DYES AND PIGMENTS
·
2018
·
IF 3.767
Xiao-Lei Zhao,Jiao Geng,Bin Hu,Dan Xu,Wei Huang
New monomethine dyes have been prepared by a simple and highly efficient method in acetic anhydride, in which the common pyridine-2,6-dione moiety and thiophene derivatives occupy each side of the methine unit. Among them, the ternary monomethine-azo dyes were first obtained by the particularly useful post-modification synthetic strategy, in order to further adjust the π -conjugated system and electronic spectra of 2-amino-3-cyano-4-chloro-5-formylthiophene based heterocyclic hydrazone/azo dyes. UV−Vis spectral analyses reveal that the synthesized heterocyclic dyes exhibit a large color gamut because of the extension of the conjugation length of the chromophore , where the maximum absorption wavelength ( λ max ) is significantly red-shifted up to 181 nm from binary monomethine to ternary monomethine-azo dyes.
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DOI
高影响因子
THERMOCHIMICA ACTA
·
2016
·
IF 1.938
X.K. Gao,X. Wen,H. Zhou,Q. Zhu,J.L. Wang,X.Y. Li
In this work, a novel and simple method was put forward to measure the isobaric specific heat capacity for the kerosene RP-3 with a flow-calorimeter at the conditions of high temperature and high pressure. Based on the energy conservation principle, the formula for heat capacity was derived and its measurement was realized by the convective mixing method between the hot and cold fuel. Taking the precision of the instrument and the error transfer into account, the relative expanded uncertainty of this method was acquired of about ± 6.38% (coverage factor k = 2). Meanwhile, the accuracy and reliability were verified by the standard material of water and n -decane. In the temperature range from (296.2–719.0) K and under pressure range from (2.4–4.0) MPa, the measurement for the kerosene RP-3 was carried out and the experimental observations were compared and agreed well with the published data. At last, an empirical correlation relationship of heat capacity due to the temperature and pressure was presented by using Garg’s model with the measured experimental data.
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高影响因子
PROCESS BIOCHEMISTRY
·
2020
·
IF 2.952
Yuan Lu,Hongqian Dai,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe 3 O 4 -Arg was selected as the optimal carrier due to its high activity recovery of immobilized cells in the preparation of Fe 3 O 4 -Arg-Cells. The optimal immobilization conditions for the preparation of Fe 3 O 4 -Arg-Cells were 30 °C, 4 h, pH 7, and 3 g dry yeast. The activity recovery of immobilized cells reached 76.8 %. For a batch reduction in a shaker in an alternating magnetic field, Fe 3 O 4 -Arg-Cells were used as a catalyst to gain ethyl ( R )-4-chloro-3-hydroxybutyrate (( R )-CHBE). For further improvement in reduction productivity, a continuous reduction in the magnetic fluidized bed reactor system (MFBRS) was completed. Under their optimal transformation conditions, it took 24 h for Fe 3 O 4 -Arg-Cells to complete the conversion of ethyl 4-chloro-3-oxobutanoate (COBE) (0.8553 mol/L) in the shaker and only 8 h for the batch reduction in an alternating magnetic field. Continuous reduction in MFBRS provided new ideas for the efficient production of ( R )-CHBE; 1.5882 mol/L (10 mL) of COBE can be completely converted in 6 h. The conversion and enantiomeric excess (e.e.) of ( R )-CHBE were 100 % and above 99.9 % respectively, in the three reaction systems mentioned above.
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高影响因子
CURRENT DRUG METABOLISM
·
2024
·Vol. 25
·期 10
·754-768
·
IF 2.1
Xiaoyun Liu,Dafang Zhong,Chongzhuang Tang,Xiaofeng Xu,Hong Lan,Xingxing Diao
Background BPI-460372 is an orally available, covalent, irreversible small molecule inhibitor of the transcriptional enhanced associate domain (TEAD) 1/3/4, which is currently in clinical development for the treatment of cancers with Hippo pathway alterations. Objectives This study aimed to determine the cytochrome P450 (CYP) phenotyping, metabolic stability, and in vitro and in vivo metabolic profile of BPI-460372. Methods The CYP phenotyping and metabolic stability were assessed by measuring the depletion of substrate. The metabolic profile in hepatocytes and rat and dog plasma was analyzed using ultra-high-performance liquid chromatography combined with Orbitrap tandem mass spectrometry (UHPLC-Orbitrap-HRMS). Results BPI-460372 was mainly metabolized by CYP2D6, CYP3A4, and CYP1A2. BPI-460372 exhibited low clearance in human, monkey, and rat hepatocytes, while moderate clearance in dog and mouse hepatocytes. A total of 10 metabolites were identified in five species of hepatocytes, and no human-unique metabolite was detected. In rat plasma and dog plasma, the primary metabolites were M407 (BPI-460430) and M423 (BPI-460456), respectively. The two metabolites were quantitatively determined in rat and dog plasma in pharmacokinetic and toxicological studies. The major metabolic site was 2-fluoro-acrylamide, and major metabolic pathways in hepatocytes, and rat and dog plasma involved oxidative defluorination, hydration, glutathione (GSH) conjugation, hydrolysis, cysteine conjugation, and N-acetyl cysteine conjugation. β-lyase pathway contributed to the metabolism of BPI-460372 in rats to a certain degree. Conclusion This study elucidated the metabolism of BPI-460372 and provided a basis for pharmacokinetic and toxicological species selection, human pharmacokinetics prediction, and assessment of clinical co-administration limitations and possible metabolic pathways in humans.
