iScience
·
2026
·
IF 4.5
Na Wang,Huirui Zhu,Dongkun Li,Xuena Wang,Ziyan Zhang,Bao Chai,Meining Li,Tao Gong
Hard-healing or non-healing diabetic wounds feature complex pathogenesis, posing significant challenges to clinical treatment. Platelet-rich plasma (PRP) is rich in various growth factors and possesses significant therapeutic potential, while its clinical application is largely limited by the rapid release of these bioactive factors. In this study, a multifunctional hydrogel dressing (GACP@PRP) based on PRP was fabricated for the promotion of type 2 diabetes wound healing via the physical cross-linking of graphene oxide-silver nanoparticles (GO-Ag NPs),chitosan (CS), and poly(N-isopropylacrylamide) (PNIPAM). The wound dressing possesses injectability, self-healing, favorable porosity, water absorption, moisture retention, adhesiveness, antibacterial and hemostatic functionalities. Moreover, the GACP@PRP hydrogel protects PRP to sustain growth factors release, promote cell proliferation and migration, which significantly accelerated wound healing rate in SD rats full-thickness skin defect model. Together with its great biocompatibility and biosafety, GACP@PRP meets the multiple functional requirements of diabetic wound dressing and is promising for clinical diabetic wounds management.
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PubMed
高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Kaibin Xia,Yuhui Du,Junhui Liang,Zhen Shen,Xiaoqi Fei,Jiahui Hou,Chen Hangning,Du Chenhao,Liuqi Wang,Da Chen
Ammonia-hydrogen energy conversion is perceived as one of the effective methods to solve the storage and transportation problems of hydrogen energy. In recent years, the plasma-assisted strategy has shown great potential in the field of low-temperature ammonia decomposition. However, its enhancement mechanism for reaction kinetics has rarely been studied. Herein, by comparing the morphology and structural changes of catalysts with and without plasma field assistance before and after the reaction, we investigate the influence mechanism of the plasma field on the kinetics of the ammonia decomposition reaction (ADR). We found that the bombardment effect of high-energy particles in the plasma field can not only excite the reactant NH 3 to the activated NH x radical, but also effectively inhibit the agglomeration of active metal Ru in the catalyst, induce the generation of oxygen vacancies and N-containing carriers on the surface of CeO 2 , and thus change the dissociation path of N ≡ N. Ultimately, under the synergistic effect of the plasma and the catalyst, the low-temperature activity of the catalyst is significantly improved. At 350 ℃, the ammonia conversion rate of the plasma-assisted catalyst (Ru/CeO 2 -PEA) reaches 71%, which is much higher than 35% of the thermocatalytic sample without plasma field assistance, and the equilibrium state of ammonia decomposition can be reached at 450 ℃. This work sets out to elucidate the mechanistic details of plasma-assisted ammonia decomposition by establishing an improved theoretical model.
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高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2020
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IF 0.593
Da-Hua Shi,Meng-qiu Song,Xiao-Dong Ma,Jia-Bin Su,Jing Wang,Xiu-Jun Wang,Yu-Wei Liu,Wei-Wei Liu,Xin-Xin Si
Four 2-phenylthiazole derivatives are synthesized, characterized, and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives are confirmed by 1H and 13C nuclear magnetic resonance spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces analysis. Hirshfeld surface analysis of the prepared compounds showed C–H···O intermolecular interactions. The cholinesterase inhibition activities of the synthesized compounds are tested by Ellman’s method. [2-(4-Benzyloxyphenyl)-thiazol-4-yl]-(3,5-dimethylpiperidin-1-yl)-methanone showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86 µM and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03 µM. A docking study demonstrates that the same compound interacts with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase.
