CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 13.2
Yaqi Cui,Zulpya Mahmut,Yangdong Xie,Fangyu Shi,Jiaqi Zhou,Yaqi Zhu,Ruilin Lou,Zhenzhou Wang,Lin Xu,Lin Wang,Biao Dong
Manipulating the “bacterial current” by targeting the electron transport chain (ETC) presents a transformative antibacterial strategy, yet achieving precise targeting and elucidating the molecular mechanism remain challenging. Here, we break through the synthetic bottleneck to engineer a robust, electron-donating nanomaterial for targeted bacterial ETC disruption. A novel in-situ sulfur-doping and vacancy-engineering strategy was employed to fabricate porous Mo(SO)₂ from MoS₂, which features abundant oxygen vacancies and expanded interlayer spacing. These vacancies serve as electron-deficient centers that facilitate a rapid and strong electron donation. By functionalizing with 4-mercaptophenylboronic acid (4-MPBA) for targeting, the electrons are specifically transferred to the bacterial ETC. We systematically unveil the molecular mechanism: the donated electrons suppress the expression of ubiC , a key chorismate lyase for ubiquinone synthesis, via interaction with the guanidyl group of Arg63. This disruption halts proton pumping and ATP synthesis, leading to bacterial death via energy depletion.
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Advances in Applied Ceramics
·
2016
·
IF 1.162
Xueyu Tao,Zhimei Xiang,Shixiang Zhou,Yabo Zhu,Wenfeng Qiu
A preceramic polymer for ZrC was successfully synthesised by chemical reaction between zirconium oxychloride (ZrOCl2·8H2O) and 2-Hydroxybenzyl alcohol via a one-pot route. The molecular structure, thermal properties and pyrolysis behaviour of the precursor were investigated. The results indicated that the precursor might be Zr–O–Zr chain polymer with 2-Hydroxybenzyl alcohol as ligand. The precursor was air-stable and exhibited excellent solubility in common organic solvents. The conversions from precursor to ZrC powders were investigated by TG-DTA, X-ray diffraction, Scanning electron microscope, TEM and Raman spectrum. The precursor underwent a thermal decomposition in four steps, and ZrC powders were formed at 1300°C via carbothermal reduction reaction of ZrO2 and carbon in argon with ceramic yield of 63.0%. The ZrC particles were fine and exhibited irregular polyhedron morphology with average size in the range of 100–300 nm.
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CHINESE CHEMICAL LETTERS
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2026
·
IF 9.5
Xiaoming Zou,Hailin Zhang,Jianzhong Zeng,Ligui Wu,Ziyun Yin,Yimei Zeng,Qunyan Zhou,Lingling Rong,Yanbo Zhou,Xubiao Luo
The extensive use of gibberellic acid (GA 3 ) in agriculture leads to residues in agricultural products, raising potential human health concerns, particularly where residue limits are not established. Microbial degradation offers a promising remediation strategy, yet progress is limited by the scarcity of highly efficient degraders and an incomplete understanding of underlying mechanisms. Here, we identify a Candida tropicalis strain (GAJ-2) that achieves 83.63 % GA 3 removal within 120 h, exceeding the efficiencies reported for previously described GA 3 -degrading strains such as Aspergillus niger and Enterococcus mundtii (55.58 %–56.90 % within 5–7 days), and we further validate its residue-removal capacity in representative fruits and vegetables. Mechanistic analyses indicate that viable-cell-mediated GA 3 biotransformation by GAJ-2 mainly involves dehydroxylation, decarboxylation, and cleavage of the tetracyclic diterpenoid scaffold. These transformations are rationalized by the electronic distribution of oxygen-bearing functional groups and the electrophilic nature of C11 and adjacent positions in GA 3 . Multi-omics analyses further reveal enhanced energy metabolism and catalytic functions, together with efflux-pump regulation, and show a strong association between GA 3 catabolism and the upregulation of key enzymes ( e.g. , decarboxylases and dehydrogenases). Docking-based interaction profiling suggests that GA 3 associates with key proteins primarily through noncovalent interactions, including hydrogen bonding, van der Waals contacts, and electrostatic effects. Collectively, this work provides multi-level experimental and computational evidence supporting a plausible framework for GA 3 biodegradation by GAJ-2 and informs improved strategies for GA 3 pollution control.
