Journal of Water Process Engineering
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2022
·
IF 7.34
Xu Chai,Huaqi Dong,Zenggao Zhang,Zhaoyang Qi,Jie Chen,Zhixian Huang,Changshen Ye,Ting Qiu
Due to natural and production activities, mercury contamination has become one of the major environmental problems in the world. Adsorption is one of the important means to solve this problem. However, most of the commercially available adsorbents exhibit relatively low adsorption capacity and slow kinetics. Therefore, a novel 4,6-diamino-2-mercaptopyrimidine-functionalised Zr-based metal-organic framework (UiO-66-DMP) was synthesised in this study. The UiO-66-DMP was characterised through X-ray diffraction, scanning electron microscopy, energy dispersive spectrometry , X-ray photoelectron spectroscopy, Fourier-transform infrared spectrometry, and thermogravimetric analysis . The potential of the UiO-66-DMP as a superior adsorbent for Hg(II) removal and the corresponding mechanisms were evaluated through batch experiments under different conditions and density functional theory calculations. Benefitting from its high specific surface area and multiple adsorption sites, the maximum Hg(II) adsorption capacity achieved in this study was 822.00 mg·g-1, which is the highest Hg(II) adsorption capacity reported to date. In addition, under the interference of Ca(II), Cd(II), Co(II), Mg(II), Mn(II), Ni(II), Cr(III), Cu(II), Zn(II) and other coexisting ions, the UiO-66-DMP could still maintain the high selective adsorption capacity for Hg(II). According to the characterization analysis and DFT calculation results, the adsorption of Hg(II) onto the UiO-66-DMP was dependent on electrostatic and covalent interactions between metal ions and abundant functional groups on the UiO-66-DMP surface.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2022
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IF 3.269
Shijie Xu,Tengfei Cao,Mingjia Ma,Yanfei Wang
The effects of solvent properties and temperature on the solid–liquid equilibrium of 2-bromodibenzofuran (NSC 1735) were investigated for the first time in terms of temperature, solvent polarity, hydrogen bonding donor and acceptor tendency, as well as cohesive energy density. Firstly, the equilibrium solubility of 2-bromodibenzofuran in 12 mono-solvents, such as alcohol, ketone, nitrile and ester, was determined by gravimetric method ranging from 278.15 ∼ 343.15 K. The values of the mole fraction solubility of NSC 1735 in all the selected solvents increased with increasing temperature. Moreover, the statistical correlations between temperature and solubility were described by the modified Apelblat equation, λh equation, Van’t Hoff equation, and NRTL model. The calculated ARD% values show that the correlation results agree well with the experimental date and the modified Apelblat equation receives the best regression performance. Solvent polarity and cohesive energy density mainly determine the solubility of NSC 1735 in various solvents. Thermodynamic studies of dissolution have shown that the dissolution of NSC 1735 in selected solvents.is endothermic and enthalpy driven. The change of dissolution enthalpy is the main contributor to the molar Gibbs free energy during the dissolution process.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Xiaozhen Zhang,Gaopan Liu,Ke Zhou,Yong Cheng,Tianpeng Jiao,Lin Huang,Yue Zou,Ming-Sheng Wang,Yong Yang,Jianming Zheng
Nickel-rich (Ni-rich) cathode materials , LiNi x Co y Mn z O 2 (NCM, x ≥ 0.9, x + y + z = 1) hold great promise for developing high energy density lithium ion batteries especially for vehicle electrification. However, the practical application of Ni-rich cathode materials is still suffered from fast structural and interfacial degradation, and the resulted capacity decay. In this study, a diazacyclo type electrolyte additive , 2-fluoropyrazine (2-FP), was explored for the first time to boost the interfacial stabilization of single crystal LiNi 0.90 Co 0.05 Mn 0.05 O 2 (NCM90) cathode. The capacity retention of the NCM90 is evidently promoted from 72.3% to 82.1% after 200 cycles at 1C (180 mA g −1 ) when adding 0.2% 2-FP into the electrolyte. The improvement of the electrochemical performance is ascribed to the generation of a compact and homogeneous cathode electrolyte interphase (CEI) film through ring-opening electrochemical polymerization of 2-FP upon the NCM90 electrode particles. This enhanced CEI layer benefits the suppression of the decomposition of LiPF 6 electrolyte and the dissolution of the transition metals (Co and Mn), thus preventing the detrimental side reactions between the NCM90 electrode and the electrolyte.
