SOLID STATE IONICS
·
2024
·
IF 3
Shengping Deng,Chongran Song,Shiyu Li,Ying Bai
NASICON-type Na 4 MnCr(PO 4 ) 3 (NMCP) has gained significant attention due to its prominent capacity and voltage platform. However, poor intrinsic electron conductivity severely obstructed its wider application. Here, the NMCP was decorated through structurally integrated with the high conductive carbon nanotubes (CNTs) component via the sol-gel method. The CNTs additive was tightly implanted NMCP bulk, providing fast electron transfer rates, further reduced charge transfer resistance and ohmic resistance , and improving the electrochemical properties of NMCP during the reversible intercalation/deintercalation of Na + . Finally, the as-prepared rambutan-like NMCP/C@CNTs could release a high reversible capability of 118.7 mAh g −1 at 0.1C and exhibit long durability over 500 cycles at a high rate of 10C. The pseudocapacitance contributions were investigated, and the Na storage mechanism was also demonstrated through in-situ synchrotron X-ray diffraction. The assembled NMCP/C@CNTs//HC full cell could deliver a high energy density of 364.4 Wh kg −1 . The encouraging electrochemical performance of the full cell will promote the development of sodium ion secondary batteries for large-scale applications in the future.
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高影响因子
CARBOHYDRATE RESEARCH
·
2022
·
IF 2.975
Hongjun Zang,Yimo Feng,Mingchuan Zhang,Kai Wang,Yannan Du,Yaxin Lv,Zixian Qin,Yunfei Xiao
3-Acetamido-5-acetylfuran(3A5AF) is a nitrogen-containing fine chemical and has broad application prospects and high research value. Herein, we report a mild and efficient method for the synthesis of 3A5AF from N-acetyl- d -glucosamine (NAG). The influence of solvent, temperature and additive on the catalytic performance was also studied. The Lewis acids with high catalytic efficiency have been smoothly screened. The highest yield (41.57%) of 3A5AF was obtained in the presence of B 2 O 3 and MgCl 2 ·6H 2 O at 180 °C for 60 min under normal atmospheric conditions. The reaction pathway was explored by LC-MS, 1 H NMR, 13 C NMR and FT-IR spectra. Compared with the microwave method and hydrothermal method , the optimized reaction condition was relatively mild. Moreover, the catalyst MgCl 2 ·6H 2 O is low-cost and environmentally friendly.
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JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Qi Chen,Fang Lei,Ying Shi,Luqiao Yin,Xiaoxiao Ji,Jianjun Xie,Lei Zhang,Lingcong Fan
The all-inorganic perovskite CsPbI 3 quantum dots are difficult to achieve pure red stable luminescence due to their poor lattice thermodynamic stability and non-radiative recombination loss caused by surface halide vacancies. Therefore, the pure red perovskites are usually achieved by mixing the composition of halides (Br and I). In this work, CsPb(Br/I) 3 quantum dots (QDs) were synthesized by the hot-injection method under the synergistic effect of homophthalic acid (HA), 2-bromoethanesulphonic acid sodium salt (SBES), and oleylamine (OAm). By adjusting the molar ratio of passivates, the synergistic effect of multiple ligands can not only passivate the unliganded Pb 2+ -related defects on the surface of NCs, but also increase the formation energy of halide vacancies. Meanwhile, due to the bidentate structure of HA, smaller size of perovskites nanocrystals were obtained. Eventually, synergistic boost in device performance is achieved for color-by-blue white light-emitting diodes (WLEDs) with CIE coordinates of (0.3319, 0.3297) and have an external quantum efficiency (EQE) of 10.13%. This strategy paves an efficient way for improving the efficiency and stability of CsPb(Br/I) 3 NCs.
