ACS Applied Materials & Interfaces
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2021
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IF 9.229
Yan Cheng,Airong Cheng,Yanlong Jia,Lin Yang,Yan Ning,Liang Xu,Yazhi Zhong,Zerui Zhuang,Jitian Guan,Xiaolei Zhang,Yan Lin,Teng Zhou,Xiusong Fan,Jianwu Li,Peng Liu,Gen Yan,Renhua Wu
Stroke is the second leading cause of death globally and the most common cause of severe disability. Several barriers need to be addressed more effectively to treat stroke, including efficient delivery of therapeutic agents, rapid release at the infarct site, precise imaging of the infarct site, and drug distribution monitoring. The present study aimed to develop a bio-responsive theranostic nanoplatform with signal-amplifying capability to deliver rapamycin (RAPA) to ischemic brain tissues and visually monitor drug distribution. A pH-sensitive theranostic RAPA-loaded nanoparticle system was designed since ischemic tissues have a low-pH microenvironment compared with normal tissues. The nanoparticles demonstrated good stability and biocompatibility and could efficiently load rapamycin, followed by its rapid release in acidic environments, thereby improving therapeutic accuracy. The nano-drug-delivery system also exhibited acid-enhanced magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging signal properties, enabling accurate multimodal imaging with minimal background noise, thus improving drug tracing and diagnostic accuracy. Finally, in vivo experiments confirmed that the nanoparticles preferentially aggregated in the ischemic hemisphere and exerted a neuroprotective effect in rats with transient middle cerebral artery occlusion (tMCAO). These pH-sensitive multifunctional theranostic nanoparticles could serve as a potential nanoplatform for drug tracing as well as the treatment and even diagnosis of acute ischemic stroke. Moreover, they could be a universal solution to achieve accurate in vivo imaging and treatment of other diseases.
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Nanoscale
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2021
·Vol. 14
·期 4
·1271-1284
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IF 7.79
Yongju He,Xingyu Fan,Xiaozan Wu,Taishun Hu,Fangfang Zhou,Songwen Tan,Botao Chen,Anqiang Pan,Shuquan Liang,Hui Xu
Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across the dense tumor matrix. Herein, we design a size-shrinkable nanocarrier that uses acid as a means of triggering a change in particle size for co-achievement of efficient tumor accumulation followed by deep tumor penetration and rapid clearance from the body. This nanocarrier is constructed from a pH-sensitive lipid layer shell and an ultrasmall amino-functionalized mesoporous silica nanoparticle core capable of loading drugs. After intravenous injection into mice bearing the 4T1 tumor, the nanocarrier with an initial hydrodynamic size of about 33 nm could effectively accumulate at the tumor site through the enhanced permeability and retention effect. Subsequently, in the acidic tumor microenvironment, the lipid layer comprising 9 alkyl-spiropyran (SP-C9) undergoes a volume shrinkage due to the conversion of hydrophobic SP-C9 to amphiphilic 9 alkyl-merocyanine (MC-C9), thus leading to a significant decrease in the entire particle size (hydrodynamic size ∼17 nm) for enhanced intratumoral penetration. Moreover, we find that this size-shrinkable nanocarrier could be rapidly excreted out of the body based on the ICP analysis, significantly reducing biosafety issues. Benefiting from the effective tumor accumulation and penetration of the nanocarrier, the released doxorubicin shows potent antitumor efficacy. This demonstrates the high potential of the designed nanocarrier in solid tumor treatment.
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CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Huijuan Jing,Xin Huang,Xiaojing Du,Ling Mo,Chaoyang Ma,Hongxin Wang
In this work, a novel synthesis strategy of sodium alginate/carboxymethyl chitosan hydrogel beads promoted by hydrogen bond was described. The beads were prepared by dropping the blends of two polymers into the citric acid solution. Besides hydrogen bonding , electrostatic interactions were also involved in the formation of the hydrogel beads. The thermal stability experiments revealed that the more the content of carboxymethyl chitosan , the better the thermal stability of the beads. The beads exhibited excellent pH sensitivity, pH reversibility, and lactoferrin loading capacity. The swelling ratio of the bead and its protein releasing profile was pH-dependent, which could prevent premature protein release in the gastric environment. Also, the circular dichroism results demonstrated that lactoferrin could maintain its structure during the loading and releasing process. The obtained results revealed that the hydrogel beads prepared in this work could be used as a potential protein carrier for oral delivery.
