MATERIALS TECHNOLOGY
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2022
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IF 3.297
Siqi Tan,Yueshan Huang,Jun Lan,Xiao Han,Renjing Cen,Xiuhua Zhao,Lao Yonghua
Mechanical properties of hyaluronic acid (HA) hydrogels are too poor to be prepared as an ultra-thin hydrogels, so to provide a supporting skeleton for them is important. Herein, the porous film based on chitosan(CS)、PEG-20000 and graphene oxide (GO) were prepared for ultra-thin hydrogels. CS is a suitable polymer to prepare films. The added PEG-20000 endowed the film porosity. And the addition of GO improved the mechanical of the film. When CS:PEG = 3:2 and the GO solution proportion was 15%, the porous film exhibited the best comprehensive properties, with a tensile strength of 5.593 MPa, an elongation at break of 45.833%, a water permeation of 1.4099 g at 12 h, a porosity of 62.3% and an average pore size of 1.88 um. Blood compatibility experiments and cell experiments have proved that the film hydrogel has strong biocompatibility, indicating it can be a promising biomaterial.
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Catalysts
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2022
·Vol. 12
·期 11
·1469
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IF 4.501
Yilin Huang,Jia Wang,Mengwei Li,Zhixiong You
We have successfully synthesized dithiocarbamate chitosan modified SBA-15 (CS2C@SBA) composites, with promise in vanadium (V(V)) elimination. Among the three composites using different mass ratios of dithiocarbamate chitosan to SBA-15, CS2C@SBA−3, which had the highest CS2substitution, showed the best performance on V(V) removal of which the maximum adsorption capacity could achieve 218.00 mg/g at pH 3.0. The adsorption kinetics were best fitted with a pseudo−second order reaction model, suggesting a chemisorption mechanism. Meanwhile, the Langmuir model fitted better with the adsorption isotherm, revealing a monolayer adsorption behavior. Through FTIR and XPS analysis, the functional group −SH was identified as dominating reduction sites on this composite, which reduced 73.1% of V(V) into V(IV) and V(III). The functional group −NH− was the main adsorption site for vanadium species. This reaction followed a catalytic reduction coupled adsorption mechanism reducing most of V(V) into less toxic vanadium species. Furthermore, CS2C@SBA−3 showed great selectivity towards V(V) in the presence of various co−existing ions in synthetic wastewater and real water samples. Moreover, CS2C@SBA−3 could retain a removal efficiency over 90% after five adsorption−desorption cycles. Based on the aforementioned results, we can conclude that CS2C@SBA−3 has great potential to be applied in efficient remediation of vanadium water−pollution.Keywords:vanadium elimination;adsorption;catalytic reduction;thiol function group;dithiocarbamate chitosan modified SBA-15
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POLYMERS FOR ADVANCED TECHNOLOGIES
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2022
·Vol. 34
·期 2
·691-701
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IF 3.348
Hai-qiang Zhang,Jiale Zhou,Hai Wang,Dongwei Lan,Yan Peng,Zhi Li,Fangyin Dai
To develop an antimicrobial membrane for wound healing, the blended k-carrageenan (KC)/carboxymethyl chitosan (CMCH) membranes were fabricated through a freeze-drying process together with a dual-ion (Cu 2+ and K + or Cu 2+ and Ca 2+ ) crosslinking approach. The dual-ion crosslinking by Cu 2+ and K + could not only make the membranes compact but could also improve the uptake capacity and mechanical properties of the fabricated membranes. The maximum tensile stress of membranes reached up to 43 MPa and the highest swelling ratio was around 5500%, exhibiting robust moisture retention property. The CMCH and Cu 2+ in blended membranes provided a good antimicrobial property against gram-positive and gram-negative bacteria. Moreover, the fabricated membranes showed good cytocompatibility. These results indicated the fabricated KC/CMCH membranes with dual-ion by Cu 2+ and K + have favorable properties and have a great potential for application in wound healing.