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高影响因子
CHEMICAL PHYSICS
·
2026
·
IF 2.4
Huifang Xu,Song Lu,Jingya Zhang,Sijia Wang,Chenyu Zhao,Bin Liu,Yuanyuan Li
Recently, we have reported the vesicle formation and vesicle-to-micelle transition (VMT) of sodium 2-ketooctanoate, a single-tailed keto-acid salt, in water with increasing concentration. Herein, we demonstrate that, upon prolonged standing at the vesicle-forming concentration, macroscopic fibrous structures spontaneously formed. Cryogenic transmission electron microscopy, atomic force microscopy, and laser scanning confocal microscopy revealed the microscopic pathway: vesicles aggregated and evolved through elongated intermediate structures (threadlike vesicles and chains of vesicles) into long strips, which ultimately assembled into floating fibers. As concentration was increased around the critical micelle concentration (CMC), these fibers transformed into bundles of nanofibers and threadlike micelles, and finally evolved to globular micelles above the CMC. The observed multi-step aggregation behavior is driven by the dynamic coexistence and rearrangement of multiple species, notably “acid-soap” dimers. This constitutes the first report detailing the microscopic transition pathway from fibrous structures to micelles for a single-tailed keto-acid salt amphiphile in water.
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高影响因子
BIOORGANIC CHEMISTRY
·
2026
·
IF 5.1
Ao Yu,Yunlong Li,Yimei Wang,Jian He,Yong Zhou,Huiming Cai,Yiqing Wang,Bo Dai,Yi Shen
Intraoperative fluorescence-guided imaging has transformed oncological surgery, yet clinically approved probes lack specificity for primary tumors and metastatic lymph nodes. Herein, we developed NY-IND, a near-infrared fluorescent (NIRF) probe targeting cyclooxygenase-2 (COX-2). NY-IND not only has high water solubility, but also boasts higher fluorescence quantum yield and excellent biosafety. NY-IND exhibited high binding affinity for the COX-2 target with a dissociation constant (Kd) of 99.69 nM, thereby endowing it with the capacity to specifically recognize COX-2-overexpressing tumor cells and tissues. Significant tumor-to-background ratio (TBR > 6) was still observed 48 h after injection, allowing for clear differentiation between subcutaneous tumors and surrounding tissues. Furthermore, the probe NY-IND exhibited a long tumor retention time (>72 h) in vivo metabolism and provided a longer imaging window for fluorescence-guided tumor surgery. NY-IND showed significantly superior specificity in detecting metastatic tumor lesions including peritoneal metastasis of lung cancer and lymph node metastasis. This work presents a promising tool for real-time intraoperative visualization of tumors and metastases, advancing surgical precision and improving patient prognosis.
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JOURNAL OF MOLECULAR STRUCTURE
·
2013
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IF 1.404
Xue Chen,Yongjun Hu,Jiao Gao
2-Aminothiazole, as a typical heterocyclic amine, may exist amino-imino tautomeric equilibrium in nature. In present report, the optimized structural parameters and vibrational wavenumbers of amino and imino tautomers of the molecule have been predicted by density functional theoretical (DFT) calculation. Comparing the experimental and the calculated Raman spectra, it indicates that the amino tautomer would be the main configuration in the 2-aminothiazole saturated solution. In the concentration-dependent SERS spectra of 2-aminothiazole adsorbed on gold nanoparticles , it is found that the tautomeric equilibrium shifts toward to the amino tautomer when the concentrations is decreased. While the amino tautomer is end-on the surface through the nitrogen atom of thiazole ring at the higher concentrations, the molecule becomes to stand on the metal surface by interacting simultaneously with two nitrogen atoms of the molecule in the diluted solution.