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TEXTILE RESEARCH JOURNAL
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2021
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IF 1.82
Long Feng,Yimiao Hou,Qingqing Hao,Mingxing Chen,Shuo Wang,Xuemin Hu,Wenxiu Yang
The deterioration of water ecology caused by the discharge of oil spill wastewater, industrial sewage, and municipal sewage has attracted wide attention worldwide. Thus, it is significant to design a simple, environmentally friendly approach to separate oil–water mixtures. In this work, three different fabrics with pH-induced wettability transition were prepared by a dip-coating process for oil and water separation. The dip-coating fabrics had the advantages of oil–water separation, photocatalytic degradation, and recycling. Polyethylene terephthalate/polyamide nonwoven fabric was used as the substrate materials of the fabric. The carboxylic acid-modified TiO2 endowed the fabric with hydrophilicity–hydrophobicity and photocatalytic properties. The Fe3O4 nanoparticles obtained by the coprecipitation method provided magnetism for the fabric, facilitating the recycling of the fabric and improving the hydrophobicity of the fabric. The fabrics coated with dipping solutions were superhydrophobic in a neutral environment and hydrophilic in an alkaline environment. Among the three coated fabrics, the fabric coated with stearic acid/TiO2-Fe3O4 (FST) had the most satisfying oil–water separation performance and durability. Under the neutral condition, the contact angle of the FST was 151° and the separation efficiency was 98%. Under the alkaline condition, the underwater oil contact angle of the FST was 150° and the separation efficiency was 95%. After 15 cycles, the oil–water separation rate of the FST was still higher than 90%. Due to the presence of TiO2, the coated fabric had an exceptional performance in the photodegradation of organic pollutants (69.9%). In addition, the fabrics can be quickly recovered due to magnetism.
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Materials Today Communications
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2021
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IF 3.383
Jun Xu,Tiantian Hao,Changlin Liu,Jingjing Bi,Jing Sun,Zheng Wen,Zhaosheng Hou,Jinjian Wei
In this paper, we synthesized a new type of pH-responsive block polyurethane (PMCU) through the condensation polymerization of N-methyldiethanolamine (MDEA), poly(ε-caprolactone) and 4,4′-dicyclohexylmethane diisocyanate. The chemical structure of the PMCU were characterized, and the influence of MDEA content on the physicochemical properties of the casted PMCU films were studied detailly. The tensile test demonstrated the good tensile properties of the PMCU films with the breaking strain of 983–425% and the ultimate strength of 11.7–31.2 MPa. The tertiary amine groups and polyester segments endowed the material with pH sensitivity and hydrolytic degradability, respectively. The pH responsiveness of the films was confirmed from the enhanced equilibrium swelling ratio (ESR) with decreasing pH value of the medium, and the ESR in acidic condition (pH 1.5) was much higher than that in neutral (pH 7.0) and basic (pH 12.0) conditions. The studies of drug sustained-release in vitro at different pH indicated a pH-dependent release efficiency, which was closely related with the ESR and almost unaffected by the slow hydrolytic degradation. In addition, the cytotoxicity assay showed that the PMCU had good cytocompatibility to L929 cells. This study showed that pH-responsive promising platform for targeted drug delivery in the biomedical areas.
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FOOD CHEMISTRY
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2021
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IF 7.514
Junmeng Lu,Weiyi Zhang,Xue Zhao,Xinglian Xu
The emulsion abilities of pale, soft, exudative (PSE)-like chicken breast protein are unsatisfied, which are urgently needed to be ameliorated. This study evaluated the improvement of pH-shifting (11.0-, 11.5- and 12.0–7.0) on emulsion properties of the PSE-like chicken breast myofibrillar proteins (MPs) and the underlined structure-driven interfacial mechanism. It was found pH-shifting promoted the exposure of buried hydrophobic groups and free sulfhydryl groups, and changed secondary structures. Emulsions stabilized by refolded MPs exhibited more uniform and dispersed distributions with more adsorbed proteins at the interface. Electrophorogram showed both disulfide and non-disulfide covalent bonds were involved during interfacial protein–protein interaction. The results from circular dichroism and front-surface fluorescence spectroscopy revealed interfacial MPs were exposed to a more hydrophobic environment and increased β-sheets enhanced their molecular interactions. In addition, interfacial proteins after pH-shifting was less likely to be replaced by Tween 20.
