APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Juwen Gu,Wanbing Gong,Yao Zhong,Yucui Liao,Minglei Sun,Jing He,Zhekang Peng,Xiaochun Li,Yuxiu Li,Bang Lan,Jun Ma,Tiejun Wang
Sulfur incorporation facilitates in situ oxygen-vacancy formation in TiO 2 . • S–O formation and S–V O coupling regulate the electronic structure of TiO 2 . • Oxygen vacancies promote furfural adsorption and activation. • Sulfur-mediated defect engineering enables selective furfural hydrogenation. • S 0.75 -TiO 2 achieves 44.0 mmol FA ·g cat. −1 ·h −1 with 99.5% FA selectivity. Photocatalytic transfer hydrogenation (PTH) of biomass-derived furfural (FF) to furfuryl alcohol (FA) using methanol as a green hydrogen donor represents a sustainable route for producing value-added chemicals, yet developing robust noble-metal-free catalysts remains challenging. Herein, we present a sulfur-doped TiO 2 photocatalyst exhibiting exceptional activity and selectivity for FF hydrogenation. The optimized catalyst delivers an impressive space-time FA yield of 44.0 mmol FA ·g cat. −1 ·h −1 with 99.5% selectivity under 500 mW·cm −2 irradiation, surpassing most state-of-the-art systems. Comprehensive characterizations and theoretical calculations reveal that lattice-substituted sulfur atoms form surface S–O species, driving oxygen vacancy formation and modulating the electronic structure of TiO 2 . The synergistic interaction between S species and V O sites regulates the electron density at active sites, thereby markedly promoting FF adsorption/activation, charge separation, and targeted hydrogenation. This work establishes a strategy for constructing high-efficiency, non-precious photocatalysts through sulfur-mediated oxygen-vacancy engineering. Download: Download high-res image (135KB) Download: Download full-size image
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ChemCatChem
·
2026
·Vol. 18
·期 19
·e00023
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IF 4.1
Zhijie Wang,Jinxuan Hao,Hongpeng Fan,Xiao Lin,Linjuan Zhang,Jian-Qiang Wang
Electrochemical oxidative dehydrogenation (ODH) of ethane in solid oxide electrolysis cells (SOECs) offers a promising alternative to energy-intensive steam cracking. This work investigates the ODH mechanism using an LSC (La 0.6 Sr 0.4 CoO 3-δ ) anode in a 5 cm*5 cm single cell, achieving high ethylene selectivity (∼44%) at 650°C. In contrast, operation at elevated temperatures (e.g., 700°C) leads to anode degradation and a shift in selectivity. Through a combination of electrochemical impedance spectroscopy with distribution of relaxation times (EIS-DRT) and detailed product analysis, we reveal a decisive shift in the dominant reaction pathway governed by the applied current density. At low current densities, the direct electrochemical oxidation of ethane by surface oxygen species prevails. As the current increases, the mechanism transitions to a tandem process where the oxygen evolution reaction occurs first, followed by the thermochemical ODH of ethane. This mechanistic crossover is rationalized by the competition between ethane diffusion to active sites and the rate of electrochemical oxygen supply. These findings provide fundamental insights into the interplay of electrochemical and thermochemical steps in high-temperature alkane electrolysis, highlighting current density as a key lever for controlling selectivity. Graphical Current density acts as a key lever for steering ethane ODH pathways in SOECs. Over an LSC anode, low currents favor direct electrochemical oxidation by surface oxygen species. Higher currents shift the mechanism to a tandem process, where OER-generated O 2 drives thermochemical ODH. Moreover, thinner LSC anodes boost ethane diffusion into the active region, favoring direct oxidation and higher ethylene selectivity.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Xu Guobin,Wang Junlong,Gu Na,Yang Tiansong
Pyroptosis is a pathogenenic mechanism of polycystic ovary syndrome (PCOS). N5-methylcytosine (m5C) methylation is a RNA modification that affects the progression of diseases. However, its role in PCOS remains not understood. This study aimed to investigate the role of NSUN7 in PCOS, particularly its impact on pyroptosis. KGN cells were treated with LPS to establish a cell model, and pyroptosis was evaluated using enzyme-linked immunosorbent assay, flow cytometry, and western blotting. The effect of NSUN7 on the m5C modification of NLRP3 was assessed using methylated RNA immunoprecipitation, dual-luciferase reporter assay, and actinomycin D treatment experiment. A PCOS rat model was generated, hormones were detected using ELISA, and pyroptosis was evaluated in the ovaries and primary granulosa cells. The results showed that NSUN7 expression was reduced in patients with PCOS and LPS-treated KGN cells. Silencing of NSUN7 inhibited LPS-induced cell pyroptosis. Moreover, NSUN7 knockdown inhibited m5C methylation of NLRP3 and reduced NLRP3 mRNA stability. Overexpression of NLRP3 reversed the pyroptosis inhibition induced by NSUN7 knockdown. Furthermore, interfering with NSUN7 alleviated hormone abnormalities and suppressed granulosa cell pyroptosis in PCOS rats. In conclusion, silencing of NSUN7 attenuates PCOS progression by inhibiting pyroptosis of granulosa cells by suppressing m5C methylation of NLRP3.
