DALTON TRANSACTIONS
·
2024
·Vol. 53
·期 4
·1849-1861
·
IF 3.5
Haodi Dong,Changcheng Liu,Que Huang,Yanjun Chen
Nowadays, the poor conductivity and unstable structure have become obstacles for the popularization of Na3V2(PO4)3 (NVP). In the current work, a dual-modified Mn0.1Cl0.3-NVP composite doped with Mn and Cl is prepared by a facile sol–gel method. When Mn2+ with a large ionic radius replaces small V3+, it can improve the stability of the NVP crystal structure. In addition, the replacement of V3+ by Mn2+ in a low valence state can generate redundant hole carriers, which is conducive to the rapid transport of electrons. The substitution of PO43− by Cl−, which is more electronegative, can reduce the impedance and facilitate the movement of Na+. Owing to the synergistic effect of Mn and Cl co-substitution, the structural stability of NVP was systematically enhanced, and the electron transfer and ion diffusion were effectively improved. Consequently, the optimized Mn0.1Cl0.3-NVP sample demonstrated superior electrochemical performance and kinetic properties. It exhibited a high reversible capacity of 109.2 mA h g−1 at 0.1C. Even at 15 and 30C, high discharge capacities of 70.3 mA h g−1 and 68.2 mA h g−1 were observed after 2000 cycles with capacity retention above 80%. Moreover, it delivered remarkable capacities of 77.1 and 73.4 mA h g−1 at 100 and 200C with retained capacity values of 50.3 and 47 mA h g−1, respectively, after 2000 cycles. Furthermore, the assembled Mn0.1Cl0.3-NVP//HC full cell delivered a high value of 94.7 mA h g−1 and lit LED bulbs, indicating its excellent application potential.
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Food Bioscience
·
2025
·
IF 5.9
Qingqing Zhou,Yajun Yu,Zuorui Xie,Yingying Zhou,Yanan Li,Ping Li,Jiangning Hu,Qing Gu
Salmonella is a prevalent foodborne pathogen that poses a significant threat to public health. Our previous study identified Lactiplantibacillus plantarum ZJ316, a strain known for its production of indole-3-lactic acid (ILA), which exhibits a broad-spectrum bacteriostatic effect. This study aimed to explore the inhibitory mechanism of ILA against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 ( S . Typhimurium) both in vitro and in vivo , as well as to assess its potential to alleviate colitis induced by S . Typhimurium. In vitro experiments revealed that ILA exerts its ant- Salmonella effect by disrupting the transmembrane proton motive force (PMF) and influencing intracellular ATP synthesis. Subsequent experiments conducted in female C57BL/6 mice demonstrated that oral administration of 45.00 mg/L ILA for 21 d effectively reduced S. Typhimurium infection-induced upregulation of pro-inflammatory cytokines (IL-1β and CXCL15; P < 0.01 and P < 0.05, respectively), while promoting the production of anti-inflammatory cytokines (IL-10 and IL-22; P < 0.001). Compared to the control group, the ILA group had a 4.15% increase in the relative abundance of Firmicutes and a 3.95% decrease in Bacteroidota. Furthermore, ILA also effectively countered the reduction of short-chain fatty acids (SCFAs) such as acetic acid and propionic acid caused by S . Typhimurium. These findings indicate that ILA may possess the capability to suppress pathogens, enhance intestinal microecology, and facilitate the repair of intestinal tissue damage.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 25
·1-8
·
IF 2.8
Hu Zhilong,Liu Hongbo,Tang Jian Guo,Lee Soo Wohn,Li Jun
NaNbO 3 (NN) has potential applications in energy storage devices due to its antiferroelectricity and environmentally friendly characteristics, but its low dielectric breakdown field strength ( E b ) and energy storage efficiency ( ƞ ) limit practical applications. In this study, the structure and electrical characteristics of NaNbO 3 were modulated by introducing Sr(Mg 1/3 Nb 2/3 )O 3 (SMN) to optimize its energy storage performance. The (1- x )NN- x SMN solid solution was synthesized using a classic solid-state reaction approach. According to X-ray diffraction analysis results, the prepared ceramics exhibit a pure phase when x is less than or equal to 0.15. With the increment of x , SMN disturbs the long-range polar order, induces pronounced relaxation ferroelectric phase (RFE) with reduced remnant polarization ( P r ), and enhances E b , leading to significant increases in recoverable energy storage density ( W rec ) and η . The optimized composition 0.875NN-0.125SMN has the best dielectric energy storage properties with a W rec of 1.28 J/cm 3 and an η of 88%.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Junyu Chen,Xuedong Zhang,Feixiang Wu,Long Xie,Feng Li,Nina Wu,Zixuan Cao,Jinwen Zhao,Yuxuan Zhang,Xin He,Hongxia Gu,Jianyu Huang,Qiao Huang