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高影响因子
Foods
·
2024
·Vol. 13
·期 12
·1878
·
IF 4.7
Yushi Wei,Dan Zhang,Junhui Pan,Deming Gong,Guowen Zhang
Indole-3-propionic acid (IPA) is a plant growth regulator with good specificity and long action. IPA may be harmful to human health because of its accumulation in vegetables and fruits. Therefore, in this study, the properties of the interaction between calf thymus DNA (ctDNA) and IPA were systematically explored using multispectroscopic and computational modeling approaches. Analysis of fluorescence spectra showed that IPA binding to ctDNA to spontaneously form a complex was mainly driven by hydrogen bonds and hydrophobic interaction. DNA melting analysis, viscosity analysis, DNA cleavage study, and circular dichroism measurement revealed the groove binding of IPA to ctDNA and showed that the binding did not significantly change ctDNA confirmation. Furthermore, molecular docking found that IPA attached in the A-T rich minor groove region of the DNA. Molecular dynamics simulation showed that DNA and IPA formed a stable complex and IPA caused slight fluctuations for the residues at the binding site. Gel electrophoresis experiments showed that IPA did not significantly disrupt the DNA structure. These findings may provide useful information on the potential toxicological effects and environmental risk assessments of IPA residue in food at the molecular level.
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PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Wei Ge,Linxuan Zhang,Fanli Meng,Chengming Tian
Poplar anthracnose caused by Colletotrichum gloeosporioides is one of the major forest diseases worldwide, causing incalculable losses in forestry production every year. In this study, an endophytic bacterium with significant antagonistic activity against C. gloeosporioides was isolated from Populus canadensis leaves, identified and named Pseudomonas atacamensis GZ-3. The specific biological functions of strain GZ-3 were analyzed using whole genome sequencing. The volatile organic compounds (VOCs) produced by strain GZ-3 had good antifungal activity against C. gloeosporioides . These VOCs could effectively inhibit mycelial growth and conidial germination of C. gloeosporioides . In addition, metabolomics analysis revealed that VOCs could help poplar resist infection of C. gloeosporioides by inducing the synthesis of flavonoids in poplar. 3-methyl-1-butanol and 2-heptanone were the main antifungal compounds in VOCs. Therefore, Pseudomonas atacamensis GZ-3 had good potential for biocontrol. This study provided a new strategy for the biological control of poplar anthracnose.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Junyan Zhang,Jiaqi Shen,Haomin Chu,Yingchun Xie,Zhenzhen Jiang,Daolin Gao,Tianlong Deng,Xiaoping Yu
With the rapid development of the new energy industry, the recovery or extraction of lithium from different resources is currently a global research hotspot. In this work, Li 3 V 2 (PO 4 ) 3 was used as the active component for electrochemical extraction of lithium from aqueous solutions. The results showed that although Li 3 V 2 (PO 4 ) 3 exhibited the reversible de-intercalation/intercalation of Li + , it suffered from severe irreversible dissolution loss in aqueous solutions. This problem was successfully solved by titanium doping. The experiments and DFT calculations showed that when the V(2)-site vanadium in Li 3 V 2 (PO 4 ) 3 was replaced by titanium, the resulting material exhibited superhigh cycle stability and lithium extraction rate. After ten cycles of de-intercalation/intercalation, the extraction capacity still reached 11.5 mg·g −1 , and the attenuation was within the error range. Particularly, because of the decrease of the band gap after doping, the electronic conductivity of the material was significantly improved, and the equilibrium time for lithium extraction was within only 5 min, which was more than 10 times faster than that of the conventional LiFePO 4 and Li 2 MnO 4 materials. This work provides a new solution for the green, efficient, and highly stable extraction of lithium from liquid lithium resources.