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CHEMICAL ENGINEERING COMMUNICATIONS
·
2026
·
IF 2.2
Xiaoxian Sun,Yining Hu,Yingtong Zhou,Xin Liu
An amino acid ionic liquid, with lysine as the cation and CF3SO3- as the anion, was synthesized by ion‐exchange between lysine and trifluoromethanesulfonic acid. This ionic liquid was then explored as a catalyst for the esterification of oleic acid with methanol to produce methyl oleate, commonly known as biodiesel. Using this catalytic ionic liquid helps to mitigate common issues in conventional biodiesel synthesis—such as difficult product separation, catalyst recovery, and waste liquid disposal. This study investigates the effect of the catalyst on the conversion of oleic acid and identifies the optimal reaction conditions, including temperature, methanol-to-oleic-acid molar ratio, catalyst loading, and reaction time. The process was first optimized using traditional single-factor experiments to evaluate the main operating variables. Subsequently, data-driven methods, including Response Surface Methodology (RSM) based on a Box–Behnken design and Random Forest regression modeling, were employed to determine the optimal conditions for maximizing methyl oleate yield. The computational approach served to significantly reduce the required number of experimental trials, and allows to systematically identify optimal reaction conditions. The verified computational results had only 0.17% deviation from the predicted values.
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JOURNAL OF ORGANIC CHEMISTRY
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2026
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IF 3.3
Min Zhao,Zhengwei Ding,Saima Perveen,Lulu Qin,Zaicheng Nie,Tao Yu,Mingming Mao,Yuanyuan Cheng,Junyu Wang,Pengfei Li
The cyclohexane skeleton is ubiquitous in small-molecule drugs and bioactive natural products. However, there remains a lack of synthetic methods for polysubstituted cyclohexanes that simultaneously satisfy the requirements of readily available starting materials, high atom economy, and low-cost catalysts, which to a certain extent limits the application of this type of skeleton in the field of drug research and development. Herein, we report the first example of a boron radical-catalyzed intermolecular (4 + 2) cycloaddition reaction between cyclobutanes and alkenes, a strategy that provides an efficient and general method for the synthesis of polysubstituted cyclohexanes. This reaction exhibits broad substrate scope, being compatible with monosubstituted, 1,1-disubstituted, and trisubstituted alkenes and can selectively construct tri-, tetra-, and pentasubstituted cyclohexane derivatives in moderate-to-excellent yields.
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Yan Huang,Siyuan Wang,Leichao Wang,Linhua Zhu,Mingqing Hua,Peng Cui,Jixing Liu,Peiwen Wu,Yanhong Chao,Wenshuai Zhu
Chitosan-derived carbon microspheres (CMs) are potential adsorbents for antibiotics wastewater treatment due to their plentiful amino and hydroxyl groups. However, a pressing challenge for their practical application is how to enrich the adsorption site to further improve the adsorption capacity. Here, a novel adsorbent via 2-methylimidazole (2MIm) functionalization of bimetallic Cu/Al doped CMs (denoted as 2MIm-Cu/Al@CMs x ) was constructed through a facile hydrothermal method and a subsequent immersion step. The optimized material of 2MIm-Cu/Al@CMs 50 achieved maximum adsorption capacity of 1616.49 mg g -1 for tetracycline (TC) with the initial concetration of 500 mg L -1 and the adsorbent dosage of 5 mg (25 °C), showing 64.62% growth compared to the non-functionalized Cu/Al@CMs counterpart. The improved adsorption performance was attributed to the additional Cu-N sites and π-π interactions via 2MIm modification, working synergistically with hydrogen bonding, electrostatic attraction, and metal complexation. Systematic adsorption kinetics, isotherms and thermodynamics analysis revealed that the adsorption of TC on 2MIm-Cu/Al@CMs 50 was spontaneous and endothermic, and obeyed the pseudo-second-order kinetic and Langmuir isotherm models. Besides, 2MIm-Cu/Al@CMs 50 exhibited excellent reusability, and practical potential in real wastewater. This work provides a strategic design of functionalized CMs for the efficient removal of antibiotic pollutants.
