JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Nan Wang,Yuanyuan Huang,You Zi,Mengke Wang,Weichun Huang
A practical and regioselective direct N-alkylation of 2-pyridones is enabled by use of α-keto esters in the P(NMe2)3-mediated deoxygenation process. The reaction proceeds under mild conditions to produce N-alkylated 2-pyridones with high selectivity and generality, and the protocol is shown to be applicable for the scale-up synthesis, which makes it promising for practical applications.
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Zixu Ren,Yu Yu,Dingyang Chen,Minsi Shi,Rui Zhao
Polyamidoxime fibers have been widely studied for uranium extraction from seawater, but improving the amidoxime (AO) group utilization and increasing the selectivity toward uranium remain challenging. Herein, a hyperbranched macromolecular cross-linking strategy was employed to construct hyperbranched polyethylenimine (PEI) among the molecular chains of polyamidoxime nanofibers (PAN/PEI-AO nanofibers). This approach simultaneously suppressed chain entanglement and effectively reduced hydrogen bond formation between amidoxime groups, thereby significantly enhancing the utilization efficiency of AO groups. Moreover, the PEI structure also facilitated the dissociation of CO32– from uranyl tricarbonate ([UO2(CO3)3]4–) and comprised amino groups as assistant groups for enhanced uranium uptake. The above cross-linking effect by PEI was confirmed by experimental data and theoretical calculation, resulting in high uranium uptake (474.8 mg g–1) alongside good deep removal capability (kd = 7.7 × 105 mL g–1) from [UO2(CO3)3]4– solution. Moreover, PAN/PEI-AO nanofibers also exhibited good selectivity and reusability toward uranium and showed a uranium extraction capacity of 8.24 mg g–1 after 20 days’ testing from natural seawater. The obtained adsorption performance of PAN/PEI-AO nanofibers exceeded traditional polyamidoxime nanofibers and many reported uranium adsorbents. Overall, this work offers a strategy to improve the performance of polyamidoxime fibers, which possess the potential to extract real uranium species from natural seawater.
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iScience
·
2025
·
IF 4.1
Qian Wang,Jie Chen,Huini Chen,Dongning Liang,Hong Zhou,Juanjuan Chen,Yuan Gui,Fang Yao,Yudan Chen,Xi Zeng,Yaxiang Ma,Dong Zhou,Haiyan Fu
Cisplatin is a commonly used chemotherapy agent for treating various solid tumors, but its clinical application is limited by nephrotoxicity. While the potential for cisplatin to cause chronic kidney disease (CKD) following repeated administration has been underexplored, effective therapeutic strategies for cisplatin-induced CKD are lacking. We found that cisplatin-induced CKD is characterized by renal dysfunction and inflammation, along with intestinal barrier impairment. 16S rRNA and metabolomics revealed that cisplatin disrupts the gut microbiome and raises levels of tryptophan metabolites- Indole-3-propionic acid (IPA). Notably, oral administration of IPA reproduced similar harmful effects in cisplatin-induced CKD. Integrated analyses of the microbiome, metabolomics, Raman spectroscopy and DESI-MSI indicated that IPA supplementation exacerbates the production of uremic toxins linked to tryptophan metabolism and promotes the growth of pathogenic bacteria. Our findings demonstrates that IPA exacerbates renal inflammation and fibrosis by regulating AHR/NF-κB signaling pathways, altering intestinal microbiome composition, and disrupting tryptophan metabolism.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Qiongyi Huang,Wenjing Xie,Peiyao Liu,Qingwei Yu,Jingying Li,Xinyu Wei,Chunying Jiang,Peixuan Tan,Ding Cao,Ying Tang
Green synthetized Ag nanoparticles are increasingly used as antimicrobial agents topically applied to human skin for sanitization and medical purposes. Despite the widespread use, little was known on their antibiofilm efficacy and dermocompatibility. This study reports a systematic investigation into the impacts of green synthetized 0–3D Ag nanostructures, including 0D nanospheres, 1D nanowires, 2D nanoprisms and 3D nanoflowers as well as Ag nanospheres modified by different phytochemicals, on anti-biofilm efficacy and biocompatibility at the nano-skin interface. It was revealed that varying the Ag morphology induces distinct effects on two established polyspecies models consisting of skin-borne microbes ( S. aureus-S. epidermidis and S. aureus-C. albicans ). Ag nanospheres and nanowires are advantageous in inhibiting the formation of early biofilms (47–61 %) while Ag nanoprisms and nanoflowers are more effective in destroying mature biofilms (68–70 %). ROS-mediated oxidative stress, physical damage to cell membrane integrity, “contact killing” of microbial cells and suppression of adhesion-related gene expression are mechanisms involved in the anti-biofilm actions of these green synthetized Ag nanostructures. Furthermore, the dermocompatibility assessments were performed in reconstructed human epidermis. Although all exposed epidermis models remained > 50 % tissue viability, more Ag nanospheres were transdermally adsorbed than other morphologies while Ag nanoprisms were shown to be more cytotoxic. These findings provide insights into the impacts of 0–3D green synthetized Ag nanostructures on skin-borne polyspecies biofilms and dermocompatibility at the nano-skin interface, highlighting the importance of taking morphology and phytochemical modification into consideration for the rational design of sustainable Ag-based antimicrobials tailored for topical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ziqi Li,Yuying Wang,Wengang Chen,Lili Zheng,Weimin Wan,Xi Wang
