BIORESOURCE TECHNOLOGY
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2012
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IF 4.98
Yongshui Qu,Chongpin Huang,Yanlei Song,Jie Zhang,Biaohua Chen
The dehydration of fructose or glucose to 5-hydroxymethylfurfural (5-HMF) using room temperature ionic liquids (ILs) as a solvent is a promising method for producing liquid fuels from renewable resources . The IL, 1-hydroxyethyl-3-methylimidazolium tetrafluoroborate ([C 2 OHMIM]BF 4 ), was used a catalyst—rather than as a solvent—in the conversion of fructose or glucose to 5-HMF. With glucose, the yield of 5-HMF reached as high as 67.3% after 1 h at 180 °C in dimethylsulfoxide (DMSO) as solvent. The catalyst was separated from the reaction mixture by distilling solvent and reused six times without loss of activity. Furthermore, a kinetic analysis was carried out to illustrate the formation of 5-HMF, and the values of the activation energy and the pre-exponential factor for the reaction were 55.77 kJ mol –1 and 1.6 × 10 4 min –1 respectively.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2012
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IF 3.35
Cheng Zhang,Guodong Li,Yihan Wang,Fuying Cui,Jien Zhang,Qingshan Huang
In this work, 5-fluorouracil-loaded- poly( l -lactic)-polyethylene glycol/polyethylene glycol (5-FU-loaded-PLLA–PEG/PEG) nanoparticles were prepared using a novel reverse emulsion-solution enhanced dispersion by supercritical fluids (reverse emulsion-SEDS) technique in an effort to obtain an efficient drug delivery system . In the experiment, 5-FU and PEG were dissolved in water PLLA–PEG was dissolved in organic solution, the aqueous solution was added dropwise to the organic solution under magnetic stirring, a reverse emulsion was immediately formed. The reverse emulsion was dried by a SEDS process so that 5-FU-loaded-PLLA–PEG/PEG nanoparticles (5-FU-NPs) were obtained. The particle size, size distribution, surface morphology, and physical and chemical properties of the 5-FU-NPs were investigated by laser diffraction particle size analysis, scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FTIR) and thermogravimetric analysis (TGA). The drug encapsulation efficiency (EE), drug loading (DL), in vitro release profile and pharmacokinetics of 5-FU-NPs in rat plasma were investigated by high-performance liquid chromatography (HPLC). The in vivo tumor inhibition effect, increase in lifespan and hepatotoxicity of placebo-NPs, 5-FU and 5-FU-NPs were determined using H22 tumor-bearing ICR mice. These results collectively suggest that 5-FU-NPs prepared using SEDS have potential anti-tumor applications as a controlled drug release dosage form without harmful drug toxicity .
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CARBOHYDRATE RESEARCH
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2012
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IF 2.332
Xingcui Guo,Quan Cao,Yijun Jiang,Jing Guan,Xiaoyan Wang,Xindong Mu
Mesoporous SBA-15 materials functionalized with propylsulfonic acid groups (SBA-15-SO 3 H) were synthesized through a conventional one-pot route. It was used as a catalyst for the selective synthesis of 5-hydroxymethylfurfural (HMF) from the dehydration of fructose using BmimCl as solvent. Reaction time, temperature and fructose concentration were investigated during the HMF synthesis procedure. The catalyst SBA-15-SO 3 H exhibits high fructose conversion (near 100%) and HMF selectivity (about 81%) with good stability in the HMF synthesis. It was a suitable catalyst to produce HMF from renewable carbohydrates in potential industrial process.
