JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Ikram Hasan,Zia Ullah,Fei Wang,Li Wang,Yibin Yan,Tingting Gong,Muhammad Madni,Dhananjoy Mondal,Hanyang Qu,Jhilik Roy,Yinghe Zhang,Shubham Roy,Bing Guo,Chunqi Chang
Multifunctional theranostic nanoplatforms enabling precise targeting and controlled deep tissue therapy are vital. Herein, we present a self-assembled, defect-engineered, biomimetic nanoplatform (CDMBBTO), in which piezoelectric material and downconversion nanoparticles (DCNPs) are co-assembled within a polymer matrix, preventing interactions between both components, thereby allowing each to retain its intrinsic properties while collectively enabling dual second near infrared fluorescence (NIR-II FL)/magnetic resonance (MR) imaging and synergistic piezo/chemodynamic therapy (PZDT/CDT). Mn/Bi codoped piezoelectric BaTiO 3 (MBBTO) NPs exhibit a significantly enhanced piezoelectric coefficient (~5 fold higher than pristine BTO) owing to bandgap modulation induced by defect engineering. The incorporated Mn 2+ not only catalyzes Fenton like reactions for sustained tumor suppression but also provides strong T 2 weighted MR contrast. Self-assembled NIR-II emissive DCNPs enable deep tissue optical imaging, forming an integrated theranostic system. Cloaking of U87 glioma cell membranes imparts homologous tumor targeting capability. In vivo dual modal imaging reveals efficient tumor accumulation, with peak NIR-II FL and MR signal intensities observed 6 h post-injection. Upon ultrasound activation, CDMBBTO elicits potent tumor ablation through synergistic reactive oxygen species generation and immune modulation, characterized by macrophage polarization (M2 → M1) and upregulation of proinflammatory cytokines (TNF-α and IL-6). This work establishes CDMBBTO as a powerful nanoplatform for dual modal imaging-guided, immune potentiated PZDT/CDT toward effective glioblastoma treatment.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Ke Xiang,Nan Liu,Gang Shu,Guohe Wang,Yupeng Chen,Shao-Kai Sun,Ran Cheng
Acute kidney injury (AKI) is a highly morbid and lethal syndrome that is often clinically “silent” in early stages. Multimodal imaging, which integrates complementary structural and functional insights from various techniques, holds great potential to enhance diagnostic sensitivity and accuracy. However, developing a single-agent probe that effectively combines multiple imaging modalities for AKI remains a significant challenge. Herein, we show neodymium-enriched carbon dots (Nd-CDs) as a novel bimodal imaging probe for the early diagnosis of AKI by using computed tomography (CT) and the second near-infrared window (NIR-II) fluorescence. Nd-CDs with high metal doping level (17.9%) can be achieved on a gram-scale (2.1 g) through a “bottom-up” strategy. The ultra-small hydrodynamic size (<2 nm) endows Nd-CDs with rapid renal clearance. Benefiting from narrow-band NIR-II fluorescence emission at 1060 nm and strong X-ray attenuation, Nd-CDs provide high-spatial-resolution CT and highly sensitive fluorescence imaging in vivo . In a cisplatin-induced AKI rat model, Nd-CDs-based bimodal imaging reveals a pronounced delay in renal metabolism caused by tubular injury, which precedes abnormalities in blood biochemical parameters, enabling early diagnosis and progression monitoring of AKI. The proposed strategy provides new insights into the development of single-agent probes integrating multiple imaging modalities and opens up a new way for early diagnosis of AKI.
