ACS Applied Bio Materials
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2019
·
IF 0
Yuan-Fu Ding,Tianlei Sun,Shengke Li,Qiaoxian Huang,Ludan Yue,Liangkui Zhu,Ruibing Wang
Orally administered colon-targeted formulations of drugs are of great importance in managing diseases in the colon. However, it is often challenging to maintain the integrity of such formulations during delivery, particularly in the gastric environment, which may lead to premature drug release before reaching the targeted colon. Herein, an oral colon-targeted drug delivery hydrogel (OCDDH) was developed through cucurbit[8]uril (CB[8])-mediated noncovalent cross-linking of phenylalanine (Phe)-modified Konjac glucomannan (KGM), in which berberine (BBR), a natural anti-inflammatory product originating from Chinese medicine, was loaded into the hydrogel matrix. With the strong host–guest complexation mediated cross-linking and the inherent reversibility of such interactions, KGM-Phe@CB[8] hydrogel exhibited a readily tunable degree of cross-linking and an excellent self-healing capability, and therefore the hydrogel retained ultrahigh stability in the gastric environment, which is important for orally administered formulations to target the colon. In the colon, KGM may get degraded by colon-specific enzymes, β-mannanase or β-glucosidase, resulting in burst release of the loaded cargoes on site. The structure and specific payload release of the hydrogel, with and without BBR, have been fully characterized in vitro, and the therapeutic effect of BBR-loaded KGM-Phe@CB[8] hydrogel was evaluated against dextran sulfate sodium (DSS) induced ulcerative colitis (UC) in a mouse model. Very interestingly, the BBR-loaded KGM-Phe@CB[8] hydrogel exhibited significantly improved therapeutic efficacy in treating colitis, without causing any systemic toxicity, when compared with free BBR. This strategy may pave a new way in the development of advanced supramolecular OCDDH.
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PubMed
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Gongduan Fan,Xiaomei Zheng,Jing Luo,Huiping Peng,Hui Lin,Minchen Bao,Liang Hong,Jinjin Zhou
The presence of acetaminophen (ACT) used for painkillers has attracted great attention in the world, which have potentially adverse effects on aquatic lives and human beings. Advanced oxidation technology applied to water repair has received increasing concerns in recent years. In this study, photodegradation ACT in aqueous solution over Ag/AgCl@ZIF-8 synthesised by a simple stirring method was investigated under visible light irradiation. The prepared photocatalyst was characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (SEM) and UV-visible diffuse reflectance spectra (UV-vis). The degradation rates of ACT under different parameters were studied to get the optimal operating conditions in water. Results showed that the photodegradation process fitted pseudo-first order model well. 99% ACT degradation achieved when Ag/AgCl@ZIF-8 was delivered to the solution compared with ZIF-8 and Ag/AgCl with the maximum value of constant ( k app ). The degradation rate obviously slowed down when the initial concentration of ACT increased to 2 mg/L while it increased with the increasing of dosage of photocatalyst. In contrast, pH has little effect on the degradation of ACT over Ag/AgCl@ZIF-8. The Ag/AgCl@ZIF-8 showed high efficiency for degradation after three repeated cycles which demonstrated the prepared photocatalyst has high stability. The O 2 − turned out to be the main active group during the photodegradation process responsible for the disappearance of ACT. Intermediate products analysis results by LC-MS showed that photolysis was the first step of photocatalytic degradation for ACT followed by a ring cleavage.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2015
·
IF 4.321
Ziwei Zhang,Fang Wang,Weiben Yang,Zhen Yang,Aimin Li
