Cell Death & Disease
·
2018
·Vol. 9
·期 6
·1-14
·
IF 5.638
Tao Liang,Lin Hongfa,Wen Jingjing,Sun Qi,Gao Yan,Xu Xi,Wang Junsong,Zhang Jianfa,Weng Dan
Endoplasmic reticulum (ER) stress contributes to the development and progression of many chronic inflammatory diseases, including type 2 diabetes, obesity, atherosclerosis, neurodegenerative diseases, and cancer. ER stress has been reported to induce inflammasome activation and release of mature IL-1β, which contributes to many inflammatory diseases. The molecular mechanisms that activate the inflammasome during ER stress are still poorly understood. Here we report that the kinase receptor-interacting protein 1 (RIP1) plays an important role in ER stress-induced activation of inflammasome. Inhibition of RIP1 kinase activity by Necrostatin-1 or siRNA-mediated RIP1 knockdown significantly reduced ER stress-induced caspase-1 cleavage and IL-1β secretion in both bone marrow-derived macrophages (BMDMs) and J774A.1 macrophages. We speculate that the mitochondria fission factor dynamin-related protein 1 (DRP1) and reactive oxygen species (ROS) might function as the effectors downstream of RIP1 to mediate inflammasome activation. Our study reveals a critical role for RIP1 in regulating ER stress-induced inflammation responses, and proposes RIP1 as a potential pharmaceutical target to treat diseases resulting from unresolved ER stress-related inflammation.
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DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Jiayin Fu,Ning Zhang,Changfu Xu,Meng Zhao,Shaofei Wu,Shihui Xu,Xulin Hong,Meihui Wang,Guosheng Fu
Synthetic vascular grafts are promising conduits for small caliber arteries. However, due to restenosis caused by intimal hyperplasia, they cannot keep long patency in vivo. In this work, through single cell RNA sequencing, we found that thrombospondin-1 (THBS1) was highly expressed in the regenerated smooth muscle cells (SMCs) in electrospun polycaprolactone (PCL) vascular grafts. The expression of THBS1 by injured SMCs was confirmed in a balloon-induced vascular injury model. Downregulation of Thbs1 expression maintained contractile phenotypes of SMCs and reduced neointimal hyperplasia after vascular injury via inhibition of FGFR1/EGR1 signaling by decreasing THBS1 expression. THBS1 small interfering RNA (THBS1-siRNA) was then loaded into macrophage membrane (MM) hybrid lipid nanoparticles (Lipid NP@MM), which were used to modify PCL vascular grafts via polydopamine (PDA) coatings. Lipid NP@MM not only protected THBS1-siRNA from degradation but also improved its internalization by SMCs to decrease the level of THBS1 expression. PCL vascular grafts modified with PDA coatings and Thbs1-siRNA-loaded Lipid NP@MM showed significantly reduced intimal hyperplasia. Thus, the downregulation of THBS1 expression in regenerated SMCs in vascular grafts is a promising strategy to inhibit intimal hyperplasia during vascular graft regeneration in vivo.
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DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2023
·
IF 5.5
Liu Ting,Yang Guanghua,Ma Juan,Zhang Huimin,Zhang Min,Chang Aimin
The development of negative temperature coefficient (NTC) thermistor materials with a wide range of operating temperatures, high resistance (R), low thermal content (B) and good stability is significant for improving the overall performance of NTC thermistors. Traditional NTC thermistors materials are of the spinel, however, their practical applications are commonly limited to temperatures below approximately 200°C.In this study, it was found that a novel perovskite-structured solid solution (1-x)Bi0.2Sr0.5La0.3TiO3-xLaMnO3 (0.05 ≤ × ≤ 0.2) (BSLT-LM) showed good NTC performance from room temperature to high temperature (600°C) due to the stable structure at high temperatures. The ρ25, ρ100, ρ600 and B25/100, B25/600 constants of Bi0.2Sr0.5La0.3TiO3-0.1LaMnO3 NTC thermistors are approximately 1.76 × 108 Ω cm, 1.13 × 107 Ω cm, 9.89 × 102 Ω cm, 4063.91 K, 5472.34 K, respectively. The electrical conductivity of these solid solution refers to the electronic transition between Mn3+ and Mn4+, and oxygen vacancies. These results demonstrate the tremendous potential of perovskite-structured (1-x) Bi0.3Sr0.5La0.2TiO3-xLaMnO3 thermistor ceramics with NTC performance.