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高影响因子
Frontiers in Immunology
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2022
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IF 8.786
Lixia Gao,Jie Yang,Jutao Feng,Ziying Liu,Ying Dong,Jiangyan Luo,Liangzhentian Yu,Jiamei Wang,Hongying Fan,Weifeng Ma,Tiancai Liu
A viable therapy is needed to overcome the deadlock of the incurable chronic hepatitis B (CHB). The prolonged existence of covalently closed circular DNA (cccDNA) and integrated HBV DNA in the nucleus of hepatocytes is the root cause of CHB. As a result, it is critical to successfully suppress HBV DNA replication and eliminate cccDNA. RNA interference has been proven in recent research to silence the expression of target genes and thereby decrease HBV replication. However, siRNA is susceptible to be degraded by RNA enzymes in vivo , making it difficult to deliver successfully and lacking of tissue targeting. To exploit the advantages of siRNA technology while also overcoming its limitations, we designed a new strategy and prepared biomimetic nanoparticles that were directed by PreS/2-21 peptides and precisely loaded HBV siRNA. Experiments on these nanoparticles in vitro and in vivo revealed that they are tiny, stable, safe and highly targetable, with high inhibitory effects on HBV DNA, pgRNA, cccDNA, HBeAg and HBsAg. PreS/2-21-directed nanoparticles loaded with HBV gene therapy drugs are expected to be promising for the treatment of CHB.
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LIPIDS
·
2022
·Vol. 57
·期 3
·153-162
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IF 1.646
Danping Wang,Jinglong Chen,Huangbing Sun,Wenjing Chen,Xiaojing Yang
Oxidative stress is an important factor in the occurrence and development of liver disease. Medium-chain fatty acids (MCFAs) have potential antioxidant function, whereas the exact underlying mechanism of MCFA in oxidative injury of hepatocytes remains unclear. In our present study, three different MCFAs, 8-carbon octanoic acid (OA), 10-carbon capric acid (CA), and 12-carbon lauric acid (LA), have been performed to observe their protective action for hepatocyte under the H 2 O 2 challenge. The result showed that MCFA treatment significantly increased the cell viability, T-AOC, and expression of antioxidant-related genes in AML12 cells under oxidative stress condition, and reduced reactive oxygen species (ROS) production. Moreover, MCFA treatment significantly increased the protein expression of Nrf2 and the phosphorylation level of ERK1/2; LA treatment significantly promoted the Nrf2 nuclear translocation. With a further test, the rescue ability of MCFA was blocked by treating with the ERK inhibitor U0126. Overall, our data suggested that MCFA treatment has positive impact on protecting AML12 cells against oxidative stress through ERK1/2/Nrf2 pathway.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 19
·11853
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IF 6.208
Zichao Wang,Pei Liu,Ziyi Fang,He Jiang
Immobilized enzymes are a significant technological approach to retain enzyme activity and reduce enzyme catalytic cost. In this work, trypsin-incorporated Zn3(PO4)2hybrid nanoflowers were prepared via mild precipitation and coordination reactions. The controllable preparation of hybrid nanoflowers was achieved by systematically investigating the effects of the raw-material ratio, material concentration and reaction temperature on product morphology and physicochemical properties. The enzyme content of hybrid nanoflowers was about 6.5%, and the maximum specific surface area reached 68.35 m2/g. The hybrid nanoflowers exhibit excellent catalytic activity and environmental tolerance compared to free trypsin, which was attributed to the orderly accumulation of nanosheets and proper anchoring formation. Further, the enzyme activity retention rate was still higher than 80% after 12 repeated uses. Therefore, trypsin/Zn3(PO4)2hybrid nanoflowers—which combine functionalities of excellent heat resistance, storage stability and reusability—exhibit potential industrial application prospects.Keywords:hybrid materials;trypsin;nanoflowers;controlled synthesis;catalytic performance
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Journal of Energy Storage
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2022
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IF 8.907
Xiaolin Sun,Kai Zhao,Zhiqiang Liu,Zhonghan Feng,Zihao Wang,Liang Cui,Jingquan Liu
The construction of cost-effective, efficient, and sustainable energy storage systems is extremely important for future fuels globally. Nickel borates display important characteristics in electrochemical catalytic applications, whereas few reports have focused on their energy storage properties in supercapacitors . Herein, Ni 3 (BO 3 ) 2 nanospheres (NSs) are fabricated on titanium (Ti) mesh to afford Ni 3 (BO 3 ) 2 NSs@Ti using a simple and scalable electrodeposition technique, whose electrochemical performance is carefully studied. The Ni 3 (BO 3 ) 2 NSs@Ti obtained at 1.2 V (Ni 3 (BO 3 ) 2 NSs-1.2V) exhibits a higher specific capacitance of 663 F g −1 with a current density of 0.5 A g −1 . Furthermore, by directly employing Ni 3 (BO 3 ) 2 NSs-1.2V as the positive electrode and activated carbon as the negative electrode , an asymmetric supercapacitor (ASC) device can be fabricated and displays the energy density up to 30.6 Wh kg −1 at the power density of 400 W kg −1 . Hence, the facile electrodeposited Ni 3 (BO 3 ) 2 NSs can be a potential platform for energy storage applications .