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JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Xiaogeng Lin,Li Chen,Chang Chen,Jianqing Rao,Jianhua Chen,Yasan He
Covalent organic frameworks (COFs) based membranes have demonstrated great potentials in molecular separation. Currently, most studies focus on developing continuous COF membranes. However, their low crystallinity compared with COF powders due to the more restricted synthesis conditions impedes their application in precise separation. Herein, we explored the assembly of highly crystalline COF powders with chitosan (CS) to construct precise-sieving membranes with high COFs loading. A post-carboxylated COFs (TATP-COOH) was synthesized, and a facile and scalable strategy was developed for constructing the assembled COF membranes (TATP-COOH@CS/TATP-COOH/CA) with TATP-COOH loading as high as 40 wt% (82 v%). Characterizations revealed TATP-COOH particles could interact with CS via H-bonding to form dense TATP-COOH@CS layers, and the TATP-COOH layer on the CA substrate was essential to obtain mechanically stable membranes. The prepared membranes exhibited precise rejection to Congo red, Coomassie brilliant blue (BB), Alcian blue and Direct blue 19 with 100% rejection and ultrafast permeance (>1350 L m −2 h −1 MPa −1 ). It also showed superior precision in separating Methyl orange and BB mixed solution with only Methyl orange passing through. This study provides a significant concept and a facile strategy to the preparation of high precise-sieving COF membranes to take advantages of highly crystalline COFs.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Yadong Wang,Jun Yuan,Li Ma,Xianze Yin,Zongmin Zhu,Pingan Song
As a very promising biodegradable polymer, polylactic acid (PLA) has been applied in various fields. Unfortunately, the disadvantages of flammability and large amounts of molten droplets limit its application. In this work, we constructed a novel flame-retardant system by combining the as-prepared bio-based chitosan derivative (CS-TE) and aluminum hypophosphite (AP), and used it to improve the flame retardancy and anti-dripping property. When 3.75 wt% CS-TE and 11.25 wt% AP were incorporated into PLA, the PLA composite had a limiting oxygen index of 28.5 % and achieved a UL-94 V-0 rating as well as showed excellent anti-dripping behavior. Meanwhile, the peak heat release rate and total smoke production decreased by 52.3 % and 73.4 % respectively.
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高影响因子
APPLIED SURFACE SCIENCE
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2022
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IF 7.392
Gang Shu,Dan Xu,Songtao Xie,Li-Jen Chang,Xinyue Liu,Jianqing Yang,Yunchun Li,Xianxiang Wang
This study aimed to develop a novel ZnO-quantum dots-Chitosan biocomposite dressing (CS-ZnO QDs) with improved antioxidant, antibacterial, and potential infected wound healing effects. CS-ZnO QDs were synthesized successfully by incorporating ZnO QDs into chitosan, and in vitro antioxidant, antibacterial and anti-biofilms tests were conducted. Furthermore, the therapeutic effects of CS-ZnO QDs for infected wound healing were investigated. The results of the character study revealed steady compatibility between chitosan and ZnO QDs. Nonetheless, the in vitro antioxidant and antibacterial studies showed that CS-ZnO QDs had better antioxidant activity, inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA), and a vigorous eradication of bacterial biofilms compared to ZnO-QDs and CS alone. CS-ZnO QDs presented stable cyto-compatibility in NIH/3T3s cells. In addition, CS-ZnO QDs facilitated MRSA-infected wound healing by inhibition of bacterial growth, regulation of the NFκB-p65 pathway to alleviate inflammation, improve wound repairing in an adequate environment, and directly enhance re-epithelialization and collagen deposition.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Rixiang Su,Peiyuan Li,Ying Zhang,Yingbin Lv,Fangzhou Wen,Wei Su
The design and development of smart shape-adaptable wound dressings with superior antimicrobial ability remain a challenge in therapeutic and clinical application. Herein, polydopamine/tannic acid/chitosan/poloxamer 407/188 hydrogel (PTCPP) was prepared with the aim of developing an in situ -formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. PTCPP possessed injectability, photothermal stability, sustained release properties and cytocompatibility. In vitro antibacterial results showed that the bactericidal rates of PTCPP against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) under NIR irradiation were 99.994 % and 99.91 %, respectively. In vivo experiments, PTCPP can adapt to shape of the wound, showing good adhesion, while promoting wound healing in bacterial infections. Therefore, PTCPP has potential application in the treatment of infectious wounds, and provides a strategic choice for developing antibacterial wound dressing combined with photothermal therapy.