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DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 21
·7143-7151
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IF 4
Lu Liang,Xiaohui Li,Xiaoge Wang,Zhaoji Luo,Kun Lin,Qiang Li,Sihao Deng,Lunhua He,Xiaojun Kuang,Xianran Xing
Mixed electronic and oxide ionic conduction was enabled in digermanate-type La2−xCaxGe2O7−x/2 containing Ge3O10 chains and isolated GeO4 units by substitution of La3+ with Ca2+. The structure and solid solution limit of Ca doped La2Ge2O7 were studied by systematic experiments, including rotation electron diffraction (RED), X-ray diffraction (XRD) and neutron powder diffraction (NPD) experiments, etc. The preferred occupation of Ca2+ and oxygen vacancies was investigated by Rietveld analysis of the NPD data. The obtained conducting material La1.925Ca0.075Ge2O6.963 exhibits superior thermal stability and an order of magnitude improvement in conductivity compared to the parent La2Ge2O7 (∼9 × 10−5 S cm−1 at 1000 °C). BVEL calculations reveal that the oxygen vacancies were stabilized and transported within the framework of La2Ge2O7 by sharing oxygen and oxygen exchange between the adjacent Ge3O10 chains and GeO4 units, exhibiting a three-dimensional oxide ion transport nature.
研究领域:
无机化学
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固态离子学
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功能材料
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结构化学
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能源材料
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晶体化学
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CATALYSIS COMMUNICATIONS
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2013
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IF 2.915
Bin Zeng,Xiaohua Chen,Xutao Ning,Chuansheng Chen,Aiping Hu,Weina Deng
Carbon nanotubes and reduced graphene oxides (CNTs/rGO) sphere decorated with Cu 2 O, CuO nanoparticles (Cu x O–CNTs/rGO) was successfully synthesized by spray drying and post-calcinating method for the first time. Scanning electron microscopy and transmission electron microscopy observations confirmed that CNTs/rGO formed a spherical micrometer structure and Cu x O nanoparticles were decorated on their surface. The experimental results indicated that this novel architecture enhanced photocatalytic performance with 97.5% decomposition of methyl orange (MO) after 20 min in the presence of H 2 O 2 under visible light irradiation, which was much higher than that of pure Cu x O powders (31.2%).
研究领域:
材料科学
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纳米科技
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光催化
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环境功能材料
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复合材料
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CERAMICS INTERNATIONAL
·
2024
·Vol. 51
·期 14
·18384-18391
·
IF 5.1
Fangliang Shen,Bingheng Sun,Tao Feng,Conghui Huang,Yin Hang,Benxue Jiang,Long Zhang,Jintai Fan
This work aims to fabricate the Yb:LuScO 3 sesquioxides transparent ceramics for use in ultrafast and ultrashort laser technology. 1 at.% Yb:LuScO 3 nanopowders were fabricated using the glycine-nitrate process. ZrO(NO 3 ) 2 was selected as the precursor of ZrO 2 which functions as a sintering aid. Yb:LuScO 3 transparent ceramics with different ZrO 2 content were fabricated by vacuum sintering at 1780 °C and HIPing at 1650 °C, among which the ceramic with 7 at.% ZrO 2 showed the highest transmittance, reaching 81 % at 2000 nm. The ceramic achieved a maximum output power of 1.5 W at 1038 nm with a slope efficiency of 34.8 % and tunable wavelength range exceeding 22 nm. The results demonstrated that Yb:LuScO 3 transparent ceramics can be considered as promising materials in 1 μm solid-state laser applications.
