Food Analytical Methods
·
2020
·Vol. 14
·期 3
·616-630
·
IF 2.667
Qi Dandan,Ma Chengying,Wang Wenwen,Zhang Licui,Li Jianke
Royal jelly produced by nurse bees from tea tree (tea royal jelly) is a special bee product in China and it is popular with consumers owing to its multiple healthcare functions. However, the volatile compound profile of tea royal jelly has not been investigated. To obtain a comprehensive understanding of volatile compound profile of tea royal jelly, a method based on headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS) and chemometric analysis was applied. Moreover, two royal jelly samples produced from pagoda tree were also investigated to reveal the difference in volatile compounds between royal jelly produced from tea tree and other plants. A total of 66 volatile compounds were identified in tea royal jelly, including 16 alkanes, 14 aldehydes, 9 alcohols, 9 ketones, 8 esters and lactones, 5 phenols, 2 organic acids, and 3 other compounds, and most of them were discovered in royal jelly for the first time. Notably, α -ionone, an important aroma compound in tea, was first identified in tea royal jelly. Moreover, the result of chemometric analysis indicates a significant difference on volatile compound profile between royal jelly produced from tea and pagoda trees. To sum up, 35 differential compounds were identified and they could well distinguish royal jelly samples. Our data offers the first characterization of volatile compound profile of tea royal jelly and significantly expands the knowledge of volatile compounds in royal jelly. It is potentially useful as a new approach to distinguish royal jelly produced from different botanical origins.
Graphical abstract
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Drug Delivery and Translational Research
·
2020
·Vol. 11
·期 3
·1218-1235
·
IF 2.664
Ma Cheng,Wu Mingjun,Ye Weifen,Huang Zhengwei,Ma Xiangyu,Wang Wenhao,Wang Wenhua,Huang Ying,Pan Xin,Wu Chuanbin
Mycobacterium tuberculosis (MTB) is one of the most threatening pathogens for its latent infection in macrophages. The intracellular MTB isolated itself from drugs and could spread via macrophages. Therefore, a mannose-modified macrophage-targeting solid lipid nanoparticle, MAN-IC-SLN, loading the pH-sensitive prodrug of isoniazid (INH), was designed to treat the latent tuberculosis infection. The surface of SLNs was modified by a synthesized 6-octadecylimino-hexane-1,2,3,4,5-pentanol (MAN-SA) to target macrophages, and the modified SLNs showed a higher cell uptake in macrophages (97.2%) than unmodified SLNs (42.4%). The prodrug, isonicotinic acid octylidene-hydrazide (INH-CHO), was synthesized to achieve the pH-sensitive release of INH in macrophages. The INH-CHO-loaded SLNs exhibited a pH-sensitive release profile and accomplished a higher accumulated release in pH 5.5 media (82.63 ± 2.12%) compared with the release in pH 7.4 media (58.83 ± 3.84%). Mycobacterium smegmatis was used as a substitute for MTB, and the MAN-IC-SLNs showed a fourfold increase of intracellular antibiotic efficacy and enhanced macrophage uptake because of the pH-sensitive degradation of INH-CHO and MAN-SA in SLNs, respectively. For the in vivo antibiotic efficacy test, the SLNs group displayed an 83% decrease of the colony-forming unit while the free INH group only showed a 60% decrease. The study demonstrates that macrophage targeting and pH-sensitive SLNs can be used as a promising platform for the latent tuberculosis infection.