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高影响因子
AICHE JOURNAL
·
2020
·Vol. 66
·期 5
·e16917
·
IF 3.519
Bofeng Zhang,Yajie Tian,Dali Chen,Ling Li,Guozhu Li,Li Wang,Xiangwen Zhang,Guozhu Liu
Multimetallic nanocatalysts have attracted increasing attention for steam reforming owing to highly exposed active sites, but often suffering from severe sintering. Herein, we design subnanometric Ni-Pt bimetal clusters (ca. 1.7 nm) encapsulated in Silicalite-1 zeolite (2Ni0.5Pt@S-1) through ligand-stabilized method to prevent sintering by fixing the metal into microporous channels. In the steam reforming of n -dodecane test, 2Ni0.5Pt@S-1 gave an excellent activity and stability with a decrease of conversion only 4% at 600°C for 4 hr, which was about a quarter that of 2Ni0.5Pt/S-1 synthesized by co-impregnation method, ascribing to superior sinter-resistance of encapsulation structure. Moreover, 2Ni0.5Pt@S-1 exhibited a higher H 2 selectivity up to 69.9% than that of 2Ni0.5Pt/S-1 (64.4%), owing to suppressed methanation reaction based on subnanometric clusters. Shape-selective steam reforming of n -dodecane and ofm -xylene was also observed, because of m -xylene could hardly diffuse into the zeolite channels due to its bulky molecular size, further preventing potential deactivation by tars in reforming process.
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JOURNAL OF POROUS MATERIALS
·
2024
·Vol. 31
·期 3
·793-808
·
IF 2.5
Yang Zhaosheng,Tang Guoqiang,Li Yichuan,Niu Xiaoyue,Cheng Lingyao,Chai Yongming
TS-1 molecular sieve spherical membranes loaded on small-sized carriers with hierarchical pore structures and high framework-titanium contents could both exhibit high catalytic performances and facilitate the separation from the products after the reaction. In this paper, a simple in situ static crystallization method was used to achieve the construction of hierarchical porous TS-1 molecular sieve membranes on the surfaces of 400-µm spherical ZrO 2 carriers using cetyltrimethylammonium bromide (CTAB) and soluble starch as mesoporous templating agents. Through the catalyst characterization and performance evaluation, soluble starch was finally selected as the mesoporous templating agent, and the film-forming mechanism was investigated by examining the effects of the proportion of precursor liquid and the crystallization conditions. In the chloropropene epoxidation reaction, the effective utilization of H 2 O 2 and the selectivity of epichlorohydrin (ECH) reached 96.72% and 93.85%, respectively.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Dongyi Cao,Ruiying Xi,Hongye Li,Zhonghui Zhang,Xiaoke Shi,Shanshan Li,Yujie Jin,Wanli Liu,Guolin Zhang,Xiaohua Liu,Shunxi Dong,Xiaoming Feng,Fei Wang
Caspase-1 plays a central role in innate immunity, as its activation by inflammasomes induces the production of proinflammatory cytokines and pyroptosis. However, specific inhibition of the enzymatic activity of this protease is not effective in suppressing inflammation, owing to its enzyme-independent function. Herein, we identified a cyclohexenyl isothiocyanate compound (CIB-1476) that potently inhibited caspase-1 activity and suppressed the assembly and activation of the NLRP3 inflammasome and gasdermin-D-mediated pyroptosis. Mechanistically, CIB-1476 directly targeted pro-caspase-1 as an irreversible covalent inhibitor by binding to Cys285 and Cys397, resulting in more durable anti-inflammatory effects in the suppression of enzyme-dependent IL-1β production and enzyme-independent nuclear factor κB activation. Chemoproteomic profiling demonstrated the engagement of CIB-1476 with caspase-1. CIB-1476 showed potent therapeutic effects by suppressing inflammasome activation in mice, which was abolished in Casp1–/– mice. These results warrant further development of CIB-1476 along with its analogues as a novel strategy for caspase-1 inhibitors.
