ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Yujun Zhou,Nan Nan Xia,Jialu Zhang,Tianxiang Li,Jianmin Wang,Qin Wu
The repeated bonding properties of wood adhesives directly influence the service life of wood. The covalent cross-linked networks of conventional thermosetting wood adhesives endow them with excellent performance but suppress the mobility of molecular chains, hindering the repeated bonding after adhesive failure via molecular chain reorganization. Here, we develop a thermoplastic hyperbranched polyurethane wood adhesive, which contains a prepolymer composed of cashew phenol, polyol, and isocyanate groups as the branching chains, a hyperbranched polyester as the core, and lipoic acid with disulfide (S–S) bonds as the terminal groups. When this adhesive breaks or cracks under external force and the broken surfaces are joined together, the molecular chains on both sides of the adhesive converge toward the breakage points driven by the highly branched structure of the hyperbranched polymer, promoting contact between the S–S bonds on both sides. Under heating conditions, dynamic reversible exchange reactions occur, stitching the cracks, and enabling the adhesive to bond repeatedly. Benefiting from this advantage, HPU-LA (100%) can retain more than 85% of its original bonding strength even after undergoing five repeated bonding cycles at 80 °C. This study addresses the issue of resource waste caused by the nonreusability of conventional adhesives as well as has notable research implications for extending the service life of wood.
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Sustainable Materials and Technologies
·
2025
·
IF 9.2
Xuemei He,Haoshun Xu,Songrun Yu,Haiyan Mao
The development of multifunctional cotton composites combining waterproof, wrinkle-resistant, anti-ultraviolet, antioxidant properties, along with good dyeability, is highly attractive for expanding their application in protective textiles. In the work, a composite cotton fabric (cWPU/CS/LA@C) was prepared via knife-coating process, using cationic waterborne polyurethane (cWPU) and chitosan (CS) as matrices, with alpha-lipoic acid (LA) serving as both the active ingredient and crosslinking agent. The mechanical properties of cWPU/CS/LA@C were significantly improved, showing a tensile strength of 58.74 MPa and an elastic modulus of 446.46 MPa. Additionally, it exhibited high hydrophobicity, excellent wrinkle resistance, good antioxidant activity and satisfactory low-temperature dyeability. Compared to the untreated cotton fabric, higher color depth (K/S) values were achieved for the modified cotton fabrics dyed with curcumin and reactive red KN-B at 30 °C and 60 °C, respectively. Meanwhile, the adsorption behavior of two dyes on modified cotton under these dyeing conditions followed the pseudo-first-order kinetic model. Furthermore, the color fastness of cWPU/CS/LA@C fabric remained at a high level even after 15 washing cycles. This research provides a simple feasible approach for preparation of multifunctional cotton composite materials and broadens their applications in technical and healthcare textile fields.
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Biomaterials Advances
·
2025
·
IF 6
Ziyuan Guo,Zongliang Wang,Peibiao Zhang
Although biological adhesives have shown advantages in replacing traditional wound suturing techniques, there are still limitations in wound closure, hemostasis, and healing, including insufficient tissue adhesion, potential biological toxicity, and complex preparation processes. In this study, a facile route for preparing injectable dual-crosslinking multifunctional hydrogel adhesive (Gel/EN/FBTA) was developed. The Gel/EN/FBTA adhesive is a dynamic cross-linked network composed of tannic acid (TA), 3-formylphenylboronic acid (3-FPBA) and gelatin, which can provide a large number of bonding sites and strengthen the adhesive cohesion through energy dissipation. The amidation reaction inside gelatin can form stable rigid crosslinks and maintain the structure of the adhesive stably. The balance between adhesion and cohesion can be regulated by adjusting the chemical composition and crosslinking density of the dual-crosslinking network. Under this equilibrium condition, the adhesion strength of Gel/EN/FBTA2 hydrogel is 3 times that of commercial fibrin glue, which shows good hemostatic effects in rat liver injury, rat tail injury, and rabbit liver cross incision models. Furthermore, Gel/EN/FBTA2 hydrogel adhesive can effectively treat wound infection, reduce inflammation level, promote re-epithelialization, accelerate collagen deposition, and achieve the healing of infectious full-thickness wounds. This dual-network design paradigm provides a versatile strategy for developing next-generation bioadhesives with tailored mechanical and bioactive properties, demonstrating significant potential for non-compressible hemorrhage and infected wound management.
