Bioactive Materials
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2023
·
IF 18.9
Shi Liu,Zhengzhe Han,Ji-Na Hao,Dapeng Zhang,Xianglong Li,Yuanyuan Cao,Jinghuan Huang,Yongsheng Li
Osteogenesis, osteoclastogenesis, and angiogenesis play crucial roles in bone regeneration. Parathyroid hormone (PTH), an FDA-approved drug with pro-osteogenic, pro-osteoclastogenic and proangiogenic capabilities, has been employed for clinical osteoporosis treatment through systemic intermittent administration. However, the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate carriers. Though several scaffolds have been developed to deliver PTH, they suffer from the weaknesses such as uncontrollable PTH release, insufficient porous structure and low mechanical strength. Herein, a novel kind of NIR-activable scaffold (CBP/MBGS/PTHrP-2) with dual-mode PTHrP-2 (a PTH derivative) release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regeneration, which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass (MBG) into the N-hydroxymethylacrylamide-modified, photothermal agent-doped, poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly process. Upon on/off NIR irradiation, the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG mesopores. Such NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone remodeling. In vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of rats. This work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration.
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Journal of Materials Chemistry B
·
2018
·Vol. 7
·期 6
·974-985
·
IF 4.776
Abid Hussain,Shengrong Guo
To prevent premature drug release from nanoparticles, it is vital to design and prepare controlled and site-specific drug release systems. We investigated a new controllable drug release mesoporous carbon nanoparticle (MCN)-based nano-system with the advantages of enhanced permeability and retention effect (EPR) to target tumors followed by the NIR-induced heat-triggered release of a chemotherapeutic drug to show anti-tumor effects. The pores of MCN with photo-thermal effects were filled with the chemotherapeutic agent doxorubicin (DOX) and the phase change material (PCM) 1-tetradecanol was used as a gatekeeper to trap DOX inside the pores of the mesoporous carbon nanoparticles and the release of DOX inside tumor cells was triggered using NIR irradiation. The surface of MCN was coated with natural sophorolipid (SLPD) to obtain nanoparticles (DOX-PCM@MCN-SLPD) with good biocompatibility, dispersibility and stability in aqueous solutions. The MCN-based nano-system had the ability to load 24% DOX trapped with the PCM before coating with SLPD. It was observed that the release of DOX was temperature-dependent above the melting point of PCM. Once DOXPCM@MCN-SLPD was delivered into MCF-7/ADR cells, the release of DOX was triggered by MCN-borne photo-thermal effects under NIR irradiation. The amount of DOX inside the tumor was visualized via confocal laser scanning microscopy, which showed a higher amount of DOX at a higher temperature compared to that at normal body temperature, further confirming the minimization of premature drug release at 37 °C.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2018
·
IF 3.779
Dandan Ju,Feng Song,Jun Zhang,Chengguo Ming,Feifei Song,Adnan Khan,Aihua Zhou,Xueqin Wang,Lisa Liu