Table of contents: Macrophage-targeting and pH-sensitive solid lipid nanoparticles (SLN) were administrated to the lung via nebulization. Macrophage targeting was achieved by appropriate particle size and surface mannose modification with synthesized MAN-SA. After being swallowed by macrophages, the prodrug, Isonicotinic acid octylidene-hydrazide (INH-CHO), quickly released isoniazid, which was triggered by the intracellular acid environment. The SLNs exhibited higher intracellular antibiotic efficacy due to their macrophage-targeting and pH-sensitive properties.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 31
·期 21
·18590-18604
·
IF 2.22
Zong Hanwen,Yang Haibo,Dong Jingjing,Ma Liang,Lin Ying,Qiu Yun,Wen Bo
Nowadays, designing and fabricating electromagnetic (EM) wave absorbers with lightweight and strong reflection loss (RL) is still urgent. Herein, rGO/CoFe 2 O 4 composite combined with magnetic CoFe 2 O 4 nanorods and reduced graphene oxide (rGO) was fabricated via molten salt method in combination with a simple etching route. The EM absorption ability of rGO/CoFe 2 O 4 nanorods composite can be regulated by changing the rGO addition amount. Particularly, the absorber for rGO/CoFe 2 O 4 nanorods composite with the rGO addition amount of 70 mg (S-70) displays favorable EM wave absorption properties. The optimal RL value is − 56.3 dB at the frequency of 16.9 GHz, when the corresponding thickness is 1.4 mm. The effective absorption bandwidth (EAB, RL < − 10 dB) is 4.3 GHz, when the thickness is 1.6 mm. Consequently, the rGO/CoFe 2 O 4 nanorods composite is a potential candidate for microwave absorbing materials.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 11
·1-11
·
IF 6.232
Cui Ying,Li Junhua,Liu Mengqin,Tong Haixia,Liu Zeng,Hu Jiawen,Qian Dong
A novel hybrid with three-dimensional (3D) hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide (CuS@Pd/N–RGO) has been prepared by a facile wet-chemical route without utilizing any template molecules and surfactants. The characterization results reveal that the 3D flower-like structure of CuS “core” is composed of interconnecting nanoplates, which is conductive to the loading of Pd nanoparticles’ “shell” and results in the robust interaction between the core and shell for the formation of CuS@Pd cauliflowers. Anchoring such appealing CuS@Pd cauliflowers on the two-dimensional N–RGO can efficaciously inhibit the aggregation of CuS@Pd cauliflowers and accelerate the kinetics of xanthine oxidation. Benefiting from the multi-functional properties and unique morphology, the sensor constructed by CuS@Pd/N–RGO exhibits excellent performance for non-enzymatic detection of xanthine including a wide detection range of 0.7–200.0 μM (0.94 V vs. SCE), a low detection limit of 28 nM (S/ N = 3), high reproducibility (relative standard deviation (RSD) = 4.1%), and commendable stability (retained 90% of the initial electrochemical responses after storage for 30 days), which is amongst the best of various electrochemical sensors reported for xanthine assays till date. Reliable and satisfying recoveries (95–105%, RSD ≤ 4.1%) are achieved for xanthine detection in real samples. The inspiring results make the uniquely structural CuS@Pd/N–RGO greatly promising in non-enzymatic electrochemical sensing applications.
A high-performance non-enzymatic xanthine sensor has been constructed by the three-dimensional hierarchical CuS@Pd core-shell cauliflowers decorated on nitrogen-doped reduced graphene oxide.
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Journal of Food Measurement and Characterization
·
2020
·Vol. 15
·期 1
·247-255
·
IF 1.648
Ouyang Mengyun,Cao Sheng,Huang Yiqun,Wang Yan
This study was aimed to investigate the effects of hot air drying (60–100 ℃, 1.5 m/s, 6–17 h; final products contained 10.50 ± 0.29% moisture) on the levels of total phenolic compounds (TPC) including both soluble phenolic compounds (SPC) and insoluble phenolic compounds (IPC) as well as ascorbic acid in pumpkin slices. IPC accounted for an average of 74.9% of the TPC in fresh pumpkin flesh, but only accounted for 49.4% (100 ℃ drying) to 59.7% (60 ℃ drying) of the TPC in the final dried pumpkin slices. As the drying temperature increased, the retention of IPC (22.8–42.7%), TPC (41.6–50.9%), and ascorbic acid (22.2–51.0%) in the dried products significantly decreased ( p < 0.05), but the retention of SPC (74.5–92.7%) significantly increased which may be due to more conversion of IPC to SPC at a higher temperature. The degradation of ascorbic acid during hot air drying fitted well to the first-order kinetic function (R 2 = 0.985–0.999), and that of IPC, SPC and TPC fitted well to zero-order reactions (R 2 = 0.887–0.997). Unlike the other three compounds, the reduced level of SPC decreased as the temperature increased ( k = 0.008–0.029/h, Ea = 33.7 kJ/mol), corresponding to the increased retention of SPC in the final dried pumpkin slices.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 21
·25895-25907
·
IF 2.478
Liu Xiaoling,Tang Zhiming,Xue Jimei,Wei Hanjun,Fan Xiaomeng,Liu Yongsheng,Cheng Laifei
Porous SiCN(Ti) composite ceramics with good microwave absorbing performance were fabricated by pyrolysis of solid polysilazane modified by tetrabutyl titanate. The introduction of Ti not only acted as active filler to react with free carbon in the matrix to form TiC, but also played the role as catalyst to promote the formation of SiC nanowires. Finally, SiCN(Ti) composite ceramics formed a microstructure containing multi-nanophases and multi-nano heterogeneous interfaces when annealing temperature reached 1500 °C. The complex microstructure annealed at 1500 °C made composite ceramics have good matching impedance, as well as greatly increase the interfacial polarization loss and dipole polarization loss. As a result, the TiC/SiC/SiCN composite ceramics showed the excellent performance of electromagnetic wave absorption in X band. The minimum reflection loss (RL) of samples was − 17.1 dB at the thickness of 1.9 mm, and the maximum effective absorption bandwidth (EAB) of composite ceramics was 3.2 GHz when the thickness of sample was 2.1 mm, which exhibited a promising prospect as a structural and microwave absorbing integration material.
