Nature Communications
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2026
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IF 18.1
Cheng Tao,Zhao Ming,Li Tianyu,Wang Shuo,Yin Yanbin,Li Xianfeng
The cation design of the multi-component dynamic concentration electrolytes that simultaneously achieve effective phase transition prevention and rapid kinetic process is challenging but vital for enhancing the performance of low-temperature zinc-bromine flow batteries. Herein, we employ NH 4 + as supporting electrolyte cation to break inherent trade-off between salting-out at low temperatures and ion transport kinetic from the alkali cations (K + , Na + and Li + ). Compared to commonly used K + in the traditional electrolyte, NH 4 + achieves an improved ability to prevent the phase transition of the electrolyte and obtains better ion transport property, which is a characteristic that Na + and Li + do not possess. Additionally, NH 4 + can significantly enhance the cycling stability by appropriately increasing the solubility of polybromides. Consequently, the zinc-bromine flow batteries supported by NH 4 + not only demonstrate sustained lifespan (>2,300 cycles at 40 mA cm −2 , 40 mAh cm −2 , over half a year) and consistent high-rate cyclic stability (charging at 200 mA cm −2 , discharging at 80 mA cm −2 , >3,300 h) at room temperature; they also exhibit stable cyclic stability (over 1,600 cycles at 40 mA cm −2 ) at −20 °C. This work provides an effective path for the design of complex electrolytes for low-temperature aqueous zinc-based flow batteries.
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PHARMACEUTICAL RESEARCH
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2026
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IF 4.1
Xu Zi-Ting,Li Bogang,Deng Jiayin,Lv Jia-Yi,Ouyang Defang,Fang Wei-Jie
Purposes Peptide drugs are a vital category of biologics. However, unlike the well-studied effects of buffers on small-molecule or macromolecule drugs, the understanding of selecting appropriate buffers for peptide formulations and their specific impacts remains insufficient. This study aimed to systematically evaluate how different buffers affect the stability of the model peptide, glucagon, and to investigate the underlying mechanisms at the molecular level. Methods This work employed glucagon as a model peptide and integrated experimental techniques with computational approaches. Experimental techniques included reverse-phase high-performance liquid chromatography (RP-HPLC), Thioflavin T fluorescence assays, and circular dichroism (CD). Molecular dynamics (MD) simulations were further conducted, utilizing models with different buffer systems and varying peptide counts, to examine the interaction mechanisms between buffers and glucagon from multiple perspectives. Results Compared with other buffers, citrate exerted a unique and significant impact on glucagon stability. RP-HPLC demonstrated its destabilizing effect on the structure, while CD and MD simulations confirmed its role in preserving glucagon’s α-helical structure, attributed to its highest binding energy. However, this strong binding reduced the ζ-potential, compromised colloidal stability, and ultimately promoted aggregation/precipitation. MD simulations further showed that citrate anions formed a denser solvation shell around glucagon, driving oligomerization and aggregation. Conclusions This work uncovers the dual role of citrate buffer on glucagon stability: maintaining local secondary structure while disrupting overall colloidal stability. It provides molecular insights into peptide-excipient interactions and offers valuable guidance for optimizing formulations for other peptide drugs. Graphical
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EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2026
·Vol. 252
·期 4
·158
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IF 4.2
Yang Bingxin,Ma Lulu,Pan Li,Zeng Qian,Chang Xinping,Liu Xin,Dong Shijian,Wu Jijun,Li Shugang
Alcoholic liver disease (ALD) is a global health concern caused by chronic excessive alcohol consumption, and dietary intervention is a key strategy for improving ALD. This study aimed to develop egg white peptides (EWP) with enhanced alcohol metabolism functionality. By optimizing the stepwise enzymatic hydrolysis process, we successfully achieved activation rates of alcohol dehydrogenase (ADH) and ABTS free radical scavenging capacity in EWP of 35.76% and 43.12%, respectively. EWP showed adequate stability during processing and in vitro digestion. LC-MS/MS analysis identified 8,220 peptides. Computer-aided analysis screened four novel ADH-activating peptides (LAPGW, WLF, WPPP, and WFLPR). Molecular docking analysis confirmed that these peptides exhibit strong and stable binding to ADH through hydrophobic interactions, hydrogen bonds, and van der Waals forces. In an alcohol-damaged HepG2 cell model, these peptides significantly reduced levels of cellular damage markers (transaminases) by more than 29%. Mechanistic studies indicated these peptides exerted protective effects against alcoholic hepatocyte injury by accelerating alcohol metabolism and potentially modulating antioxidant enzyme activities—such as glutathione synthesis and superoxide dismutase—to synergistically alleviate oxidative stress. Graphical
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Nature Communications
·
2026
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IF 18.1
Zhao Lekai,Li Qiang,Han Shuang,Ma Xiao,Zhou Ming,Wang Qiuyue,Feng Shasha,Low Ze-Xian,Zhong Zhaoxiang,Xing Weihong
Humic acid (HA), a complex organic compound of natural matter, is harmless on its own but can form carcinogenic disinfection byproducts, such as trihalomethanes and haloacetic acids, during water chlorination and disinfection processes, posing serious risks to aquatic organisms and human health. We present a B-site dual-metal-doping strategy to fabricate ferromagnetic perovskite-type adsorbents for rapid and efficient HA degradation. Perovskite oxides, specifically LaFeO 3 , were selected for their unique crystal structure, tunability, and inherent ferromagnetic properties. By doping Ti and Co at the B-site, we created a bifunctional perovskite absorbent that exhibits a rapid HA adsorption rate with a high adsorption capacity of 381 mg g -1 , while also enabling regeneration in situ or magnetic recovery for Fenton regeneration. Computational simulations provide molecular-level insights into the interactions between the perovskite adsorbent and HA. Our findings reveal the potential of perovskite materials as highly effective, regenerable catalytic adsorbents for organic compounds, paving the way for their development in sustainable water remediation applications.