✓ 已验证
产品关联
DOI
高影响因子
Light-Science & Applications
·
2026
·Vol. 15
·期 1
·229
·
IF 24
Yu Dechao,Liu Haisheng,Lv Mengting,Li Benchun,Zhou Yayun,Han Xinxin,Zhang Dawei
New generation of Cr 3+ -free eco-friendly phosphors (no risk of Cr 3+ → Cr 6+ oxidization toxicity) are highly sought to develop broadband NIR light sources. As an essential element for body health, Fe 3+ ion would be an exceptional alternative in strong octahedral crystal field. Here, the Fe 3+ activators were utilized in orthoborate-pyroborate A 2 Sc 2 B 4 O 11 for creating novel NIR-emitting phosphors. A broad absorption over 240–450 nm due to O 2- → Fe 3+ charge transfer transition was recorded for Sr 2 Sc 2 B 4 O 11 :Fe 3+ (SSBO:Fe 3+ ) at 370 nm and Ba 2 Sc 2 B 4 O 11 :Fe 3+ (BSBO:Fe 3+ ) at 355 nm. Resultant NIR emissions with large full width at half maximum about 170 nm were obtained for SSBO:Fe 3+ peaked at 975 nm and BSBO:Fe 3+ at 930 nm. The unique excitation of Fe 3+ doping towards near-ultraviolet (near-UV) region was initially achieved for potential advantage of coupling a mainstream UV chip. Codoping of Yb 3+ into A 2 Sc 2 B 4 O 11 :Fe 3+ made emission peak red-shift towards 1000 nm and ~ 160-fold enhancement in the integral intensity owing to a robust energy extraction from the major dark (nonluminous) Fe 3+ . The optimized SSBO:0.02Fe 3+ ,0.15Yb 3+ exhibited considerable internal and external quantum efficiency ~ 78% and 48%, respectively. Compared to the luminescence thermal stability of ASBO:Fe 3+ (32%@373 K, i.e., sustaining 32% of its room-temperature emission intensity at 373 K), the Yb 3+ codoping endowed much superior stability > 63%@373 K, and additional temperature sensing with relative sensitivity ~ 1.5% K −1 at 423 K. Ultimately, by coating the novel phosphors onto UV ~ 365 nm chips, the home-made pc-LEDs were applied in night vision, food inspection, biomedical imaging, and spectroscopy analysis.
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Tao Qin,Lian Qin,Yang Zhao,Yin Chen,Qianyue Liu,Xiaoguang Lin,Yongfeng Lan,Yaohui Huang,Yan Liu,Ke Zhang,Lifan Pan,Jiaxiao Li,Kunpeng Duan,Hao Liang,Mingjing Yin,Guiyang Fan,Lian Liu,Yu Deng,Lin Liao,Danke Su,Ming Gao,Junyu Lu
Sepsis induced acute liver injury (SALI), is a type of acute and severe disease that is generally characterized by producing significant amounts of reactive oxygen species (ROS) in liver tissue, and in response to excessive ROS, producing huge amounts of inflammatory factors by hepatocytes. Considering the crucial role of ROS in SALI, a Pd doped CeO 2 (CP) nano-heterojunction with enhanced ROS scavenging capacity is developed to act as a catalytic nanomedicine for the treatment of SALI. Combining with near infrared (NIR) irradiation, it exhibits excellent scavenging capacity of ROS including hydroxyl radical (•OH), superoxide anion (•O 2 − ), as well as singlet oxygen ( 1 O 2 ) for CP. Significantly, it also demonstrates the excellent antioxidant and anti-inflammatory activities for lipopolysaccharides (LPS) stimulated macrophages (RAW264.7), and cecum ligation and puncture (CLP) treated C57BL/6J mice via reducing intracellular ROS levels, decreasing inflammatory factors expression levels, as well as activating Keap1/Nrf-2/HO-1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation and promote liver tissue repair, finally achieving the alleviation of SALI. It provides a promising therapeutic strategy of CP+NIR with high efficacy and biosafety for the management of SALI.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 41
·15451-15461
·
IF 8.307
Huimin Jiang,Ruoping Wang,Qian Zhang,Liang Song,Xia Sun,Junpeng Shi,Yun Zhang
Persistent luminescence nanoparticles (PLNPs) possess advantages for high-sensitivity bioimaging and continuous photodynamic therapy (PDT) because they can emit persistent luminescence (PerL) after excitation ceases. However, PLNPs are limited to single-wavelength emission, which can only efficiently realize one of the functions of bioimaging or PDT. In addition, most PLNPs are excited by shallow tissue penetrating excitation light, which makes it difficult to achieve repeatable in vivo applications with high efficiency. Herein, X-ray-excited PLNPs (Zn3Ga2Ge2O10:Cr3+,Mn2+, ZGGCM) with dual emission for in vivo X-rays repeatedly activated PerL imaging and tumor PDT are reported for the first time. ZGGCM exhibits dual-emission peaks after X-ray excitation/re-excitation, located at 698 nm and 532 nm, respectively. Additionally, ZGGCM is modified with the photosensitizer rose bengal (RB) to construct a dual-functional nanoplatform based on PerL imaging and PDT. The results indicate that the PerL emission peak (698 nm) of Cr3+ ions in ZGGCM possesses excellent near-infrared (NIR) PerL imaging performance, and the green PerL emission peak (532 nm) of Mn2+ ions can activate RB effectively and generate reactive oxygen species (ROS), thereby causing a significant antitumor effect. This unique dual-functional nanoplatform is expected to further promote the application of PLNPs in the integration of efficient tumor diagnosis and treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2021
·Vol. 32
·期 2
·478-485
·
IF 3.543
Abdallah Rusul Mohammed,Al-Haddad Raad M. S.
