CHEMICAL ENGINEERING SCIENCE
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2026
·
IF 5.1
Yingrun Wang,Yanhui Zheng,Zichuan Ma
Siloxanes are detrimental trace impurities that can severely impair the performance and operational efficiency of biogas combustion systems, making their effective removal essential. Given the relatively high concentration of cyclic siloxanes and their susceptibility to acid-catalyzed ring-opening polymerization, a combined adsorption–polymerization approach on a solid acid adsorbent may offer higher removal efficiency compared to conventional adsorption methods. In this work, we employed activated carbon as a support and fabricated sulfuric acid-supported activated carbon (CSA) via a simple impregnation method. This study represents the first systematic investigation of the synergistic adsorption and acid-catalyzed polymerization of decamethylcyclopentasiloxane (D5) using this material. The activated carbon function as an adsorbent, providing mass transfer channels for D5, whereas the supported sulfuric acid serves as a catalyst to promote its ring-opening polymerization. Dynamic adsorption tests showed that CSA exhibited a high D5 removal capacity, with a theoretical maximum capacity ( Q m, th ) of 3219.7 mg g −1 at 0 °C. A series of characterizations, kinetic interpretation, mass balance analysis and density functional theory (DFT) calculations were also conducted to elucidate the potential adsorption/polymerization mechanisms responsible for D5 removal. The results confirmed that the formation of highe-molecular-weight polysiloxane structures on the CSA surface imparted a high degree of hydrophobicity to the spent CSA material. These findings highlight the potential of CSA as a cost-effective and practical solution for siloxane removal.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123828
·
IF 7.5
Ziyi Ding,Qingze Chen,Haoyang Fu,Fangxin Deng,Yanping Zhu,Yunfei Xi,Runliang Zhu
Dechlorination and valorization of waste polyvinyl chloride (PVC) are vital for environmental sustainability, but conventional hydrothermal methods struggle to simultaneously achieve efficient dechlorination and the production of value-added products. Herein, we exploit the dual reactivity of magnetite to concurrently drive dechlorination and carbonization, enabling one-step hydrothermal conversion of PVC into a heterogeneous Fenton catalyst. As an electron donor and provider of solid acid sites, magnetite can synergistically promote the cleavage of C-Cl bonds in PVC during hydrothermal processes through both reductive dechlorination and catalytic hydrolysis pathways, with a high dechlorination efficiency of 96.2∼98.9%. Moreover, affected by these two enhanced dechlorination pathways, PVC-derived hydrochar exhibits a higher graphitization degree and a larger oxygen-containing functional group content than the control (without magnetite). Besides, magnetite inhibits PVC melting agglomeration to reduce particle size, and facilitates the carbonization of organic intermediates, thereby increasing the carbon yield of hydrochar from 74.7% to 97.3%. The resulting composite exhibited efficient heterogeneous Fenton catalytic activity for Bisphenol A degradation, particularly achieving a 97% degradation efficiency within 30 min when natural magnetite was employed. This research could provide valuable insights into the chemical recycling of chlorinated plastics, helping to reduce environmental pollution and promote the efficient utilization of products.
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Nature Communications
·
2026
·
IF 18.1
Chen Yini,Ke Jingwen,Ye Wenbin,Zhou Yuxuan,Song Lei,Hu Weizhao,Geng Zhigang,Hu Yuan
The seawater contains approximately 99% of Earth’s bromide reserves. Therefore, the extraction of bromine from the seawater offers a promising approach to ensure a sustainable supply of bromine. However, the traditional electrochemical extraction method for direct bromine extraction are inapplicable, owing to the low concentration of bromide in seawater (~60 ppm). In this work, we develop an electrolysis-driven styrene enrichment process for efficient bromide recovery from seawater. As for the electrooxidation of bromide, we screen a series of metal phthalocyanines supported on carbon nanotube as the electrocatalysts. Through accelerating the bromine evolution reaction and suppressing the side reaction, nickel phthalocyanine supported on carbon nanotubes exhibit the highest activity with the Faradic efficiency of 97.8% for bromine production among all catalysts. Coupling this catalyst with the ESE process for direct bromine extraction from the Yellow Sea’s seawater, the extraction efficiency of 90.0% is achieved with the product of pure KBr powder. Moreover, the co-produced styrene oxide can be efficiently separated via vacuum distillation, significantly promoting the economic value of this ESE process.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2026
