RSC Advances
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2016
·Vol. 6
·期 41
·34096-34102
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IF 3.289
Wen-Ze Qiu,Yan Lv,Yong Du,Hao-Cheng Yang,Zhi-Kang Xu
High performance nanofiltration (NF) membranes are facilely fabricated via the co-deposition of catechol (CCh) and polyethylenimine (PEI) on the surface of a polysulfone (PSf) ultrafiltration membrane, with subsequent cross-linking by glutaraldehyde (GA). The surface properties of the studied membranes have been investigated in detail by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning election microscopy, atomic force microscopy, zeta potential, and water contact angle. The NF performance of the membranes are dependent on the CCh/PEI ratio, co-deposition time and cross-linking condition. Results reveal that the optimum membrane yields a rejection of 88% and a permeation flux of 25 L m−2 h−1 when filtrating the 1000 mg L−1 MgCl2 solution at 0.6 MPa. And the negatively charged membrane surface is related to the following salt rejection sequence: MgSO4 > Na2SO4 > MgCl2 > CaCl2 > NaCl. Meanwhile, the membranes show excellent operation stability during a 240 h consistent filtration test.
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高影响因子
Journal of Applied Biomaterials & Functional Materials
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2016
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IF 0.934
Junyan Yao,Shijie Zhang,Wudan Li,Yujie Li
BackgroundThe amorphous poly(lactic acid-co-lysine) (PLL) with hydrophilic reactive groups was synthesized by the condensing copolymerization and the blending miscibility of poly(L-lactic acid) (PLLA) and PLL was investigated.MethodsThe miscibility of PLLA and PLL was evaluated by analyzing the thermal properties, crystallization behaviors, crystal morphologies and mechanical properties of the PLLA/PLL blends.ResultsThe results indicated that amorphous PLL changed the crystallization behaviors and thermal properties of PLLA, decreasing the crystallinity of PLLA in the blends. The amorphous PLL molecule chains in PLLA/PLL blends were able to enter into the lamellars of PLLA spherulites and affect the crystallization behaviors of PLLA, resulting in imperfect, spherulite structures of PLLA. The formation of hydrogen bonds between PLLA molecular chains and PLL molecular chains enabled partial compatibility in this blend system.ConclusionsThe existence of PLL improved the hydrophility of PLLA/PLL blends, led to a higher content of PLL in the PLLA/PLL blend system, and better hydrophilic properties of the blend system. The PLL was partially miscible with the PLLA, and the PLLA/PLL blend with 10 wt% PLL had improved tensile properties.
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PubMed
高影响因子
RSC Advances
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2016
·Vol. 6
·期 107
·105442-105448
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IF 3.289
Yue Cao,Yan Li,Yin Wu,Wenliang Li,Chunlei Yu,Yanxin Huang,Luguo Sun,Yongli Bao,Yuxin Li
Co-Encapsulated angiostatin (AS) and curcumin (Cur) in poly(ethylene glycol)-b-poly(ε-caprolactone) polymersomes (PEG–PCL-PMs) were prepared by film hydration method. The size and zeta potential of the prepared PEG–PCL-PMs were about 153 nm and −0.22 mV, respectively. Transmission electron microscopy was employed to confirm the polymersomal structure of PEG–PCL-PMs. In vitro drug release profiles showed a sustained release of angiostatin and curcumin from the dual-drug loaded polymersomes under physiological conditions (pH 7.4). In addition, confocal laser scanning microscopy and flow cytometry showed that drug-loaded polymersomes were delivered efficiently into the cytoplasm and nuclei of human microvascular endothelial cell line (HMEC-1) and then released active drugs in cells. Dual drug-loaded polymersomes (AS–Cur-PMs) remarkably inhibited proliferation and migration of HMEC-1 cells compared to those treated with the single drug. The chick chorioallantoic membrane assay showed that AS–Cur-PMs inhibited vessel sprouting in the chicken chorioallantoic membrane. Our data demonstrates a synergistic effect of angiostatin and curcumin in inhibiting angiogenesis, both in vitro and in vivo.