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Food Packaging and Shelf Life
·
2025
·
IF 10.6
Fengyan Liang,Jinwen Geng,Ziming Yang,Wanqi Cen,Miaoyu Zhao,Xunting Huang,Changbin Wei,Puwang Li,Kaidong Liu
Amphiphilic chitosan (DA-CS-AG) was synthesized and incorporated with ursolic acid (UA) to develop an active coating film. Characterization techniques confirmed the preparation of DA-CS-AG, and UA was successfully entrapped in the active coating films. With the weight ratios of UA to DA-CS-AG increasing from 1:20, 2:20–4:20, the coating films exhibited increased thickness, improved water resistance, higher tensile strength, and enhanced antioxidant and antibacterial properties. As the UA/DA-CS-AG weight ratio increased from 1:20–2:20, the films ’ UV-shielding capability, water vapor barrier properties, and elastic properties increased. However, these properties deteriorated when the weight ratio increased to 4:20. Preservation experiments of papaya fruits demonstrated that UA/DA-CS-AG-2 coating films delayed the ripening of papaya at 25 º C for 16 days based on appearance, color changes, quality indexes, and sensory evaluation. In conclusion, these active coating films can serve as packaging materials for fruits and vegetables.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yicheng Yang,Qinan Huang,Lipei Miao,Qihong Zhang,Chongyang Wu,Weike Su,Jingbo Yu
Crocetin (CT), a natural carotenoid dicarboxylic acid known for its high medicinal value, faces challenges such as poor water solubility, low bioavailability and instability, limiting its therapeutic applications. To overcome these challenges, this study introduces a novel Pickering emulsion gel stabilized by naturally sourced chitosan (CS) and γ -polyglutamic acid ( γ -PGA) nanoparticles (CS/ γ -PGA NPs) as a potential transdermal carrier for CT. The CS/ γ -PGA NPs were synthesized using an electrostatic crosslinking method pretreated by mechanical ball-milling, producing uniform and stable nanoparticles. These NPs stabilized a CT-loaded Pickering emulsion gel (CT-PE) with cornmint oil as the oil phase, achieving up to 98.53 % encapsulation efficiency. The CT-PE exhibited enhanced rheological properties, storage stability, sustained and targeted in vitro transdermal release, potent antioxidant activity, and effective antimicrobial effects with no cytotoxicity. Microstructural analysis revealed a dense network of aggregated particles forming a moderately strong gel structure, wherein encapsulated CT enhances emulsion stability through interaction with the gel network. The synergy between CS and γ -PGA facilitated a biocompatible and efficient carrier system, markedly boosting CT's therapeutic effectiveness. These results highlight CT-PE's potential as an effective transdermal carrier for CT, promising for future dermatological treatments and drug delivery systems.
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Journal of Functional Foods
·
2025
·
IF 4
Hanju Fan,Meng Yan,Yongshuai Jing,Ziyan Li,Yaqian He,Zhiwei Li,Junna Song,Lanfang Wu
Crataegus pinnatifida is the dried fruit of Crataegus pinnatifida . Crataegus pinnatifida polysaccharides (CPPs) eluted with water as the mobile phase (CPPs-H-1) is one of the important active components. CPPs-H-1 has anti-oxidation and blood lipid regulation activities in vitro. Therefore, we investigated the effects of CPPs-H-1 on nonalcoholic fatty liver disease (NAFLD) in C57/BL6J mice. As a result, CPPs-H-1 inhibited the rapid growth of body weight and alleviated the liver injury caused by high-fat diets, significantly reducing the liver index and blood lipid levels in the model group, inhibiting the production of inflammation and cytokines, and inhibiting oxidative stress. CPPs-H-1 also enhanced intestinal barrier function. At the phylum level, CPPs-H-1 reduced the ratio of Firmicutes to Bacteroides (F/B) and regulated the content of short-chain fatty acids (SCFAs). The CPPs-H-1 may regulate intestinal flora composition, and improve intestinal barrier function, ultimately delaying the progression of NAFLD in mice. Also, CPPs-H-1 improved NAFLD progression by enhancing the Amp-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor α (PPARα) signaling pathway to enhance fatty acid oxidation. All these results confirm that CPPs-H-1 plays a multi-pathway and multi-target role in the improvement of NAFLD.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hong Zhang,Xin Zhang,Bo Wang,Bo Ren,Xiaodong Yang
Food spoilage leads to plenty of food being wasted every year. Safe and multifunctional food preservation packaging is urgently required to prevent food from contamination. Chitosan/gallic acid/Fe 3+ (CSGA-Fe 3+ ) composite films were synthesized by incorporating gallic acid (GA) and Fe 3+ into a chitosan solution. The integration of GA forms covalent and hydrogen bonds with chitosan, whereas Fe 3+ addition establishes metal-ligand interactions with both chitosan and GA, resulting in a film characterized by a multi-crosslinked network structure. This multi-crosslinked system substantially enhanced the material's mechanical properties and increased resistance to oxidation and ultraviolet degradation. The data indicate that the mechanical strength of chitosan/gallic acid (CSGA) films, with an inclusion of 0.3 mmol of GA, improved by 37.5 % over pure chitosan (CS) films. Moreover, the mechanical strength of the CSGA-Fe 3+ films saw a significant increase of 124.2 %, escalating from 1.32 MPa to 17.72 MPa. Additionally, the free radical scavenging capacities of the CSGA and CSGA-Fe 3+ films rose by 279.4 % and 255.0 %, respectively, compared to the pure CS film. The UV-blocking efficacy of the CSGA-Fe 3+ films, evaluated at 365 nm, reached 84.9 %. The water contact angle of the CSGA-1.5Fe 3+ film increased by 18.08 % compared to the CS film. This study provides innovative ideas to promote the broader application of safe and multifunctional chitosan-based composite films in food preservation packaging.