Dynamic tuning upconversion color is the most convenient approach through modulation of pump power density and NIR wavelength for anti-counterfeiting. However, most of bulk upconversion systems suffer from the insensitive response to excitation power and NIR wavelength (980 nm and 1550 nm). Herein, we demonstrate that the excitation power density sensitivity and NIR wavelength sensitivity of bulk microcrystals could be improved via co-doping Li + /Lu 3+ ions. More interestingly, co-doping ions with different valences affect the emission color tendency at 1550 nm excitation, which is contrary to previous reports. The emission color of bulk NaYF 4 :Er/Yb/Li/Lu microcrystals transform from yellow to bright green color through adjusting pump power density and pump wavelength (980 nm and 1550 nm). Moreover, the mechanism of the results has been systematically discussed. The tunable emission colors of bulk NaYF 4 :Er/Yb/Li/Lu microcrystals can be easily distinguished with naked eyes and difficultly counterfeited. Therefore, the upconversion materials have a promising application in transparent anti-fake printing.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Bo Xu,Guoxiang Pan,Xinyu Fan,Haijie Zhou,Chengcong Qiu,Yuhua Guo,Minhong Xu,Jingwei Sun,Xinhui Xia
The existing jungle camouflage coatings cannot accurately simulate the near-infrared spectral characteristics of water peaks in the 1400–1900 nm region of green vegetation. Compared with the peak area of vegetation water absorption, the smaller water valley area of camouflage coatings is the most serious problem faced by camouflage coatings. This article proposes a new camouflage coating based on hydrotalcites, and the camouflage coating was characterized using XRD, FT-IR, TG-DTA, and SEM equipment. The experimental results show that the spectral water valley area of the camouflage coating is close to that of the vegetation, and the similarity calculation with the vegetation spectrum reaches 95.62%. Especially, the coating has long-term weather resistance, which can accurately simulate the near-infrared spectral characteristics of green vegetation. The hyperspectral imaging results of the camouflage coating confirm that the prepared camouflage coating has a camouflage effect similar to that of green vegetation. This work innovatively proposes a new type of camouflage coating based on hydrotalcites, providing a new research direction for the development of vegetation camouflage.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2016
·
IF 8.328
Jing Hu,Haiqiang Wang,Fan Dong,Zhongbiao Wu
Photothermal effect was for the first time utilized to capture the energy from infrared light and to promote the photocatalytic oxidation activity of NO by a simply mechanical mixing of traditional photocatalysts and core-shell structured Fe 3 O 4 @SiO 2 . Fe 3 O 4 @SiO 2 absorbed the infrared light, transferred it into thermal energy based on photothermal effect, which then accelerated the NO photocatalytic activity of traditional photocatalysts. This promotion effect led by the addition of Fe 3 O 4 @SiO 2 was confirmed by several classical photocatalysts such as TiO 2 , g-C 3 N 4 , BiOI and CeO 2 . To quantitatively characterize the photothermal effect, thermo images were taken with a thermo imager to obtain the average temperature rise of samples under the illumination of simulated solar light. Specially, P25/Fe 3 O 4 @SiO 2 was studied in depth for illustration of the promotion mechanism. Experimental results showed that with the contribution of SiO 2 shell, the photocorrosion of Fe 3 O 4 didn’t occur during photocatalytic oxidation process and the photothermal effect of Fe 3 O 4 was maintained. The quantity of Fe 3 O 4 @SiO 2 was a vital factor for promotion of photocatalytic activity and the optimum mass ratio of P25 and Fe 3 O 4 @SiO 2 was 3–1. After 120 min of illumination, the temperature of optimum P25/Fe 3 O 4 @SiO 2 rose to 57.4 °C from 25 °C and its NO conversion capability showed an enhancement of 38.9% with the comparison to pure P25. The experimental results confirmed that the rise of temperature was attributed to the photothermal effect and its contribution was the same as the directly heating of photocatalysts. Furthermore, the enhancement of NO conversion capability around 30–40% was observed for the Fe 3 O 4 @SiO 2 mixed anatase TiO 2 , g-C 3 N 4 , ZnO, BiOI and CeO 2 . In sum, we developed a new strategy for utilization of NIR light of solar energy to facilitate the photocatalytic reactions.