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高影响因子
RSC Advances
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2016
·Vol. 6
·期 83
·79268-79274
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IF 3.289
Shuo Shi,Qing-Yun Wu,Lin Gu,Kunyu Zhang,Haibin Yu
The present work reports novel bio-based, amorphous, biodegradable and biocompatible polymer networks which were synthesized from polylactide (PLA)-based tetraols and hexamethylene diisocyanate trimer. These bio-based polymer networks exhibit a glass transition temperature (Tg) in the range of 13.4–32.9 °C, which can be adjusted between room temperature and body temperature by variation of the molecular weight of macrotetrols and incorporation of caprolactone (CL) units. Tensile strength and elongation of the resulting polymer networks could be tuned in a wide range from 14 MPa to 43 MPa and 10% to 176%, respectively. A series of shape memory tests indicate that the obtained polymer networks show excellent shape memory behavior at body temperature with a shape recovery rate higher than 90%. Alamar blue assay was used to evaluate the potential biocompatibility of the synthesized polymer networks, and the results demonstrated that all the obtained networks had no cytotoxicity, making them suitable for biomedical applications.
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高影响因子
JOURNAL OF POWER SOURCES
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2017
·
IF 6.395
Chao Yang,Shu Yu,Yu Ma,Chunfu Lin,Zhihao Xu,Hua Zhao,Shunqing Wu,Peng Zheng,Zi-Zhong Zhu,Jianbao Li,Ning Wang
Ti 2 Nb 10 O 29 is an advanced anode material for lithium-ion batteries due to its large specific capacity and high safety. However, its poor electronic/ionic conductivity significantly limits its rate capability. To tackle this issue, a Cr 3+ –Nb 5+ co-doping is employed, and a series of Cr x Ti 2–2 x Nb 10+ x O 29 compounds are prepared. The co-doping does not change the Wadsley–Roth shear structure but increases the unit-cell volume and decreases the particle size. Due to the increased unit-cell volumes, the co-doped samples show increased Li + -ion diffusion coefficients . Experimental data and first-principle calculations reveal significantly increased electronic conductivities arising from the formation of impurity bands after the co-doping. The improvements of the electronic/ionic conductivities and the smaller particle sizes in the co-doped samples significantly contribute to improving their electrochemical properties . During the first cycle at 0.1 C, the optimized Cr 0.6 Ti 0.8 Nb 10.6 O 29 sample delivers a large reversible capacity of 322 mAh g −1 with a large first-cycle Coulombic efficiency of 94.7%. At 10 C, it retains a large capacity of 206 mAh g −1 , while that of Ti 2 Nb 10 O 29 is only 80 mAh g −1 . Furthermore, Cr 0.6 Ti 0.8 Nb 10.6 O 29 shows high cyclic stability as demonstrated in over 500 cycles at 10 C with tiny capacity loss of only 0.01% per cycle.
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高影响因子
MATERIALS RESEARCH BULLETIN
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2016
·
IF 2.435
Honghong Liu,Hong Gong,Mingming Zou,Heng Jiang,Rasaki Sefiu Abolaji,Ayesha Khan Tareen,Branislav Viliam Hakala,Minghui Yang
Mo-N-co-doped mesoporous TiO 2 microspheres were synthesized via a solvothermal method, followed by nitriding treatment under ammonia gas flow. The efficiency of the samples was investigated by monitoring the degradation of Rhodamine-B under visible light irradiation. The experimental results revealed that Mo-N-co-doped mesoporous TiO 2 microspheres showed better performances than Mo-TiO 2 microspheres. It was observed that; 0.1% molar quantity of Mo doped on TiO 2 at 500 °C for 2 h under nitriding conditions gave highest photocatalytic activities. The nitridation under ammonia gas of Mo-TiO 2 samples created oxygen vacant sites and led to incorporation of substitutional and interstitial Nitrogen. The enhanced visible light photocatalytic activities of Mo-N-co-doped TiO 2 photocatalyst was attributed to the large surface areas, narrow band gap and intense light absorbance in visible region. This study may create a promising and eco-friendly method towards synthesis of metal and non-metals co-doped on semiconductor materials to improve their photocatalytic activities and applications.