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Journal of Materials Research and Technology-JMR&T
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2022
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IF 6.267
Liguo Wang,Yu Zhang,Le Guo,Fengjuan Wang,Siyi Ju,Shiyu Sui,Zhiyong Liu,Hongyan Chu,Jinyang Jiang
Studying the mechanism by which organic admixtures affect the hydration and dissolution of tricalcium silicate (C 3 S) reveals the effect of organic admixtures on ordinary Portland cement and enables target regulation of cement-based materials. In this study, the effects of citric-acid-modified chitosan (CAMC) on the hydration exotherm, hydration products, and microscopic morphology of C 3 S were investigated. The interface structures, ion adsorptions, and dissolution properties of CAMC and C 3 S were analyzed using a molecular dynamics simulation method. The results showed the presence of an attraction between the C 3 S surface and CAMC due to the existence of O p -H w , O p -Ca s , and H p -O w ion pairs. CAMC adsorbed most of the Ca ions released upon dissolution of C 3 S in the aqueous solution and the resulting pairs exhibited low solubilities. The Ca ions were located on the surfaces of C 3 S particles, preventing the dissolution of the particles and proving the interference effect of additives on the hydration of the cement silicate phase.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Yan Sun,Youlu Chu,Chao Deng,Huining Xiao,Weibing Wu
In recent years, aerogel has been reported as a good thermal insulation material. However, it has remained a great challenge to realize high mechanical property and excellent anti-fouling performance concurrently of aerogel in practical applications. Here, a composite aerogel was developed via directional freezing and chemical vapor deposition (CVD) modification using chitosan (CS) and montmorillonite (MMT) as heat-resistant raw materials and cellulose nanofibrillated fiber (CNF) as reinforcing filler. The intercalation between the CS molecular chain and MMT endows the aerogel with excellent mechanical properties . Due to the anisotropic structure, the axial Young's modulus is high up to 630 KPa, and the radial thermal conductivity is as low as 31 mW m −1 K −1 . Meanwhile, the aerogel shows a high limiting oxygen index (LOI) value of 43%. Furthermore, CVD treatment increases the contact angles to water and various oils higher than 150°, which portects the aerogle from being contaminated by common liquids. Compared to conventional insulation materials, this aerogel can maintain excellent insulation performance in extreme environments such as heavy rain or oil leakage. The composite aerogel is expected to play an important role in the fields of house warmth, vehicle interior, aviation, and etc.
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International Journal of Nanomedicine
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2022
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IF 7.033
Chunyan Shao,Ziwei Yu,Tongwang Luo,Bin Zhou,Quanjiang Song,Zhuoyue Li,Xiaoqiang Yu,Sheng Jiang,Yingshan Zhou,Wanyu Dong,Xingdong Zhou,Xiaodu Wang,Houhui Song
Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly prevalent and endemic swine pathogen that causes significant economic losses to the global swine industry. Selenium nanoparticles (SeNPs) have attracted increasing attention in the biomedical field, given their antiviral effects. This study aimed to investigate the inhibitory effect of chitosan-coated SeNPs (CS-SeNPs) on PRRSV replication. Methods In this study, CS-SeNPs were synthesized by chemical reduction and characterized by assessing the morphology, size distribution, zeta potential, and element composition. Marc-145 cells were infected with r-PRRSV-EGFP (0.1 MOI) and inoculated with CS-SeNPs (10 μM). Subsequently, the concentrations of hydrogen peroxide (H 2 O 2 ) and glutathione (GSH), and glutathione peroxidase (GSH-Px) activity were measured using specific commercial assay kits. ORF5 RNA expression, viral titer, and nucleocapsid (N) protein expression were assessed using qRT-PCR, TCID 50 , and Western blot. ROS generation, apoptosis rates, and JNK /caspase-3/PARP protein expression were evaluated using dihydroethidium staining, flow cytometry, and Western blot. Results The results showed that CS-SeNPs treatment significantly suppressed oxidative stress induced by r-PRRSV-EGFP infection by increasing GSH-Px activity, promoting GSH production, and inhibiting H 2 O 2 synthesis. CS-SeNPs treatment significantly inhibited ORF5 gene expression, viral titers, and N protein of r-PRRSV-EGFP at 24 and 48 hours post-infection (hpi) in Marc-145 cells. The increase in apoptosis rates induced by r-PRRSV-EGFP infection was significantly decreased by CS-SeNPs inoculation through inhibiting ROS generation, JNK phosphorylation levels, and cleavage of caspase-3 and PARP mainly at 48 hpi. Conclusion These results demonstrated that CS-SeNPs suppress PRRSV-induced apoptosis in Marc-145 cells via the ROS/JNK signaling pathway, thereby inhibiting PRRSV replication, which suggested the potential antiviral activity of CS-SeNPs that deserves further investigation for clinical applications.