In this study, a novel macroporous amination resin (named as GMDA) with the matrix of divinylbenzene and glycidyl methacrylate was synthesized and utilized to remove 8-amino-1-naphthol-3,6-disulfonic acid (H-acid) from water. The adsorption behaviors of the synthetic resin were studied systematically and compared with three commercial resins (the hypercrosslinked resin NDA-88, the anion-exchange resin D-301, and the macroporous resin XAD-4) in terms of adsorption capacity, equilibrium time, isotherm adsorption , the effect of existing inorganic ions and regeneration properties. The characteristic methods of BET surface area, pore size distribution, SEM , FTIR , XPS and Zeta potential were investigated to analyze the resins and adsorption process . The GMDA resin has wider pore diameter than the NDA-88 resin to attract H-acid more quickly with higher adsorption amounts; the larger BET surface area of the GMDA resin ensures more binding sites than the D-301 resin in the adsorption process; the functional groups on the surface of the GMDA resin is more effective than the hydrophobic matrix of the resin XAD-4 in the removal of H-acid. Especially, the regeneration and dynamic experiments indicate the anti-fouling performance of GMDA resin is much better than the others. This research not only provides guidance for understanding the adsorption mechanism of H-acid onto the four resins, but also gives theoretical basis for the design of resin structure according to the targeted contaminants.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2014
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IF 2.045
Kelei Zhuo,Hao Ren,Yujing Wei,Yujuan Chen,Jingjing Ma
Activity coefficients of the 1-alkyl-3-methylimidazolium bromide [Cnmim]Br (n = 3 to 8) ionic liquids (ILs) in fructose + water mixed solvents at 298.15 K were determined by cell potential measurements. The molalities of [Cnmim]Br ranged from (0.005 to 0.1) mol·kg–1 and those of fructose from (0.2 to 0.8) mol·kg–1. Gibbs free energy interaction parameters were also obtained together with salt constants. The interactions between [Cnmim]Br and fructose are mainly controlled by electrostatic interactions. Gibbs free energy interaction parameters (gES) and salting constants (kS) are negative for the ILs (n = 3 to 6), indicating fructose are salted-in by the ILs in water, whereas fructose are salted-out by the ILs (n = 7 and 8).
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2013
·
IF 3.473
Lijie Sun,Yuyuan Yao,Lie Wang,Yajun Mao,Zhenfu Huang,Daichuan Yao,Wangyang Lu,Wenxing Chen
The development of a pH-tolerant Fenton-like catalyst is an active and challenging project in water treatment. In this study, activated carbon fibers (ACFs) supported 8-hydroxyquinoline ferric (QuFe) has been reported as a heterogeneous Fenton-like catalyst (QuFe@ACFs) for efficient removal of dyes. The catalyst possessed remarkable catalytic performance across a wide range of pH values (3–9). Moreover, it also presented excellent sustained catalytic ability and regeneration capability in the experiments, causing reducing secondary contamination. Importantly, with the introduction of ACFs, QuFe@ACFs exhibited a greatly enhanced catalytic activity in comparison with bare QuFe. The hydroxyl radicals ( OH) are confirmed as the active species in QuFe@ACFs/H 2 O 2 system by the use of electron paramagnetic resonance (EPR) and fluorescence spectra. In addition, the central composite design (CCD) matrix and response surface methodology (RSM) were applied in designing the experiments for evaluating the interactive effects of temperature, pH, initial dye concentration and catalyst dosage. This study not only opens a novel avenue for designing pH-tolerant heterogeneous Fenton-like catalyst, but also provides a viable process for efficient elimination of dyes effluent.
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高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2015
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IF 2.979
Hui Liu,Yong-Sheng Wang,Xian Tang,Hui-Xian Yang,Si-Han Chen,Hui Zhao,Shan-Du Liu,Yu-Feng Zhu,Xiao-Feng Wang,Yan-Qin Huang
A sensitive, lable-free and low cost fluorescence aptasensor was developed for detecting 8-hydroxy-2′-deoxyguanosine (8-OHdG) by using 8-OHdG aptamer (Apt) as a recognition probe and N-methyl mesoporphyrin IX (NMM) as a reporter. The method is based on the conformational switching of a K + -stabilized G-quadruplex to a 8-OHdG-stabilized one. NMM can selectively bind to K + -stabilized G-quadruplex instead of 8-OHdG-stabilized one. The addition of 8-OHdG in the solution of Apt - K + ions leads to a sharp change in fluorescence intensity, which showed a good linear response toward 8-OHdG concentration ranging from 3.96 nM to 211 nM with a detection limit of 1.19 nM. The relative standard deviation and the recovery were 1.23–3.26% ( n = 11) and 94.8–106.7%, respectively. The proposed aptasensor consists of only an aptamer probe and a specific dye NMM, avoiding the complex and expensive labeling procedure. Thus it is much cheaper and more applicable.