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Stem Cell Research & Therapy
·
2025
·Vol. 16
·期 1
·1-22
·
IF 7.3
Shi Zhan,Lu Xiaowen,Fei Haiyi,Liu Xiu,Xu Shiqian,Lin Yuhan,Fang Ling,Jiang Lingling,Zhang Songying
Background Unexplained recurrent spontaneous abortion (URSA) is a distressing pregnancy disorder with no effective medical intervention. As a potential treatment for URSA, human umbilical cord mesenchymal stem cells (hucMSCs) undergo apoptosis and release apoptotic bodies (ABs) shortly after transplantation. However, the medical effects and the exact doses of ABs in the therapy for URSA remain unclear. Methods Staurosporine (STS) and ultraviolet (UV) induced apoptosis in hucMSCs. Differential centrifugation, transmission electron microscopy, immunofluorescent staining, and flow cytometry were used to isolate and characterize hucMSC-derived ABs (hucMSC-ABs), respectively. Two mouse abortion models (LPS-induced and CBA/J×DBA/2 immune-mediated) mimicked URSA. Flow cytometry, real-time quantitative PCR, immunofluorescence staining, and western blotting were used to analyze macrophage polarization and inflammatory pathways. Untargeted metabolomic analysis was used to detect the metabolic composition of hucMSC-ABs. RNA sequencing analysis was used to detect the transcriptome of macrophages (Macs). Dorsomorphin was used to inhibit the AMPK signaling pathway. Small interfering RNA (siRNA) was used to knock down Gys1 in raw246.7 macrophages. Results STS- and UV- induced hucMSC-ABs effectively alleviated abortion in both models, depended on Macs. However, excessive dosage of hucMSC-ABs induced pro-inflammatory Macs (pro-inflam Macs), worsening fetal loss. Appropriate doses suppressed the NF-κB pathway in Macs, while high doses activated it. Neither RNase nor trypsin fully abolished hucMSC-ABs’ regulatory effects on macrophage polarization. Metabolomics identified linoleamide and palmitic acid (PA) as the dominant hucMSC-AB metabolites (~ 1:1 ratio). RNA-seq revealed hucMSC-ABs modulated Nfkb1 and Gys1 in Macs, linked to linoleamide. Appropriate doses of the 1:1 mixture of linoleamide and PA induced anti-inflam Macs, while high dosages of the mixture induced pro-inflam Macs. Linoleamide alone activated AMPK, suppressed NF-κB via Gys1, and protected pregnancy, whereas PA induced pro-inflam Macs and promoted abortion. Conclusion Appropriate doses of hucMSC-ABs induce anti-inflam Macs in the uterus and prevent fetal loss, while high doses promote the polarization of pro-inflam Macs and lead to fetal loss. The effects of hucMSC-ABs in regulating Macs and treating URSA are related to different doses of linoleamide and PA on Macs. Linoleamide activates AMPK and suppresses NF-κB via Gys1. This study revealed the effect and mechanism of hucMSC-ABs intervention in fetal loss and provided a new idea for the treatment of URSA. Graphical abstract
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Journal of Magnesium and Alloys