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Nano-Micro Letters
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2026
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IF 38.5
Xiaoxiao Li,Minqiang Jiang,Kai Chen,Zhixiang Cai,Yingxin Zhang,Jiamei Luo,Lei Hou,Yazhou Zhou,Chao Zhang,Hui Zhang,Feili Lai,Yue-E Miao,Tianxi Liu,Klaus Müllen
Highlights A biomimetic polyphenol-gated strategy is proposed to promote interfacial Li + - selective transport in composite solid electrolytes by chemically bonding the polymer matrix and ceramic nanofibers. The polyphenol interlayers serve as the chemical gates with –OH and –NH groups to immobilize lithium salt anions and carbonyl groups to coordinate Li + , thus lowering the energy barrier and promoting rapid Li + transport at interface. The assembled Li||LiFePO 4 batteries exhibits an impressive capacity of 151.6 mAh g −1 and long lifespan over 600 cycles. Solid-state lithium (Li) batteries offer high-energy density and operational safety but face sluggish Li + transport in polymer/ceramic composite solid-state electrolytes. Herein, we propose a bioinspired polyphenol-gated interfacial engineering that mimics ion-selective protein channels to enhance Li + -selective transport across the polymer–ceramic interface. Polyphenols such as polydopamine, poly-tannic acid, and poly-gallic acid chemically couple La 0.56 Li 0.33 TiO 3 ceramic nanofibers and glycidyl polyether matrix. Within this interface, carbonyl groups selectively coordinate Li⁺ and facilitate directional migration. On the other hand, hydroxyl and amino groups immobilize anions via hydrogen bonding. This chemical gating nearly doubles interfacial Li + concentration and boosts transference number to 0.68. The corresponding Li||LiFePO 4 battery exhibits stable cycling over 600 cycles with 85.5% capacity retention at 1 C, while the pouch cell delivers reliable operation under mechanical stress caused by bending and puncturing. This work demonstrates that polyphenol-gated interfaces are essential for promoting selective and efficient cross-phase Li⁺ transport for high-performance solid-state lithium-metal batteries. Supplementary Information The online version contains supplementary material available at 10.1007/s40820-026-02127-6.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Tang Jinping,Qian Fuqiang,Wang Yuhai,Wang Chunxu,Kong Dewen
Ferroptosis is a novel form of programmed cell death distinct from apoptosis, necrosis, and autophagy, characterized by the abnormal accumulation of iron-dependent lipid peroxides. Increasing evidence suggests that ferroptosis is widely involved in various diseases, including neurodegenerative disorders, cancers, and cardiovascular diseases. However, the mechanisms of enzymes promoting lipid peroxidation remain poorly understood. The endoplasmic reticulum monooxygenase (MMO) mainly composed of cytochrome P450 (CYPs) and cytochrome P450 reductase (CPR) transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to molecular oxygen, leading to the generation of reactive radical intermediates and hydrogen peroxide. Subsequently, peroxidation of unsaturated liposomes disrupts membrane integrity and leads to ferroptosis. Herein, we elucidate the molecular details of MMO-liposome interactions and reveal their association with phospholipid membrane permeabilization in ferroptosis. Using Raman spectroscopy, we found that MMO interacted with unsaturated liposomes in the presence of electron donors, disrupting the conformation order of fatty acid chains. Furthermore, the degree of unsaturation in the liposomes positively correlates with the extent of peroxidation. Simultaneously, through the Raman spectra of the CYP 3A4 redox center, the relationship between MMO-liposome interactions and reactive oxygen species (ROS) generation is revealed, providing new insights into the mechanistic analysis of MMO-mediated ferroptosis. Moreover, the addition of Fe 3+ promotes the generation of reactive hydroxyl radicals, accelerating the extent of liposomal peroxidation. This study provides new mechanistic insights into how MMO promotes ferroptosis through lipid peroxidation and offers a theoretical basis for the development of novel anticancer therapeutic strategies. Graphical abstract
The alternative text for this image may have been generated using AI.