Core–shell nanoparticles (CSNPs) have attracted attention in biomedical applications as they have highly useful materials with modified characteristics, such as high stability, dispersibility, higher permeability to certain target cells and reduction in consumption of precious materials. Synthesis of core–multishell nanoparticles with suitable sizes, structural characteristics and absorption using simple methods continues to be a challenge. In this study, \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs were synthesized in three stages to control their size and the potential for tuning their properties. Field emission scanning electron microscope images confirmed that \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs have a small particle size of about 22.5 nm, average crystalline size in X-ray diffractometer analysis was 22.8 nm, stability was about − 49.1 mV, and synthesis with magnetic and optical properties improved their biocompatibility. Treatment of CAL-51 and HBL-100 cell lines by \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs under NIR laser and alternating magnetic field generated enough heat to increase cell death.
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 39
·395703
·
IF 3.874
Zhihua Li,Xin Ding,Bing Yu,Yu Min,Bin He,Youqing Shen,Hailin Cong
Near-infrared (NIR) emission materials can be widely applied in various fields, such as food detection, imaging, treatment, electronic products. With the trend of miniaturization of equipment, smaller materials are needed. In this work, we successfully synthesized a series of M2Ga2GeO7:N3+ (M = Ca, Ba, Sr; N = Cr, Nd, Er) samples and then focused on the study of Nd3+ doped Sr2Ga2GeO7 (SGGO). A series of SGGO:xNd3+ sub-micron phosphors were prepared via a microwave-assisted sol–gel process combined with subsequent calcination at 750 ℃, and the structural information and luminescent properties were systematically studied. SGGO is a representative tetragonal crystal and belonging to the space group of P4¯21m (113). The Nd3+ ions occupy eight-coordinated Sr2+ sites in the crystal lattice. From SEM analysis, the average particle size distribution is 219.7 ± 41.4 nm. The sub-micron phosphors have rich excitation spectra ranging from 350 nm to 850 nm and can produce multiband NIR emissions of 1331, 1056, and 905 nm when excited by ultraviolet and NIR light. The maximum emission intensity was obtained by optimizing the doping ratio of Nd3+ ions. A commercial chip was then utilized to fabricate light-emitting diodes (LEDs) to verify its application potential in NIR-II mini-LEDs. Compared with blue light LEDs, the as-prepared LEDs had good imaging penetration depth and could be clearly observed under 10 mm of chicken breast coverage. The maximum imaging penetration depth can be 33 mm.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Lei Huang,Wenxi Yan,Bo Cai,Yu Song,Qiying Lv,Guobin Wang,Lin Wang,Zheng Wang
To engineer tumor-tropic cells as drug delivery vehicles is a promising strategy to improve therapeutic specificity and efficacy for cancer treatment. However, conventional genetically engineered cell-based drug delivery systems are often capable of initiating single-mode therapy, and lack precise spatiotemporal control over the release of therapeutic payloads at tumor local, thus possibly causing severe systemic toxicity. Here, the macrophages are genetically engineered to encode a non-secreted form of EGFP-TNFα fusion protein and intracellularly carry near-infrared (NIR)-responsive heat-nanogenerators (HIMs). Owing to macrophages' intrinsic tumor tropism and HIMs’ photo-responsiveness to NIR, these macrophages ( [email protected] ET ) can actively accumulate at tumor sites and undergo controlled photothermolysis induced by NIR-induced HIMs-mediated photothermal effects (PTE). Such heat-induced cell explosion enables spatiotemporally controlled release of non-secreted TNFα from macrophages and effectively kills cancer cells. Importantly, in a preclinical tumor model, [email protected] ET actively migrate to tumors where PTE and released EGFP-TNFα exhibit an enhanced antitumor effect, suppressing tumor growth and significantly prolonging animal survival without eliciting adverse side effects. Thus, this study demonstrates the potential of such dual-engineered macrophages in bi-modal cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CANCER RESEARCH
·
2023
·
IF 11.2
Zhu Yuan-Yuan,Song Liang,Zhang Yong-Qu,Liu Wan-Ling,Chen Wei-Ling,Gao Wen-Liang,Zhang Li-Xin,Wang Jia-Zheng,Ming Zi-He,Zhang Yun,Zhang Guo-Jun
Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence of metastatic disease. Detection of SLN metastasis largely hinges on examination of frozen sections or paraffin-embedded tissues post-SLN biopsy. To improve detection of SLN metastasis, we developed a second near-infrared (NIR-II) in vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles (ErNPs) with bright down-conversion fluorescence at 1556 nm. To visualize SLNs bearing breast cancer, ErNPs were modified by balixafortide (ErNPs@POL6326), a peptide antagonist of the chemokine receptor CXCR4. The ErNPs@POL6326 probes readily drained into SLNs when delivered subcutaneously, entering metastatic breast tumor cells specifically via CXCR4-mediated endocytosis. NIR fluorescence signals increased significantly in tumor-positive versus tumor-negative SLNs, enabling accurate determination of SLN breast cancer metastasis. In a syngeneic mouse mammary tumor model and a human breast cancer xenograft model, sensitivity for SLN metastasis detection was 92.86% and 93.33%, respectively, and specificity was 96.15% and 96.08%, respectively. Of note, the probes accurately detected both macrometastases and micrometastases in SLNs. These results overall underscore the potential of ErNPs@POL6326 for real-time visualization of SLNs and in vivo screening for SLN metastasis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Jiu-ba Zhang,Bin Wang,Yun-fei Zhang,Yi Wu,Ming-xuan Li,Ting Gao,Tu-lin Lu,Zhen-hua Bian,Lian-lin Su
Gastrodia elata (GE) is traditionally subjected to steaming, and steaming duration plays a crucially important role in determining GE quality. This study examined the variations in bioactive components during the steaming process and proposed the utilization of electronic eye and Fourier Transform near-infrared (FT-NIR) spectroscopy for quality assessment. The findings revealed that the levels of parishin E parishin B, parishin A, and gastrodin initially rose and subsequently declined, while 4-Hydroxybenzyl alcohol exhibited a rapid decrease followed by stabilization. With prolonged steaming, the brightness of GE decreased, while the red and yellow tones became more pronounced and the color saturation increased. FT-NIR divided the steaming process into three stages: 0 min (raw GE), 0–9 min (partially steamed GE), and 9–30 min (fully steamed GE), and the partial least squares regression models effectively predicted the levels of five components. Overall, this study provided valuable insights into quality control in food processing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiaoyong Zhang,Meiyue Jin,Liping Ding,Jinmei He,Yongping Bai,Lidong Zhang
Inspired by nature, hydrogel actuators are important for designing soft robots and become one of the most essential components of intelligent research. However, classical actuation method, such as Near-Infrared (NIR) light stimulates the actuator to complete the motions then it automatically recovers original state when the light is off, cannot provide continuous in situ dynamic motion stay and recovery under one NIR light. In this study, a novel network-polycaprolactone (Net-PCL)-poly N -isopropylacrylamide (PNIPAM) hydrogel actuator (Net-PCL-Gel) is proposed through a layer-by-layer stacking technology, leading to the co-existence of Net-PCL with photoinduced shape memory capability and PNIPAM hydrogel segments showing de-swelling/swelling phase transition. Owing to the shape memory property of Net-PCL, the Net-PCL-Gel exhibits in situ dynamic bending and recovering stay behavior in response to NIR irradiation with the active force of PNIPAM. Different from the conventional hydrogel system, the Net-PCL-Gel also displayed remarkable decryption performance in information reading and hiding, while retaining excellent accuracy and stability. Due to its simplicity, this strategy shows great potential for the biomimetic operation of soft grippers and multifunctional actuators.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 18
·12609-12617
·
IF 3.9
Tao Gong,Xiaoyu Wang,Huirui Zhu,Chaochao Wen,Qing Ma,Xiaoning Li,Meining Li,Rui Guo,Wenting Liang
The combination of chemo-photothermal therapy with high efficiency and fewer side effects has a good application prospect in cancer treatment. It is of great significance to construct a nano-drug delivery system with cancer cell targeting, high drug loading and excellent photothermal conversion efficiency. Therefore, a novel nano-drug carrier MGO-MDP–FA was successfully constructed by coating folic acid-grafted maltodextrin polymers (MDP–FA) on the surface of Fe3O4-modified graphene oxide (MGO). The nano-drug carrier combined the cancer cell targeting of FA and the magnetic targeting of MGO. A large amount of anti-cancer drug doxorubicin (DOX) was loaded by π–π interaction, hydrogen bond interaction and hydrophobic interaction, with the maximum loading amount and loading capacity of 657.9 mg g−1 and 39.68 wt%, respectively. Based on the excellent photothermal conversion efficiency of MGO, MGO-MDP–FA showed good thermal ablation effect of tumor cells in vitro under NIR irradiation. In addition, MGO-MDP–FA@DOX showed excellent chemo-photothermal synergistic tumor inhibition in vitro (tumor cell killing rate reached 80%). In conclusion, the novel nano-drug delivery system MGO-MDP–FA constructed in this paper provides a promising nano-platform for chemo-photothermal synergistic treatment of cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）