·
2025
·
IF 13.8
Shixuan He,Dongdong Li,Xingqing Duan,Jinting Chen,Bogu Liu,Yawei Li,Haixiang Huang,Haoyuan Zheng,XinHua Wang,Ying Wu
Catalysis is an effective means to improve the slow kinetics of hydrogen absorption and desorption, as well as the poor cycle life of the 2LiBH 4 +MgH 2 composite system. In this study, The TiVC MXene was obtained by etching TiVAlC and introduced into 2LiH + MgB 2 by ball milling. Products obtained were heated and hydrogenated to prepare the 2LiBH 4 + MgH 2 (LMBH) system, which exhibits distinguished kinetic performance and capacity retention rate. In the LMBH + 6 wt% TiVC, a 9.3 wt% hydrogen is released within 35 min at 400 °C as well as hydrogenation is completed within 30 min at 350 °C, 9 MPa. Moreover, the capacity retention rate was up to 96 % after the 15 th cycle. During the heating and hydrogenation process, the TiH and V 8 C 7 are generated in-situ as active products, and stably exist in the subsequent process to catalyze the hydrogen absorption-desorption reactions of the composite. The presence of TiH/LiH/V 8 C 7 /MgB 2 interface improves the kinetic performance of the system. Reversibility is improved by inhibiting the generation of polyborane and the aggregation during the hydrogen absorption-desorption process. The interface structure-activity relationship is first elucidated that between bimetallic MXene and 2LiBH 4 + MgH 2 composite system during hydrogen absorption-desorption processes, providing a novel viewpoint and optimization path for the modification research of 2LiBH 4 + MgH 2 composites.
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ACS Catalysis
·
2025
·
IF 13.1
Liping Ren,Kaini Zhang,Yu-Cheng Huang,Ying Rui Lu,Hao Deng,Yan Ding,Chunying Chen,Bo Huang,Weibo Hua,Lin Fu,Xiaohui Zhao,Shaohua Shen,Jinjia Wei,Jie Chen
Interatomic interactions play a crucial role in electrocatalysts for the efficient hydrogen evolution reaction (HER). However, understanding the effect of interatomic interactions in high-entropy alloys (HEAs) on HER is challenging due to their complex compositions. In this study, we meticulously designed a series of quinary and senary HEAs (PtPd- and PtPdRu-HEA) with tailored interatomic interactions. Notably, a specific hydrogen spillover pathway facilitated by atomic interactions in PtPd-HEA was unveiled. By means of the hydrogen spillover effect (HSE), a decent alkaline HER performance was achieved with PtPd-HEA, exhibiting an overpotential of only 12 mV at 10 mA cm–2, and a stability exceeding 200 h in 1 M KOH. Moreover, using PtPd-HEA as a cathode and NiFe-LDH as an anode, the as-fabricated anion exchange membrane water electrolyzer exhibited a high operational stability exceeding 100 h at 1 A cm–2. And, the detrimental role of Ru to weaken the desorption of *H on PtPdRu-HEA via decreasing the lattice distortion rate of the (111) plane was identified. Consequently, PtPdRu-HEA exhibited HER activity lower than that of PtPd-HEA.