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RESEARCH ON CHEMICAL INTERMEDIATES
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2026
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IF 3.3
Jiang Yu,Yang Qiusheng,Wang Yanji,Lu Yao,Zhai Peng,Zhang Dongsheng
This study developed an environmental and highly efficient synthetic route for preparation of amino-methyl-N-phenylcarbamate (TMC). Using commercially available nano-iron powder as a heterogeneous catalyst, methyl metholylcarbamate (MTCM) was converted to TMC via direct amination in hexafluoroisopropanol (HFIP) solvent. Key parameters including amination agent, feedstock ratio, catalyst dosage, reaction time and temperature were explored systematically. The optimized reaction conditions were MTCM/amination agent (molar ratio) 1:1.8, nano-iron powder (0.1 g) catalyst, conducted at 40 ℃ for 3 h. Under these conditions, the overall TMC yield reached 66.14%. Characterization revealed that the nano-iron powder exhibits high purity (Fe content: 99.20 wt.%) and a well-defined crystalline structure, with a surface featuring a mixed Fe 2+ /Fe 3+ oxide layer. The catalyst showed no significant decline in activity after five cycles, indicating excellent stability and industrial application potential. Furthermore, possible reaction pathway involved free radical species and proton transfer step was proposed for the amination.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2026
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IF 3.5
Zhou Fengfeng,Li Chenglin,Che Fengyuan
To explore the effect of Licochalcone A on cuproptosis in glioma and the underlying mechanism, U87 MG and U251 cells were treated with 10, 20, and 30 µM Licochalcone A for 24 h. Key assays including immunofluorescence, TEM, mitochondrial membrane potential and morphological analysis, as well as other cuproptosis-related indexes were detected. Furthermore, the cuproptosis activator elesclomol, inhibitor TTM, and Ras activator ML-098 were used. An in vivo nude mouse xenograft model was established. Our results demonstrated that Licochalcone A triggered cuproptosis in a dose-dependent manner, and in U87 and U251 cells, 30 µM Licochalcone A treatment increased the Cu²⁺ accumulation by 2.86 ± 0.67 folds and 1.96 ± 0.39 folds, elevated pyruvic acid levels by 2.15 ± 0.23 folds and 2.57 ± 0.46 folds, reduced mitochondrial membrane potential by 34.13 ± 1.70% and 40.43 ± 9.05%, downregulated the protein expression of FDX1 and LIAS, and increased cellular ROS levels by 4.74 ± 0.85 folds and 5.10 ± 2.16 folds, respectively. These changes were accompanied by obvious mitochondrial swelling and cristae disruption, resulting in a significant inhibition of cell proliferation. Mechanistically, it promoted cuproptosis by inactivating RAS/ERK. In vivo, 10 mg/kg Licochalcone A reduced tumor volume/weight by 42.27 ± 11.63%/45.13 ± 13.15%, with consistent protein changes (FDX1, LIAS, RAS, p-MEK and p-ERK). Collectively, it induces glioma cuproptosis via inactivating RAS/ERK, providing a potential therapeutic target.
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WATER AIR AND SOIL POLLUTION
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2026
·Vol. 237
·期 16
·948
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IF 3.5
Shi Shengnan,Su Xinran,Shi Linna,Li Shuang,Pu Yunhong,Zeng Qianzhi,Yang Bowen,Wu Yaxuan,Sun Yue,Ma Yulian,Yang Xinyu,Wang Xin,Gong Zheng
As a substitute for perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA) has been detected in various environments, while its impact on sediment bacteria was unclear. PFHpA exposure altered the whole and the rare bacterial community structure in sediment. Concurrently, PFHpA selectively enriched bacteria involved in C/N/P/S cycling. PFHpA induced intracellular reactive oxygen species (ROS) overproduction, triggering both the antioxidant defense system and the SOS response. PFHpA upregulated functional gene and enzymatic activities involved in C/N/P cycling, while downregulated those involved in S cycling. Based on the co-occurrence patterns between ARGs and MGEs, it might be speculated that HGT potential was increased upon PFHpA exposure. PLS-PM analysis indicated that the rare bacteria had more significant and direct effects on C/N/P/S cycling and transmission of ARGs. These findings will prove useful for understanding the effects of PFHpA on bacterial community, C/N/P/S cycling and transmission of ARGs in sediment.
