optimized polyphenolic coating exhibited a promising oil/water separation efficiency (higher than 99%) with a high average water permeation flux of 5.2 times higher than that of the pristine membrane. Meanwhile, the modified membranes illustrated a good stability under acidic conditions (pH = 2–7). The novel method proposed in this study is facile, cost-saving and environment-friendly. The advantages of the proposed method and the modified membranes demonstrated the great significance of the proposed method in practical applications.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Shanshan Dong,Liumin Fan,Yunfang Ma,Juan Du,Qisen Xiang
Cold plasma-induced inactivation of polyphenol oxidase (PPO) in plant-derived foods has been recognized, but the underlying mechanisms are not fully understood. The present study aimed to elucidate the kinetics and mechanisms of PPO inactivation using dielectric barrier discharge (DBD) plasma. The PPO solution (2 mL) was treated with DBD plasma at different times. The results showed that PPO activity decreased by 70.2%, 85.7%, and 94.2% after DBD plasma exposure at 19.4, 26.4, and 32.6 W, respectively, for 3 min. The PPO inactivation curves were well fitted by the Weibull and logistic models. DBD plasma exposure resulted in a significant decrease in the intrinsic fluorescence intensity of PPO, suggesting the disruption of its tertiary structure. Circular dichroism analysis indicated that DBD plasma caused the unfolding of PPO, thereby increasing content of β-sheets and decreasing the α-helices. DBD plasma also induced the oxidative degradation and carbonylation of PPO. After DBD plasma exposure at 26.4 W for 3 min, the surface hydrophobicity of PPO decreased by 60.9%, and the sulfhydryl content declined by 31.2% ( p < 0.05). In summary, DBD plasma induced significant changes in the structure and oxidative modification of PPO, which might be responsible for the loss of its enzymatic activity.
研究领域:
食品科学
·
等离子体技术
·
酶学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Shaomin Li,Zhixian Li,Jiafeng Pang,Jing Chen,Hongdi Wang,Qiuling Xie,Yanbin Jiang
This study reports a facile approach to construct versatile zein-polydopamine-casein core–shell nanocomposites (ZPCs) for polyphenol delivery systems. The surface of zein particles was first modified with mussel-inspired polydopamine (PDA), and then coated with casein, forming stable colloidal particles against environmental stresses including pH, salinity, storage, redispersion, and UV irradiation. Compared with free resveratrol (RES), the encapsulation of RES into ZPCs (RES-ZPCs) enhanced approximately 5-fold and 2.5-fold antioxidant activity for DPPH and ABTS assays, respectively. Cellular H2O2 scavenging assay of RES-ZPCs presents 100% exogenous reactive oxygen species elimination, whereas free RES eliminates only 63.5%. In vitro cell uptake and cytotoxicity assays show that ZPCs could be uptake and exhibits nontoxic on the cell proliferation. This concept of combining PDA and polyphenols with antioxidant activity and stability may provide new insights into designing highly active, stable polyphenol delivery systems and holds promise for applications in food, dietary supplement, and pharmaceutical industries.
研究领域:
纳米技术
·
食品科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Yiming Bu,Jingjing Huang,Shiyu Zhang,Yinghua Wang,Shaojin Gu,Genyang Cao,Hongjun Yang,Dezhan Ye,Yingshan Zhou,Weilin Xu
With the ever-increasing oil spillages, oil-water separation has attracted widespread concern in recent years. In this work, a nature-inspired polyphenol method has been developed to fabricate the durable superhydrophobic surfaces for the oil-water separation. Inspiring from the adhesion of polyphenol and reducing capacity of free catechol/pyrogallol groups in polyphenol, firstly, the simple immersion of commercial materials (melamine sponge, PET, and nonwoven cotton fabrics) in tannic acid (TA) solution allows to form a multifunctional coating on the surface of sponge or fabrics, which was used as reducing reagent to generate Ag nanoparticles (NPs). Then, decoration of 1 H , 1 H , 2 H , 2 H -perfluorodecanethiol (PFDT) molecules produced superhydrophobic surfaces. The surface topological structure, chemical composition, and superhydrophobic property of the as-prepared surface are characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), energy dispersive spectroscopy (EDS), and water contact angle (WCA) measurements. The WCAs of as-prepared sponge and fabrics were higher than 150°. The stability, absorption capacity, and recyclability of as-prepared sponge and fabrics were investigated. The as-prepared sponge demonstrates high oil/water selectivity and high absorption capacity (66–150 g/g) for a broad variety of oils and organic solvents, and was chemically resistant, robust against abrasion, and long-term durability in harsh environments. Most important of all, it can continuously separate various kinds of oils or organic pollutants from the surface of water. This study presents a facile strategy to fabricate superhydrophobic materials for continuous oil-water separation, displaying great potential in large-scale practical application.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Cancer Nanotechnology