Targeted and stimuli-responsive drug delivery systems (DDS) hold significant potential for improving therapeutic efficacy and mitigating adverse effects in cancer treatment. Here, we developed a pH-responsive nanocarrier through a surface modification strategy, which enables active targeting of hepatocellular carcinoma (HCC) cells for the delivery of drug curcumin (Cur), a poorly water-soluble therapeutic agent. Briefly, a polydopamine (PDA) layer was first deposited onto the surface of cellulose nanocrystals (CNCs) via the self-polymerization of dopamine hydrochloride. Subsequently, 3-carboxyphenylboronic acid (CA) was grafted onto the PDA-coated surface to obtain CNCs@PDA-CA. After that, Cur was loaded onto CNCs@PDA-CA by forming a boronate ester linkage with the boronic acid groups of CA, resulting in the final nanocomposite CNCs@PDA-CA-Cur with a drug loading capacity of 10.58 ± 1.32 %. This nanocarrier not only exhibited active targeting ability toward HCC cells, but also achieved controlled Cur release in response to the acidic tumor microenvironment. Specifically, CNCs@PDA-CA-Cur showed high pH-responsive ability that released 3.18-folds of Cur in acidic environments (pH = 5.4) more than in neutral environments (pH = 7.2). Furthermore, the nanocarrier demonstrated efficient active targeting to HCC cells, leading to elevated intracellular Cur accumulation and enhanced cytotoxicity in both 2D and 3D HCC models in vitro. Collectively, these results highlight the potential of the targeted and pH-responsive nanocarrier to improve the therapeutic delivery of poorly soluble drugs for HCC treatment.
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PROCEEDINGS OF THE COMBUSTION INSTITUTE
·
2025
·
IF 5.2
Meng Yang,Chang Liu,Chenglong Tang,Zuohua Huang
Hypergolic ionic liquids have wide range of potential applications in the propulsion field due to their low toxicity, high thermal stability, and safe handling; however, their high costs and unclear hypergolic ignition mechanisms have limited their development to date. In this work, nitromethane (NM), as an additive, was blended with 1-ethyl-3-methylimidazolium dicyanamide ([EMIm][DCA]) to obtain a new fuel with low viscosity and cost. The hypergolic ignition behaviors of [EMIm][DCA]/NM blends reacting with white fuming nitric acid (WFNA) were then investigated through drop tests. Two high speed cameras and a time-resolved infrared camera were used to record the macro and micro hypergolic ignition processes and the reaction region’s temperature evolution. The effects of the Weber number and NM blend ratio ( α ) on the hypergolic probability and ignition delay time (IDT) of the [EMIm][DCA]/NM blends were investigated. The results show that with increasing impact velocity, more smoke-like vapor and tiny droplets were formed, which promotes the hypergolic ignition probability and decreases the IDT. As increasing NM blend ratios, the hypergolic ignition performance is initially similar to pure [EMIm][DCA] ( α ≤ 30 %) and then decreases rapidly ( α > 30 %). This indicates that when α ≤ 30 %, fuels with excellent hypergolic ignition characteristics can be obtained, whose raw materials costs may be up to ∼25 % lower than pure [EMIm][DCA]. Finally, a hypothesized pre-ignition pathway of [EMIm][DCA]/NM was proposed based on the experimental data and physical characteristics of the system.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiangyu Han,Jiaqi Wang,Yongguang Liu,Lei Dai,Ling Wang,Shan Liu
All-solid-state sodium-ion batteries (ASSIBs) with inorganic solid electrolytes can achieve high safety and high energy density when paired with a high-voltage cathode. However, the slow charge transfer and chemical instability between the high-voltage cathode and rigid electrolyte seriously restrict its development. Herein, a high energy density Na4MnCr(PO4)3-based ASSIBs have been achieved by using a simple low-temperature brazing strategy. The in situ generated secondary phase can not only achieve close contact and rapid charge transfer between the Na4MnCr(PO4)3 cathode and electrolyte but also change the interface electric field distribution and reduce interface side reactions effectively. This strategy is simple and easy to implement and has important guidance for the development of other high-energy all-solid-state batteries.