Integrating conversion-type cathodes (such as iron-based fluorides (IBFs)) into sulfide all-solid-state batteries (ASSBs) significantly enhances energy density but faces challenges including unstable cathode/electrolyte interfaces. To mitigate these issues, a near-amorphous Li1.26Mg0.12Zr1.86(PO4)3 (LMZP) coating technology is developed to protect nano-sized FeF2 (n-FeF2) and micro-sized FeF3 (m-FeF3) cathodes from reacting with the sulfide electrolyte for the first time. The LMZP coating approach offers simplicity, low energy consumption and scalability. With the LMZP-coated cathodes and lithium–indium (Li–In) anode, the ASSBs achieve a discharge capacity of 310 mAh g−1 after 600 cycles and a maximum areal capacity of 2 mAh cm−2 for n-FeF2, and 301 mAh g−1 after 700 cycles with a maximum areal capacity of 3.1 mAh cm−2 for m-FeF3. When using a lithium (Li) metal anode, the ASSBs maintain a discharge capacity of 310 mAh g−1 after 300 cycles for n-FeF2 and 300 mAh g−1 after 600 cycles for m-FeF3, demonstrating excellent cycling stability and capacity retention. Notably, a discharge capacity of 280 mAh g−1 is sustained after 200 cycles for n-FeF2 and 301 mAh g−1 after 180 cycles for m-FeF3, with a reduced stack pressure (10 MPa). These results are unprecedented in IBF-based ASSBs, highlighting the potential of advanced coating strategies to enable scalable, high-performance metal fluoride cathodes in ASSBs with higher energy densities.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Junyan Zhang,Jiaqi Shen,Haomin Chu,Yingchun Xie,Zhenzhen Jiang,Daolin Gao,Tianlong Deng,Xiaoping Yu
With the rapid development of the new energy industry, the recovery or extraction of lithium from different resources is currently a global research hotspot. In this work, Li 3 V 2 (PO 4 ) 3 was used as the active component for electrochemical extraction of lithium from aqueous solutions. The results showed that although Li 3 V 2 (PO 4 ) 3 exhibited the reversible de-intercalation/intercalation of Li + , it suffered from severe irreversible dissolution loss in aqueous solutions. This problem was successfully solved by titanium doping. The experiments and DFT calculations showed that when the V(2)-site vanadium in Li 3 V 2 (PO 4 ) 3 was replaced by titanium, the resulting material exhibited superhigh cycle stability and lithium extraction rate. After ten cycles of de-intercalation/intercalation, the extraction capacity still reached 11.5 mg·g −1 , and the attenuation was within the error range. Particularly, because of the decrease of the band gap after doping, the electronic conductivity of the material was significantly improved, and the equilibrium time for lithium extraction was within only 5 min, which was more than 10 times faster than that of the conventional LiFePO 4 and Li 2 MnO 4 materials. This work provides a new solution for the green, efficient, and highly stable extraction of lithium from liquid lithium resources.
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Journal of Energy Storage
·
2025
·
IF 9.8
Jicong Zhang,Luwei Shi,Sheng Fei Zhao,Yan Lin,Tao Hu,Ulla Lassi,Ruguang Ma,Chang Ming Li
Na 4 MnV(PO 4 ) 3 is a typical Na-super-ionic-conductor (NASICON), which shows great promise as cathode material for high-performance cost-effective sodium ion batteries. However, sluggish Na + diffusion kinetics coupling with Jahn-Teller effect severely deteriorate its high-rate capability and long-term stability. In this work, we report a regulation strategy of jointly doping dual heteroatoms (Fe and Ni) to realize structural stability of Na 4 MnV(PO 4 ) 3 by shortening bond length and fast ion diffusion. The FMVN electrode delivers a highly reversible capacity of 98 and 79 mAh g −1 at 0.1C and 10C, respectively, while maintaining a stable cycling life over 2000 cycles at 10C. Theoretical calculations and kinetic analysis unveil that the regulation of crystal structure by Fe and Ni joint substitution effectively reduces the Na + migration barrier and simultaneously increases the reversible capacity. Additionally, in-situ x-ray diffraction investigation verifies reversible structure evolution and minor volumetric change (∼4.91 %) in the sodiation/desodiation process. An assembled full cell (FMVN||HC) demonstrates an energy density of 353.9 Wh kg −1 at 0.1C and outstanding cycling durability with 89 % capacity retention after 100 cycles at 2C. This dual substitution strategy in this work holds great promise to develop high-performance NASICON-type cathodes for practical applications.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-20