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Journal of Materials Chemistry B
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2021
·Vol. 10
·期 4
·562-570
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IF 6.331
Shun Liu,Yun Zhao,Meili Shen,Yujiao Hao,Xiaodong Wu,Yixuan Yao,Yapeng Li,Qingbiao Yang
Atherosclerosis is a global disease with an extremely high morbidity and fatality rate, so it is necessary to develop effective treatments to reduce its impact. In this work, we successfully prepared a multifunctional drug-loaded nano-delivery system with pH-responsive, CD44-targeted, and chemical–photothermal synergistic treatment. Dendritic mesoporous silica nanoparticles capped with copper sulfide (CuS) were synthesized via an oil–water biphase stratification reaction system; these served as the carrier material and encapsulated the anticoagulant drug heparin (Hep). The pH-sensitive Schiff base bond was used as a gatekeeper and targeting agent to modify hyaluronic acid (HA) on the surface of the nanocarrier. HA coating endowed the nanocomposite with the ability to respond to pH and target CD44-positive inflammatory macrophages. Based on this multifunctional nanocomposite, we achieved precise drug delivery, controlled drug release, and chemical–photothermal synergistic treatment of atherosclerosis. The in vitro drug release results showed that the nanocarriers exhibited excellent drug-controlled release properties, and could release drugs in the weakly acidic microenvironment of atherosclerotic inflammation. Cytotoxicity and cell uptake experiments indicated that nanocarriers had low cytotoxicity against RAW 264.7 cells. Modification of HA to nanocarriers can be effectively internalized by RAW 264.7 cells stimulated by lipopolysaccharide (LPS). Combining CuS photothermal treatment with anti-atherosclerosis chemotherapy showed better effects than single treatment in vitro and in vivo. In summary, our research proved that H-CuS@DMSN-NC-HA has broad application prospects in anti-atherosclerosis.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Xue Hu,Xiaodan Zhang,Haiyan Cao,Yuming Huang
Copper nanoclusters (Cu NCs) have emerged as promising platform for biosensing, but it remains a challenge to fabricate highly stable Cu NCs with controllable photoluminescence . Herein, we propose a new and elaborate strategy to prepare photoluminescent Cu NCs by using Cu-based metal-organic frameworks (Cu-MOFs) as the precursor. The generated Cu NCs display ordered nanowire structure and superior stability due to the crystal structure of Cu-MOFs. Moreover, the Cu NCs possess unique pH-dependent photoluminescence property. With pH increasing, the yellow-green emission of Cu NCs at 520 nm decreases, and new cyan emission at 455 nm appears and increases gradually. This process might be related to the structure change of the Cu NCs from aggregated nanowire into dispersed spherical particle. On the basis, a facile ratiometric fluorescent sensing platform for pH is fabricated. This ratiometric sensor has great anti-interference capacity and excellent reversibility . In addition, it was successfully applied to monitor the pH of microorganisms, demonstrating the great potential in bioassays. This new synthetic strategy for preparing Cu NCs with tunable emission property may propose new opportunities for their applications.
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ANALYTICAL CHEMISTRY
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2021
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IF 6.986
Xiao-Qiong Li,Xiang-Nan Liu,Yi-Lei Jia,Xi-Liang Luo,Hong-Yuan Chen,Jing-Juan Xu
Lysosomal acidification is essential for its degradative function, and the flux of H+ correlated with that of K+ in lysosomes. However, there is little research on their correlation due to the lack of probes that can simultaneously image these two ions. To deeply understand the role of K+ in lysosomal acidification, here, we designed and fabricated a nanodevice using a K+-aptamer and two pH-triggered nanoswitches incorporated into a DNA triangular prism (DTP) as a dual signal response platform to simultaneously visualize K+ and pH in lysosomes by a fluorescence method. This strategy could conveniently integrate two signal recognition modules into one probe, so as to achieve the goal of sensitive detection of two kinds of signals in the same time and space, which is suitable for the detection of various signals with the correlation of concentration. By co-imaging both K+ and H+ in lysosomes, we found that the efflux of K+ was accompanied by a decrease of pH, which is of great value in understanding lysosomal acidification. Moreover, this strategy also has broad prospects as a versatile optical sensing platform for multiplexed analysis of other biomolecules in living cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yaqi Zhang,Hongliang Wei,Bingya Hua,Chunwang Hu,Wenjing Zhang