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ACS Omega
·
2025
·
IF 4.3
Kanghua He,Yuqian Mao,Guowen Qian,Huan Yu
Poly(L-lactic-acid) (PLLA) has shown significant promise in the fields of orthopedics and dentistry. However, its lack of inherent osteogenic activity limits its potential for further application in bone repair and fixation. In this study, we synthesized strontium carbonate (SrCO3) nanoparticles and incorporated them into PLLA to prepare bioactive composite scaffolds using selective laser sintering technology. The synthesized SrCO3 particles exhibited a unique microrod morphology with spike-like structures. In vitro degradation experiments demonstrated that SrCO3 effectively neutralized acidic byproducts and promoted the degradation of PLLA in a dose-dependent manner. Furthermore, in vitro cell culture experiments revealed that composite scaffolds containing 1–2 wt % SrCO3 significantly enhanced the adhesion, proliferation, and osteogenic differentiation of mouse bone marrow mesenchymal stem cells compared to the PLLA scaffolds. This can be attributed to the sustained release of Sr ions from the composite scaffolds. Overall, our study elucidates the positive effects of incorporating SrCO3 into the PLLA matrix, highlighting its potential as an alternative to the currently used PLLA implants for promoting degradation and facilitating osteogenesis.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Peixin Zhang,Haoran Shen,Kangling Tang,Jinjiang Lv,Haoliang Huang,Yingju Liu
Seawater splitting has been considered an environmentally friendly and cost-effective method for hydrogen production. However, developing efficient electrocatalysts capable of enduring the severe corrosive conditions of natural seawater for extended durations remains a notable technical challenge. Herein, the Ni 3 S 2 -supported NiFe oxalate ((NiFe)C 2 O 4 /Ni 3 S 2 ) nanorod arrays were synthesised through hydrothermal and impregnation precipitation methods. Structural and spectroscopic analyses revealed that the (NiFe)C 2 O 4 /Ni 3 S 2 catalyst formed an integrated oxide-sulfide interface with coexisting Ni–O/Ni–S coordination. This dual coordination environment, coupled with the presence of Fe in a higher oxidation state, confirmed interfacial electronic reorganization characterized by directional electron transfer from Ni to Fe. The resulting charge transfer pathway enhanced the electron delocalisation between active centers, thereby improving active site utilisation. The obtained (NiFe)C 2 O 4 /Ni 3 S 2 demonstrated remarkable catalytic activity for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in a simulated alkaline seawater solution (NaCl + KOH), with overpotentials of 363 mV (HER) and 295 mV (OER) at a current density of 500 mA cm −2 for industrial electrolysis requirements and remarkable stability over 100 h of durability testing. Additionally, the (NiFe)C 2 O 4 /Ni 3 S 2 electrode pairs only required a cell voltage of 1.81 V to achieve 100 mA cm −2 with Faradaic efficiency of 98 % in 1.0 M KOH + seawater. This study presents a novel approach for fabricating multifunctional electrocatalysts, providing a promising pathway for advancing seawater electrolysis and supporting the development of cost-effective green hydrogen production technologies.
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ACS Catalysis
·
2026
·
IF 13.6
Shuangfeng Ren,Yihui Li,Ye Chen,Xiaoling Mou,Ziang Zhao,Hejun Zhu,Xiaoyan Liu,Yu Meng,Li Yan,Apoorva Ravi,Amol Amrute,Ronghe Lin,Yunjie Ding
The rational design of selective, earth-abundant Ni-based catalysts for the reverse water–gas shift (RWGS) reaction is often hampered by an incomplete understanding of their operando active states. This study reveals that the CO2 hydrogenation selectivity over Ni–Zn catalysts is governed by a support-dependent, reaction-induced dynamic restructuring, rather than by any static, preformed sites. Through a combination of in situ characterization and theoretical calculations, we demonstrate that the active Ni–Zn intermetallic core encapsulated by ZnO forms dynamically only under the RWGS atmosphere on ZrO2 and TiO2 supports, but not on Al2O3 or during mere H2 reduction. Crucially, we identify in situ-generated CO as the essential inducer of this reconstruction, likely via facilitating ZnO reduction. Furthermore, the product selectivity (CO vs CH4) is dictated by the kinetic competition between CO desorption and its deep hydrogenation, a principle quantitatively linked to the evolved electronic structure of the active surface. This work shifts the paradigm toward designing catalysts that evolve into optimal structures in operando and provides a fundamental kinetic framework for selective CO2 conversion.