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Acta Biomaterialia
·
2017
·
IF 6.319
Yanna Yu,Zhipeng Zhang,Yun Wang,Hao Zhu,Fangzhou Li,Yuanyuan Shen,Shengrong Guo
It is a great challenge to combat multidrug resistant (MDR) cancer effectively. To address this issue, we developed a new near-infrared (NIR) triggered chemotherapeutic agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG) co-release system by aid of NIR induced photothermal effect of gold nanocages (AuNCs) and temperature sensitive phase-change property of 1-tetradecanol at its melting point of 39 °C, which could simultaneously exerted chemo/photothermal/photodynamic treatment on MDR human breast cancer MCF-7/ADR cells. This nano-sized system was constructed by filling the interior of AuNCs with DOX, ICG and 1-tetradecanol, and modifying the surface with biotinylated poly (ethylene glycol) via Au-S bonds, termed as DOX/ICG@biotin-PEG-AuNC-PCM. The DOX and ICG co-release from DOX/ICG@biotin-PEG-AuNC-PCM was much faster in PBS at 40 °C or under 808 nm NIR irradiation at 2.5 W/cm 2 than at 37 °C (e.g. 67.27% or 80.31% vs. 5.57% of DOX, 76.08% vs. 3.83% of ICG for 20 min). The flow cytometry and confocal laser scanning microscopy (CLSM) results showed, the AuNCs were taken up by MCF-7/ADR cells via endocytosis , thus enhancing DOX uptake; the biotin on AuNCs facilitated this endocytosis; NIR irradiation caused the heating of the AuNCs, triggering the DOX and ICG co-release and enhancing the distribution of DOX in nuclei, the released ICG generated ROS to take photodynamic therapy. Due to the above unique properties, DOX/ICG@biotin-PEG-AuNC-PCM exerted excellent anti-tumor effects under NIR irradiation, its IC 50 against MCF-7/ADR cells was very low, only 0.48 µg/mL, much smaller than that of free DOX (74.51 μg/mL). Statement of Significance A new near-infrared (NIR) triggered chemotherapeutic agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG) co-release system by aid of NIR induced photothermal effect of gold nanocages (AuNCs) and temperature sensitive phase-change property of 1-tetradecanol at its melting point of 39 °C, was prepared, termed as DOX/ICG@biotin-PEG-AuNC-PCM, which could simultaneously exerted chemo/photothermal/photodynamic treatment on MDR human breast cancer MCF-7/ADR cells. DOX/ICG@biotin-PEG-AuNC-PCM exerted excellent anti-tumor effects under NIR irradiation, its IC 50 against MCF-7/ADR cells was very low, only 0.48 µg/mL, much smaller than that of free DOX (74.51 μg/mL).
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Zepeng Liang,Zelin Sang,Yumei Li,Zhenhua Chen,Xifan Mei,Xiuli Ren
Design of tough and functional hydrogel based on carbohydrate polymers is always attracting. Injectable hydrogel based on polyvinyl alcohol (PVA) and sodium alginate (Alg) have great potential for wound repair. However, simple hydrogel lacks functionality, such as antibacterial, which limits its application. Herein, we proposed a strategy of using Ag@MXene nanozyme to functionalize hydrogel and construct a near-infrared laser (NIR) responsive, reactive oxygen species (ROS) generating, and antibacterial platform for wound repair. Epigallocatechin gallate (EGCG) and Ag cluster modified Ti 3 C 2 (E-Ag@Ti 3 C 2 ) was prepared to enhance the performance of injectable PVA-alginate hydrogel (E-Ag@Ti 3 C 2 @H). The functionalized hydrogel presents porous structures (67 % porosity percentage) and excellent compressive and tensile properties (elongation up to 157 %). Under NIR laser irradiation, E-Ag@Ti 3 C 2 @H showed photothermal conversion efficiency and ROS generation ability. The inhibition rate for Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli ( E. coli ) can reach to 91.2 % and 90.3 %, respectively. Molecular biology experiments showed that the composite hydrogel could promote angiogenesis and wound healing by upregulating the expression of anti-inflammatory factors. The obtained injectable E-Ag@Ti 3 C 2 @H hydrogel is potential in accelerating diabetic wound healing.
