ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Shuting Liu,Mingde Tong,Qingkun Tang,Xinyan Lv,Zuyun Chen,Songshan Zeng,Xiaoyuan Yu
Abstract Sustainable wearable electronics demand flexible energy-storage and sensing devices made by greener, low-impact routes. Aqueous zinc-based hydrogel electrolytes are attractive here, but their use is limited by uncontrolled zinc dendrite growth and by the difficulty of combining fast Zn2+ transport with controlled interfacial deposition. Most hydrogels resist dendrites only through passive physical confinement, without actively governing interfacial zinc deposition. Herein, using chitosan, a renewable polysaccharide obtained from chitin-rich seafood waste, we construct an interfacial Si–O–Zn coordination motif within a hydrogel electrolyte through a mild, all-aqueous, one-step in situ polymerization that requires no separate activation step. Chitosan and acrylamide form the matrix, zinc trifluoromethanesulfonate (Zn(OTf)2) is the zinc source, and nanosilicon acts as a functional filler. Chitosan bridges the organic and inorganic domains through its -NH2/-OH groups, while free Zn2+ ions coordinate with surface silanols to form interfacial Si–O–Zn coordination interactions. The optimized CAA-6-Si(3:1) electrolyte delivers a high ionic conductivity (36.04 ± 1.71 mS cm–1), a wide electrochemical stability window (2.56 V), and a Zn2+ transference number of 0.583. Spectroscopic and structural analyses reveal that the interfacial Si–O–Zn sites actively steer Zn2+ toward the low-energy (002) plane, suppressing dendrites rather than merely blocking them; accordingly, Zn || Zn symmetric cells cycle stably for 1820 h at 2 mA cm–2 and 535 h at 5 mA cm–2. The same electrolyte integrates readily into multiple flexible devices: zinc-ion hybrid capacitors retain 90.4% capacity after 50,000 cycles at 10 A g–1, with stable performance under bending, and strain sensors (gauge factor = 1.54) reliably monitor physiological signals. By coupling interfacial coordination chemistry to zinc deposition, this chitosan hydrogel electrolyte combines fast Zn2+ transport with (002)-oriented, dendrite-suppressed plating. Made from a renewable feedstock through a mild, low-impact process, it offers a sustainable route to flexible energy-storage and sensing devices.
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高影响因子
XENOBIOTICA
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2026
·
IF 1.5
Jiexin Qiu,Beibei Yao,Qing Yu,Jiajie Wang,Lingling Huang,Jiale Chen,Yufeng Lu,Chunying Wang
Cis-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (cis-THSG), a photoisomer of the major bioactive component in Polygoni Multiflori Radix Praeparata (He-Shou-Wu), has enhanced hypolipidemic activity but is associated with idiosyncratic hepatotoxicity. Its metabolic fate under pathological conditions and key clearance enzymes remain unclear.This study aimed to compare metabolite profiles of cis-THSG in normal and hyperlipidemic rats in vivo and in vitro, identify metabolites, and characterise enzyme kinetics in rat liver microsomes (RLMs) and major CYP450 isoforms. Metabolites in plasma, urine, faeces, bile, and intestinal bacteria incubation fluids were analysed by UHPLC-Q-TOF-MS/MS. Enzymatic kinetics and CYP450 isoforms were investigated via chemical inhibition assays.A total of 27 metabolites were characterised; cis-THSG underwent rapid glucoside hydrolysis, and its aglycone underwent phase I and II reactions. Hyperlipidaemia reduced metabolites to 20 and markedly increased plasma cis-THSG and aglycone abundance. Kinetic parameters were Km 32.86 μmol/L, Vmax 0.7285 μmol/(min·mg protein), CLint 0.02217 L/(min·mg protein). Rat liver microsomal CYP isoforms analogous to human CYP3A4 and CYP2C9 mediated cis-THSG oxidative metabolism.This study provides the first comprehensive metabolite map of cis-THSG, identifies its aglycone as a potential bioactive form, and reveals a disease-related metabolic shift. CYP phenotyping offers a mechanistic basis for predicting clinical drug–drug interactions.