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IF 2.5
Pengcheng Rao,Tairan Zhang,Ju Li,Weideng Wei,Xiaoqiang Xia,Qianming Chen,Xiaoping Xu,Xiaodong Feng
Cisplatin-based chemotherapy responses are highly heterogeneous across cancers, with the mechanisms governing drug sensitivity remaining incompletely understood. Using genome-wide CRISPR-Cas9 knockout screening, we systematically characterized regulators of cisplatin response and uncovered a counterintuitive finding: mTOR inhibition promotes cisplatin tolerance, contradicting the canonical view that PI3K-AKT-mTOR activation confers chemoresistance. Mechanistically, both mTOR suppression and cisplatin treatment converge to activate cytoprotective autophagy, which enhances cancer cell survival under therapeutic stress. The amino acid transporter SLC7A5 was identified and validated as a key integrator of the mTOR-autophagy axis that modulates cisplatin sensitivity. SLC7A5 expression positively correlates with cisplatin sensitivity across cancer cell lines, and its downregulation is associated with cisplatin resistance in multiple cancer types, supporting its potential as a mechanistically grounded predictive biomarker. Translationally, leucine supplementation sensitizes cancer cells to cisplatin in an SLC7A5-mTOR-autophagy-dependent manner. Collectively, our study defines a novel mTOR-autophagy adaptive loop governing cisplatin tolerance, positions SLC7A5 as a central regulatory node with both biomarker and therapeutic target value, and proposes leucine supplementation as a simple, translatable strategy to improve cisplatin efficacy in SLC7A5-expressing tumors.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Biaobiao Wang,Haoyu Wang,Xingbo Yu,Sitong Wu,Xing Guo,Jianlong Ji,Shengbo Sang,Chuangang Zhou,Dong Zhao,Deliang Shen
Integrates FeGa magnetostrictive effect to eliminate gravity induced interference and amplify film deformation for enhanced biosensor sensitivity. • Employs detection antibody based dual signal amplification, achieving a low NT-proBNP LOD of 0.01 pg/mL in PBS. • Exhibits stable linear ranges (0.01–1.5 pg/mL and 1.6–15 pg/mL) and high recoveries (96%–106%) in pooled saliva. • This product exhibits excellent anti-interference performance and long-term stability for non-invasive heart failure diagnosis. While the low concentration of salivary N-terminal pro-B-type natriuretic peptide (NT-proBNP) has hindered its use in early diagnosis and monitoring of heart failure (HF), its non-invasiveness and convenience are favored by many. In this study, a biosensor based on multi field coupling and sandwich immunoassay with matched capture and detection antibodies has been developed for high-sensitivity detection of NT-proBNP. Based on the magnetostrictive effect of Fe Ga alloy under magnetic field, the gravity interference of the sensitive layer in traditional sensors is eliminated, the deformation of the thin film is amplified, and the sensitivity of the sensor is improved. In addition, by adding detection antibodies to achieve secondary binding of antigens and antibodies, the surface stress is further amplified, reducing the detection limit of the sensor to 0.01 pg/mL. In addition, the accurate detection of NT-proBNP in pooled saliva samples (PSS) indicates that the prepared biosensor has good practicality. All these results show that the multi field coupling and the dual-antibody sandwich strategy contributes to improving the performance of the biosensors and provides a platform for high-sensitivity detection of clinical biomarkers. Download: Download high-res image (144KB) Download: Download full-size image
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ACS Omega
·
2026
·Vol. 11
·期 31
·46382-46390
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IF 5.2
Wang Yu-Ting,Su Pengcheng,Zhang Kang,Xu Duolin,Chen Wenhui,Zhang Mengyan,Tang Hongwei,Li Yihui
Ammonium vanadates (NVO) have presented great potential
in serving
as host materials for ammonium ions, yet they are still impeded by
sluggish ammonium-ion kinetics. Herein, an interlayer cation-modulation
strategy is proposed to promote the ammonium-ion storage capability
of the NH 4 V 3 O 8 cathode. By rationally
modulating the number of interlayer ammonium ions, the proposed NVO
possesses an expanded interlayer distance and weakened electrostatic
repulsion between the stored NH 4 + and the NVO
host, resulting in enhanced performance in both the three-electrode
system and full-cell system. This work is anticipated to boost the
application potential of NVO cathodes in aqueous ammonium-ion batteries.