研究领域:
物理化学
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光谱学
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理论化学
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纳米材料
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分析化学
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高影响因子
Foods
·
2022
·Vol. 11
·期 18
·2865
·
IF 5.561
Jinghe Sun,Shuang Song,Chunqing Ai,Beiwei Zhu,Jingfeng Yang
Sulfate polysaccharides, such as heparin sulfate, have been found to have inhibitory activity against SARS-CoV-2. An abalone polysaccharide, AGSP, was deeply sulfate modified using the chlorosulfonic acid/pyridine method, yielding S-AGSP. AGSP and S-AGSP inhibitions of SARS-CoV-2 infection of Vero E6 cells were tested in vitro. The interference of AGSP or S-AGSP on the binding interaction between the SARS-CoV-2 spike protein and angiotensin-converting enzyme was tested using a biolayer interferometry assay. Results showed that S-AGSP, above a concentration of 1.87 µg/mL, significantly inhibited SARS-CoV-2 infection of Vero E6 cells. Compared with AGSP, S-AGSP obviously weakened the affinity between the SARS-CoV-2 spike protein and ACE2. The polysaccharide’s sulfate content played a vital role in influencing the binding affinity of spike protein to ACE2. Therefore, S-AGSP has potential as a COVID-19 competitive inhibitor as well as a candidate to be repurposed as a prophylactic COVID-19 therapeutic.Keywords:sulfated;polysaccharide;SARS-CoV-2;biolayer interferometry;ACE2
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高影响因子
ChemistrySelect
·
2022
·Vol. 7
·期 35
·e202202475
·
IF 2.307
Zhiqiang Zhang,Qingyan Chu,Yuan Sun,Hao Wang,Deming Lu,Yuying Liu,Haibin Xiao,Ping Wang,Hongyou Cui,Ming Wang
Graphical The hierarchical TS-1 with abundant mesopores was prepared by TPAOH/TIPA treatment, which was applied to the reaction of the ammoximation-oxidation of acetone to 2-nitropropane. Hierarchical TS-1 catalyst performed excellent reusability and catalytic activity with 97.5 % conversion and 96.8 % selectivity. The novel technology for clean and mild synthesis of nitroalkanes has been developed. Modified TS-1 catalysts for the acetone ammoximation-oxidation reaction were prepared by post-treating TS-1 with different concentrations of TPAOH/TIPA, and the effects of alkali treatment on the catalytic performance were systematically investigated. The techniques such as XRD, SEM, TEM and N 2 sorption were used to characterize the catalyst samples, which exhibited that the introduction of alkali increased the volume and quantity of mesopores, while there was no obvious influence on the framework structure and titanium content in the framework. And the improvement in catalyst performance after alkali treatment was attributed to the increase of mesopores and the decrease in diffusion limitation. In addition, three common ammoximation catalysts (Ti-MOR, Ti- MWW and TS-1) were systematically investigated in this reaction. Ti-MOR showed superiority in the ammoximation to oxime, while TS-1 displayed the best catalytic performance in the ammoximation oxidation of ketones to nitroalkanes. It was indicated that modified TS-1 could be a promising catalyst for the ammoximation-oxidation reaction of acetone.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 10
·4911-4919
·
IF 3.3
Zhen Li,Yirong Wang,Ce Xu,Xianghong Li,Bingguang Zhang
A cyclometalated ruthenium complex (1) using 2-phenylimidazole as the C, N-ligand was successfully synthesized and used as a chromogenic sensor. The as-prepared sensor displayed a good absorption centered at 565 nm in the visible region. Due to strong hydrogen bonding, the complex demonstrated high sensitivity and selectivity to fluoride over other common anions in CH3CN solution. A large red-shift from 565 to 618 nm accompanied by a solution color change from red to green was achieved. However, in CH3CN/Britton-Robinson buffer (V/V = 1 : 9, pH 4.5), the competition with water resulted in no changes for fluoride. Only the presence of nitrite caused the absorption intensity between 400 and 600 nm to decrease remarkably with the solution color fading to yellow. This phenomenon could be attributed to the formation of ruthenium nitrosyl, which was then isolated and characterized by MS, FT-IR and NMR spectra. Therefore, complex 1 can be used as a chromogenic chemosensor to detect fluoride in CH3CN and nitrite in an acidic aqueous system, respectively.