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Acta Biomaterialia
·
2024
·
IF 9.4
Xingchen Li,Ming Hao,Annan Liu,Lei Li,Maja D. Nešić,Bai Yang,Weiwei Liu,Quan Lin
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region, and its treatment is limited by hypoxia and inadequate oxygen supply. Continuous oxygen delivery combined with photodynamic therapy (PDT) is the key to addressing this issue. Here, a dual-enzyme activity sea urchin-like Au@Pt-Ce6-HN-1 nanoplatform was designed to serve as an "oxygen pump" to alleviate tumor hypoxia for synergistic photodynamic/photothermal therapy (PTT). In this design, the photosensitizer chlorin e6 (Ce6) is covalently linked to the Au@Pt nanozyme for PDT treatment. The Au@Pt nanozyme exhibits catalase-like activity, continuously decomposing H 2 O 2 in the tumor microenvironment to enhance O 2 levels, thereby achieving efficient PDT. Furthermore, Au@Pt can perform PTT and increase oxygen levels under NIR-II light to further promote PDT. The Au@Pt nanozyme also exhibits peroxidase-like activity, generating ·OH for chemodynamic therapy (CDT). Additionally, HN-1 guides the direction of "sniping" OSCC, and its high specificity benefits Au@Pt-Ce6-HN-1 at the tumor site. Au@Pt-Ce6-HN-1 exhibits bright fluorescence (FL), strong CT signal, and photothermal imaging capabilities, laying the foundation for subsequent guided PDT/PTT. This nanoplatform, which combines advantages such as continuous oxygen production, tumor targeting, and multimodal imaging, is expected to provide valuable insights into the treatment of OSCC. Statement of Significance Accurate clinical diagnosis and treatment of OSCC are challenging. We report a dual-enzyme activity sea urchin-like Au@Pt-Ce6-HN-1 nanoplatform, serving as an "oxygen pump" to guide photodynamic therapy (PDT) and photothermal therapy (PTT) for OSCC. This nanoplatform targets OSCC for preoperative CT diagnosis and offers fluorescence visualization for surgical navigation, demonstrating potential in clinical cancer detection and surgery guidance. This innovative approach addresses OSCC hypoxia and enhances treatment efficacy through continuous oxygen production, tumor targeting, and multimodal imaging, significantly improving patient outcomes in OSCC treatment.
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JOURNAL OF RARE EARTHS
·
2024
·
IF 5.2
Jiantong Wang,Changshuai Gong,Sihan Yang,Qi Zhu,Xuejiao Wang,Ji-Guang Li
Phosphor-converted near-infrared light-emitting diodes (NIR pc-LEDs) are finding applications in various fields including food quality analysis, biomedical imaging, night vision, and biomedicine. The crucial factor in the development of NIR pc-LEDs devices lies in the advancement of high-performance broadband NIR phosphors. In this work, novel Cr 3+ -activated silicate phosphors NaRESi 3 O 9 (RE = Y, Lu, Sc) are reported. This silicate has a special 3D network structure in which RE has four different sites, forming four octahedrons and providing suitable occupation sites for Cr 3+ . The phosphors demonstrate a wide emission spectrum ranging from 750 to 1450 nm when excited by light at 468 nm. The full width at half maximum (FWHM), which benefits from the presence of Cr 3+ ions occupying multiple sites, is measured to be 203 nm. Notably, the strongest emission peak is observed at a longer wavelength of 984 nm compared to most other systems activated by Cr 3+ . The Na 3 ScSi 3 O 9 lattice provides a weak crystal field ( Dq / B = 1.97) and weak phonon-photon coupling for Cr 3+ , and the integrated emission intensity of Na 3 ScSi 3 O 9 :0.03Cr 3+ is 4.66 times stronger than that of Na 3 YSi 3 O 9 :0.03Cr 3+ .