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Nanomaterials
·
2026
·Vol. 16
·期 12
·715
·
IF 4.8
Wendi Xu,Jia Zhang,Junjie Xie,Tianzhu Xu,Jia Wu,Hong Wang
Physical unclonable function (PUF) based on intrinsic device randomness has emerged as promising hardware security primitives, yet combining secure encryption with neuromorphic recognition within a single device platform remains challenging. Here, we demonstrate a photosensing PUF based on an intrinsically random SnTe memristor capable of both image encryption and memristive neural network recognition. The SnTe memristor, fabricated with an In2O3:SnO2/SnTe/Nb:SrTiO3structure, exhibits stable resistive switching and stable retention exceeding 4000 s. Synaptic biomimetic behaviors including learning-experience emulation, short-term plasticity and long-term plasticity are also realized. Notably, the device displays pronounced optical sensitivity that produces stochastic photocurrent fluctuations originating from unavoidable device-to-device variations under illumination. By quantizing these random photocurrents, an encryption key stream is generated and utilized for image scrambling and diffusion. A memristive neural network is constructed to classify the encrypted images, achieving a recognition accuracy of 95.1% with a loss of 0.15 after 300 training epochs. This work establishes a viable pathway from intrinsic optical randomness to secure neuromorphic computing, highlighting the multifunctional potential of SnTe memristors in integrated hardware security and brain-inspired computation.
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Cell Reports Medicine
·
2026
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IF 14
Qi Liu,Qiqi Xiong,Guanglei Xie,Qidi Chen,Shujie Yang,Yuhang Wu,Liuqi Zhao,Ting Gao,Xinyuan Qiu,Jian Jiang,Xi Wang,Jiawei Shao,Mingqi Xie,Songmin Ying
Gene therapies that selectively eliminate tumor cells within a heterogenous population remain an elusive goal in oncology, largely due to the difficulty to achieve cancer specificity by strict definition. Here, we engineer a therapeutic gene circuit capable of identifying cells that harbor oncogenic gain-of-function aberrations in E26 transformation-specific (ETS) transcription factors. Using a machine learning-guided random forest framework, we develop a cancer-selective promoter P ETS∗ that only activates during ETS overexpression and/or gene fusion events, while remaining inactive under physiological RAF-MEK-ERK signaling or in rapidly proliferating healthy tissues. When delivered using adenoviral vectors, P ETS∗ enables tumor-restricted viral replication in vivo as well as long-lasting tumor suppression and complete survival of treated mice. Specifically, intratracheal delivery of P ETS∗ -driven adenoviruses achieves sustained control of metastatic lung tumors for over 140 days. This work overcomes key barriers of synthetic biology and oncolytic virotherapy and could open up important avenues for future cancer treatment.
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SENSORS AND ACTUATORS A-PHYSICAL
·
2026
·
IF 5.1
Haoshuo Wang,Xianglong Xia,Kezhen Fan,Chenlin Men,Peng Pan,Zhengchun Yang,Rui Zhang,Jie He,Huayi Li
A trilayer porous PDMS sensor with gradient porosity and modulus is developed for pressure sensing. • The sensor achieves a sensitivity of 4.87 kPa⁻¹ over 0–660 kPa with stable cycling performance. • The sensor enables wearable pulse monitoring and dual-channel PTT/PWV detection. Flexible pressure sensors for wearable biomedical applications require high sensitivity, a wide pressure detection range, and long-term mechanical stability. Here, we report a three-layer piezoresistive flexible pressure sensor with a hierarchical architecture and engineered composite materials. The device consists of a dense top layer, an intermediate porous layer, and a highly porous bottom layer based on a PDMS matrix. Conductive carbon fillers were selectively introduced to construct a CNT/CB-assisted conductive network, while ammonium bicarbonate was used as a sacrificial template to create the gradient porous structure. By tuning the ethyl cellulose/dibasic ester content (15 wt% and 7.5 wt%) in different layers, a modulus gradient along the thickness direction is achieved. This trilayer design enables progressive deformation and continuous reconstruction of conductive pathways under pressure, resulting in stable electrical responses over a broad pressure range. The sensor exhibits a sensitivity of 4.87 kPa −1 , calculated from the linear fitting slope of the loading branch over the full pressure range of 0–660 kPa, along with fast response and recovery times of approximately 60 and 80 ms, respectively. Moreover, excellent durability is demonstrated by stable performance over 5000 loading-unloading cycles. Owing to its capability to detect subtle pressure variations, the proposed sensor shows strong potential for wearable biomedical applications, particularly in physiological signal monitoring such as pulse detection. Download: Download high-res image (123KB) Download: Download full-size image