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高影响因子
International Journal of Environmental Research
·
2026
·Vol. 20
·期 6
·302
·
IF 4.3
Jinkui Zhong,Runyujie Ma,Caiya Zhu,Lina Yang,Li Liu,Xiaowen Li,Jing Chen,Yaxin Hu,Xuewen Zhu
Phenolic compounds are widespread industrial pollutants that threaten aquatic ecosystems and human health. Herein, carbon nanotube-supported Fe₃O₄-loaded nano-zero-valent iron (CNTs-Fe₃O₄-nZVI) composites were synthesized via liquid-phase reduction and employed as heterogeneous Fenton-like catalysts with H₂O₂ to degrade bisphenol F (BPF) and bisphenol S (BPS) in aqueous solution. The effects of H₂O₂ concentration, catalyst dosage, and initial pH on degradation efficiency were systematically investigated, and reaction conditions were optimized using the Box-Behnken response surface methodology (RSM). Results showed that at 25 °C, pH 3.0, a catalyst dosage of 0.8 g L⁻ 1 , and H₂O₂ concentrations of 10 mmol L⁻ 1 (for BPF) and 15 mmol L⁻ 1 (for BPS), the degradation efficiencies of BPF and BPS reached 98.03% and 94.30%, respectively, in good agreement with the model-predicted values (96.94% and 93.92%). After four reuse cycles, the degradation efficiencies remained above 70%, confirming good stability and reusability. Isotherm data fitted the Freundlich model better than the Langmuir model for both BPF ( R 2 = 0.9484) and BPS ( R 2 = 0.9091), with negative intercepts indicating multilayer adsorption on heterogeneous surfaces. The adsorption affinity for BPF ( K F = 8.25) was nearly double that for BPS ( K F = 4.37), revealing structure-dependent interfacial interactions. Radical quenching and mass spectrometry indicated HO· oxidation and benzene ring cleavage as the primary BPS degradation pathways. The optimized conditions were determined as H₂O₂ 10.74 mmol L⁻ 1 , catalyst 0.733 g L⁻ 1 , and pH 2.836 by RSM. TOC removal reached 64.22% for BPF and 67.97% for BPS, and ecotoxicity assessment confirmed that the degradation intermediates exhibited substantially reduced toxicity, demonstrating effective detoxification.
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高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Xuefen Song,Haoren Zheng,Jie Zhang,Xuejiang Zhang,Jian Cui,Muhammad Ayyob,Chuangwei Liu,Panpan Su,Zhongwei Chen
The development of Ru-based electrocatalysts with superior activity and stability for proton exchange membrane water oxidation remains a significant challenge. A key strategy is the precise engineering of the lanthanide–O–Ru structure to tailor surface species and continuously modulate Ru–O covalency, thereby optimizing the adsorption energy of intermediate species for enhanced catalytic performance. In this study, density functional theory (DFT) calculations predict that incorporating the late lanthanides (Tm–O–Ru) into the RuO2 structure significantly enhances the density of states near the Fermi level to a greater extent than the middle lanthanide (Gd–O–Ru). This leads to a lower energy barrier for *OOH as the rate-determining step of the oxygen evolution reaction (OER). Additionally, the strength of *OH adsorption follows the Tm–O–Ru > Gd–O–Ru > RuO2 trend. Experimental results confirm the theoretical predictions: Tm–O–Ru structure enhances the Ru–O covalency, tunes the electronic structure of Ru, and optimizes *OH adsorption. These modifications result in good OER performance with an overpotential of 201 mV and robust stability over 1000 h at 10 mA cm–2. Furthermore, a Tm–RuO2-based PEMWE device stably operates at 100 mA cm–2 for 200 h with a low degradation rate of 0.195 mV h–1, outperforming most Ru-based catalysts reported in the literature.
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高影响因子
MOLECULAR MEDICINE
·
2025
·Vol. 31
·期 1
·1-23
·
IF 6.4
Wang Qiuhong,Wei Dong,Li Chunman,Yang Xiawei,Su Kun,Wang Tao,Zou Renchao,Wang Lianmin,Cun Dongyun,Tang Bo,Wu Tao
Section
Background
Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in the regulation of m6A. However, the therapeutic potential of METTL3 in pancreatic cancer is unclear.