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ChemCatChem
·
2017
·Vol. 9
·期 19
·3646-3654
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IF 4.803
Bin Zhang,Qifan Wu,Chao Zhang,Xinluona Su,Ruhui Shi,Weiwei Lin,Yan Li,Fengyu Zhao
Graphical Stability from the support : The excellent stability of a Ru/ZSM-5 catalyst for levulinic acid hydrogenation in water relies on the higher tetrahedral-coordinated Al content and preferable pore connectivity in well-crystallized ZSM-5 zeolite, which suppress Ru aggregation and leaching and the formation of carbonaceous residues in the acidic environment. A long-life topic in the field of heterogeneous catalysis has been to develop supported catalysts that are stable against the aggregation of active metal and carbon deposition. Herein, we report a highly stable Ru/ZSM-5 catalyst for the hydrogenation of levulinic acid in water, which can be recycled at least 10 times without apparent loss of activity (conv. >95 %, yield >85 %). The influences of types of Al species, structure of support, Ru sizes, Ru leaching, and carbon deposition, etc. on activity and stability were discussed in detail. It was confirmed that the tetrahedral-coordinated framework Al in ZSM-5 contributed to the favorable metal–support interaction, and thus suppressed the aggregation and leaching of ruthenium during recycling. Besides, the suitable pore volume and channel network connectivity successfully prevent from deposition of carbonaceous residues.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Shiling Zhao,Kaizhi Wang,Shaoqi Mao,Beibei Yang,Yu Zhao
In the pursuit of high-selective oxidation of 5-hydroxymethylfurfural (HMF) to valuable derivatives such as 5-hydroxymethylfuroic acid (HMFCA), 5-formyl-2-furanoic acid (FFCA), and furan-2,5-dicarboxylic acid (FDCA), we have developed a diethylenetriamine pentaacetic acid (DTPA)-assisted strategy to construct a highly effective photothermal catalyst with maximized Ag–CeO2 interfaces and rich oxygen vacancies. Under optimal reaction conditions, this catalyst achieves remarkable yields of 99% for HMFCA, 99% for FFCA with a turnover frequency (TOF) of 163 h–1, and 98% for FDCA. Combined theoretical calculations and a series of characterization analyses reveal that the superior performance is due to the unique properties of the maximized Ag–CeO2 interfaces and the rich oxygen vacancies, which enhance electron transport and synergistically enhance the catalytic activity of silver clusters. In contrast to other photocatalytic oxidation systems for HMF, this work showcases high selectivity in the oxidation of HMF to HMFCA, FFCA, and FDCA. These findings not only elucidate the mechanisms behind selective oxidation but also offer a promising approach for the directional photosynthesis of high-purity chemicals in related applications.
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Royal Society Open Science
·
2024
·Vol. 11
·期 8
·
IF 2.9
Junchi Zheng,Zhifeng Wang,Qiulan Shi,Lipeng Jiang,Cuiping Yang,Yuan Zhang,Jianbo Zhao
Trivalent ruthenium (Ru) can catalyse the oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). However, the structure of Ru itself is unstable and is prone to aggregation and oxidation, leading to a decrease in catalytic activity. Therefore, it is necessary to prepare a stable, reliable, Ru-based catalyst. Based on the catalytic properties of trivalent Ru, a stable spinel structure with zinc ferrite was designed and loaded onto different carbon supports to prepare a homogeneous and stable Ru-based catalyst. The structure and physico-chemical properties were characterized through scanning electron microscopy, X-ray diffraction, transmission electron microscopy and other techniques, and the catalyst was applied to the oxidation of HMF for the preparation of FDCA. The results show that the prepared magnetic activated carbon-supported Ru-based catalyst has a concentrated particle size distribution in the range of 5–8 nm, with a loading amount of 3.61 at%. It exhibits strong soft magnetism, which is beneficial for Ru loading. Additionally, it can be reused in the oxidation of HMF to prepare FDCA over 10 cycles, with the product yield remaining essentially unchanged. The catalyst prepared in this study is characterized by recyclability and structural stability, making it promising for practical applications.