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Guojun Lv,Yan Chen,Xuyang Zou,Jiangzhang Wang,Tao Wang,Xubin Zhang,Fumin Wang
There are few reports concentrated on the interactions between lipophilic surfactants and hydrophobized hollow TS-1 zeolite particles in the stabilization of emulsions. In this study, hydrophobized hollow TS-1 zeolite particles were synthesized and applied as emulsifier to stabilize the W/O Pickering emulsions employing cyclohexanone and water, and the influence of addition of lipophilic Span 80 on the stability of the W/O Pickering emulsions was systematically studied. Surprisingly, a phase inversion was induced by simply changing the Span 80 concentration. At fixed concentration of TS-1 zeolite particles (2 wt%), emulsions are water in oil (W/O) when the concentration of Span 80 is lower than 0.5 mM. Then the emulsions invert to oil in water (O/W) when the Span 80 concentration is between 1 mM and 8 mM. In this process, different emulsifiers dominate the composition of the interfacial layer, and the emulsion type is correspondingly controlled. When Span 80 concentration is lower than 0.5 mM, hydrophobized hollow TS-1 zeolite particles are in domination, and W/O emulsions are obtained. At Span 80 concentration of 1–8 mM, the emulsions are stabilized mainly by Span 80, and the emulsion type is O/W.
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高影响因子
LANGMUIR
·
2021
·
IF 3.882
Liang Pan,Guoxi Li,Zhaoyang Wang,Dongbao Liu,Weikang Zhu,Chunyi Tong,Rilong Zhu,Shilin Hu
To reduce the corrosion of Q235 steel, environment-friendly and efficient N-doped carbon dots (N-CDs) were synthesized using 4-amino salicylic acid (4-ASA) and l-histidine (l-His) as precursors. The corrosion inhibition behavior of N-CDs for Q235 steel in 1 M HCl solution was systematically investigated using a weight-loss experiment, an electrochemical test, and corrosion morphology. Results showed that N-CDs could effectively inhibit the corrosion of Q235 steel, and the inhibitory efficiency reached 93% at 50 mg L–1. Quantum chemistry and molecular dynamics were used to study the inhibition mechanism of N-CDs. The results demonstrated that N-CDs exhibited a strong adsorption force on metal and the adsorption process followed the Langmuir adsorption isotherm, indicating physical/chemical mixed adsorption.
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CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Alimujiang Yalikun,Yanhong Wang,Nian Shi,Yiwen Chen,Hao Huang,Hyun-Joo Koo,Zhongwen Ouyang,Zhengcai Xia,Reinhard K. Kremer,Myung-Hwan Whangbo,Hongcheng Lu
We prepared a new polar layered quantum magnet Ba2Cu3(SeO3)4F2, by a combined use of F– and pyramidal SeO32– anions, determined its crystal structure by X-ray diffraction, and characterized its magnetic properties by magnetization, electron spin resonance (ESR) and specific heat measurements, and by density functional theory calculations. The title compound has first experimentally reported bitriangular chains of Cu2+ ions aligned along the b direction to form layers parallel to the ab plane, and these layers are separated by Ba2+ ions. The magnetic susceptibility data reveal that, despite strong predominant antiferromagnetic intrachain interactions indicated by the large negative Weiss temperature θ of −143.9 K within bitriangular chains, no long-range order occurs down to 2 K. The latter, further confirmed by the specific heat measurements, is attributed to the extremely weak interlayer interaction. The spins in each bitriangular chain become ferrimagnetically ordered to exhibit a 1/3-magnetization plateau, which persists at least up to 30 T. This reveals that each bitriangular chain acts as an S = 1/2 entity at low temperatures, as observed from the decrease of the effective magnetic moment Peff from 3.67 μB in the high temperature range to 1.89 μB in the low temperature range, equivalently, from three free Cu2+ ions to only one effective Cu2+ ion per formula unit. In each layer of Ba2Cu3(SeO3)4F2, the interaction between adjacent ferrimagnetic chains is ferromagnetic rather than antiferromagnetic, contrary to the observations in other reported cases.