Section
Methods
By means of functional gain and loss experiments, the relationship between METTL3 and gemcitabine resistance as well as ferroptosis was explored. The target genes of METTL3 were screened, and the influence of O-GlcNAcylation on the stability and ubiquitination modification of METTL3 was dissected.
Section
Results
We found that METTL3 is highly expressed in pancreatic cancer and regulates ferroptosis and gemcitabine resistance by promoting the degradation of HMGB1 in an m6A-YTHDF2-dependent manner. O-GlcNAcylation modulates the METTL3’s stability. The interaction between the deubiquitinase EIF3H and METTL3 is influenced by O-GlcNAcylation.
Section
Conclusion
METTL3 affects pancreatic cancer progression by promoting degradation of HMGB1. The O-GlcNAcylation of METTL3 not only stabilizes METTL3 but also augments EIF3H-mediated deubiquitination. These findings uncover potential mechanisms underlying gemcitabine resistance in pancreatic cancer and offer potential therapeutic strategies for the treatment of this disease.
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PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Cuicui Duan,Cheng Wu,Hui Liu,Siyang Sui,Hongru Wang,Lin Ma,Fumin Ma,Xiaolei Li,Dan Li
In this study, a ternary complex was prepared using soybean protein isolate (SPI), (−)-epigallocatechin gallate (EGCG), and exopolysaccharides (EPS) produced by Lacticplantibacillus plantarum A114. It systematically evaluated the stabilization on W 1 /O/W 2 emulsions and protective effects on the encapsulated L. plantarum A114 upon long-term storage, pasteurization, and in vitro simulated gastrointestinal digestion. The physical stability and microstructure of the emulsions were analyzed by particle size, ζ-potential, creaming index, and rheological behaviors. The survival rate of the strain was determined by flow cytometry during 28-day of storage (4 °C), after pasteurization and in vitro simulated gastrointestinal digestion to assess their protective efficacy. The results showed that compared with the emulsions stabilized by native SPI, (EGCG-SPI)-EPS stabilized emulsion was with the smallest particle size and the lowest degree of emulsion separation during 28-day storage period, and the survival rate of L. plantarum A114 increased by 1.23 times during storage, 0.88 times after pasteurization, and 1.45 times after in vitro simulated gastrointestinal digestion. These results suggested that the emulsions stabilized by (EGCG-SPI)-EPS complex exhibited superior physical stability and protective effects on encapsulated strains. In addition, this study further observed the microstructure of the strains encapsulated in the emulsion stabilized by different complex using confocal laser scanning microscopy (CLSM). The results indicated that the introduction of EGCG and EPS could construct a composite interface layer with stronger physical barriers and antioxidant protection through the synergistic effect with SPI, thereby significantly improving the stability of W 1 /O/W 2 emulsion system and the protective effect on L. plantarum A114. To sum up, the (EGCG-SPI)-EPS ternary complex presented the best protective synergistic effect and was an extremely promising targeted delivery system for probiotics. This study has important guiding significance for the development of probiotic functional foods with high survival rates.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Tao Wang,Qiudi Zhang,Xupeng Zhu,Yasi Wang,Mengjie Zheng,Jing Wang,Wenbo Liu,Yahui Wang,Xiaojun Pan,Huimin Shi
Transition-metal-based catalysts with asymmetric coordination structures are promising candidates for industrial oxygen evolution reactions. However, the large-scale synthesis of catalysts with precisely constructed asymmetric coordination structures is still challenging. Herein, we developed an industry-compatible roll-to-roll combustion technology to synthesize NiFc–MOFs with reasonably constructed asymmetric Fe–O–Ni coordination. Owing to the modulated electronic spin states, regulated adsorption configurations of oxygen-containing intermediates, and charge redistribution, the as-prepared NiFc–MOF achieved ultralow overpotentials of 196 mV and 257 mV at η10 and