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SOLID STATE IONICS
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2024
·
IF 3
Qin Zhou,Cong Xia,Ji Li,Amei Cheng,Jianwen Liu,Hongying Liu,Lin Li,Shiquan Wang
Metal-organic framework (MOF-5) material was synthesized by solvothermal method. Porous carbon (C) and sulfur-doped porous carbon (S/C) were fabricated by calcining and vulcanization of MOF-5. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and Raman spectroscopy were used to characterize the crystal structure and morphology of the samples. The electrochemical performance of C and S/C materials were tested as anode materials for lithium ion batteries (LIBs) and sodium ion batteries (SIBs). The S/C exhibits the high reversible capacity (1114.8 mAh g −1 after 100 cycles at 0.1 A g −1 and 485 mAh g −1 after 500 cycles at 2.0 A g −1 ), as anode for LIBs. It behaves a reversible discharge capacity of 268.8 mAh g −1 after 100 cycles at 0.1 A g −1 and a capacity of 157 mAh g −1 after 1000 cycles at 2.0 A g −1 , as anode for SIBs. Compared with C, the electrochamical performance of S/C material is significantly improved. This is mainly because the bigger specific surface area and the doping of sulfur atoms increases the layer spacing and facilitates the kinetics of the intercalation and deintercalation of Li + and Na + ions, especially Na + ions.
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CATALYSIS TODAY
·
2024
·
IF 5.2
Wei Lv,Yao Wang,Hong Chen,Yongqi Tang,Yongdan Li
Nitrogen atom-doped biomass carbon prepared from corn stover is a newly discovered metal-free catalyst that shows good activity on the selective oxidation of 5-hydroxymethylfurfural (5-HMF) to 2,5-diformylfuran (DFF). Here, the presence of graphitic nitrogen on the catalyst surface activated the oxygen adsorbed on the carbon sites next to the graphitic nitrogen in the carbon material and promoted the formation of oxygen radicals on the surface-active sites, improving the HMF oxidation process. The results show that the catalyst NC-800 reacted with acetonitrile as the reaction solvent at 110 °C and 1.0 MPa O 2 for 8 h to obtain 93.0 % HMF conversion and 94.4 % DFF selectivity, and the 5-HMF conversion and DFF selectivity were maintained at more than 85 % after five cyclic tests, with excellent cyclic stability. One of the main factors influencing the material flaws is the variation in pyrolysis temperature. Using maize stover, a readily available and renewable biomass, in the catalytic oxidation of biomass platform compounds may improve biomass utilization more extensively.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ang Gao,Yong Li,Yinjing He,Can Zheng,Lidan Liu,Zhike Liu,Dapeng Wang,Shengzhong Frank Liu
The quality of organic–inorganic hybrid perovskite films directly affects the application prospect of perovskite solar cells (PSCs), where organic and inorganic cations are the core elements that affect the quality of the perovskite. The additive strategy has been widely used to passivate cation-related defects in perovskite films. Here, the perovskite precursor solution introduced 5-bromopyridine-3-sulfonic acid (BOH) with a potential all-cation passivation function. The experimental results verified that the N atom on pyridine in the BOH molecular structure passivated the defects in perovskite by binding with undercoordination Pb2+, and the sulfonic acid group inhibited nonradiative recombination through their interactions with FA+ and Pb2+, improving perovskite grain size and crystallinity, and enhancing film quality. Thanks to the all-cationic targeted anchoring effect of BOH, the efficiency of the BOH-treated device upgraded from 22.32 to 24.33%. Importantly, PSCs with BOH showed excellent stability after exposure to 25% humidity for 1200 h at room temperature.