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BIOMATERIALS
·
2025
·
IF 12.9
Nana Meng,Jiasheng Lu,Jianfen Zhou,Shengmin Yang,Chen Zhang,Ruiyi Jia,Yuan Ding,Yanning Bao,Jun Wang,Xiaopei Ma,Ruohan Chen,Zhixuan Jiang,Cao Xie,Linwei Lu,Weiyue Lu
One of the challenges for the clinical translation of active targeting nanomedicines is the adverse interactions between targeting ligands and blood components. Herein, a novel regularity, which reveals the interactions between cyclic RGD (Arg-Gly-Asp) peptide-modified liposomes and complement components in blood, is reported. As the nucleophilicity of arginine guanidine group within the cyclic RGD-like peptide increases, targeting liposomes potentiate complement cascade via the amplification loop of complement 3 (C3), ultimately leading to accelerated blood clearance, increased deposition in the reticuloendothelial system (RES) organs, enhanced immune responses, and potential side effects. By appropriately reducing the nucleophilicity of guanidine group, cyclic R2 peptide is designed for modification of liposomes to target integrin α v β 3 . Compared to the widely used targeting molecule c(RGDyK), R2 eliminates the negative effects of C3 opsonization and specific antibody production, significantly improves the in vivo immunocompatibility of targeting liposomes, and demonstrates superior anti-tumor efficacy in mouse models of orthotopic breast cancer and glioma. Thus, the proposed regularity of interactions between guanidine nucleophilicity and C3, along with the successful application of the low complement activation capacity targeting ligand R2, provides new insights for addressing challenges related to complement activation in the clinical translation of active targeting nanomedicines.
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DYES AND PIGMENTS
·
2021
·
IF 4.889
Pengyue Sun,Diya Yang,Jing Li,Yaodong Zhang
In this work, 4-formyl-3-hydroxybenzoic acid (FHBA), which does not contain a large conjugated ring structure, exhibited aggregation-induced emission (AIE) in aqueous solvents. On this basis, FHBA and a metal-organic framework material (i.e., ZIF-8) form into a complex (FHBA@ZIF-8), which presents the AIE characteristics of FHBA. Then, lanthanide metal (i.e., Eu 3+ ) coordinates with guanosine 5′-monophosphate disodium (GMP) salt to synthesize a coordination polymer (LnCP), which combines with FHBA@ZIF-8 do afford a novel double-emitting fluorescence probe (FHBA@ZIF-8@Eu-GMP, FZE) for tetracycline antibiotics (TCAs). TCAs coordinate with Eu 3+ and act as antenna ligand. Thus, an “antenna effect” comes into being and effectively enhances the emission intensity of Eu 3+ at 616 nm. Moreover, the UV–vis spectra of TCAs largely overlap with the excitation spectrum of FHBA, resulting in an inner filter effect (IFE) and quenching of blue-green fluorescence from FHBA molecules at 473 nm. The ratio of fluorescence signal (F 616 /F 473 ) showed a good linear relationship with the concentration of tetracycline hydrochloride (TC) in the range of 0.1–200.0 μM, and the detection limit was 60 nM (S/N = 3). This fluorescence probe can also effectively respond to oxytetracycline hydrochloride (OTC) and chlortetracycline hydrochloride (CTC). The probe was applied to determine TC in milk, and the recoveries ranged from 94.0% to 101.4%, indicating the application potential of this method. This study provides a novel idea for the construction of ratiometric fluorescence sensing platforms and shows the application potential of the AIE effect of FHBA.