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CELL
·
2022
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IF 66.85
Liming Yan,Yucen Huang,Ji Ge,Zhenyu Liu,Pengchi Lu,Bo Huang,Shan Gao,Junbo Wang,Liping Tan,Sihan Ye,Fengxi Yu,Weiqi Lan,Shiya Xu,Feng Zhou,Lei Shi,Luke W. Guddat,Yan Gao,Zihe Rao,Zhiyong Lou
Summary Decoration of cap on viral RNA plays essential roles in SARS-CoV-2 proliferation. Here, we report a mechanism for SARS-CoV-2 RNA capping and document structural details at atomic resolution. The NiRAN domain in polymerase catalyzes the covalent link of RNA 5′ end to the first residue of nsp9 (termed as RNAylation), thus being an intermediate to form cap core (GpppA) with GTP catalyzed again by NiRAN. We also reveal that triphosphorylated nucleotide analog inhibitors can be bonded to nsp9 and fit into a previously unknown “Nuc-pocket” in NiRAN, thus inhibiting nsp9 RNAylation and formation of GpppA. S-loop (residues 50-KTN-52) in NiRAN presents a remarkable conformational shift observed in RTC bound with sofosbuvir monophosphate, reasoning an “induce-and-lock” mechanism to design inhibitors. These findings not only improve the understanding of SARS-CoV-2 RNA capping and the mode of action of NAIs but also provide a strategy to design antiviral drugs.
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Journal of Biomedical Research
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2022
·
IF 0
Mo-qiu Jia,Yong-jin Wang,Kang Fu,Han Jiao,Jia Sun,Yuanqing Gao
Orexin signaling has been associated with energy expenditure and brown adipose tissue (BAT) function. However, conflicting data exist in the field about how orexin signaling regulates BAT thermogenesis. In this study, we show that a specific orexin receptor type 2 (OX2R) agonist [Ala11, D-Leu15]-OxB (OB-Ala) inhibited intrascapular brown adipose tissue (iBAT) thermogenesis by reducing sympathetic output to iBAT. This effect is mediated by OX2Rs located on afferent nerve endings innervating iBAT instead of brown adipocyte itself. Microinjection of OB-Ala into iBAT inhibited iBAT thermogenesis in mice upon cold exposure and neuronal activity in the paraventricular nucleus. Findings suggest that OB-Ala could inhibit iBAT thermogenesis by attenuating sensory input thereby inhibiting the sympathetic-sensory iBAT feedback loop. Our study uncovers a novel primary action site of orexin in the regulation of energy balance.
