SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2023
·
IF 6.9
Yifan Jia,Guoxing Liao,Yang Wu,Oleksandr Mykhaylyk,Paul D. Topham,Xue-Hui Dong,Changzhong Chen,Qianqian Yu,LinGe Wang
Form-stable phase change fibers (PCFs) that are composed of stable supporting material (as polymer matrix) and phase change material (PCM, as working ingredient) have become novel smart materials, being widely applied in energy storage, thermal regulation and the biomedical field . However, the inherent limitation of PCFs is the restriction of the supporting material on the crystallization of the PCM, which results in low phase change enthalpy (Δ H ). Here, six different types of PCF comprised of poly(lactic acid) (PLA, as supporting material) and poly(ethylene glycol) (PEG, as PCM) have been fabricated. Their morphology, phase change performance and structural transitions during phase change have been extensively studied. We reveal that the crystallizability and glass transition temperature of PLA have a dominating influence on Δ H . In the optimum system, PLA/PEG PCFs can achieve up to 104 J/g Δ H which is close to the theoretical value of pristine PEG. This high-performance PCF also exhibits only 2.5% Δ H loss after 100 thermal cycles and good ability in thermal energy storage and thermal regulation. This work provides a promising form-stable PCF and introduces a new strategy towards developing high Δ H PCFs by selecting suitable supporting materials.
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Pharmaceutics
·
2019
·Vol. 11
·期 3
·107
·
IF 4.773
Huiyun Zhang,Qilong Wang,Congyong Sun,Yuan Zhu,Qiuxuan Yang,Qiuyu Wei,Jiaxin Chen,Wenwen Deng,Michael Adu-Frimpong,Jiangnan Yu,Ximing Xu
6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism. Herein, 6-shogaol loaded in micelles (SMs) were designed to improve 6-shogaol’s solubility and bioavailability. The micelles of a PEG derivative of linoleic acid (mPEG2k-LA) were prepared by the nanoprecipitation method with a particle size of 76.8 nm, and entrapment of 81.6 %. Intriguingly, SMs showed a slower release in phosphate buffer saline (PBS) (pH = 7.4) compared to free 6-shogaol while its oral bioavailability increased by 3.2–fold in vivo. More importantly, the in vitro cytotoxic effect in HepG2 cells of SMs was significantly higher than free 6-shogaol. Furthermore, SMs could significantly improve the tissue distribution of 6-shogaol, especially liver and brain. Finally, SMs showed a better hepatoprotective effect against carbon tetrachloride (CCl4)-induced hepatic injury in vivo than free 6-shogaol. These results suggest that the novel micelles could potentiate the activities of 6-shogaol in cancer treatment and hepatoprotection.Keywords:6-shogaol;cytotoxic effect;HepG2 cells;micelles;hepatoprotection
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
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2019
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IF 4.067
Jianning Yue,Liangliang He,Yuanzhang Tang,Liqiang Yang,Baishan Wu,Jiaxiang Ni
A novel nano-formulations of biocompatible, biodegradable and thermo-responsive graphene quantum dots (GQDs) loaded dextran/poly( N -isopropylacrylamide) (Dex/PNIPAM) copolymeric matrix was synthesized and analyzed the materials characterization, sustained drug delivery system , tissue feasibility in the tissue implantation site. This research report was aimed to grafting and functionalizing thermo-responsive (Dex/PNIPAM) copolymeric composite with presence of graphene quantum dots to achieve thermal responsive drug delivery (TrDD) with no harm effect in the implantation site. The synthesized GQD by using ionic liquid were evaluated by spectroscopic (DLS, PL, XRD and Raman spectroscopy) and Transmission electron microscopic analysis (TEM). The ultra-small GQDs loaded Dex/PNIPAM and was appeared to be asymmetric and open uniform porous structure, which can be significantly favorable for cell uptake and greatly influenced to be an effective drug carrier into the cellular compartment with good fluid flow. The PNIPAM polymeric composite were exhibited sustained and enhanced drug release percentages with increasing temperature at above low critical solution temperature (LCST) is 39 °C comparable to the cumulative drug release profile of below LCST (32 °C), which demonstrated that thermo-responsive polymer was played a significant role in the delivery system. The treated group of GQDs-Dex/PNIPAM was observed that no inflammation and shows noteworthy stromal cell infiltration , demonstrating that the synthesized drug carriers did not harm to the nerves and tissues and only was responsible for the pain management.