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CHEMOSPHERE
·
2022
·
IF 8.943
Xiaocong Zhong,Xianliang Yi,Fanqi Cheng,Huiyan Tong,Weiping Xu,Xiaojing Yang
There has been a growing concern about plastic pollution , both from a health and ecological perspective. One of the major concerns with plastic debris, especially microplastics (MPs) relates to their strong potential for releasing additives and chemicals. Di-2-ethylhexyl phthalate (DEHP) is a common plastic additive widely used as plasticizer in plastic products, and is of global concern due to its widespread contamination in the environment. In this study, two conventional nondegradable plastics (polyethylene (PE) bags and PE mulch) and two biodegradable plastics (poly(butylene adipate co-terephtalate)-starch-based-polylactic acid bags (PBAT/PLA bags) and PLA mulch) were selected to investigate the release of DEHP to seawater. The results showed that leaching potentials of DEHP from different types of MPs varied. Among the four selected MPs, PE mulch had the highest leaching potential (6.88 μg/g), followed by PE bags (4.24 μg/g), PLA mulch (1.10 μg/g) and PBAT/PLA bags (0.89 μg/g). The DEHP leaching kinetic curves of the four MPs were all in line with the pseudo first order model. The potential risk of environmental and human exposure to the leached DEHP was assessed using the average Phthalate Pollution Index (PPI). The calculated PPI indicated low pollution risks of DEHP released by the four MPs in seawater.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Haonan Ma,Chi Zhang,Long Chen,Mengning Xi,Zhiqiang Wang,Zheng Ni,Kecheng Zhu,Hanzhong Jia
Sorption processes at the mineral–water interface are of great importance in dominating the fate and availability of metalloid contaminants in natural environment. Aiming at a thorough understanding of the complexation of antimony (Sb) on metal hydroxide, we conducted first-principles molecular dynamic (FPMD) simulations and batch adsorption experiments to elucidate the quantitative mechanism of Sb complexation on Mg(OH) 2 . Batch experiments showed the sorption of Sb(III) is nearly pH-independent, while increasing pH markedly weakened Sb(V) sorption; the measured sorption isotherm curves were well fitted by Langmuir model. Subsequently, molecular-level mechanism of Sb(V)/Sb(III) on brucite basal and edge surfaces were revealed by FPMD, including microscopic surface reactive sites, local complexing structures and coordination geometries, and complexing free energies. Results showed that Sb(III)/Sb(V) can form outer-sphere complexation on basal surface by hydrogen bonding. On edge surface, Sb(III)/Sb(V) formed stable inner-sphere mononuclear monodentate and binuclear bidentate complexes. The calculated free energies indicated that the binuclear bidentate complexing was more favorable than monodentate structure, and the complexation of Sb(III) was more stable than Sb(V). Accordingly, reaction pathway of the ligand exchange and thermodynamic stability of the different inner-sphere complexes were clarified. This study provides theoretical basis for evaluating the environmental risk of Sb and improving the engineering efficiency of Sb-contaminated water management.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Chunle Wei,Xiong Yang,Shaojie Shi,Lian Bai,Deyu Hu,Runjiang Song,Baoan Song
3-Hydroxy-2-oxindole motif constitutes a core structure in numerous natural products and imparts notable biological activities. Here, we describe the design and synthesis of four series of novel 3-substituted-3-hydroxy-2-oxindole derivatives containing sulfonamide moiety along with their antiviral activities against potato virus Y (PVY). Compound 10b displayed optimal antiviral activity and superior anti-PVY activity compared with the lead compound and commercial Ningnanmycin in terms of curative and protective effects. Additionally, 10b considerably inhibited PVY systemic infection in Nicotiana benthamiana. Physiological and biochemical analyses revealed that the activities of the four crucial defense-related enzymes increased in the tobacco plant following treatment with 10b. RNA-sequencing analysis revealed that 10b substantially induced the upregulation of 38 differentially expressed genes, which were enriched in the photosynthesis pathway. These findings suggest that 10b is a promising antiviral agrochemical that can effectively control PVY infection and trigger plant host immunity to develop virus resistance. This study provides novel molecular entities and ideas for developing new pesticides.
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高影响因子
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