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Food Frontiers
·
2025
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IF 6.9
Xiaoli Qin,Yan Lu,Yawen Luo,Yafang Cui,Kai Zhao,Yang He,Muhammad Aziz ur Rahman,Shengnan Min,Wenfang Wang,Fuyu Yang,Binghai Cao,Huawei Su
Alfalfa is rich in flavonoid compounds, which are known for their antioxidative and anti-inflammatory properties, suggesting therapeutic potential for alfalfa flavonoids (AF) in inflammation-related diseases. This study investigated the effects of AF on Salmonella -induced colitis, a severe inflammatory bowel disorder characterized by oxidative damage and inflammatory response. In vitro, antioxidant assays revealed AF's concentration-dependent radical scavenging, significantly reducing electron paramagnetic resonance (EPR) signals for HO • and O 2 •− by 42% and 54%, respectively. In vivo, AF treatment significantly mitigated body weight (BW) loss by 6%, increased colon length by 11%, and reduced liver and spleen weights by 19% and 81%, respectively, compared to the colitis group. Mechanistically, AF suppressed inflammation by downregulating the Toll-like receptor 4 (TLR4)/IκB/nuclear factor-κB (NF-κB)/cyclooxygenase-2 (COX-2) pathway and inhibiting nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation, thereby lowering levels of pro-inflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin 6 [IL-6], interleukin 1 beta [IL-1β]). Concurrently, AF enhanced antioxidant defense via the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while increasing catalase (CAT) (69%), glutathione peroxidase (GPx) (83%), and superoxide dismutase (SOD) (21%) activities. Moreover, AF preserved epithelial and mucosal barriers by reducing apoptosis and upregulating tight junction proteins (Claudin1, ZO-1, E-cadherin) and goblet cell marker Ulex europaeus (Gorse) Agglutinin I (UEA-1). Microbiota analysis revealed that AF significantly enriched beneficial bacteria, including Akkermansia , Oscillibacter , and butyrate-producing taxa, thereby counteracting Salmonella -induced dysbiosis. Furthermore, AF restored the disrupted profile of short-chain fatty acids (SCFAs), strengthening the relationship between symbiotic microbiota and mucosal defense. Overall, AF exerted multifaced protection against Salmonella -induced colitis by alleviating oxidative stress, stabilizing intestinal homeostasis, and thus attenuating inflammation. These findings make AF a promising phytopharmaceutical for the prevention and treatment of inflammatory diseases.
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Foods
·
2025
·Vol. 14
·期 10
·1825
·
IF 5.1
Jiawei Zhao,Xueling Qin,Ying Liu,Qingyun He,Junwei Qin,Fei Shen,Zhenqiang Wu
Chenpi extracts (CPEs) are highly valued for their rich bioactive compounds and distinctive aromatic properties, but their environmental sensitivity poses stability challenges in food applications. In this study, CPE microcapsules were fabricated using corn peptide as the wall material, and the functional properties of spray-dried microcapsules (SDMCs) and freeze-dried microcapsules (FDMCs) were systematically characterized and compared. The results demonstrate that SDMCs exhibit superior characteristics compared to FDMCs, including reduced moisture content, lower hygroscopicity, enhanced solubility, smaller particle size, and a more uniform microstructure. Both FDMCs and SDMCs showed excellent thermal stability. The SDMCs of CPE encapsulated 93.45% of flavonoids, 90.35% of polyphenols, and 81.32% of sugars from the CPE, while also demonstrating exceptional retention of key terpene volatile compounds, particularly D-limonene (44.63%), γ-terpinene (45.18%), and β-myrcene (40.17%). In contrast, FDMCs exhibited stronger retention of alcohol-based volatile compounds. Furthermore, SDMCs displayed higher antioxidant and hypoglycemic activities, along with improved storage stability. In vitro digestion results reveal that SDMCs provide enhanced protection for CPE flavonoids and polyphenols, achieving bioaccessibility rates of 95.64% and 94.57%, respectively. These findings offer a theoretical basis for optimizing the drying processes in CPE microencapsulation, striking a balance between functional properties and flavor preservation for advanced food applications.