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ENERGY CONVERSION AND MANAGEMENT
·
2017
·
IF 5.589
Li-Sheng Tang,Jie Yang,Rui-Ying Bao,Zheng-Ying Liu,Bang-Hu Xie,Ming-Bo Yang,Wei Yang
Polyethylene glycol (PEG)/graphene oxide aerogel (GA) composite phase change materials (PCMs) were prepared by introducing PEG into GAs from graphene oxide (GO) with different oxidation degree via vacuum impregnation. The structures of GAs were tuned by the oxidation levels of GO. A series of characterizations were used to analyze the chemical structure of GOs, including X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy analysis. Structural analyses confirmed that the oxygenated functional groups increased and the hydroxyl groups were transformed into carboxyl and epoxy groups with increasing oxidation level. In addition, the graphitic nature of GO decreased while the sp 3 domains of GOs increased owing to the disruption of the graphitic stacking order. Morphology analysis showed that the breakage of graphene sheet became more serious with the oxidation level increasing. When GAs prepared with GOs of higher oxidation levels were used, the composite PCMs showed excellent shape-stability during phase change and excellent thermal repeatability. The change of dimension for PGA6-40 heated from 35 °C to 150 °C was negligible under the load of a constant force (7 N). Efficient photo-to-thermal energy conversion and storage was realized in the composite PCMs.
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BIOMACROMOLECULES
·
2014
·
IF 5.788
Qiuming Liu,Hongshi Zhu,Jingya Qin,Haiqing Dong,Jianzhong Du
Presented in this article is the preparation of a new theranostic vesicle which exhibits excellent in vitro and in vivo T1 magnetic resonance (MR) imaging contrast effect and good anticancer drug delivery ability. The theranostic vesicle has been easily prepared based on an amphiphilic biocompatible and biodegradable dibock copolymer, poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (PEG-b-PLGA) and bovine serum albumin-gadolinium (BSA-Gd) complexes. Dynamic light scattering (DLS), transmission electron microscopy (TEM), UV–vis spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES) measurements confirmed the formation and physiological stability of BSA-Gd@PEG-b-PLGA vesicles. Furthermore, the in vitro and in vivo MR imaging experiments revealed their excellent T1-weighted MR imaging function. Red blood cell hemolysis and cytotoxicity experiments confirmed their good blood compatibility and low cytotoxicity. Doxorubicin (DOX) loading and release experiments indicated a more retarded release rate of DOX in those theranostic vesicles than sole PEG-b-PLGA nanoparticles without BSA. Overall, this new biocompatible and biodegradable vesicle shows promising potential in theranostic applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ming Ouyang,Xi Yu,Jiani Zhong,Yan Mao,Yunqian Cui,Huiqin Jiang,Xiaoying Lu,Weiyu Cao,Zeting Yuan,Jingbo Yin
The inflammatory environment of periodontitis with bacteria, excessive reactive oxygen species (ROS) and limited regenerative capacity of alveolar bone makes reconstruction of periodontium become a huge challenge. The present strategies, such as local debridement and antibiotic injection, are difficult to solve above problems completely. Thus, to reverse the progression of the disease, Ca 2+ -tannic acid nanocomposites loaded into injectable sodium alginate/4-arm polyethylene glycol-lipoic acid hydrogel (CaTA@Gel) were fabricated, including Ca 2+ ‑sodium alginate (SA) ionic crosslinking and radical polymerization of lipoic acid-modified 4-arm polyethylene glycol (PEG-SS 4 ) under UV illumination. In our results, the double networks of hydrogel not only had good mechanical property, but also sustainedly released CaTA nanocomposites which could inhibit bacteria, scavenge ROS due to TA, and promote osteogenesis of bone mesenchymal stem cells (BMSCs) via Ca 2+ . The antibacterial rates of CaTA (1 mg/mL) against E. coli and S. aureus were 97.3 ± 1.25 % and 96.7 ± 2.57 %, respectively. Meanwhile, ·OH and ·O 2− could be inhibited obviously by CaTA (100 μg/mL), whose inhibition rate were 59.6 ± 2.98 % and 62.4 ± 3.12 %, respectively. Finally, the up-regulation of osteogenetic genes and successful alveolar bone regeneration in rat models indicated this injectable nanocomposite hydrogel provided a promising strategy for the treatment of periodontitis.