η1000, respectively. The long-term stability evaluation of catalysts in a three-electrode system demonstrates excellent durability of 2000 h at 2 A cm–2. Further, the assembled anion exchange membrane water electrolyzer (AEMWE, NiFc–MOF||R–Ni) operated at a current density of 1 A cm–2 achieved high overall water splitting with a low cell voltage of merely 2 V and maintained outstanding durability for over 500 h under ambient atmosphere. More importantly, the NiFc–MOF maintained high stability for over 250 h at 1 A cm–2 in simulated seawater. This study offers a reliable pathway to the large-scale synthesis of low-cost NiFe-based catalysts for ampere-level oxygen evolution in both pure and seawater.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Dingping Huang,Yanlin Li,Jia Lei,Xiaofang Feng,Xiaotong Yang,Rong He,Rui Zhang,Hongyuan Wei,Wanjun Mu,Huanhuan Liu,Wenkun Zhu
The selective separation of 90 Sr from its daughter 90 Y is crucial for obtaining carrier-free 90 Y. Herein, we demonstrate a La doping strategy to modulate the microstructure and surface properties of Sb 2 O 5 to enhance the separation performance of Sr/Y. Batch studies show that 7%-LaSb exhibits significantly enhanced separation performance compared to Sb 2 O₅ across a broad range of HNO₃ concentrations, achieving a remarkable separation factor of 3449 for Sr 2+ in 0.3 M HNO₃. The equilibrium isotherms align with the Langmuir model, yielding a maximum Sr 2+ adsorption capacity of 40.82 mg/g for 7%-LaSb. Column experiments further validate the practical efficacy of Sr 2+ separation from Y 3+ -containing streams. Mechanistic studies indicate that the high separation performance is attributed to the changes in surface microenvironment induced by La doping: (i) defect-rich porous pathways for Sr 2+ ion access, (ii) a more electronegative surface for enhanced Sr 2+ attraction, and (iii) abundant active Sb-OH sites for specific ion-exchange. This work provides a promising new adsorbent for the separation of Sr/Y in strong acid environments.
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高影响因子
Journal of Integrative Plant Biology
·
2026
·
IF 12.5
Zhiyao Wang,Naichao Zhang,Peimin Wu,Fei Chen,Ying Cao,Jing Wang,Yiming Qin,Wenhui Zheng,Yinghua Sheng,Shuai Chen,Baojing Li,Lei Wei,Junli Zhang,Yuqing Liu,Ninghua Tan,Wei Wang,Min Chen
Phillyrin, a unique antiviral lignan exclusive to Forsythia suspensa , shows potent anti-influenza activity. However, its broad pharmaceutical application is hindered by low and variable natural accumulation, underscoring the need to elucidate its biosynthetic pathway for sustainable production. In this study, we used an integrated metabolomic and transcriptomic approach to investigate tissue-specific phillyrin biosynthesis in F. suspensa . We identified two O -methyltransferases (FsE4MT01 and FsE4MT02) that catalyze the methylation of (+)-epipinoresinol to form phillygenin and a UDP-glycosyltransferase (FsP4′GT) that glucosylates phillygenin to yield phillyrin. Using recombinant proteins expressed in Escherichia coli , we validated their in vitro catalytic activities and determined their kinetic parameters. Molecular docking and site-directed mutagenesis of key residues further revealed the structural basis of their catalytic mechanisms. The in vivo functions of these enzymes were confirmed through heterologous expression in Nicotiana benthamiana and F. suspensa leaves. Importantly, by developing a transient leaf-expression system in F. suspensa , we demonstrated that overexpression of FsE4MTs and FsP4′GT substantially increased the production of phillygenin and phillyrin, respectively, whereas virus-induced gene silencing (VIGS) of these genes reduced the accumulation of the corresponding products. Notably, enhanced phillyrin production was also achieved by expressing FsE4MTs and FsP4′GT in the related species Forsythia × intermedia , highlighting the potential of these key enzymes for metabolic engineering. Our findings elucidate the terminal steps of phillyrin biosynthesis and provide a strategic foundation for engineering the sustainable production of this pharmaceutically valuable compound.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yanni Li,Zhigui Zhang,Baobao Wang,Runguo Zheng,Dan Wang,Zhishuang Song,Yanguo Liu,Zhiyuan Wang
