INORGANIC CHEMISTRY COMMUNICATIONS
·
2026
·
IF 5.9
Xiaofei Guo,Zhongyao Guo,Chen Wang,Candong Liu,Honghui Cheng,Kuikui Wang
The highly active and stable oxygen reduction reaction (ORR) process is essential for driving the development of zinc-air batteries (ZABs). Therefore, by integrating the precise regulation of precursors, the tannic acid (TA) etching and nitrogen coordination strategy, a nitrogen-rich hierarchical porous Fe-N-C catalyst was successfully constructed. The uniform dispersion of particles was achieved by controlling the formation of the Fe-ZIF-8 precursor. Subsequent TA etching formed a rich mesoporous/microporous structure to improve active-site exposure. During the high-temperature pyrolysis process with melamine as the nitrogen source, a highly dispersed Fe-N X coordination structure was formed. Based on this rational design, the obtained catalyst presents a hierarchical porous structure, high nitrogen content and superior ORR activity, with a half-wave potential of 0.91 V in 0.1 M KOH solution. When applied to liquid and flexible ZABs, the catalyst delivers peak power densities of 186 mW cm −2 and 75 mW cm −2 , respectively, and cycling stability of over 1486 h is maintained in the liquid system-surpassing the performance of commercial Pt/C + RuO 2 . This research offers a fresh perspective on the design and synthesis of efficient ND-FeNC-TA catalysts and promotes the practical application of ZABs.
✓ 已验证
产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2026
·
IF 5.2
Shihao Zhang,Feng Liu,Lei Ding,Jingjing Qi,Yuzheng Wang,Yuhan Wu,Laishi Li,Xudong Sun,Yusheng Wu
The persistent contamination of aquatic systems by tetracycline antibiotics necessitates the development of efficient and sustainable adsorbents. Herein, a one-step deep eutectic solvent (DES) strategy is developed for the synthesis of carbon/oxygen co-doped hexagonal boron nitride (BCNO) nanosheets, using a ternary DES (H 3 BO 3 /urea/guanidine hydrochloride) as an all-in-one precursor and self-templating medium. The resulting BCNO material exhibits an ultrahigh tetracycline adsorption capacity of 428.5 mg g −1 . In situ pyrolysis analysis combined with theoretical simulations reveals that the DES-guided process facilitates synergistic heteroatom doping and the formation of a hierarchically porous structure enriched with Lewis acid-base sites. The adsorption process follows a multilayer chemisorption mechanism, driven by the concerted contribution of π-π stacking, hydrogen bonding, and Lewis acid-base coordination. The material exhibits excellent regenerability, retaining >85% of its original adsorption efficiency after five consecutive cycles. This work not only presents a scalable and eco-friendly route to functional BN nanomaterials but also provides fundamental insights into the molecular-level design of high-performance adsorbents for environmental remediation.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Xiaojing Liu,Fozia Sultana,Ting Xiao,Qiurong Wang,Meijie Shi,Xiaoqing Yan,Tongtong Li,Renhong Li
High-entropy alloy (HEA) catalysts derived from metal-organic frameworks (MOFs) pave the way for efficient electrochemical energy conversion. Herein, we report the synthesis of C@FeCoNiMnMo/NF, C@FeCoNi/NF and C@FeCoNiMn/NF catalysts via a one-step hydrothermal process coupled with subsequent calcination. Structural and morphological characterizations (XRD, XPS, SEM, and TEM) verifies the successful formation of a carbonized MOF-derived high-entropy alloy with uniform metal dispersion. Among these catalysts, C@FeCoNiMnMo/NF exhibits superior urea oxidation reaction (UOR) activity, achieving E 10 = 1.24 V and E 100 = 1.32 V (corresponding to 10 and 100 mA·cm −2 , respectively), with excellent durability over 30 h of continuous operation. The enhanced adsorption of key intermediates induced by Mo doping, as evidenced by both electrochemical analysis and DFT calculations, is identified as the primary factor responsible for the accelerated UOR kinetics. This work establishes an innovative approach for the rational design of MOF-derived HEA catalysts, which boosts the efficiency of urea-assisted hydrogen production from water.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Shuting Han,Jiaru Wang,Jiao Xue,Junjie Miao,Xingyu Liu,Shuhui Yin,Qian Wang,Jing Jin