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产品关联
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高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Nana Meng,Jiasheng Lu,Jianfen Zhou,Shengmin Yang,Chen Zhang,Ruiyi Jia,Yuan Ding,Yanning Bao,Jun Wang,Xiaopei Ma,Ruohan Chen,Zhixuan Jiang,Cao Xie,Linwei Lu,Weiyue Lu
One of the challenges for the clinical translation of active targeting nanomedicines is the adverse interactions between targeting ligands and blood components. Herein, a novel regularity, which reveals the interactions between cyclic RGD (Arg-Gly-Asp) peptide-modified liposomes and complement components in blood, is reported. As the nucleophilicity of arginine guanidine group within the cyclic RGD-like peptide increases, targeting liposomes potentiate complement cascade via the amplification loop of complement 3 (C3), ultimately leading to accelerated blood clearance, increased deposition in the reticuloendothelial system (RES) organs, enhanced immune responses, and potential side effects. By appropriately reducing the nucleophilicity of guanidine group, cyclic R2 peptide is designed for modification of liposomes to target integrin α v β 3 . Compared to the widely used targeting molecule c(RGDyK), R2 eliminates the negative effects of C3 opsonization and specific antibody production, significantly improves the in vivo immunocompatibility of targeting liposomes, and demonstrates superior anti-tumor efficacy in mouse models of orthotopic breast cancer and glioma. Thus, the proposed regularity of interactions between guanidine nucleophilicity and C3, along with the successful application of the low complement activation capacity targeting ligand R2, provides new insights for addressing challenges related to complement activation in the clinical translation of active targeting nanomedicines.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 4
·047501
·
IF 3.3
Yaping Zhang,Gao Si,Yilong Wang,Zhendong Wang,Zutian Li,Haiyan Wei,Huaixia Yang,Fuchun Si,Xiaofei Li
The sensitive detection of down-regulator of transcription 1 (DR1) provides important information for early noninvasive diagnosis and treatment of Hashimoto thyroiditis (HT). In this study, a label-free electrochemical biosensor for DR1 detection was constructed based on electrodeposited gold nanoparticles (AuNPs) and poly(lactic-co-glycolic acid) (PLGA). The AuNPs were first modified to the electrode surface by electrodeposition to increase the specific surface area of the electrode, thus loading more target molecules to increase the sensitivity of the sensor. Then, a sandwich structure was formed on the electrode surface based on the specific recognition of antigen and antibody. PLGA was fixed on the electrode surface by binding with antibody 2 (Ab2) through amide bond to further improve the sensitivity of the sensor. Induced by the dual signal amplification, the sensor has a linear detection range of 50 fg·ml−1 to 50 ng·ml−1, with a detection limit as low as 19.4 fg·ml−1. Moreover, the sensor has good selectivity, specificity, and anti-interference capability, which holds great potential for the early diagnosis of HT and analysis of other disease markers.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiangyu Han,Jiaqi Wang,Yongguang Liu,Lei Dai,Ling Wang,Shan Liu
All-solid-state sodium-ion batteries (ASSIBs) with inorganic solid electrolytes can achieve high safety and high energy density when paired with a high-voltage cathode. However, the slow charge transfer and chemical instability between the high-voltage cathode and rigid electrolyte seriously restrict its development. Herein, a high energy density Na4MnCr(PO4)3-based ASSIBs have been achieved by using a simple low-temperature brazing strategy. The in situ generated secondary phase can not only achieve close contact and rapid charge transfer between the Na4MnCr(PO4)3 cathode and electrolyte but also change the interface electric field distribution and reduce interface side reactions effectively. This strategy is simple and easy to implement and has important guidance for the development of other high-energy all-solid-state batteries.
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DOI
PubMed
高影响因子
Materials Express
·
2023
·Vol. 13
·期 8
·1339-1345
·
IF 0.7
Liao Wanrong,Fang Wang,Xu Juan
Lung cancer is a common malignancy of the respiratory system with a high morbidity and mortality. We intended to identify the apoptosis-promoting role of tripterine in lung cancer. Lung cancer SPC-A-1 cells were exposed to low, moderate, and high dosage of tripterine (2, 5 and 10 μmol/L)
with the model group not being intervened. After treatment, the role of tripterine in SPC-A-1 cell apoptosis was observed. In addition, lung cancer cells were transfected with TNF-α mimic (pc-TNF-α group) and TNF-α inhibitor (si-TNF-α group).