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PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2014
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IF 2.063
Wenlu Guo,Xiangguo Meng,Yan Liu,Liang Ni,Zhaoyong Hu,Rui Chen,Minjia Meng,Yun Wang,Juan Han,Min Luo
The new 8-hydroxyquinoline (8-HQ) modified magnetic mesoporous carbon (8-HQ-Ni-CMK-3) was prepared and applied for adsorption of multivariate metal ions from aqueous solution. The prepared adsorbent was characterized by Fourier transform infrared, X-ray diffraction, scanning electron microscopy, transmission electron microscope, nitrogen adsorption-desorption isotherm, elemental analysis, and vibrating sample magnetometer. The static adsorption behaviors toward multivariate metal ions on graphite, the modified graphite by 8-HQ, magnetic mesoporous carbon, and 8-HQ-Ni-CMK-3 were compared, which showed that 8-HQ-Ni-CMK-3 had excellent adsorption capacity. The removal of multivariate metal ions using 8-HQ-Ni-CMK-3 by fixed-bed column was further investigated.
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高影响因子
ANALYTICAL BIOCHEMISTRY
·
2014
·
IF 2.305
Hui Liu,Yong-Sheng Wang,Jia-Cheng Wang,Jin-Hua Xue,Bin Zhou,Hui Zhao,Shan-Du Liu,Xian Tang,Si-Han Chen,Ming-Hui Li,Jin-Xiu Cao
A highly sensitive, low-cost colorimetric aptasensor was developed for the determination of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in human urine. The method is based on a conformational switching of the 8-OHdG aptamer to form a G-quadruplex structure in the presence of 8-OHdG. The resulting G-quadruplex assembles into a peroxidase-like DNAzyme with hemin , which effectively catalyzes the oxidation of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS 2− ) by H 2 O 2 to ABTS + , resulting in an increase in the absorption signal at 416 nm along with a color change of the solution. The response signals linearly correlated with the concentration of 8-OHdG, ranging from 466 pM to 247 nM with a detection limit of 141 pM. The relative standard deviation and the recovery were 1.97–3.47% ( n = 11) and 98.8–100.2%, respectively. The proposed method avoids the label and derivatization steps in common methods and allows direct analysis of the samples by the naked eye without costly instruments, which is reliable, inexpensive, and sensitive.
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PubMed
高影响因子
PLoS One
·
2015
·Vol. 10
·期 9
·e0137066
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IF 3.234
Yan Zhang,Junling Shi,Laping Liu,Zhenhong Gao,Jinxin Che,Dongyan Shao,Yanlin Liu
Pinoresinol diglucoside (PDG) and pinoresinol (Pin) are normally produced by plant cells via the phenylpropanoid pathway. This study reveals the existence of a related pathway in Phomopsis sp. XP-8, a PDG-producing fungal strain isolated from the bark of the Tu-chung tree ( Eucommiaulmoides Oliv.). After addition of 0.15 g/L glucose to Phomopsis sp. XP-8, PDG and Pin formed when phenylalanine, tyrosine, leucine, cinnamic acid, and p -coumaric acid were used as the substrates respectively. No PDG formed in the absence of glucose, but Pin was detected after addition of all these substrates except leucine. In all systems in the presence of glucose, production of PDG and/or Pin and the accumulation of phenylalanine, cinnamic acid, or p -coumaric acid correlated directly with added substrate in a time- and substrate concentration- dependent manner. After analysis of products produced after addition of each substrate, the mass flow sequence for PDG and Pin biosynthesis was defined as: glucose to phenylalanine, phenylalanine to cinnamic acid, then to p -coumaric acid, and finally to Pin or PDG. During the bioconversion, the activities of four key enzymes in the phenylpropanoid pathway were also determined and correlated with accumulation of their corresponding products. PDG production by Phomopsis sp. exhibits greater efficiency and cost effectiveness than the currently-used plant-based system and will pave the way for large scale production of PDG and/or Pin for medical applications.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2014