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Journal of Future Foods
·
2025
·
IF 7.2
Li Zhen,Qian Wang,Huimin Cui,Yifen Wang,Jianxin Cao,Yaping Liu,Hesham R El-Seedi,Guiguang Cheng
Goji ( Lycium barbarum L.) leaves are widely processed as a healthy tea (GT) in China for their multiple biological activities. In this study, different polar segments from GT ethanolic extract were obtained using the liquid-liquid fractionation method. n -Butanol fraction (GN) had the highest antioxidant activity while ethyl acetate fraction (GE) showed the highest inhibitory effect on the α -glucosidase enzyme. The anti-diabetic effect of GE was further investigated in type 2 diabetic mellitus (T2DM) mice. The oral administration of GE (300 or 600 mg/kg) reduced fasting blood glucose (FBG) levels, improved glucose tolerance ability, and ameliorated insulin resistance (IR) in T2DM mice. GE intervention could enhance the cholesterol transportation in the serum in coincidence with decreased total cholesterol, triglyceride levels, and non-esterified fatty acid. Transcriptomic, immunofluorescence and western blotting analysis revealed that GE significantly up-regulated insulin receptor substrate 1 (IRS1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT), glycogen synthesis (GS), and glucose transporter 4 (GLUT4). AMP-activated protein kinases (AMPK)-mediate gluconeogenesis and glycogenolysis, such as phosphoenolpyruvate carboxy kinase (PEPCK) and glucose-6-phosphatase (G6Pase) in the liver and kidney tissues of GE groups were decreased. Thus, GE alleviated the liver, kidney, and pancreatic tissue damage. The phytoconstituents of GE were characterized, and rutin, neochlorogenic acid, and its acylated derivatives have hypoglycemic effects. Furthermore, these findings suggested that Goji tea might be used as a promising hypoglycemic candidate.
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Nano Today
·
2025
·
IF 10.9
Xinrui Zhao,Rong Yang,Yage Sun,Wenguang Liu
Abnormal neuronal discharge due to disordered neurotransmitter homeostasis and harsh inflammation in epileptic focus is prone to cause recurrent seizures. However, current difficulties in drug delivery across blood-brain barrier (BBB) and regulation of complex pathological microenvironment hinder complete control of epilepsy with clinical therapies. Herein, a novel microenvironment-responsive drug-loaded polyelectrolyte nanocomplex (HCT-Fu@VB 6 ) formed by electrostatic self-assembly between tryptophan-modified hydroxypropyl chitosan (HCT) and fucoidan (Fu) with efficient vitamin B 6 (VB 6 ) loading, is developed for potent epilepsy treating, innovatively aiming to modulate neurotransmitters balance and attenuate the neuroinflammatory responses. Specifically, HCT confers the nanoparticles with specific binding affinity towards L-type amino acid transporter 1 expressed on brain endothelial cells, thereby significantly contributing to enhanced trans-BBB drug delivery efficiency. The fucoidan-containing polyelectrolyte nanocomplexes serve to provide intrinsic antioxidant property. Notably, the prepared polyelectrolyte nanocomplexes are dissociated in response to the mimic pathological neuronal discharges due to disturbed electrostatic equilibrium, facilitating accelerated VB 6 release for enhanced oxidative stress mitigation and effective neurotransmitter homeostasis modulation, acting as a competitive antagonist of ATP-gated purinergic P2RX7. The developed HCT-Fu@VB 6 nanoparticles demonstrate significant therapeutic efficacy as an electrically responsive trans-BBB drug delivery system, remarkably reducing seizure in epileptic rats while maintaining an excellent safety profile.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Hongkai Xie,Hailu Liao,Xinhao Wan,Yinlei Mao,Fengjiao Fan,Yuhong Fu,Li Wang,Liwei Mao,Yan Li,Zhuoli Li
Single-layer films lack sufficient mechanical, barrier, and controlled-release properties. Thus, a three-layer gelatin/gelatin-dextran/gelatin film incorporated with defatted rice bran-derived carbon dots (DRB-CDs) was prepared to overcome these issues and preserve scallops. DRB-CDs were non-toxic to HaCaT cells (<2 mg/mL). They enhanced the film's thermal stability and formed hydrogen bonds with the matrix polymer. Increasing the DRB-CDs concentration improved the film's UV-blocking, antioxidant, and antimicrobial properties. Adding 3 % DRB-CDs reduced the film's water vapor permeability by 35 %, increased the tensile strength 2.09-fold, and increased the elongation at break 1.15-fold. The three-layer structure enabled the sustained release of DRB-CDs in food simulants. Scallops wrapped with 3 % DRB-CDs-loaded films showed enhanced chemical and microbial stability, extending their shelf life by ≥6 days. In conclusion, this study proposes a sustainable and effective active packaging strategy using food-byproduct-derived nanomaterials to maintain seafood quality, showing significant potential to replace petroleum-based packaging.
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