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Cell Death & Disease
·
2021
·Vol. 12
·期 1
·1-13
·
IF 8.469
Ge Wenhao,Wang Tao,Zhao Yang,Yang Yunxia,Sun Qi,Yang Xiao,Gao Yan,Xu Xi,Zhang Jianfa
The biological clock is an endogenous biological timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled in livers. However, how the clock genes respond to toxins and influence toxicity keeps unclear. We identified the clock gene Per1 was specifically elevated in mice exposed to toxins such as carbon tetrachloride (CCl 4 ). Mice lacking Per1 slowed down the metabolic rate of toxins including CCl 4 , capsaicin, and acetaminophen, exhibiting relatively more residues in the plasma. Liver injury and fibrosis induced by acute and chronic CCl 4 exposure were markedly alleviated in Per1 -deficient mice. These processes involved the binding of PER1 protein and hepatocyte nuclear factor-1alpha (HNF-1α), which enhances the recruitment of HNF-1α to cytochrome P450 2E1 ( Cyp2e1 ) promoter and increases Cyp2e1 expression, thereby promoting metabolism for toxins in the livers. These results indicate that PER1 mediates the metabolism of toxins and appropriate suppression of Per1 response is a potential therapeutic target for toxin-induced hepatotoxicity.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-9
·
IF 5.833
Zhang Dongwei,Liu Yang,Ding Jina,Hayat Kashif,Zhan Xuejia,Zhou Pei,Zhang Dan
A short ssDNA (Apt-21) rationally truncated from the parent 100 nt As(III) aptamer was used for colorimetric determination of As(III). Apt-21 serves dual functions, i.e., recognition of trace As(III) and regulation of AuNPs dispersion by surface attachment, while gold nanoparticles (AuNPs) functioned as colorimetric signal reporters. Under the optimal conditions, the ratio of the absorbance at 650 nm to 520 nm (A 650 /A 520 ) of AuNPs changed proportionally with increasing concentration of As(III), which showed a linear relationship within the concentration ranges 1–30 ppb and 30–100 ppb with a detection limit of 0.18 ppb. The feasibility of this assay was demonstrated by determining As(III) in spiked water samples with mean recoveries ranging from 96.5–107.1%. Graphical abstract
Schematic representation of colorimetric detection of As(III) based on the short ssDNA (Apt-21) and gold nanoparticles (AuNPs)
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COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 299
·期 1
·37-47
·
IF 1.536
Wang Xiaotao,Xu Junyang,Xie Xun,Li Xuefeng,Liu Zuifang
Poly(vinyldiaminotriazine) nanoparticles adsorbed 5-fluorouracil, thymine, theobromine, and xanthine in aqueous phase. Each drug molecule formed triple hydrogen bonds with a diaminotriazine moiety at the nanoparticle surface. Adsorption isotherm studies suggested monolayer adsorption while the adsorption capacity was strongly dependent on the drug compositions/structures (0.053 mmol/g 5-fluorouracil, 0.094 mmol/g thymine, 0.0078 mmol/g theobromine, and 0.0065 mmol/g xanthine). The drug compositional/structural effects were also reflected in the adsorption kinetics. In addition to neutral pH adsorption, studies were performed at pH below the polymer’s pKa and above the drugs’ pKa, separately. Reducing hydrophobicity of the hydrogen bonding sites by protonating the diaminotriazine moieties at pH 4.5 resulted in more than 3 times decrease in adsorption capacities whereas deprotonating the drug molecules at pH 9 increased the adsorption capacity due to electrostatic attraction between the negatively charged drugs and the positively charged nanoparticles, which was supported by strong dependency of the adsorption capacity on ionic strength. The adsorption was reversible for all the four drugs. While increasing temperature caused faster desorption, reducing hydrophobicity of the diaminotriazine moieties by protonation at pH 4.5 had a stronger effect on both cumulative desorption and burst release. The results of this study demonstrated an important role of synergistic interaction between hydrogen bonding and hydrophobic affinity in poly(vinyldiaminotriazine) nanoparticle adsorption of the drugs in the aqueous phase.