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高影响因子
ECS Journal of Solid State Science and Technology
·
2015
·Vol. 4
·期 5
·M25
·
IF 1.558
Vantu Nguyen,Yueli Liu,Yang Li,Shah Abdul Hakim,Xue Yang,Wen Chen
Fe2(MoO4)3/carbon nanotubes (CNTs) nanocomposite was prepared by a precipitation method and used as a cathode for sodium-ion batteries (SIBs). The field emission scanning electron microscopy (FESEM) test showed that the CNTs and Fe2(MoO4)3 nanosheets formed an interpenetrating network structure. The X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis confirmed that the Fe2(MoO4)3 was a monoclinic crystal structure and mixed with element states in the nanocomposite. The electrochemical properties of the Fe2(MoO4)3/CNTs nanocomposite were studies by electrochemical impedance spectroscopy (EIS) and galvanostatic charge-discharge measurement. The results indicated that Fe2(MoO4)3/CNTs nanocomposite had high specific capacity and good cycling stability as a cathode material for SIBs. As the charge/discharge curent density is at 1 C, the initial specific capacity of Fe2(MoO4)3/CNTs nanocomposite is 85 mAhg−1, and it remains 79.81 mAhg−1 after 50 cycles.
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高影响因子
GENOME BIOLOGY
·
2024
·Vol. 25
·期 1
·1-26
·
IF 10.1
Sun Daming,Bian Gaorui,Zhang Kai,Liu Ning,Yin Yuyang,Hou Yuanlong,Xie Fei,Zhu Weiyun,Mao Shengyong,Liu Junhua
Background The function of diverse ruminal microbes is tightly linked to rumen development and host physiology. The system of ruminal microbes is an excellent model to clarify the fundamental ecological relationships among complex nutrient–microbiome–host interactions. Here, neonatal lambs are introduced to different dietary regimes to investigate the influences of early-life crosstalk between nutrients and microbiome on rumen development. Results We find starchy corn-soybean starter-fed lambs exhibit the thickest ruminal epithelia and fiber-rich alfalfa hay-fed lambs have the thickest rumen muscle. Metabolome and metagenome data reveal that indole-3-carboxaldehyde (3-IAld) and prostaglandin D2 (PGD2) are the top characteristic ruminal metabolites associated with ruminal epithelial and muscular development, which depend on the enhanced ruminal microbial synthesis potential of 3-IAld and PGD2. Moreover, microbial culture experiment first demonstrates that Bifidobacterium pseudolongum is able to convert tryptophan into 3-IAld and Candida albicans is a key producer for PGD2. Transcriptome sequencing of the ruminal epithelia and smooth muscle shows that ruminal epithelial and muscular development is accompanied by Wnt and Ca 2+ signaling pathway activation. Primary cell cultures further confirm that 3-IAld promotes ruminal epithelial cell proliferation depending on AhR-wnt/β-catenin signaling pathway and PGD2 accelerates ruminal smooth muscle cell proliferation via Ca 2+ signaling pathway. Furthermore, we find that 3-IAld and PGD2 infusion promote ruminal epithelial and musculature development in lambs. Conclusions This study demonstrates that early-life ruminal microbiome-derived 3-IAld and PGD2 are effective promoters of rumen development, which enhances our understanding of nutrient–microbiome–host interactions in early life.
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Yunjia Hu,Tengchao Guo,Kangsen Peng,Shujuan Tan,Cheng Xu,Jie Deng
In this study, Ce 1−x Cu x O 2−x (x = 0, 0.01, 0.03, 0.05, 0.07) samples were prepared by hydrothermal method . The structure, microstructure, and elemental composition of the powders were characterized by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, whereas the electrical conductivity , ultraviolet–visible absorption spectroscopy , and infrared emissivity at 3–5 μm were measured as well. Moreover, the effects of Cu 2+ doping concentration on the microstructure, morphology, bandgap, conductivity, and infrared emissivity of Cu-doped CeO 2 powders were systematically studied. The effects of Cu 2+ doping on infrared reflection and absorption in a 3–5 μm band and their mechanisms were explained based on electromagnetic theory, lattice vibration absorption, and free carrier absorption . Our result indicated that the emissivity of 1% Cu-doped powder reached the lowest emissivity of 0.200 at 800 °C. When the doping concentration was above 1%, the curve of infrared emissivity versus temperature exhibited a “U” shape, with the minimum point shifting towards the low-temperature region with the increase of Cu doping amount. This phenomenon was attributed to the different enhancement amplitude of reflectivity and absorbance of CeO 2 powder by Cu 2+ at different temperatures.