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Food Packaging and Shelf Life
·
2025
·
IF 10.6
Li Liu,Can He,Liang Zhu,Zhonghao Zhu,Kaijun Xiao
A block polyether esters (PBTF) with excellent toughness was synthesized in this study by polybutylene glycol 2,5-furandicarboxylate (PBF) as the hard segment and polytetrahydrofurandiol (PHTF) as the soft segment. The degradable and modified atmosphere films were developed by blending PBTF with poly (butyleneadipate-co- terephthalate) (PBAT). PBTF/PBAT film containing 3 % PBTF demonstrated outstanding mechanical properties and gas permeability. The tensile strength was increased by 17.21 % and the degradation properties of the film were improved. The CO 2 /O 2 gas separation coefficient was found to be as high as 13.99 and the water vapour permeability was reduced to 3.54 × 10 −13 g·cm/(cm 2 ·s·Pa), a reduction of 22.75 %. These properties contributed to maintaining a favorable atmosphere inside the package (2.6 %-3.5 % CO 2 and 15.6 %-16.7 % O 2 ) and inhibited microbial growth and nutrient loss, extending the shelf life of strawberries to 18 days (8 ℃). This degradable PBTF/PBAT modified atmosphere film has significant potential for use in fruit and vegetable packaging.
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 46
·24444-24452
·
IF 8.867
Xiaoxiao Ji,Huihui Zeng,Xianjing Gong,Fangchang Tsai,Tao Jiang,Robert K. Y. Li,Hengchong Shi,Shifang Luan,Dean Shi
Herein, a self-supporting comb-like Si-PEG copolymer with flexible Si–O–C bonds in the main chain and pending short PEG chains as the side chain was synthesized to improve the low temperature performance and overcome the quandary between good mechanical and electrochemical properties of the polymer electrolyte in lithium-ion batteries. The tensile strength of Si-PEG polymer electrolytes (SPH15) is 0.8 MPa at 30 °C, which is high enough to inhibit the growth of lithium dendrites. The ion conductivities of Si-PEG (SPH15) are 1.2 × 10−4 S cm−1 at 30 °C and 3.2 × 10−5 S cm−1 at 10 °C, which are one order of magnitude higher than those for PEG-based copolymer electrolytes without Si doping. The assembled LiFePO4/SPH15/Li half batteries can deliver the specific capacities of 84 mA h g−1 at 10 °C and present 75% capacity retention after 500 charge–discharge cycles at 0.5C.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 34
·期 4
·1209-1219
·
IF 3.348
Wenju Hu,Haozhi Sun,Lixia Pan,Chaoqun Zhang,Xin Shen,Feng Su,Jie Song
The encapsulation and release of hydrophobic drugs from polymersomes are of great importance in drug delivery. A significant challenge is to enhance the encapsulation capacity of finding better drug-polymer compatibility. Herrin, poly(trimethylene carbonate)-b-poly(ethylene glycol) (PTMC-PEG) diblock copolymers were successfully synthesized by ring opening polymerization of trimethylene carbonate using monomethoxy poly(ethylene glycol) (mPEG) as macro-initiator and stannous octoate as catalyst. The resulting diblock copolymer were characterized by 1 H NMR, FTIR, GPC, and DSC techniques. Blank and paclitaxel (PTX) loaded micelles was prepared by co-solvent evaporation method and characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). The influence of hydrophilic/hydrophobic segment length to drug loading and release was explored. All micelles have the sustained hydrophobic drug release properties of the micelles. Moreover, the cytotoxicity of micelles was evaluated by MTT and live-dead cell staining assay using L929 cell lines, showing the good biocompatibility. Therefore, PTMC-PEG micelles could be a suitable material for the loading and releasing of hydrophobic drugs.