·
2022
·Vol. 13
·期 1
·1-16
·
IF 7.917
Wu Yunchao,Zhu Jinqian,Li Qianzhe,Yang Mengyu,Sun Xin,Zheng Guojun,Du Fengyi,Zhang Miaomiao
Background Nanoparticle-based photothermal therapy (PTT) is capable of inducing immunogenic cell death (ICD) and eradicating local tumor via hyperthermia. However, it can hardly prevent tumor recurrence and metastasis owing to inadequate immune activation. Results To this end, manganese-coordinated polyphenol carbon dots (MP-CDs) were synthesized by hydrothermal carbonization and metal–polyphenol coordination. This prepared MP-CDs had ultra-small particle size of 5 nm, excellent optical performance, good dispersibility in water and favorable biocompatibility. Under 808 nm near-infrared laser irradiation, the MP-CDs with high photothermal conversion efficiency could kill tumor cells and induce the release of damage-associated molecular patterns (DAMPs) from tumor cells. Notably, the MP-CDs can promote the maturation and antigen presentation ability of dendritic cells (DCs) via manganese-mediated immune activation. Conclusion The present work offers a versatile strategy to integrate functional metal into CDs via metal–polyphenol coordination for photothermal/immune therapy.
研究领域:
纳米技术
·
癌症治疗
·
免疫学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Food Science & Technology
·
2023
·
IF 2.3
Yuqian Zhou,Bushra Huma,Zhongxin Tan
Plant polyphenols’ antibacterial capabilities are just beginning to be applied in the environment. In this study, solvent recovery and concentration techniques were used to achieve zero-waste extraction of pineapple peel polyphenol (PPP) powder on an industrial scale. For environmental sterilization, PPP antibacterial agents (PAAs) were created. Their physicochemical and antibacterial qualities were examined, and technical and financial analysis was done. The results showed that (1) among the major PPP components, protocatechuic acid content was the highest (48.90 mg/L), followed by quercetin dihydrate (17.56 mg/L); (2) PAA sprays passed the tests for physicochemical properties like pH and heat resistance; (3) at the 8 mg/mL concentration, PAA achieved 100% bacterial inhibition below 40 °C; and (4) the production cost of 8 mg/mL PAA spray was only $273.41/t at 100,000 t industrial scale. These findings might offer an application prospect in the development of renewable bacteriocins from fruit and vegetable waste materials.
研究领域:
环境科学
·
生物技术
·
废物管理
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2023
·Vol. 17
·期 6
·5594-5605
·
IF 3.4
Yu Yuyuan,Shi Yongqing
The interaction between quinoa glycopeptides (QGs) and three polyphenols [(−)-epigallocatechin-3-gallate (EGCG), gallic acid (GA) and tannic acid (TA)] was investigated by particle size, potential, fluorescence spectrum, and Fourier infrared spectrum, and the changes of antioxidant activity after compound were investigated by in vitro antioxidant experiments. The results showed that the average particle size of quinoa glycopeptide decreased and its distribution became more uniform after it was combined with three polyphenols. The intrinsic fluorescence was quenched and decreased with the increase of polyphenol content, and the maximum emission wavelength of the intrinsic fluorescence spectrum was redshifted. When combined with EGCG, GA and TA, the surface hydrophobicity of quinoa glycopeptides decreased significantly. The quenching type of EGCG, GA, and TA on quinoa glycopeptides was static quenching. The addition of polyphenols changed the hydrophobic amino acid groups in quinoa glycopeptides, and the hydrophobic interaction was the main force. Additionally, the secondary structure of QG was slightly changed after the binding of polyphenols to QG. Moreover, DPPH and ABTS radical scavenging abilities and ferric reducing antioxidant power analysis showed that EGCG, GA, and TA enhanced significantly the antioxidant capacity of QG. Therefore, this study can guide the preparation of quinoa functional food.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）