Graphical abstract
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 39
·期 6
·736-744
·
IF 3.603
Wang Hao,Liu Han-Chao,Zhang Yao,Xu Hu,Jin Bi-Qiang,Cao Zhen-Xing,Wu Hai-Tao,Huang Guang-Su,Wu Jin-Rong
It remains a challenge to use a simple approach to fabricate a multi-shape memory material with high mechanical performances. Here, we report a triple crosslinking design to construct a multi-shape memory epoxy vitrimer (MSMEV), which exhibits high mechanical properties, multi-shape memory property and malleability. The triple crosslinking network is formed by reacting diglycidyl ether of bisphenol F (DGEBF) with 4-aminophenyl disulfide, γ -aminopropyltriethoxysilane (APTS) and poly(propylene glycol) bis(2-aminopropyl ether) (D2000). The triple crosslinking manifests triple functions: the disulfide bonds and the silyl ether linkages enable malleability of the epoxy network; the silyl ether linkages impart the network with high heterogeneity and broaden the glass transition region, leading to multi-shape memory property; a small amount of D2000 increases the modulus difference between the glassy and rubbery states, thereby improving the shape fixity ratio. Meanwhile, the high crosslinking density and rigid structure provide the MSMEV with high tensile strength and Young’s modulus. Moreover, integrating carbon fibers and MSMEV results in shape memory composites. The superior mechanical properties of the composites and the recyclability of carbon fiber derived from the dissolvability of MSMEV make the composites hold great promise as structural materials in varied applications.
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CELLULOSE
·
2021
·Vol. 28
·期 3
·1527-1540
·
IF 5.044
Tang Zuwu,Miao Yanan,Zhao Jing,Xiao He,Zhang Min,Liu Kai,Zhang Xingye,Huang Liulian,Chen Lihui,Wu Hui
Hydrogels are attractive due to their various applications in the fields of biomedical materials, cosmetics, and biosensors. To enhance UV protection and prevent skin penetration behaviors, inspired by the mussel adhesive proteins, the functional polydopamine (PDA) is employed herein to fabricate polydopamine/carboxymethyl cellulose/polyacrylic acid (PDA/CMC/PAA) adhesive hydrogels. To disperse PDA nanoparticles well in the PAA matrix, dopamine was self-polymerized in CMC solution to form PDA/CMC complex. Acrylic acid was polymerized in PDA/CMC complex solution and cross-linked to construct UV-resistant PDA/CMC/PAA hydrogel. The morphology, rheological behavior, mechanical properties and adhesion strength of PDA/CMC/PAA hydrogels were studied by scanning electron microscopy, rotational rheometer, universal test machine. Owing to the hydrogen bonding interaction between the PDA/CMC complex and PAA, the PDA/CMC/PAA hydrogels showed high resilience and compressive strength to withstand large deformation. The hydrogels exhibited strong adhesion to various substrate surfaces, such as stainless steel, aluminum, glass and porcine skin. The biocompatibility and UV-shielding properties were investigated through culture of cells and UV irradiation test. The adhesiveness of PDA promoted cell adhesion and provided the PDA/CMC/PAA hydrogels good biocompatibility with 96% of relative cell viability. The hydrogels possessed excellent UV-shielding ability to prevent collagen fibers from being destroyed during UV irradiation, which has promising potential in the practical applications for UV filtration membrane and skin care products.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2021
·Vol. 31
·期 6
·2511-2520
·
IF 3.543
Amin Bilal Ul,Yu Haojie,Wang Li,Fahad Shah,Nazir Ahsan,Haq Fazal,Mahmood Sahid,Uddin Md Alim,Shen Di,Liang Ruixue
To overcome the migration problems of burning rate catalysts (BRCs), ferrocene-based amide compounds (AM-Fcs) were synthesized. The successful synthesis of AM-Fcs were confirmed by proton nuclear magnetic resonance, and Fourier transform infrared spectroscopy. The electrochemistry behaviors of AM-Fcs were examined by cyclic voltammetry (CV). The CV experimental results indicated that these AM-Fcs showed good electrochemical performances, which were contributable to their burning rate (BR) catalytic activity in composite solid propellants. The anti-migration test of AM-Fcs verified significantly slower migration than ferrocene and the most commonly used BRCs catocene. Thermal stability and BR catalytic impact of AM-Fcs on the thermal decomposition of ammonium perchlorate (AP) were studied by thermogravimetry and differential thermogravimetry. These AM-Fcs revealed good catalytic behaviors on the thermal degradation of AP.
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