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JOURNAL OF NANOBIOTECHNOLOGY
·
2020
·Vol. 18
·期 1
·1-25
·
IF 6.518
Zhao Baohua,Wang He,Dong Wenjing,Cheng Shaowen,Li Haisheng,Tan Jianglin,Zhou Junyi,He Weifeng,Li Lanlan,Zhang Jianxiang,Luo Gaoxing,Qian Wei
Background Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest.Results In this study, we developed a multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT and NO release for synergistic therapy against MDR Gram-negative bacteria and their biofilms. When located at the infected sites, TG-NO-B was able to selectively bind to the surfaces of Gram-negative bacterial cells and their biofilm matrix through covalent coupling between the BA groups of TG-NO-B and the bacterial LPS units, which could greatly improve the antibacterial efficiency, and reduce side damages to ambient normal tissues. Upon single NIR laser irradiation, TG-NO-B could generate hyperthermia and simultaneously release NO, which would synergistically disrupt bacterial cell membrane, further cause leakage and damage of intracellular components, and finally induce bacteria death. On one hand, the combination of NO and PTT could largely improve the antibacterial efficiency. On the other hand, the bacterial cell membrane damage could improve the permeability and sensitivity to heat, decrease the photothermal temperature and avoid damages caused by high temperature. Moreover, TG-NO-B could be effectively utilized for synergistic therapy against the in vivo infections of MDR Gram-negative bacteria and their biofilms and accelerate wound healing as well as exhibit excellent biocompatibility both in vitro and in vivo.Conclusion sOur study demonstrates that TG-NO-B can be considered as a promising alternative for treating infections caused by MDR Gram-negative bacteria and their biofilms.
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Advanced Energy and Sustainability Research
·
2022
·Vol. 3
·期 12
·2200138
·
IF 0
Linlin Zhang,Lu Liu,Xiaodong Zhang,Chengjun Ge,Jianjun Liao
Pharmaceuticals and personal care products (PPCPs) have attracted widespread attention due to their durability to the environment. Therefore, it is highly desirable to develop new technologies that are environmentally friendly, energy saving, and compatible to degrade these pollutants. In this study, a vis–NIR-driven and highly efficient S-scheme photocatalyst, WO 3− x /S doped g-C 3 N 4 , is used for PPCPs degradation. The results show that the photocatalytic activity of WO 3− x /S doped g-C 3 N 4 composite system for PPCPs is much higher than that of WO 3− x and g-C 3 N 4 . The introduced WO 3− x has a great positive effect on the photocatalytic performance of WO 3− x /S doped g-C 3 N 4 S-scheme composite photocatalyst for both naproxen and diclofenac. Due to the fast photogenerated carrier separation brought by the S-scheme, the WO 3− x /S-doped g-C 3 N 4 nanocomposite exhibits enhanced performance in photocatalytic PPCPs degradation. The degradation rate of naproxen is 99.2%, and the degradation rate of diclofenac can also be as high as 99.5%. This research has important reference value for the synthesis of WO 3 -based S-scheme photocatalysts for energy and environmental applications.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xianqing Huang,Yana Fu,Yicheng Guo,Yuzheng Cai,Tiange Li,Peijun Zhao,Yan Ma,Lianjun Song,Tianlin Wang
Given the increase in public safety incidents due to bacterial infections, sensitive detection and real-time inactivation of pathogenic bacteria have garnered increasing attention in the field of food safety, clinical diagnosis, and environmental monitoring. In this study, we constructed a “two-in-one” PB@DPA-Ce-GMP@Van (PCV) nanoplatform possessing enzyme-like properties and photothermal therapeutic (PTT) and photodynamic therapeutic (PDT) abilities for the detection and inactivation of pathogenic bacteria. PCV was captured on the surface of S. aureus to form a PCV/S. aureus complex. After centrifugation, PCV suspensions could catalyze non-fluorescent Amplex Red (AR) into fluorescent substrates and fluorescent scopolamine (SC) into non-fluorescent substrates. Hence, a ratiometric fluorescence probe with SC/AR reading was constructed for the sensitive detection of bacteria. The detection range reached 10 1 –10 7 colony-forming unit (CFU)/mL, and the detection limit was as low as 5.0 CFU/mL. Furthermore, approximately 99.7 % of free S. aureus can be inactivated by the PTT and PDT abilities of PCV. Thus, this nanoplatform exhibits a novel advantage in detecting and inactivating bacteria. Moreover, the bacterial infection wound model indicated that PVC exerts good disinfection ability. This study is of immense significance in the application of targeted sensing, eliminating bacterial infection, and even clinical therapy.
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