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Crystals
·
2022
·Vol. 12
·期 2
·266
·
IF 2.67
Runqing Liu,Hongping Wu,Hongwei Yu,Zhanggui Hu,Jiyang Wang,Yicheng Wu
A new noncentrosymmetric cadmium indium borate, Cd4InO(BO3)3(CIBO) has been successfully developed via a standard solid-state reaction. Its crystal structure was confirmed by the single crystal X-ray diffraction, which shows that CIBO belongs to the non-centrosymmetric and polar space groupCm. Its structure contains the distorted InO6and CdOn(n = 6, 8) polyhedra, which link together by sharing an edge or corner to build a three dimensions framework with BO3triangles accommodated in tunnels. Benefiting from the approximately parallel configuration of BO3triangles, CIBO exhibited a strong second harmonic generation (SHG) effect (3 × KDP), and moderate birefringence of 0.077@1064 nm. Further optical and thermal characterizations suggest that CIBO possesses a wide transparent window and good thermal stability. Theoretical calculation reveals that the macroscopic SHG coefficients of CIBO results from the synergistic effect of the parallel arrangement of BO3groups andd10Cd2+cation.
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CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Yajuan Zhang,Airong Xu,Benlian Lu,Zhiyong Li,Jianji Wang
The development of highly efficient cellulose solvents is imperative to the effective utilization of cellulose. In this work, ionic liquids (ILs) with the same 1-allyl-3-methylimidazolium cation ([Amim] + ) but different carboxylate anions, such as formate ([HCOO] − ), acetate ([CH 3 COO] − ), propionate ([CH 3 CH 2 COO] − ), butyrate ([CH 3 CH 2 CH 2 COO] − ), glycollate ([HOCH2COO] − ), lactate ([CH 3 CHOHCOO] − ) and benzoate ([C 6 H 5 COO] − ) were synthesized, and their thermal properties and viscosities were determined. Then these ILs were used to investigate the effect of anion structure on solubility of cellulose in the ILs. It was shown that the viscosity and cellulose solubility depended strongly on the anion structure of the ILs. For example, at 30 °C solubility of cellulose in [Amim][CH 3 CH 2 COO] was as high as 19.0%, whereas cellulose was not soluble in [Amim][HOCH 2 COO], [Amim][CH 3 CHOHCOO] and [Amim][C 6 H 5 COO]. In addition, solvatochromic UV/vis probe and 13 C NMR measurements were performed to demonstrate dissolution mechanism of cellulose in the ILs. The results suggested that although cations of the ILs have un-negligible contribution to the highly efficient dissolution of cellulose, hydrogen bonding interactions of anions of the ILs with cellulose is predominant.
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Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 43
·15312-15321
·
IF 6.4
Rui Rui Yang,Fangrui Cheng,Bang Lan
Trivalent rare earth Eu3+-doped luminescent materials have been used successfully for illumination and displays due to their narrow emission lines and extreme stability. Extending the excitation band to the UV, near UV and blue region via doping lanthanide ions as a sensitizer is highly desired for white LED application. However, the complex redox reaction and forward/backward energy-transfer pathway between the sensitizer ion and Eu3+ ion in the same lattice of the phosphor host limits the potential of this strategy. Herein, we present the luminescence properties of hierarchical porous composite materials with the formula Tb(C12H8N2)2(NO3)3@Ca0.9Eu0.1MoO4 and report how interfacial energy-transfer enhanced the absorption range of the Eu3+-doped material in the UV region. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images illustrated that the obtained Ca0.9Eu0.1MoO4 had a hierarchical porous structure, and the Tb(C12H8N2)2(NO3)3 was evenly filled inside the holes or the surface. The photoluminescence and decay data indicated the existence of interfacial forward energy transfer from Tb3+ → Eu3+. Furthermore, the thermal stability of the composited Tb(C12H8N2)2(NO3)3 was improved, indicating the potential of the composite materials for application in UV light-emitting diodes.
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