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高影响因子
Inorganic Chemistry Frontiers
·
2018
·Vol. 5
·期 3
·619-625
·
IF 5.106
Ying Liu,Maxim S. Molokeev,Quanlin Liu,Zhiguo Xia
Crystal structure evolution and temperature-dependent phase transition of solid solutions are much desired for the understanding of the optimization of functional properties. Herein, the NASICON-type NaZr2(PO4)3–SrZr4(PO4)6 solid solutions with the formula Na(2−2x)Srx[ ]xZr4(PO4)6 (0 ≤ x ≤ 1), where [ ] represents the vacancy, were prepared by the sol–gel method, and their crystal structures, phase transitions and thermal expansion properties were investigated in detail. In the range of x = 0.3–0.35, there is a reversible structural phase transition Rc ↔ R and the different structural models of the R phase and Rc phase were built to better understand the phase transition mechanism. We determined the phase transition boundary between the Rc and R structures and predicted the phase transition temperature of Na(2−2x)Srx[ ]xZr4(PO4)6 with any x for further investigation of controlled physical properties. The results indicated that Na0.5Sr0.75[ ]0.75Zr4(PO4)6 showed a near zero thermal expansion in the temperature range of 450–600 K, which can find potential applications.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 1
·1-9
·
IF 2.8
Song Peiqi,Zhu Zhe,Yao Zhonghua,Hao Hua,Cao Minghe,Liu Hanxing
Piezoelectric materials are widely used in the direction of sensors. PZT-based ceramics are very suitable for precision sensors. However, due to the low Curie temperature, the application temperature range of the material is relatively narrow. Here we show a high-performance material 0.6PZT–0.4PNN. In this case, a morphotropic phase boundary (MPB) region was artificially designed in the 0.6Pb(Zr x Ti 1 −x )O 3 –0.4Pb(Ni 1/3 Nb 2/3 )O 3 ( x = 0.35–0.41) ceramics to develop high-performance piezoelectric compositions which could cofire with low-cost Ag/Pd inner electrode by 0.2wt% Li 2 CO 3 addition. The ceramic composition at x = 0.39 near MPB possess exceptional properties with high piezoelectric coefficient d 33 ∼ 611 pC/N, planar electromechanical coupling coefficient k p ∼ 53.5%, low mechanical quality factor Q m ∼ 64.5 piezoelectric strain of 0.17%, and suitable Curie temperature T c ∼ 191 °C, respectively. The fact that d 33 was detected close to T c , and no noticeable change below 6.6% in cycling stability was observed at 20 kV/cm means a robust temperature-independence and fatigue reliability of the piezoelectric ceramics. Thus, this research provides a novel high-piezoelectricity configuration with elemental regulation, comparable to the commercial PZTs.
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高影响因子
SYNLETT
·
2018
·Vol. 29
·期 09
·1244-1248
·
IF 2.369
Xiangwen Kong,Lihua Liu,Siqin Luo,Shilu Fan,Haisheng Qian,Hua Xiao
A triphenylphosphine-promoted [3+2] cycloaddition of α,γ-bis-substituted allenoates and N-tosylaldimines followed by alkene isomerization was disclosed, affording a series of functionalized 2-pyrroline derivatives in moderate chemical yields with random diastereoselectivities.
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高影响因子
IONICS
·
2023
·Vol. 29
·期 6
·2271-2285
·
IF 2.8
Yan Ji,Zhu Jiuzhou,Zhang Libo,Li Yan,Wang Heng,Wang Lizhen
Lithium-sulfur batteries present a promising potential in meeting the demand of high energy and low-cost energy storage system. However, it suffers from the severe shuttle effect of lithium polysulfides and sluggish sulfur chemistry kinetics. Herein, NASICON-type ceramic material Na 3 V 2 (PO 4 ) 3 is developed to decorate on polypropylene (PP) membrane as a catalysis layer to adsorb lithium polysulfides and accelerate the conversion of sulfur electrochemistry redox reaction. Meanwhile, the sophisticated architecture on separator provides additional lithium ion intercalaction-extraction behavior, which helps to hamper the shuttle effect of lithium polysulfides. The collaborative contribution of above virtues endows the Li–S batteries with excellent capacitive performance of 1045.3 mA h g −1 at 0.2 C current density, superior rate capability (590.4 mA h g −1 ) at 4 C although the cycling stability over 400 cycles at 4C is still needed to improve. This work offers an elaborate ceramic coating layer engineering on separator to act as an electro-catalyst role to improve the conversion reversibility and kinetics in lithium sulfur battery with high-energy.
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高影响因子
Science China-Chemistry
·
2013
·Vol. 57
·期 3
·397-401
·
IF 1.327
Zhang QiBo,Hua YiXin,Wang Rui
Direct electroreduction of solid cuprous chloride to prepare copper powder in a “neutral” ambient-temperature ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid (BMIMBF 4 ) was investigated. Cyclic voltammetry of the CuCl powder in a Pt-powder cavity microelectrode exhibited that solid CuCl can be electrochemical reduced in the ionic liquid. Chronoamperometry of the salt powder filled Mo-cavity electrode (current collector) in the ionic liquid further demonstrated the conversion of chloride-to metal inside the cavity, as confirmed by scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction spectra.
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高影响因子
危险品化学品经营许可证（带存储）