·
IF 14.7
Liu Jinhu,Zhao Huajun,Gao Tong,Huang Xinyan,Liu Shujun,Liu Meichen,Mu Weiwei,Liang Shuang,Fu Shunli,Yuan Shijun,Yang Qinglin,Gu Panpan,Li Nan,Ma Qingping,Liu Jie,Zhang Xinke,Zhang Na,Liu Yongjun
Cytotherapy is a strategy to deliver modified cells to a diseased tissue, but targeting solid tumours remains challenging. Here we design macrophages, harbouring a surface glypican-3-targeting peptide and carrying a cargo to combat solid tumours. The anchored targeting peptide facilitates tumour cell recognition by the engineered macrophages, thus enhancing specific targeting and phagocytosis of tumour cells expressing glypican-3. These macrophages carry a cargo of the TLR7/TLR8 agonist R848 and INCB024360, a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, wrapped in C16-ceramide-fused outer membrane vesicles (OMV) of Escherichia coli origin (RILO). The OMVs facilitate internalization through caveolin-mediated endocytosis, and to maintain a suitable nanostructure, C16-ceramide induces membrane invagination and exosome generation, leading to the release of cargo-packed RILOs through exosomes. RILO-loaded macrophages exert therapeutic efficacy in mice bearing H22 hepatocellular carcinomas, which express high levels of glypican-3. Overall, we lay down the proof of principle for a cytotherapeutic strategy to target solid tumours and could complement conventional treatment.
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PubMed
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Wei Ge,Linxuan Zhang,Fanli Meng,Chengming Tian
Poplar anthracnose caused by Colletotrichum gloeosporioides is one of the major forest diseases worldwide, causing incalculable losses in forestry production every year. In this study, an endophytic bacterium with significant antagonistic activity against C. gloeosporioides was isolated from Populus canadensis leaves, identified and named Pseudomonas atacamensis GZ-3. The specific biological functions of strain GZ-3 were analyzed using whole genome sequencing. The volatile organic compounds (VOCs) produced by strain GZ-3 had good antifungal activity against C. gloeosporioides . These VOCs could effectively inhibit mycelial growth and conidial germination of C. gloeosporioides . In addition, metabolomics analysis revealed that VOCs could help poplar resist infection of C. gloeosporioides by inducing the synthesis of flavonoids in poplar. 3-methyl-1-butanol and 2-heptanone were the main antifungal compounds in VOCs. Therefore, Pseudomonas atacamensis GZ-3 had good potential for biocontrol. This study provided a new strategy for the biological control of poplar anthracnose.
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Foods
·
2024
·Vol. 13
·期 12
·1878
·
IF 4.7
Yushi Wei,Dan Zhang,Junhui Pan,Deming Gong,Guowen Zhang
Indole-3-propionic acid (IPA) is a plant growth regulator with good specificity and long action. IPA may be harmful to human health because of its accumulation in vegetables and fruits. Therefore, in this study, the properties of the interaction between calf thymus DNA (ctDNA) and IPA were systematically explored using multispectroscopic and computational modeling approaches. Analysis of fluorescence spectra showed that IPA binding to ctDNA to spontaneously form a complex was mainly driven by hydrogen bonds and hydrophobic interaction. DNA melting analysis, viscosity analysis, DNA cleavage study, and circular dichroism measurement revealed the groove binding of IPA to ctDNA and showed that the binding did not significantly change ctDNA confirmation. Furthermore, molecular docking found that IPA attached in the A-T rich minor groove region of the DNA. Molecular dynamics simulation showed that DNA and IPA formed a stable complex and IPA caused slight fluctuations for the residues at the binding site. Gel electrophoresis experiments showed that IPA did not significantly disrupt the DNA structure. These findings may provide useful information on the potential toxicological effects and environmental risk assessments of IPA residue in food at the molecular level.