Chemoresistance is a significant factor in the failure of cancer treatment. Although some chemotherapeutic combination regimens are linked to DNA damage repair processes, the therapeutic potential of TCM-derived small molecules that target these mechanisms is still underexplored. Alloimperatorin (Alloi) has demonstrated the ability to inhibit tumor growth; however, the efficacy and molecular mechanisms of its combination with chemotherapeutic agents are not yet fully understood. Here, we demonstrate that Alloi sensitizes multiple tumor cell lines to gemcitabine (GEM) both in vitro and in vivo. Using functional assays, we confirmed a potent synergistic inhibitory effect of the Alloi-GEM combination, which markedly suppressed pancreatic cancer progression in vivo with minimal adverse effects. By integrating transcriptome sequencing with network pharmacology, we identified downregulation of c-MYC and Nijmegen Breakage Syndrome 1 gene (NBS1) as a key mechanistic event, a finding subsequently validated through multiple assays. Mechanistically, the Alloi-GEM regimen induces sustained DNA damage via disruption of the c-MYC-NBS1 axis, thereby impairing the DNA damage response pathway. Collectively, our findings establish that Alloi enhances tumor sensitivity to GEM through modulation of the c-MYC/NBS1 axis and identify this combinatorial strategy as a promising approach for cancer treatment. Alloi enhances the antitumor effect of GEM by suppressing the c-MYC/NBS1 axis. Downregulation of c-MYC reduces NBS1 expression and impairs MRN complex-mediated DNA damage response signaling, including ATM/CHK2 activation and DNA repair. As a result, GEM-induced DNA damage is sustained, ultimately promoting tumor cell death. Download: Download high-res image (238KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yu Zou,Xu Zhang,Chen Yue Lin,Shu Jun Zhen,Lei Zhan,Cheng Zhi Huang
Home-Förster resonance energy transfer (Homo-FRET) has been widely utilized in artificial light-harvesting systems to construct antenna structures with enhanced energy-capture efficiency. Although these systems typically exhibit remarkable antenna effects and signal amplification capabilities, their application in detection systems remains limited. Herein, we reported a rationally designed homo-FRET mediated three-donor/one-acceptor (3D-A) antenna nanostructure assembled on a rigid DNA tetrahedron scaffold for the quantitative detection of Hepatitis C virus (HCV) DNA. Robust homo-FRET interactions among the three donors significantly amplified the hetero-FRET efficiency to the single acceptor, generating an enhanced antenna effect. Upon target recognition, the system provided a ratiometric readout, where the fluorescence intensity ratio between Cy5 and Cy3 increased proportionally with HCV DNA concentration. The proposed 3D-A nanoprobe exhibited a linear response range from 1 to 100 nM with a detection limit of 65 pM. Furthermore, by simply altering the target-binding sequence, this system offered a high versatile platform for universal DNA detection detection.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Tiancong Hao,Yuhang Liu,Peili Zhang,Yuhang Xiang,Xiaoning Yang,Qingya Sun,Aming Xie
Magnetic-dielectric synergy is critical to the electromagnetic wave absorption (EWA) performance of carbon/metal absorbers and is closely related to their nanoscale structure. In this work, aromatic dianhydrides with different conjugation lengths (PMDA, NTDA, and PTCDA) were used for ligand engineering of phthalocyanine-derived Ni/C nanocomposites, yielding Ni/C-PMDA, Ni/C-NTDA, and Ni/C-PTCDA. The resulting nanostructural variation regulated carbon ordering, Ni dispersion, and interfacial coupling at the Ni/C heterointerface, thereby redistributing dielectric and magnetic loss behavior. As a result, Ni/C-PMDA shows deep absorption with a reflection loss of −53.30 dB at 2.99 mm, while Ni/C-NTDA achieves a wide effective absorption bandwidth of 6.00 GHz at a thin thickness of 1.92 mm. Moreover, far-field radar cross section simulations on a Ni/C nanocomposite-coated perfect electric conductor (PEC) plate show reduced scattering compared with bare PEC. This work offers a ligand engineering strategy for designing Ni/C nanocomposites with optimized magnetic–dielectric synergy for electromagnetic wave absorption.