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International Journal of Nanomedicine
·
2023
·
IF 8
Hao Wu,Qingxiang Zhong,Rongling Zhong,Houcai Huang,Zhi Xia,Zhongcheng Ke,Zhenhai Zhang,Jie Song,Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration. The physicochemical properties of the micelles, including zeta potential, morphology, particle size, solubility, drug loading, and drug entrapment efficiency were characterized. OA release from micelles was slower than that from the free drug system. OA uptake by A549 non-small-cell lung cancer (NSCLC) cells was enhanced by the micelles. A tumor model was established by injecting A549 cells into nude mice. In vivo imaging showed that OA-micelles could accumulate in the tumors of nude mice. Additionally, smaller tumor size and increased expression of pro-apoptotic proteins were observed in OA-micelle-treated mice, indicating that OA-micelles are more effective than free OA in treating cancer. In vitro experiments were performed using two NSCLC cell lines (A549 and PC-9). Cytotoxicity evaluations showed that the half-maximal inhibitory concentrations of free OA and OA-micelles were 36.8±4.8 and 20.9±3.7 μM, respectively, in A549 cells and 82.7±7.8 and 56.7±4.7 μM, respectively, in PC-9 cells. Apoptosis assays revealed that the apoptotic rate of OA-micelle-treated A549 and PC-9 cells was higher than that of cells treated with the same concentration of free OA. Wound healing and transwell assays showed that migration and invasion were significantly suppressed in OA-micelle-treated cells. Immunofluorescence and Western blot analyses confirmed that the epithelial–mesenchymal transition was reversed in OA-micelle-treated cells. Mixed micelles are a promising nano-drug delivery system for lung cancer treatment.
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MACROMOLECULES
·
2019
·
IF 5.997
Yuhan Wei,Jiliang Tian,Zekun Zhang,Chenhui Zhu,Jing Sun,Zhibo Li
Supramolecular two-dimensional (2D) nanomaterials from block copolymers have received great interest for their unique structure and properties. Here, we report the formation of ultrathin nanosheets from self-assembly of amphiphilic poly(ethylene glycol)-b-poly(N-(2-phenylethyl)glycine) (PEG-b-PNPE) diblock copolymers, which contain rigid crystallizable polypeptoid segment. The PEG-b-PNPE copolymers were synthesized via ring opening polymerization (ROP). The obtained PEG-b-PNPE diblock copolymers can spontaneously form highly ordered structures in PEG selective solvents such as water and methanol. The copolymers with short PNPE segment can directly form nanosheets in water, and the obtained 2D nanosheets have a uniform thickness of 4–5 nm. In contrast, the copolymers with relatively long PNPE segment can only assemble into nanosheets with the assistance of methanol. It is proposed that the crystallization and π–π stacking of PNPE blocks play critical roles in the formation of the nanosheet as suggested by grazing incidence wide-angle X-ray scattering (GIWAXS). During the process of adding water into copolymer methanol solution, the nanosheets were observed to evolve from individual nanofibers, to parallel aligning nanofibers, and eventually to the nanosheet structures verified by transmission electron microscopy (TEM) and cryo-TEM characterizations. We demonstrated that the preassembled filament behave as a fundamental packing motif to align laterally and further fuse into platelet-like structures. The assembly structure evolution process was tracked by TEM, atomic force microscopy, and cryo-TEM techniques. The understandings of supramolecular 2D nanosheet formation offer a new opportunity to make hierarchical nanostructures from polypeptoids containing copolymers.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2019
·
IF 2.29
Wentian Li,Hu Lin,Nan Song,Gaoquan Chen,Xinbao Li,Hongkun Zhao
Solubilities of gimeracil (form P) in aqueous co-solvent mixtures of isopropanol, N,N -dimethylformamide (DMF), ethylene glycol (EG) and dimethylsulfoxide (DMSO) were investigated via the isothermal dissolution equilibrium method at (283.15–328.15) K under ambient pressure p = 101.2 kPa. Experimental solubility was increased with increasing temperature and mass fraction of each co-solvent. The largest solubility was found in neat co-solvents. The solids equilibrated with liquid phase were characterized by X -ray power diffraction, indicating no polymorphic transformation, solvate formation or crystal transition according to the spectral data. The Jouyban-Acree model was adopted to correlate the obtained solubility. The highest RAD and RMSD values were, respectively, 2.61 × 10 −2 and 14.96 × 10 −4 . Quantitative values for the local mole fraction of DMF (EG, DMSO or isopropanol) and water around gimeracil (form P) were acquired by using the Inverse Kirkwood–Buff integrals method. The preferential solvation parameters for isopropanol were positive in the isopropanol mixtures in intermediate and isopropanol-rich compositions, which indicated that gimeracil (form P) was preferentially solvated by isopropanol. Gimeracil (form P) could act mainly as a Lewis acid interacting with proton-acceptor functional group of isopropanol. Within the same region, gimeracil (form P) was not preferentially solvated by DMF, EG and DMSO. Furthermore, the method of linear solvation energy relationships was performed with a suitable combination of solvent polarity descriptors to explain the nature of intermolecular interactions resulting in the solubility variation in the co-solvent mixtures.
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