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ACS Applied Polymer Materials
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2022
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IF 4.855
Yadong Wu,Miaomiao Jin,Yudong Huang,Fang Wang
As an emergent interdisciplinary subject, tissue engineering is widely used in the maintenance, repair, replacement, and reconstruction of the structure and function of cartilage, blood vessels, heart, skin, and liver. Tissue engineering includes three elements: seed cells, tissue engineering scaffolds, and tissue construction. Among them, tissue engineering scaffolds, especially porous scaffolds, play an important role. The support material should have ideal physical, chemical, and mechanical properties matching with the actual application, such as specific size and shape, an appropriate pore size, and appropriate porosity and surface properties. As a kind of natural biopolymeric linear polysaccharide, chitosan (CHi) has sterling properties including being nontoxic, nonirritant, biocompatible, bacteriostatic, and excellently hydrophilic. Aramid fibers (AF) belong to a class of synthetic fibers that are thermally stable, chemically stable, and highly temperature-resistant and have low mass and a long service life. Previous studies have demonstrated that bulk AF can be effectively split into aramid nanofibers (ANFs) via dissolution in a system of dimethyl sulfoxide (DMSO)/potassium hydroxide (KOH). Composite aerogels own a three-dimensional and pore-like structure with the advantages of light weight, high porosity, and large specific surface area, which are suitable for use in the field of tissue engineering. Addressed herein is the composite aerogel synthesized from CHi and ANFs using chemical crosslinking with glutaraldehyde (GA) for a tissue engineering scaffold, named ANFs/CHi/GA. The composite was characterized using Fourier transform infrared spectroscopy and X-ray diffraction. ANFs/CHi/GA was bacteriostatic with abundant cell adhesions and a uniform cell distribution. Cytotoxicity tests prove that the composite aerogel materials are nontoxic and the cells could proliferate greatly in their leaching solutions. Cells can adhere to and distribute well on the surface of the composite aerogel material, which is suitable for use in scaffold materials.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Xu Zhang,Bowen Tan,Yanting Wu,Min Zhang,Xi Xie,Jinfeng Liao
Hydrogels can mimic extracellular matrix and provide a suitable microenvironment for accelerating wound healing. Nevertheless, the complicated wound condition, the disturbance of external forces, and the manufacturing process of the dressing were still difficult problems. An injectable self-healing hydrogel with mild photothermal therapy (MPTT) was developed for wound healing via dynamic Schiff bonds. After covalently incorporating GO-BPEI (branched polyethyleneimine grafting graphene oxide), an observable mechanical strength improvement and photothermal conversion property of GO-BPEI/carboxymethylated chitosan (CMCS) /aldehyde terminated polyethylene glycol (PEG-CHO) (GCP) hydrogel has been witnessed. MPTT induced by near-infrared (NIR) irradiation could accelerate NIH-3 T3 cells proliferation in vitro . Moreover, in vivo wound defect healing and histological analysis suggested that GCP hydrogels incorporated with MPTT significantly accelerated wound healing by improving collagen fibers deposition, enhancing re-epithelialization, and promoting granulation tissue neogenesis. The GCP hydrogels provide a unique route for wound dressing and present new inspirations for complicated wound management.
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