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PubMed
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 4
·047501
·
IF 3.3
Yaping Zhang,Gao Si,Yilong Wang,Zhendong Wang,Zutian Li,Haiyan Wei,Huaixia Yang,Fuchun Si,Xiaofei Li
The sensitive detection of down-regulator of transcription 1 (DR1) provides important information for early noninvasive diagnosis and treatment of Hashimoto thyroiditis (HT). In this study, a label-free electrochemical biosensor for DR1 detection was constructed based on electrodeposited gold nanoparticles (AuNPs) and poly(lactic-co-glycolic acid) (PLGA). The AuNPs were first modified to the electrode surface by electrodeposition to increase the specific surface area of the electrode, thus loading more target molecules to increase the sensitivity of the sensor. Then, a sandwich structure was formed on the electrode surface based on the specific recognition of antigen and antibody. PLGA was fixed on the electrode surface by binding with antibody 2 (Ab2) through amide bond to further improve the sensitivity of the sensor. Induced by the dual signal amplification, the sensor has a linear detection range of 50 fg·ml−1 to 50 ng·ml−1, with a detection limit as low as 19.4 fg·ml−1. Moreover, the sensor has good selectivity, specificity, and anti-interference capability, which holds great potential for the early diagnosis of HT and analysis of other disease markers.
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Data
·
2025
·Vol. 11
·期 1
·4
·
IF 2
Nataliya G. Luzgina,Svetlana N. Tarbeeva,Daniil D. Romashin,Konstantin G. Ptitsyn,Svetlana A. Khmeleva,Leonid K. Kurbatov,Sergey P. Radko,Anna S. Kozlova,Polina A. Veselova,Ekaterina V. Ilgisonis,Alexander L. Rusanov
The aryl hydrocarbon receptor (AhR) plays a crucial role in mediating xenobiotic responses, as well as regulating broader metabolic, differentiation, and stress response programs. In this study, we present a comprehensive long-read RNA sequencing dataset that examines transcriptional changes in the HepaRG human cell line during differentiation induced by dimethyl sulfoxide (DMSO) and acute activation of the AhR with 3-methylcholanthrene (3-MC). We identified 946 genes that were differentially expressed between the NonDiff and Diff conditions (303 genes upregulated and 643 genes downregulated), and 1786 genes that showed differential expression between Diff and Ind conditions (961 genes upregulated and 825 genes downregulated). The acute induction of 3-MC produced a robust AhR signature, characterized by the robust induction ofCYP1A1andCYP1B1, along with a coordinated downregulation of several constitutive hepatic genes involved in drug metabolism (e.g.,CYP3A4andCYP2C8). To facilitate further analysis and reuse of our data, we have provided processed gene-level count matrices, transcript per million (TPM) tables, and detailed differential expression results, as well as analysis scripts. This resource supports research into AhR biology, pharmacogene regulation, and the development of methods for long-read transcriptomics in liver models.Dataset:https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1366635Dataset License:CC-BY 4.0
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Experimental and Therapeutic Medicine
·
2017
·Vol. 14
·期 3
·2721-2727
·
IF 1.261
Rui Wu,Li Long,Qiqi Chen,Xiaodan Wu,Jing Zhu,Bin Zhou,Jia Cheng
The objective of the present study was to investigate the effects of Tim‑3 silencing on cell viability and lipopolysaccharide (LPS)‑induced inflammatory reactions in fibroblast‑like synoviocytes (FLS). T‑cell immunoglobulin mucin domain molecule (Tim)‑3 expression in FLS obtained from patients with rheumatoid arthritis (RA) and normal controls were detected by western blot analysis and reverse transcription‑polymerase chain reaction (RT‑PCR). Small interfering (si)RNA was transfected using Lipofectamine® 2000 to decrease Tim‑3 expression. Following transfection, FLS were stimulated by LPS. An MTT assay, RT‑PCR and western blot analysis were performed to measure cell viability, Toll‑like receptor 4 (TLR4) signaling pathway‑related protein expression and inflammatory cytokine release, respectively. The results of the present study indicated that Tim‑3 expression was increased in FLS from patients with RA compared with FLS from healthy controls. Transfection of Tim‑3 siRNA significantly decreased Tim‑3 expression in FLS from patients with RA. Notably, Tim‑3 silencing decreased FLS cell viability. Following stimulation with LPS, cell viability and the expression of TLR4, myeloid differentiation protein gene 88 (MyD88) and nuclear factor‑κB (NF‑κB) p65 were enhanced in FLS. By contrast, Tim‑3 silencing attenuated LPS‑induced cell proliferation and the expression of TLR4, MyD88 and NF‑κB p65. In addition, LPS significantly increased levels of cytokines in the supernatant, including tumor necrosis factor‑α, interferon‑γ and interleukin‑6 (P<0.01). By contrast, Tim‑3 silencing significantly decreased LPS‑induced cytokine release (P<0.01). However, Tim‑3 silencing did not affect TLR4, MyD88 and NF‑κB p65 expression and the release of cytokines in cells that did not undergo treatment with LPS. Therefore, the results of the present study indicate that Tim‑3 silencing decreases the viability of FLS in RA and attenuates the LPS‑induced inflammatory reaction.
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