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Nature Communications
·
2026
·
IF 18.1
Zhao Dongfang,Chen Hui,Jin Dongdong,Cao Hanyu,Liu Xiaojia,Wang Yong,Du Xingzhou,Yu Jiangfan,Guo Jinhong,Zhang Li,Ma Xing
Surface-enhanced Raman spectroscopy (SERS) offers exceptional sensitivity but faces a critical trade-off in living systems: rigid substrates lack biological adaptability, while colloidal nanoprobes suffer from poor signal reproducibility. Herein, we present a bioadaptive SERS platform using magnetically guided swarming nanoprobes. These probes integrate a magnetic core, plasmonic gold/silver layers, and a biocompatible silica coating, enabling programmable assembly under magnetic fields into chain-like nanostructures with interparticle gap-dependent hotspots, followed by coordinated reconfiguration into dynamically stable swarms. Multiphysics simulations reveal that cyclic assembly-disassembly generates transient electromagnetic hotspots while inducing convective flows to actively recruit analytes. This dual mechanism achieves reproducible enhancement factors exceeding 2.9×10 7 , an order of magnitude higher than colloidal systems. In vivo, swarming nanoprobes deployed in rabbit models demonstrate over 10.3-fold Raman signal amplification during intravascular detection. By leveraging active matter physics to synergize nanoscale sensing, this work establishes a new paradigm for in vivo molecular diagnostics.
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INFLAMMATION
·
2026
·Vol. 49
·期 1
·146
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IF 5.4
Zhou Tingting,Huang Linlin,He Yanqiu,Cheng Xi,Ren Qian,Zeng Cheng,Gong Qiming,Li Yanqun,Ma linqiang,Jiang Zongze,Long Yang,Wan Qin,Xu Yong,Huang Wei
Diabetic kidney disease (DKD) is one of the predominant microvascular complications in diabetes. In recent years, the nuclear factor E2-related factor 2 (Nrf2)-mediated anti-oxidative stress pathway is tightly regulated by multiple post-translational modifications, governing its role in countering oxidative stress and DKD pathogenesis. Recent studies have found that the principal constituent of ketone bodies, β-hydroxybutyrate (β-HB), not only serves as an alternative energy source, but also induced lysine β-hydroxybutyrylation (Kbhb), which has various unknown pathophysiological functions. Previous research reports that β-HB activates Nrf2 and then treats DKD, yet its underlying molecular mechanism remains unclear. To explore the mechanism of β-HB induced Kbhb in DKD, β-HB was administered in both in vivo and in vitro . Our results verified that exogenous β-HB supplementation alleviated dysglycolipidemia, inhibited proteinuria and renal dysfunction. Meanwhile, β-HB enhanced Nrf2 Kbhb modification, and activated the Nrf2 signaling to mitigate renal inflammatory-fibrotic injury in diabetes. However, inhibition of Kbhb partially reversed β-HB-mediated Nrf2 activation and nephroprotection. In conclusion, our data reveal that β-HB attenuates DKD, β-HB-induced Nrf2 Kbhb modification may be an important molecular mechanism in the pathogenesis and treatment of DKD.
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Nature Communications
·
2026
·
IF 18.1
Liu Xiang,Zhou Tiancong,Yuan Bo-Jun,Shi Qiujin,Zhou Peiyun,Wang Ye,Li Jing,Zhang Chunyu,Shao Mingfei,Duan Haohong
Electrooxidation of organic compounds to produce organic acid in an acidic electrolyte can circumvent product acidification step with high cost in alkaline electrolyte. However, catalysts often suffer from low stability in acid owing to severe leaching. Herein, we report a strategy to dynamically attract leached metal species to stabilize catalyst in a strong acid. In electrooxidation of glucose to formic acid over a lead dioxide (PbO 2 ) catalyst, switching the electrolyte from HClO 4 to H 2 SO 4 reduces Pb 2+ leaching by up to 30 times. As a result, a 275-hour stable performance at 1 A cm ‒2 is achieved in H 2 SO 4 (pH 0.3) using a membrane electrode assembly. Experimental evidence demonstrates that the SO 4 2− ion attracts the leached Pb 2+ —generated from chemical reduction of PbO 2 by glucose—by in-situ forming PbSO 4 precipitate on the electrode, which is then oxidized to the active PbO 2 phase. Benefiting from acidic electrolysis, we achieve raw cellulose conversion to formic acid without intermediate separation through an acid hydrolysis−electrolysis tandem process. This work demonstrates an efficient strategy to stabilize electrocatalysts that suffer from leaching issues in acidic conditions.
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