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高影响因子
POLYMER
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2016
·
IF 3.586
Cai Xiaodong,Yang Xiangui,Wang Gongying
Multiblock poly(carbonate-co-esters) (PBC-PBSe) containing poly(butylene carbonates) (PBC) and poly(butylene sebacate) (PBSe) were synthesized successfully via chain-extension of dihydroxyl terminated PBC (PBC-OH) and PBSe (PBSe-OH) using 1,6-hexmethylene diisocyanate (HDI) as chain extender. The chemical structures , molecular weights , crystallization behaviors , thermal, degradation as well as mechanical properties of the copolyesters were characterized by Proton nuclear magnetic resonance spectroscopy ( 1 H NMR), Fourier transform infrared spectroscopy (FT-IR), Gel permeation chromatography (GPC), Differential scanning calorimetry (DSC), Thermogravimetry analysis (TGA), hydrolytic degradation and mechanical testing, respectively. The results indicated that the introduction of PBSe segment not only significantly enhanced the crystallization rate of PBC, but also displayed the same crystallization mechanism within the investigated crystallization temperature range despite of the variation of the PBSe segment content. Furthermore, the thermal stability and hydrolytic degradation rate of PBC-PBSe multiblock copolymers increases with increasing PBSe content. The mechanical properties of copolymers can be adjusted by changing the feed composition .
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高影响因子
DESIGNED MONOMERS AND POLYMERS
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2015
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IF 2.78
Nian Deng,Xufeng Ni,Zhiquan Shen
Poly (diethyl vinylphosphonate-co-2-chloroethyl methacrylate) (P(DEVP-co-CEMA)) copolymers are synthesized by free radical copolymerization initiated by benzoyl peroxide. The reactivity ratios for the free radical copolymerization of CEMA (M1) and DEVP (M2) are r1 = 19.45 and r2 = 0.11, respectively. The desired amphiphilic copolymers with relatively low polydispersity index (PDI) and different DEVP contents are isolated and purified from the reaction mixtures through precipitation fractionation. The structures and molecular characteristics of the obtained products are characterized by 1H NMR, FTIR, and SEC analysis. All of these fractionated copolymers have a unimodal distribution and moderate PDI. The thermal properties of the P(DEVP-co-CEMA) copolymers are investigated by TGA and differential scanning calorimetry (DSC) measurements. Single glass transition temperature (Tg) appears in the DSC profiles differing from the existence of two Tgs in the blend of poly (diethyl vinylphosphonate) and poly (2-chloroethyl methacrylate), which indicates the random structure of the copolymers. The MALDI–ToF mass analysis further reveals that DEVP and CEMA units are randomly distributed in the copolymer chains. The self-assembly behavior of the P(DEVP-co-CEMA) copolymers in aqueous solution is preliminarily investigated.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2015
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IF 3.088
Cheng Wang,Min Li,Tie Yang,Xuefang Ding,Xiuli Bao,Yang Ding,Hui Xiong,Ying Wu,Wei Wang,Jianping Zhou
A new cationic polymer eprosartan-graft-PEI (ESP) containing eprosartan (ES) and polyethylenimine 1.8K was successfully developed and employed as a safe gene vector to assemble a drug (ES) and gene co-delivery complex (ESP/pDNA). Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes. The CS/ESP/pDNA complexes with desirable particle size and zeta potential, exhibited amidase-responsive drug release and CS-mediated endocytosis in vitro . As compared with ESP/pDNA complexes, in vivo imaging results demonstrated decreased reticuloendothelial system uptake and remarkably increased tumor accumulation of CS/ESP/pDNA complexes. All these findings indicated the potential of CS/ESP/pDNA as a promising tumor-targeted drug and gene co-delivery system.