Chitosan based hydrogels with multiple stimulus responses have broad application prospects in many fields. Considering the advantages of semi interpenetrating network (IPN) technology and the special temperature and ion responsiveness of polymers containing zwitterionic groups, a semi-IPN hydrogel was prepared through in situ free radical polymerization of N , N -dimethyl acrylamide and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide with polyethylene glycol dimethacrylate as a crosslinker and carboxymethyl chitosan as filler. The gel mass fraction and swelling ratio were measured, and the preparation conditions were optimized. The result indicated that the hydrogel possessed a unique thermo-/pH−/ ion-sensitive behavior. The swelling ratio increased with the increase of temperature and ion concentration, and showed a decreasing trend with the increase in pH. In addition, the hydrogel was stable when the stimuli changed. Adsorption behavior of the hydrogel to Eosin Y (EY) was systematically investigated. The adsorption process can be described well by the pseudo-second-order kinetic model and Langmuir isotherm model, indicating that it was a chemical adsorption. The experiments indicated that the hydrogel exhibited good antifouling and reusability features. Therefore, the semi-IPN hydrogel with antifouling properties and thermo-/pH−/ion-sensitivity can be easily manufactured is expected to find applications in water treatment fields.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
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2023
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IF 4.7
Liang Yang,Yao Wang,Yijia Liang,Haibin Deng,Jun Wang,Yuhao Dai,Fuyou Guo,Hong Zhou,Shili Li,Wei Ding
Ralstonia solanacearum ( R. solanacearum ) is one of the most devastating pathogens in terms of losses in agricultural production. Bentonite (Bent) is a promising synergistic agent used in development of effective and environmentally friendly pesticides against plant disease. However, the synergistic mechanism of Bent nanoclays with benzothiazolinone (BIT) against R. solanacearum is unknown. In this work, acid-functionalized porous Bent and cetyltrimethylammonium bromide (CTAB) were employed as the core nanoclays, and BIT was loaded into the clay to form BIT-loaded CT-Bent (BIT@CT-Bent) for the control of bacterial wilt disease. BIT@CT-Bent exhibited pH-responsive release behavior that fit the Fickian diffusion model, rapidly releasing BIT in an acidic environment (pH = 5.5). The antibacterial effect of BIT@CT-Bent was approximately 4 times greater than that of the commercial product BIT, and its biotoxicity was much lower than that of BIT under the same conditions. Interestingly, R. solanacearum attracted BIT@CT-Bent into the nanocomposites and induced cytoplasmic leakage and changes in membrane permeability, indicating an efficient and synergistic bactericidal effect that rapidly reduced bacterial density. In addition, BIT@CT-Bent significantly inhibited R. solanacearum biofilm formation and swimming activity, by suppressing the expression of phcA , solR and vsrC . Indeed, exogenous application of BIT@CT-Bent significantly suppressed the virulence of R. solanacearum on tobacco plants, with control effect of 75.48%, 72.08% and 66.08% at 9, 11 and 13 days after inoculation, respectively. This study highlights the potential of using BIT@CT-Bent as an effective, eco-friendly bactericide to control bacterial wilt diseases and for the development of sustainable crop protection strategies.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Jianpeng Cui,Shuangqing Sun,Zhenkun Chen,Junjie Fan,Jianwen Hu,Songqing Hu,Zhikun Wang
Responsive Pickering emulsions capable of responding to external stimuli have been extensively studied, however, there are few studies on double-responsive Pickering emulsions. Here in, a novel ferrocene surfactant (FcACUa) was synthesized and combined with aminated silica nanoparticles (0.5 wt%) to stabilize pH and redox sensitive smart Pickering emulsions. The carboxyl groups act as pH-sensitive parts, while ferrocene serves as the redox-responsive center. Stability and pH/redox response performance of the emulsions were investigated through various methods, such as the contact angle, macroscopic states, creaming index, microscopic images, droplet size distributions, etc. All atom molecular dynamics and dissipative particle dynamics simulations were used to probe the distribution of nanoparticles and surfactant at the water-oil interface, as well as to reveal the stabilization and pH/redox response mechanisms of the Pickering emulsions. Pickering emulsions can be reversibly switched between stable and unstable by adding HCl and NaOH or adding H 2 O 2 and N 2 H 4 ·H 2 O. After five pH-induced cycles, the emulsion shows no significant degradation or morphological changes. However, for the redox induced emulsification demulsification process, the size of the emulsion drops increases with the increase of the number of cycles. This work provides insights into the Pickering emulsion stabilization mechanism and the regulation mechanisms of pH and redox stimulation, which may have potential value in emulsion polymerization , biphasic catalysis, and oil and gas transportation.
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危险品化学品经营许可证（带存储）