✓ 已验证
产品关联
DOI
高影响因子
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2026
·
IF 3.5
Liwei Jia,Yu Zhong,Baoyue Xu,Qianqian Liu,Xin Meng
Orientin inhibited xanthine oxidase with moderate in vitro potency. • Global kinetic fitting supported a mixed-type inhibition mechanism. • Fluorescence quenching verified direct XO–orientin interaction. • Molecular simulations indicated a stable XO–orientin binding mode. • C-glycosylation altered ADMET-related properties versus luteolin. Xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine. It further oxidizes xanthine to uric acid, making it an important target for treating hyperuricemia. This study focused on orientin as a model flavonoid for xanthine oxidase inhibition. We examined whether the C-glycosyl group changes its inhibitory potency, binding pattern, and predicted ADMET profile. In vitro enzyme activity was determined to be 364.79 ± 8.21 μM for the half-inhibitory concentration (IC 50 ) of orientin. Kinetic analysis suggested a mixed-type inhibition pattern. Intrinsic fluorescence quenching further supported the interaction between orientin and XO. Molecular docking and molecular dynamics simulations provided structural insight into the binding mode and stability of the orientin–XO complex. ADMET analysis indicates that orientin has promising pharmaceutical properties. These findings provide a basis for future research focusing on structural optimization, metabolic transformation, and in vivo evaluation. Download: Download high-res image (385KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Liang Zhou,Mingkang Zhang,Jingyi He,Hongbo Wang,Minjia Luo
• Co/TiO 2 @C composites are derived from bimetallic MOF. • • Minimum reflection loss of −64.5 dB at 1.8 mm thickness is achieved. • • Effective absorption bandwidth of 3.2 GHz in X-band. • • Hierarchical structure boosts interfacial and dipole polarization. In this study, disk-shaped MIL-125(Ti,Co)- x precursors were synthesized via a solvothermal method with varying CoCl 2 ·6H 2 O content, and subsequently Co/TiO 2 @C composites were fabricated through a two-step pyrolysis process. The precursor morphology transforms from intact micron-scale disks into thinner flakes, and ultimately into fragmented structures with increasing the cobalt content. The pyrolysis temperature concurrently governed the composition of TiO 2 phase, the degree of carbon graphitization, and the distribution of nanoparticles. The optimized Co/TiO 2 @C(700)-2 composite achieves a minimum reflection loss of −64.5 dB at a matching thickness of 1.8 mm, and exhibits an effective absorption bandwidth of 3.2 GHz at 2.1 mm. The outstanding electromagnetic wave absorption properties stem from a favorable synergy between adequate attenuation and satisfactory impedance matching, supported by the conductive carbon network, abundant defect sites, multiple TiO 2 /carbon heterointerfaces, and hierarchical porous architecture. These results establish the cooperative regulation of electromagnetic wave absorption properties by cobalt content and pyrolysis temperature, offering a strategy for the design of MOF-derived lightweight absorbers with tunable electromagnetic wave absorption. Download: Download high-res image (139KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Ying Li,Fangyuan Qiu,Wanyou Huang,Xuesong Tian,Limei Wang,Ruixia Chu,Hang Li,Yibo Gao
Developing low-cost, high-performing non-noble-metal catalysts for the oxygen reduction reaction (ORR) to replace Pt-based catalysts for practical metal-air batteries remains an enormous challenge. Herein, Co 3 O 4 /α-MnO 2 /C composite catalysts with different mass ratios are synthesized, and a heterostructured Co 3 O 4 /α-MnO 2 /C catalyst is successfully constructed. Benefiting from the synergistic interaction between Co 3 O 4 and α-MnO 2 , together with the enhanced conductivity imparted by the carbon support, the catalyst exhibits outstanding electrocatalytic activity. Furthermore, derivative analysis of the LSV curves is employed to accurately determine the ORR onset potential and half-wave potential, providing a quantitative approach for evaluating the electrochemical activity of the Co 3 O 4 /α-MnO 2 /C catalyst. Furthermore, a Zn-air battery driven by the Co 3 O 4 /α-MnO 2 /C catalyst shows excellent electrochemical performance, delivering a high open-circuit voltage of 1.458 V and long-term cycling stability for 300 h. Notably, its overall performance is close to that of commercial Pt/C catalysts. This work highlights the considerable promise of non-noble-metal catalysts for renewable energy storage and conversion applications.