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Food Bioscience
·
2024
·
IF 4.8
Yilun Huang,Yuwei Liu,Wenting Liu,Huiyu Hu,Daoxue Zhou,Xiaoxiang Peng,Chang Li,Yi Chen,Qiang Yu,Yuting Wang
5 Hydroxymethylfurfural (5-HMF) is a heat-induced hazard that common in baked goods. Although bioactive compounds such as catechins and polysaccharides could inhibit 5-HMF, their inhibition efficiency was limited when used alone. Therefore, this study aimed to explore the synergistic inhibitory impact of catechins and polysaccharides on 5-HMF in biscuits. Epigallocatechin gallate (EGCG), chitosan, and sodium alginate were screened out due to their high maximum inhibition rates (55.90, 67.20 and 66.62%, respectively), and their synergistic inhibitory effects on 5-HMF were investigated by isobologram analysis. The interaction index (γ) varies inversely with the synergism. When γ < 1 or >1, it represented synergism or antagonism, respectively. The results showed the EGCG/chitosan ratios of 1:1 (γ = 0.221) had better synergism than that of 1:2 (γ = 0.671) and 1:3 (γ = 0.523). Moreover, EGCG and sodium alginate only showed a synergistic effect at ratio of 1:1 (γ = 0.358), while an antagonistic effect was observed at ratios of 1:2 and 1:3 (γ = 1.12 and 1.25, respectively). The optimal inhibitory effect (54.57%) was achieved when EGCG-sodium alginate (1:1) at 0.2 g/kg. Compared with those used alone, the co-addition of EGCG and chitosan could decrease the dosage of EGCG to 1/5 and that of chitosan to 1/7, indicating a significant improvement of inhibit efficiency. Finally, Inhibitors’ concentration correlated negatively with 5-HMF content and browning index, suggesting they might inhibit 5-HMF by hindering Maillard or caramelization reactions. This study provided an efficient and cost-effective solution for 5-HMF control in baking products.
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Foods
·
2025
·Vol. 14
·期 14
·2437
·
IF 5.1
Yongtai Wu,Bei Hu,Yuxin Wen,Zuowei Xiao,Lin Li,Xia Zhang,Zhenhui Zhang,Bing Li
Soy sauce (SS) is one of the most popular condiments in the world. However, Nε-carboxymethyl-lysine (CML) and 5-hydroxymethylfurfural (5-HMF), harmful Maillard reaction products, are present in SS. Worse still, their primary sources in SS production remain unclear, and their contents increase during the consumption of heated SS. In this study, CML and 5-HMF were simultaneously monitored, and thermal treatment and the addition of natural product were used to simultaneously reduce their contents during SS production and consumption. During SS production, CML and 5-HMF primarily originated from the raw materials used in SS production, Maillard reactions during fermentation, and the addition of food additives. Also, CML and 5-HMF were simultaneously found in commercial light soy sauce, dark soy sauce, and infant SS, and thermal treatment could increase their contents. Fortunately, additional thermal treatment of semi-finished SS (especially raw sauce and rude light SS) and appropriate concentrations of (−)-epicatechin (100 μM) and ascorbic acid (5 μM), respectively, added to SS for direct and heated consumption, could simultaneously reduce the CML and 5-HMF contents. This study highlights the presence of CML and 5-HMF in SS and proposes practical methods to simultaneously minimize their contents during production and consumption.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2025
·
IF 3.3
Gahlot Himanshi,Kang Sun Chul
Synergistic therapy is unwaveringly developing as a potential approach to enhance the effectiveness of anticancer medications in chemotherapy. Incorporating adjuvants alongside conventional anticancer medications has demonstrated selective cytotoxicity toward cancer cells while mitigating adverse effects such as DNA damage and systemic toxicity in normal cells. The extended use of 5-FU, a synthetic medicine used in chemotherapy, has many adverse effects, which limit its long-term use in clinical settings. Numerous investigations have demonstrated that luteolin exhibits anticancer effects and alleviates inflammation in mammalian cells. In this study, we provide the first experimental evidence of the synergistic interaction between luteolin and 5-FU in murine melanoma (B16F10) cells, compared to monotherapies (luteolin and 5-FU alone). Using MTT assay for cell viability, flow cytometry for cell cycle analysis, and Western blotting for apoptosis markers, we demonstrate that simultaneous exposure to luteolin and 5-FU speeds up oxidative stress and enhances the production of endogenous ROS. The combination therapy induced the G1-phase cell cycle arrest (65.39%) and decreased the cell viability of B16F10 cells to 34.6%. This, in turn, activates the DNA damage response and initiates the apoptotic pathway by suppressing autophagy and the DNA repair system. Further, the co-treatment of luteolin and 5-FU significantly decreases the mitochondrial membrane potential and reduces ATP production. The results indicate that the combination of luteolin and 5-FU may improve treatment efficacy while potentially decreasing the necessary dosage of 5-FU, therefore reducing its toxicity in clinical settings.
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