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Nature Communications
·
2026
·
IF 18.1
Shu Yang,Chang Qing,Lin Ziying,Ko Pao-Fen,Chen Jingyi,Qiu Yuyueyang,Chen Feixiang,Zhao Zhen,Clark Glenn Thomas,Monreal Anette Vistoso,Ahn David,Liu Zhaoyang,Xu Jian,Chen Jian-Fu
Temporomandibular joint (TMJ) arthritis is a craniofacial disorder characterized by joint dysfunction and orofacial pain. Lymphatic regulation and function in TMJ remain unknown. Using genetic reporter mice, human tissues, tissue clearing, 3D volume imaging, and functional studies, we identified a synovial lymphatic system in TMJ. In a mouse model of TMJ arthritis, inflammation induces extensive lymphatic remodeling and leads to synovial lymphatic dysfunctions. Functional genetics and single-cell RNA sequencing (scRNA-seq) revealed that lymphatic deficiency induces a population of fibroblast-macrophage hybrid cells and enhances inflammation, exacerbating cartilage defects, bone loss, synovitis, and pain behaviors in TMJ arthritis mice. Conversely, lymphatic function promotion via a hydrogel-mediated VEGF-C delivery prevents TMJ pain, inflammation, and arthritis-like pathogenesis. Thus, we identified synovial lymphatics in TMJ and found that lymphatic dysfunction drives TMJ arthritis and pain, suggesting its potential as a therapeutic target.
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ACS ES&T Engineering
·
2026
·
IF 6.3
Xu Pan,Jiangkun Xie,Mingze Jiao,Liang Shan,Hongyuan Qi,Wenjun Huang,Zan Qu,Naiqiang Yan,Haomiao Xu
Methane selective catalytic reduction (CH4-SCR) represents a promising strategy for nitrogen oxides (NOx) abatement, yet its practical application is hindered by catalyst deactivation in the presence of water, caused by competitive adsorption on acid sites and irreversible hydroxylation of active metal species. In this study, we developed a dual-functional In@H-Beta/Fe2O3 catalyst through sequential ion-exchange and impregnation. This architecture confines indium species within the channels of H-Beta zeolite, while Fe2O3 nanoparticles are dispersed on the external surface, creating a synergistic system featuring a hydrophobic layer and strong Fe–O–In interfacial interactions. Under 5% H2O conditions, the optimized catalyst achieves 85% NOx conversion (vs 40% for conventional In@H-Beta). The enhanced water resistance is attributed to two factors: first, Fe2O3 establishes a physical barrier that protects acid sites and stabilizes InO+ active sites via Fe–O–In bonding, thereby inhibiting hydroxylation; second, strong interfacial Fe–O–In interactions further stabilize InO+ active sites against aqueous deactivation. Additionally, the Fe2+/Fe3+ redox cycle is proposed to facilitate O2 activation. In situ DRIFTS studies under 5% H2O confirm effective CH4 activation, as indicated by markedly more intense C–H stretching bands compared with In@H-Beta. The reaction pathway involves NO activation over Brønsted acid sites to form nitrate species, and CH4 activation on InO+ sites generating methyl radicals, which subsequently participate in NOx reduction. This work offers a new design strategy for developing highly active and water-tolerant CH4-SCR catalysts suitable for industrial flue gas treatment.
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JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 6
·e71150
·
IF 4.1
Hongan Li,Huanhuan Wang,Zeyuan Deng,Yao Pan,Hongyan Li
Flavored puffed bean products (FPBP) were primarily prepared from soybean flour or soybean flour supplemented with okara, which were mixed with sodium carbonate and water and subsequently subjected to a puffing treatment. In this study, the effects of the combined use of emulsifiers and moisture retention agents and incorporating okara into bean flour on the textural properties of puffed bean products were investigated. It was shown that both approaches effectively enhanced the springiness and resilience of FPBP while decreasing their hardness and cohesiveness. In vitro simulated digestion was performed on texture-enhanced FPBP. Determination of free amino acids revealed that FPBP exhibited a rich amino acid composition. Characteristic flavor compounds of the FPBP were identified using HS-SPME-GC–MS, and nine compounds with variable importance in projection (VIP) values exceeding 1 were selected as key flavor compounds. Furthermore, it was found that the texture-enhancing treatment effectively retained the unique flavor of FPBP and inhibited flavor degradation during storage. This research provided a theoretical basis and technical support for the optimization of production processes and flavor analysis of FPBP. Practical Applications This study helps improve flavored puffed bean snacks: adding specific additives or 20% okara keeps them springy and flavorful longer. They stay consistently “juicy” and tasty during shelf life, unlike regular snacks that harden or lose flavor. The method also works for other legume puffed snacks, aiding companies in developing new products efficiently.
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