研究领域:
材料科学
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光学工程
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固体激光技术
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无机非金属材料
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先进陶瓷
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Environmental Science-Nano
·
2023
·Vol. 10
·期 4
·1109-1125
·
IF 7.3
Xiao Huang,Wen Yan,Jingxiang Sun,Tao Hu,Jinxi Feng,Zhen Huang,Shuanghong Tian,Ya Xiong
The achievement of highly active and stable piezocatalysts is still challenging for the efficient transformation of mechanical energy to chemical energy. Herein various SnOxHy species were prepared by a simple precipitation–thermal treatment method and applied for the piezocatalytic degradation of tricyclazole. It is found that the catalytic activity depended on the thermal treatment and follows the order SnO(OH)2 (80 °C) > SnO2.55H1.1 (200 °C) > SnO2.3H0.6 (300 °C) > SnO2.22H0.24 (400 °C) > SnO2 (500 °C) > rutile SnO2 (800 °C). SnO(OH)2 (80 °C) boosted the degradation of tricyclazole and the reaction constant reached as high as 0.0354 min−1, 7.1 fold that of SnO2 (800 °C). The differences among these SnOxOHy piezocatalysts mainly stemmed from the dissimilarity of the relative content of SnO(OH)2. In addition to the Sn–O piezoelectric motif, SnO(OH)2 had rich hydrogen bond networks, which work like molecular springs under external pressure. Due to such a special structure, SnO(OH)2 had not only a super high piezoelectric constant (d33) of 409.1 pm V−1 among the currently reported piezomaterials, but also a 0.49 eV-higher valence band than SnO2, being beneficial to the generation of stronger oxidative ˙OH. This is the first example of inorganic hydrogen-bonded piezomaterials, which opens a new window to develop advanced piezocatalysts for highly efficient degradation of refractory pollutants by piezocatalysis.
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ACS Nano
·
2023
·
IF 17.1
Chuansheng He,Linlin Yang,Xiaohui Peng,Shangheng Liu,Jia Wang,Chengyuan Dong,Delin Du,Leigang Li,Lingzheng Bu,Xiaoqing Huang
Thickness regulation of transition metal hydroxides/oxides nanosheets with superior catalytic properties represents a promising strategy to enhance catalytic performance, but it remains an enormous challenge to achieve precise control, especially when it comes to the ultrathin limit (several atomic layers). In this work, a facile strategy of alkylamine-confined growth is proposed for the synthesis of thickness-tunable metal hydroxide/oxide nanosheets. Specifically, ultrathin cobalt hydroxide and cobaltous oxide hybrid (Co(OH)2-CoO) nanosheets (Co–O NSs) with a thickness in the range of 2–6 nm (5–13 atomic layers) are synthesized by using alkylamines with different carbon chain lengths as the ligand to modulate vertical coordination ability. Co–O NSs with a thickness of 2 nm (Co–O NSs-2 nm) exhibit excellent oxygen evolution reaction (OER) performance with an overpotential of 278 mV at 10 mA/cm2. The maximized number of active sites including oxygen vacancies, optimal adsorption strength, and the highest electrical conductivity are considered as the potential factors contributing to the excellent OER performance of Co–O NSs-2 nm. This work holds great significance for the precise thickness-tunable synthesis of transition metal layered hydroxide nanosheets with modulated and improved catalytic performance.
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ACS Omega
·
2023
·
IF 4.1
Hao Wu,Xuefeng Ding,Yun Chen,Yanfei Cai,Zhaoqi Yang,Jian Jin
Antibody–drug conjugates (ADC) are an inevitable trend in the development of modern “precision medicine”. The goal of this work is to produce enzyme-responsive antibody nanoparticle-loaded medication (FMSN-Dox-H2-AE01) based on the EGFR antibody (AE01) and human serum albumin (HSA) shelled mesoporous silica nanoparticles. HSA and antibodies on the surface of the particlescan not only enhance the biocompatibility of the particle and avoid early drug leakage but also allow selective biodegradation triggered by matrix metalloproteinase-2 (MMP-2), which are overexpressed enzymes in some tumor tissues. The cytotoxicity test confirmed favorable safety and efficacy of the ADC. The mortality rate of cancer cells is about 85–90%. Moreover, the antibody nanoparticle-loaded drug showed distinguishing controlled release efficiency toward cancer cells induced by different levels of MMP-2 and pH. This enzyme-responsive FMSN-Dox-H2-AE01 offers a promising option for cancer therapy.
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