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2026
·
IF 6.7
Rongrong Mu,Xiaowen Tang,Xinyan Huang,Yajie Ma,Huiming Lin
Fe 2 N@C nanospheres integrate NO release, PTT, and CDT for DFU therapy. • NIR-II-triggered hyperpyrexia amplifies POD-like activity of Fe 2 N@C. • Inorganic Fe 2 N@C acts as a novel NO donor with high release capacity. • Acidic biofilm microenvironment facilitates NO release and CDT activity. • Dynamic therapy possesses great potential on infective DFU therapy. Diabetic foot ulcer (DFU) is one of the most severe complications of diabetes, and its multiple pathological factors render treatment more challenging. We synthesized Fe 2 N@C nanomaterials to integrate synergistic photothermal therapy/chemical dynamic therapy/nitric oxide (PTT/CDT/NO) for DFU therapy. First, Fe 2 O 3 and urea were used as precursors to synthesize Fe 2 N@C nanomaterials via nitridation. The nanomaterial can serve as a new NO donor that releases NO triggered by H + and reactive oxygen species (H 2 O 2 and O 2 ). Furthermore, Fe 2 N@C possess superhigh peroxidase (POD)-like activity (V max = 21.1 Ms. −1 , pH 5.5), catalyzing endogenous H 2 O 2 into hydroxyl radicals ( OH). POD activity can also amplify NO and peroxynitrite (ONOO − ) production. In addition, Fe₂N@C nanomaterials reveal high near-infrared II (NIR-II) light harvest and photothermal conversion efficiency (43.94%). Hyperthermia also synergistically boosts POD-like activity and NO release. Under NIR-II laser irradiation, the combination of PTT/CDT and high NO concentration of can quickly clear bacterial infection. In addition, NO can down-regulate the expression of heat shock proteins (HSPs) to amplify PTT performance. Then, the mild NO supply (without irradiation) further facilitates the reversal of inflammation (M2 macrophage polarization) and tissue regeneration (angiogenesis). This dynamic synergistic therapy promotes fast normal DFU healing. Download: Download high-res image (259KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Journal of the American Chemical Society
·
2026
·
IF 16.6
Mimi Wu,Junzhong Xie,Guangyou Huo,Xiaolin Yu,Xueqin Yang,Yi Xing,Wei Su,Yang Zheng,Yuechang Wei,Maofa Ge,Ding Ma
Precise engineering of the metal–support interaction (MSI) is paramount for manipulating the geometric and electronic structures of supported metal catalysts, yet tailoring the local anchoring microenvironment at the atomic level remains a challenge. This study demonstrates how modulating the hydroxyl chemistry on CeO2 can direct the MSI to stabilize distinct Pd species─from single atoms to subnanometric PdOx ensembles. We show that conventional terminal hydroxyl groups on CeO2 favor the anchoring of Pd single atoms, whereas engineered bridging hydroxyl nests effectively confine undercoordinated PdOx clusters. This PdOx ensemble results in a moderate 4d orbital occupancy of Pd sites, which optimizes the σ-electron-acceptance and back-donation processes critical for C–H bond activation. Consequently, the PdOx ensemble catalyst achieves a dramatic decrease in methane combustion temperatures (T50 and T90 values are 340 and 402 °C, lowered by 175 and 226 °C, respectively) compared to the single-atom counterpart, alongside exceptional stability and water resistance under practical conditions. This work establishes the engineering of the support’s hydroxyl microenvironment as a powerful strategy for designing highly efficient metal ensemble catalysts.
✓ 已验证
产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 13
·750
·
IF 3.5
Meng Chunhui,Li Yuena,He Qitong,Hao Yue,Yin Wenjun,Zhou Huang,Li Ping
Titanium dioxide (TiO 2 )-mediated photodynamic therapy has emerged as a promising antibacterial strategy. To further enhance the photocatalytic activity of TiO 2 , we have rationally designed cobalt-doped TiO 2 nanocomposites (C/Co/TiO 2-x ) via a sol–gel synthesis approach. The synthesized materials were systematically characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and UV–Vis diffuse reflectance spectroscopy (UV–Vis DRS). Structural analyses confirmed the presence of Ti, O, C, and Co elements, exhibiting a block-like morphology with a dominant anatase crystalline phase. Notably, the optimized material exhibits an extended visible-light absorption edge (762 nm) accompanied by a reduced band gap (1.63 eV), demonstrating significantly enhanced visible-light harvesting efficiency. Antibacterial evaluations revealed that the C/Co/TiO 2-x nanocomposite (5 mg/mL) achieved complete inactivation of Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) within 60 and 100 min, respectively, under visible-light irradiation (7 W LED). Radical trapping experiments identified photogenerated holes (h + ) and hydroxyl radicals (·OH) as the predominant reactive species responsible for bacterial inactivation. In vitro cytotoxicity assessment demonstrated excellent biocompatibility of the material. This study successfully illustrates the synthesis of C/Co/TiO 2-x nanocomposites, which exhibit promising potential for antibacterial applications.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）