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Qianqian Ouyang,Hongjiao Qu,Weiyan Quan,Yongkai Tang,Xufeng Zhu,Luming Deng,Xian Xie,Kefeng Wu
Microneedle patches have emerged as promising tools for wound repair. However, their clinical utility is limited by poor adhesion and insufficient interfacial stability, which often lead to secondary wound separation and inefficient drug delivery. Here, we report a seaweed-derived bioadhesive microneedle patch that integrates robust tissue adhesion with sustained drug release for effective skin regeneration. The hydrogel patch, composed of chitosan and poly(vinylpyrrolidone) (PVP), absorbs wound exudates and forms mechanically stable adhesion on tissue surfaces. As such, it maintains long-term fixation and protects the wound site. The microneedle array, fabricated via electrostatic interactions between seaweed-derived polysaccharides (contained α -D-Glcp-1→, →4,6)- α -D-Glcp-(1→, and →4)- α -D-Glcp-(1 → units, with a molecular weight of 27,476 Da, named SFP) and chitosan, exhibits rigid, sharp conical tips that enable efficient skin penetration while ensuring strong interfacial adhesion through conformal contact and hydrogen bonding. This intimate microneedle–tissue integration facilitates localized, continuous release of the antibacterial polysaccharide at the wound interface, thereby ensuring sustained therapeutic efficacy. Furthermore, in vivo studies demonstrated accelerated wound closure, enhanced collagen deposition, promoted angiogenesis, and reduced inflammation. Together, these findings establish the seaweed-derived microneedle patch as a multifunctional platform that stabilizes the wound interface, enhances therapeutic delivery, and holds broad potential for diverse biomedical applications.
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CHEMICAL PHYSICS LETTERS
·
2026
·
IF 2.9
Guangling Zuo,Hongyong Ye,Xingda Zhang,Rong Wang,Jia Du,Xin Ding
Photocatalytic hydrogen evolution represents a promising strategy for sustainable energy conversion, yet its efficiency is often limited by the rapid recombination of photogenerated carriers and insufficient redox capabilities. In this work, an S-scheme ZnMn 2 O 4 /CdO (ZMO/CdO) heterojunction was successfully fabricated via a simple solvothermal method to address these challenges. Based on band structure analysis, the composite satisfies the thermodynamic prerequisites for photocatalytic hydrogen evolution. The establishment of an S-scheme charge transfer pathway, driven by the combined effect of an internal electric field (IEF) and band bending, enables photogenerated electrons (e − ) to accumulate in the conduction band (CB) of ZnMn 2 O 4 (ZMO), while holes (h + ) are retained in the valence band (VB) of CdO. This mechanism not only promotes the spatial separation of photogenerated electron–hole pairs (PEHP) but also preserves the strongest redox ability of the system. Under optimized conditions (pH = 8 with triethanolamine (TEOA)), the ZMO/CdO composite achieves an outstanding hydrogen evolution rate of 2237 μmol∙g −1 ∙h −1 , which is approximately 4.38 and 2.84 times higher than that of pure CdO and ZMO, respectively. Moreover, the photocatalyst maintains high hydrogen production activity and structural stability in diverse real water samples, including municipal water, natural surface water, and even wastewater, highlighting its strong potential for practical solar-driven hydrogen production in complex environments.
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PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Jiang Qi,Qiu Yihe,Li Peirong,Yu Caini,Meng Tingting,Hu Fuqiang,Wang Cheng,Yuan Hong
Objective Cancer remains a critical public health challenge. Conventional anti-tumor drugs are often limited by their short half-life and the requirement for frequent and/or high-dose administration, highlighting the urgent need for drug delivery systems that can enhance intracellular drug accumulation. Methods Given that current research on drug delivery systems primarily focuses on developing active or passive targeting strategies to improve therapeutic efficacy, biocompatible cholesterol-based lipid nanoparticles (Cls-LNPs) were developed in this study. The Cls-LNPs were designed to function as an "intracellular drug reservoir" by enhancing cellular uptake and retention, thereby meeting the core requirement of enhanced intracellular drug accumulation. Results The reservoir capacity is likely attributed to the ability of Cls-LNPs to evade lysosomal degradation and target the endoplasmic reticulum (ER). When combined with the emerging anti-tumor technology of photodynamic therapy (PDT) and utilizing Ce6 as a model photosensitizer, the prepared Ce6@Cls-LNPs exhibited enhanced anti-tumor efficacy both in vitro and in vivo compared to free drugs. The therapeutic effect was achieved through the induction of ER stress, lipid peroxidation, and apoptosis, and it also exhibited a “bystander effect”. Conclusion This study offers valuable insights into the application of cholesterol in drug delivery systems and proposes innovative strategies for the development of retention-enhancing formulations. Graphical
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