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INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Qian Zhao,Changzhong Liao,Guangyuan Chen,Ruixi Liu,Zeru Wang,Anhu Xu,Shiyin Ji,Kaimin Shih,Lin Zhu,Tao Duan
Effective capture of radioactive iodine is highly desirable for decontamination purposes in spent fuel reprocessing. Cu-based adsorbents with a low cost and high chemical affinity for I2 molecules act as a decent candidate for iodine elimination, but the low utilization and stability remain a significant challenge. Herein, a facile in situ confined synthesis strategy is developed to design and synthesize a copper-encapsulated flaky silicalite-1 (Cu@FSL-1) zeolite with a thickness of ≤300 nm. The maximum iodine uptake capacity of Cu@FSL-1 can reach 625 mg g–1 within 45 min, which is 2 times higher than that of a commercial silver-exchanged zeolite even after nitric acid and NOX treatment. The Cu nanoparticles (NPs) confined within the zeolite exert superior iodine adsorption and immobilization properties as well as high stability and fast adsorption kinetics endowed by the all-silica zeolite matrix. This study provides new insight into the design and controlled synthesis of zeolite-confined metal adsorbents for efficient iodine capture from gaseous radioactive streams.
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yong Lu,Huixia Feng,Hou Xia,Wu Hai Xia
Polyaniline has a wide application in the field of corrosion protection, the poor solubility of polyaniline limited its application as a corrosion inhibitor. Water-soluble carboxymethyl cellulose -polyaniline composites was synthesized by chemical oxidation polymerization in a mild way without other inorganic or organic acids added. Corrosion inhibition performance of composites was evaluated for Q235 steel corrosion in 1 M HCl corrosive solution using weight loss and electrochemical measurements at various concentrations. The results show that carboxymethyl cellulose -polyaniline composites exhibit good inhibition properties and the remarkable increase in inhibition efficiency, i.e., 94.24% is achieved while the maximum concentration of the experiment is 1000 ppm. The composites in corrosive solution suppress the cathodic hydrogen evolution reactions and anodic metal dissolution of the substrate. Adsorption of the inhibitor on the steel surface follows a Langmuir adsorption isotherm.
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高影响因子
Current Nanoscience
·
2024
·Vol. 21
·期 4
·757-765
·
IF 1.4
Zirui Liu,Dan Li,Baofeng Zhao,Xifan Mei
BackgroundGouty arthritis, characterized by excruciating pain and discomfort, poses a significant burden on patients. While nanomedicines have shown promise in addressing this ailment, their complicated synthesis processes often involve potentially toxic procedures, contributing to adverse side effects in disease management.MethodsIn this study, we introduce a straightforward and elegant solution by utilizing easily prepared gold platinum (AuPt) nanoparticles for the treatment of gouty arthritis. The synthesis of these nanoparticles involves the use of gold and platinum precursors in conjunction with NaBH4, simplifying the manufacturing process. Experimental models of gout were established in both in vivo and in vitro settings through lipopolysaccharide and monosodium urate crystal induction.ResultsOur findings revealed that AuPt nanoparticles exhibited potent anti-inflammatory effects against gout. This effect was attributed to their ability to activate the Nrf2/HO-1 pathway, resulting in pain alleviation and the inhibition of inflammation, ultimately leading to the reduction of joint edema. With their uncomplicated synthesis and promising therapeutic potential, these simply prepared AuPt nanoparticles emerge as a compelling candidate for pharmaceutical intervention in the treatment of gouty arthritis.ConclusionThis approach not only holds the promise of delivering effective relief to patients but also minimizes the risk of unwanted side effects associated with complex nanomedicine synthesis processes.
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