High-entropy oxides (HEOs) represent promising anode materials for lithium-ion batteries, yet understanding the intricate relationship between their multi-element composition, crystal structure, and lithium storage mechanism remains a fundamental challenge. This study systematically investigates this relationship in (XCoNiCuZn)O (X = Li, Na, Mg) HEOs by modulating the fifth element. While all compositions form a single rock-salt structure, the cationic radius and valence state of X dictate both the lattice parameters and the electrochemical reaction pathway. It is revealed that (LiCoNiCuZn)O and (MgCoNiCuZn)O undergo a conversion-dominated phase transition mechanism, whereas (NaCoNiCuZn)O follows a solid-solution reaction. This mechanistic divergence, elucidated through in-situ EIS, ex-situ XRD/XPS, and kinetic analysis, directly governs the electrochemical performance. The Li-based HEOs (LiCoNiCuZn)O demonstrates exceptional performance, delivering a high capacity of 549.7 mAh g −1 with 83.4% retention after 300 cycles at 0.5 A g −1 , attributable to its effective charge compensation and superior ion conductivity. This work establishes a clear correlation from cationic modulation to storage performance, offering critical guidance for the rational design of HEOs for energy storage.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Fangmin Wu,Jun Nan,Tianzuo Wang,Zhencheng Ge,Bohan Liu,Meng Chen,Xuesong Ye
The activity and selectivity of the cathode towards electrosynthesis of H 2 O 2 are critical for electro-Fenton process. Herein, nickel-foam modified with N, O co-doped graphite nanosheets (NO-GNSs/Ni-F) was developed as a cathode for highly efficient and selective electrosynthesis of H 2 O 2 . Expectedly, the accumulation of H 2 O 2 at pH= 3 reached 494.2 mg L −1 h −1 , with the selectivity toward H 2 O 2 generation reaching 93.0%. The synergistic effect of different oxygen-containing functional groups and N species on the performance and selectivity of H 2 O 2 electrosynthesis was investigated by density functional theory calculations, and the combination of epoxy and graphitic N (EP + N) was identified as the most favorable configuration with the lowest theoretical overpotential for H 2 O 2 generation. Moreover, NO-GNSs/Ni-F was applied in the electro-Fenton process for p-nitrophenol degradation, resulting in 100% removal within 15 min with the kinetic rate constant of 0.446 min −1 and 97.6% mineralization within 6 h. The efficient removal was mainly attributed to the generation of bulk ·OH. Furthermore, NO-GNSs/Ni-F exhibited excellent stability. This work provides a workable option for the enhancement of H 2 O 2 accumulation and the efficient degradation of pollutants in electro-Fenton system.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Yingyu Zeng,Xusheng Li,Kailan Yuan,Bo Chen,Wenbao Zhang,Chao Wang,Jianxia Sun,Hosahalli S. Ramaswamy,Weibin Bai
Hydroxyphenyl-pyranoanthocyanins (PACNs), derived from anthocyanins (ACNs) reacted with hydroxycinnamic acids, have higher practical application value because of better physicochemical stability than their precursors. However, the slow formation rate restricted their broader applications. In the present study, cyanidin-3- O -glucoside (C3G) was chosen to react with four kinds of hydroxycinnamic acids in a model solution. Changes of color and the production of hydroxyphenyl-PACNs were monitored. The formation of derivatives was time-dependent, and the orange-yellow changing trend was correlated with the formation of PACNs and the consumption of C3G. In addition, high-pressure processing (HPP) as a widely-used non-thermal processing method in the food industry was conducted to investigate its impact on hydroxyphenyl-PACNs formation. The results showed that HPP significantly improves the yield of two types of hydroxyphenyl-PACNs (C3G-4-vinylcatechol and C3G-4-vinylphenol) and the retention of total residual pigments during 56 days of storage. Therefore, HPP contributed to color-protecting and the transformation of hydroxyphenyl-PACNs.
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高影响因子
危险品化学品经营许可证（带存储）