Tripterine +pc-TNF-α group was set up to determine the interaction between tripterine and TNF-α. The cell survival rate, TNF-α and Caspase-3 expression levels then were detected by MTT and flow cytometry. Tripteryglide treatment dose-dependently decreased
lung cancer cell viability and induced cell apoptosis, resulting in an increase of TNF-α expression. However, when TNF-α expression was inhibited upon transfection, SPC-A-1 cell apoptosis was suppressed. TNF-α mimics activated apoptosis and up-regulated
Caspase-3 expression. Combination of tripteryglide and TNF-α mimics more significantly elevated apoptotic rate of lung cancer cells when elevating the content of Caspase-3. SPC-A-1 cells are highly sensitive to TNF-α and TNF-α significantly increases
the activity and expression of Caspase-3. Tripteryglide can up-regulate TNF-α expression to facilitate lung cancer cell apoptosis and increase Caspase-3 expression.
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Biomolecules
·
2023
·Vol. 13
·期 10
·1464
·
IF 5.5
Xiaoyan Yuan,Junting Yang,Yuling Huang,Jia Li,Yuanyuan Li
There has been a growing interest in studying the communication of gut microbial metabolites between the gut and the liver as liver fibrosis progresses. Although 3-Indolepropionic acid (IPA) is regarded as a clinically valuable gut metabolite for the treatment of certain chronic diseases, the effects of oral administration of IPA on hepatic fibrosis in different animal models have been conflicting. While some mechanisms have been proposed to explain these contradictory effects, the direct impact of IPA on hepatic fibrosis remains unclear. In this study, we found that IPA could directly activate LX-2 human hepatic stellate cells in vitro. IPA upregulated the expression of fibrogenic marker genes and promoted the features associated with HSCs activation, including proliferation and contractility. IPA also increased reactive oxygen species (ROS) in mitochondria and the expression of inflammation-related genes in LX-2 cells. However, when a ROS-blocking agent was used, these effects were reduced. p38 and JNK, the downstream signaling cascades of ROS, were found to be required for the activation of LX-2 induced by IPA. These findings suggest that IPA can directly activate hepatic stellate cells through ROS-induced JNK and p38 signaling pathways.Keywords:gut–liver axis;3-Indolepropionic acid;HSCs;liver fibrosis
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 4.384
Wenyan Li,Zheng Jiao,Yanhui Liu,Jiacheng Yao,Guodong Li,Jing Dong
Biapenem is a carbapenem antibiotic. It is excreted predominantly through the kidney as unchanged forms. However, the molecular mechanism of renal excretion of biapenem and potential drug-drug interactions (DDIs) were still unknown. In the present study, the role of organic anion transporters (OAT) 1/3 and organic cation transporters (OCT) 2 in the renal excretion of biapenem, and the potential DDIs between biapenem and six clinical commonly prescribed antibiotics and antiviral drugs that acted as substrates or inhibitors of OAT3 were evaluated in vitro . Further, the effect of probenecid on the pharmacokinetics of biapenem was explored in the rats. We observed that biapenem could not inhibit the transport activities of OAT1 or OCT2, while mildly inhibited OAT3 (IC 50 >500 μM). Among the tested antibiotics and antiviral drugs, the relatively high DDI index values (maximal unbound plasma concentration over IC 50 , I max,u /IC 50 ) were found for piperacillin, linezolid and benzylpenicillin, which were 2.84, 1.7 and 0.62, respectively. Although probenecid had the highest DDI index (27.1) in vitro , no significant impact of it on the pharmacokinetics of biapenem was observed in the rats. Our results indicated that biapenem was primarily eliminated by the glomerular filtration, while OAT3-mediated renal tubular secretion was a minor route. Biapenem is not a clinically relevant substrate or inhibitor because of its low affinity to OAT3. According to current results, it would be safe to use biapenem with other antibiotics and antiviral drugs that acted as substrates or inhibitors of OAT3.
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PubMed
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