·
IF 2.235
Lu Lin,Tong Zhang,Xiongfu Zhang,Haiou Liu,King Lun Yeung,Jieshan Qiu
In this work, we fabricated a new type of Pd/SiO2@ZIF-8 core–shell catalyst composed of a Pd/SiO2 microsphere as the core and a ZIF-8 membrane as the shell. The preparation procedure involves first loading Pd nanoparticles onto nonporous SiO2 microspheres to obtain the Pd/SiO2 core and then coating a perfect layer of ZIF-8 shell on the core by electrostatic induction to form a Pd/SiO2@ZIF-8 core–shell structure. It is crucial that the modification of the Pd/SiO2 core with polyelectrolyte was employed to improve the charge distribution of the core surface and preferably adsorb Zn2+ cations in the synthesis solution so as to assist the formation of a continuous ZIF-8 shell. The compactness and thickness of the shell were optimized by increasing the number of cycles of ZIF-8 growth. The hydrogenations of alkenes with different molecular sizes showed that the Pd/SiO2@ZIF-8 catalysts can provide excellent product selectivity and antipoisoning and antileaching properties for the hydrogenations of alkenes.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Lu Lin,Haiou Liu,Xiongfu Zhang
MOFs-based yolk-shell composites are newly-presented but promising catalysts in the area of catalysis. In this work, a kind of unique rattle-type Pd/ZnO@hollow ZIF-8 yolk-shell catalyst is developed via a ZnO-template approach, in which there exist two processes of both ZnO-induced ZIF-8 formation and ZnO dissolution. Of prime importance is that ZnO was selected as the sacrificial template since it can not only be etched in the solution of ligands but also assist the formation of compact ZIF-8 shell by providing nucleation sites via linker activation. It is also proposed that sufficient amount of Zn(NO 3 ) 2 ·6H 2 O and 2-methylimidazole added in the growth solution of ZIF-8 should accelerate the outward growth of ZIF-8 layer as well as dissolution of ZnO. This way, the final construction of Pd/ZnO@hollow ZIF-8 yolk-shell materials is achieved. Compared to the Pd/ZnO counterparts, Pd/ZnO@hollow ZIF-8 rattle-type catalysts demonstrate a promoted behavior in terms of size-selectivity for the liquid hydrogenations of alkenes due to the outer ZIF-8 shell acting as a molecular sieve. It can also protect the catalytically active Pd NPs from poisoning and leaching, giving rise to an excellent stability. Moreover, the yolk-shell catalysts manifest a better activity beyond their core-shell counterparts since the presented interior hollow space between core and shell is likely to expose more active surfaces to reactants.
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 50
·31365-31371
·
IF 3.108
Rong-Mei Kong,Yan Zhao,Yiqun Zheng,Fengli Qu
Zeolitic imidazolate frameworks (ZIF) are attracting considerable attention for their applications in adsorbents/separation as well as catalysis. In this article, we proposed a simple strategy to fabricate semiconductor–ZIF core–shell nanocomposites, which exhibited remarkable coherent function for adsorption and photocatalytic degradation of organic pollutants. The current nanocomposites were composed of ZnO/CdS and ZIF-8, where spindle-like ZnO nanoparticles not only acted as the seeding material but also worked as the Zn2+ source for the formation of ZIF-8. The as-prepared ZnO/CdS@ZIF-8 core–shell nanocomposites displayed distinct photocatalytic activity for methylene blue (MB) and rhodamine B (RhB) owing to the unique pore structure and thus absorption effect of the ZIF-8 shell. To this end, the ZnO/CdS@ZIF-8 core–shell nanocomposites could find important applications in photocatalytic degradation of pollutants.
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高影响因子
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