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Analytical Methods
·
2022
·Vol. 14
·期 39
·3911-3920
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IF 3.532
Limin Yang,Xiaolong Zhang,Mingming Li,Linjiao Qu,Zhen Liu
Immobilization of enzymes is one of the key steps in the development of high-performance enzymatic electrochemical biosensors, and various nanostructured materials have been designed and developed to achieve this goal. Herein, hybrid nanoflowers (HNFs) were synthesized using acetylcholinesterase (AChE) as an organic component and copper phosphate (Cu3(PO4)2) as an inorganic component. These AChE–Cu3(PO4)2 HNFs exhibit a three-dimensional hierarchical flower-like structure, which not only has a large specific surface area but also promotes the affinity between AChE and its substrate with better catalytic activity. Not only that, the surface modification of the glassy carbon electrode (GCE) by the joint use of gold nanoparticles (AuNPs) and graphene oxide (GO) extended the electroactive area. Using square-wave voltammetry (SWV), the as-prepared biosensor (i.e., AChE–Cu3(PO4)2 HNF/AuNP/GO/GCE) demonstrated superior sensing performance in the detection of dichlorvos. The detection limit is as low as 0.07 pM, and the linear detection range can range from 0.5 pM to 10 μM. In addition, the biosensor was feasible in real agricultural samples with satisfactory recoveries (98.65% to 103.43%). The reported biosensor provides an alternative tool for the direct measurements of AChE activity and its inhibition. Besides organophosphorus pesticides represented by dichlorvos, this biosensor has the potential to detect other AChE inhibitors, such as carbamate pesticides, drugs for Alzheimer's disease, etc., thus having broader applications in food safety and drug screening.
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Frontiers in Cellular and Infection Microbiology
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2022
·
IF 6.073
Yin Lujun,Shen Wang,Liu Jun-Sheng,Jia Ai-Qun
Siderophore is necessary for the survival of microorganisms and is interregulated with quorum sensing (QS) systems. It is related to growth, proliferation, virulence, and other bacterial social activities as a virulence factor. Thus, we speculated that the QS system could be occluded by inhibiting siderophore production. 2-Hydroxymethyl-1-methyl-5-nitroimidazole (HMMN), one siderophore inhibitor of Pseudomonas aeruginosa PAO1 (P. aeruginosa PAO1), was obtained by using the Chromeazurol S (CAS) method. We found that HMMN inhibited siderophore production and influenced the biological effects of QS regulation, including biofilm formation and pyocyanin production. HMMN (150 μg/ml) inhibited the siderophore production of P. aeruginosa PAO1 by 69.37%. In addition, HMMN could inhibit pyocyanin production and biofilm formation and erase the formed biofilm of P. aeruginosa PAO1. HMMN (150 μg/ml) inhibited the biofilm formation of P. aeruginosa PAO1 by 28.24%. The erasure rate of the formed biofilm reached 17.03%. Furthermore, HMMN (150 μg/ml) inhibited P. aeruginosa PAO1 pyocyanin production by 36.06%. Meanwhile, positive-control hordenine (500.0 μg/ml) reduced the biofilm formation and pyocyanin production of P. aeruginosa PAO1 by 14.42% and 34.35%, respectively. The erasure rate of hordenine to the formed biofilm is 11.05% at 500 μg/ml. Quantitative real-time polymerase chain reaction (qRT-PCR) showed that HMMN downregulates not only siderophore-related genes but also QS-related genes, as well as hordenine. These results suggest that a siderophore inhibitor could be used as a QS inhibitor to occlude the QS system and reduce virulence.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 27
·21976-21984
·
IF 2.779
Sha Ke,Lin Feng Li,Liu Bing,Song Kai Xin,Zhang Jia Heng
Dense (Sr 1 − x Ca x ) 2 (Ti 1 − x Sn x )O 4 ( x = 0.0, 0.05, 0.10, 0.15) ceramics were synthesized by a standard solid-state reaction method. The formation of solid-solution with an I 4/ mmm space group was revealed from the X-ray diffraction patterns and Rietveld refinement results. The variation of the microwave dielectric properties was systematically analyzed using the dielectric polarizability and complex chemical bond theory. The dielectric constant ( ε r ) was mainly determined by the ionic polarizability per unit volume. Qf value was closely associated with the increasing amount of Sr 3 Ti 2 O 7 secondary phase and the declined lattice energy. Meanwhile, the variation of Qf value was further analyzed by extrapolating the intrinsic dielectric loss from the infrared reflectivity spectra. τ f value was successfully adjusted toward zero, which could be explained by the enhanced bond energy. The optimal microwave dielectric properties were achieved at x = 0.10, with ε r = 33.6, Qf = 73,150 GHz, and τ f = 115 ppm/°C.
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