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PubMed
高影响因子
ELECTROCHIMICA ACTA
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2015
·
IF 4.504
Aili Liu,Wei Li,Huile Jin,Xiaochun Yu,Yongfeng Bu,Yuhua He,Huihui Huang,Shun Wang,Jichang Wang
Graphene co-doped with fluorine and chlorine heteroatoms was prepared through a one-step synthesis and was investigated as the oxygen reduction electrocatalysts. Voltammetric measurements show that fluorine and chlorine co-doped graphene has remarkable catalytic activity toward the electrochemical reduction of oxygen in alkaline solution. Besides having a high tolerance to methanol crossover effect, the co-doped graphene also showed a better stability than that of commercial Pt/C electrocatalysts and of the chlorine-doped graphene that was prepared by the same approach. The charge transfer resistance of the co-doped graphene was substantially lower than that of the chlorine-doped graphene, suggesting that there may exist a synergistic interaction between fluorine and chlorine dopants. The rapid synthetic method reported here provides an effective approach for future investigation of halogen (co-) doped graphene.
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高影响因子
ENVIRONMENTAL POLLUTION
·
2014
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IF 3.902
Chi Wang,Hao Li,Shaohua Liao,Di Zhang,Min Wu,Bo Pan,Baoshan Xing
The K d of sulfamethoxazole (SMX) on activated carbon (AC) was larger than that of SMX on single-walled carbon nanotubes (SC), but the competition of SMX with carbamazepine (CBZ) for adsorption sites was weaker on AC than SC. Thus, a large K d value does not necessarily reflect a high affinity. The analysis of the apparent sorption , competition, desorption hysteresis, and the sorption thermodynamics for SMX and CBZ did not provide sufficient information to distinguish their sorption affinities. The release of the adsorbed CBZ was not altered with SMX as the competitor, but SMX release increased significantly after CBZ addition. The higher sorption affinity of CBZ may be explained by the interactions of the CBZ benzene rings with the aromatic structures of the adsorbents. Although the thermodynamic meaning cannot be described, the release ratio of the adsorbed pollutants provides useful information for understanding pollutant sorption strength and associated risks.
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PubMed
高影响因子
Oncotarget
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2015
·
IF 6.359
Peng-fei Liu,Yan-wei Cao,Shu-dong Zhang,Yang Zhao,Xiao-guang Liu,Hao-qing Shi,Ke-yao Hu,Guan-qun Zhu,Bo Ma,Hai-tao Niu
A tumor microenvironment may promote tumor metastasis and progression through the dynamic interplay between neoplastic cells and stromal cells. In this work, the most representative and significant stromal cells, fibroblasts, endothelial cells, and macrophages were used as vital component elements and combined with bladder cancer cells to construct a bladder cancer microenvironment simulation system. This is the first report to explore bladder cancer microenvironments based on 4 types of cells co-cultured simultaneously. This simulation system comprises perfusion equipment, matrigel channel units, a medium channel and four indirect contact culture chambers, allowing four types of cells to simultaneously interact through soluble biological factors and metabolites. With this system, bladder cancer cells (T24) with a tendency to form a ‘reticular’ structure under 3 dimensional culture conditions were observed in real time. The microenvironment characteristics of paracrine interactions and cell motility were successfully simulated in this system. The phenotype change process in stromal cells was successfully reproduced in this system by testing the macrophage effector molecule Arg-1. Arg-1 was highly expressed in the simulated tumor microenvironment group. To develop “precision medicine” in bladder cancer therapy, bladder cancer cells were treated with different clinical ‘neo-adjuvant’ chemotherapy schemes in this system, and their sensitivity differences were fully reflected. This work provides a preliminary foundation for neo-adjuvant chemotherapy in bladder cancer, a theoretical foundation for tumor microenvironment simulation and promotes individual therapy in bladder cancer patients.
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高影响因子
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