Biomedical Materials
·
2024
·Vol. 19
·期 6
·065033
·
IF 3.9
Shungen Huang,Xian Yang,Yajuan Gao,Haoying Huang,Tuanwei Li,Meng Li,Feng Wu,Hongcao Yang,Chunyan Li
The high heterogeneity of neuroblastoma (NB) is currently the main challenge in clinical treatment, impeding the complete eradication of the tumor through monotherapy alone. In this study, we propose a combination strategy using a targeted nano co-delivery system (ADRF@Ag2Se) comprising phototheranostic agents, differentiation inducers and chemotherapy drugs for sequential therapy of NB. Upon intravenous injection, ADRF@Ag2Se demonstrates effective tumor targeting by the specific binding of AF7P to MMP14, which is overexpressed on the surface of NB cells. Subsequent implementation of local photothermal therapy (PTT) leverages the robust photothermal conversion capabilities of the amphiphilic photothermal reagent PF. This is followed by the temperature-triggered release of differentiation-inducing agent 13-cis-retinoic acid and chemo-drug doxorubicin to synergistically eliminate the residual lesions. This nanotherapeutic strategy facilitates in vivo targeted delivery and PTT under the supervision of NIR-II fluorescence, and it also enhances the chemotherapeutic response through differentiation induction of poorly differentiated cancer cells. In the NB tumor model, this co-delivery strategy effectively inhibited tumor growth and significantly prolonged the survival of the mice.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Haodong Zhang,Xin Ye,Shaoyang Wu,Fan Wu,Yiming Zhang,Zhengping Ding,Yurong Ren,Peng Wei
As a mainstream commercial cathode material for lithium-ion batteries (LIBs), LiFePO4 (LFP) is still limited by its inherently low electronic conductivity and slow diffusion kinetics. Therefore, a unique and innovative synthesis strategy must be devised to overcome these deficiencies. Hereby, we successfully synthesized N,F co-doped carbon encapsulated hollow LFP nanoshuttles (LFP-NFC) using an iron-based metal–organic framework (Fe-MOF) as the precursor. Benefitting from the hollow and porous structure derived from Fe-MOF, as-synthesized LFP-NFC effectively shortens the lithium-ion diffusion path and accelerates the ion diffusion speed. Moreover, the carbon layer doped with N and F heteroatoms induces more active sites for lithium storage and improves the electronic conductivity. The optimized LFP-NFC exhibits excellent electrochemical performance with a specific discharge capacity of 162.74 mAh g–1 at 0.1 C and a superior rate capability (102 mAh g–1 even at 10 C).
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Chenyu Cao,Yifei Li,Fangzhou Shi,Shanshan Jiang,Yutong Li,Leilei Yang,Xinyi Zhou,Yuqiong Gao,Feiyan Tang,Huan Li,Shulan Han,Zhuo Yu,Yifang Zou,Jianfeng Guo
Doxorubicin (DOX) is a chemotherapy drug used for hepatocellular carcinoma (HCC) treatment, but its effectiveness can be dramatically dampened by cancer cell chemoresistance. Signal transducer and activator of transcription 3 (STAT3) is implicated with drug resistance in a range of cancers (e.g., HCC), and the STAT3 inhibition can reverse the resistance of cancer cells to chemotherapeutic drugs. In the present study, a combination regimen to improve the efficiency of DOX was provided via the STAT3 blockade using plumbagin (PLB). A poly(lactic-co-glycolic acid) decorated by polyethylene glycol and aminoethyl anisamide was produced in the present study with the hope of generating the nanoparticles for co-delivery of DOX and PLB. The resulting co-formulation suppressed the STAT3 activity and achieved the synergistic chemotherapy, which led to tumor inhibition in the mice with subcutaneous DOX-resistant HCC, without causing any toxicity. The present study reveals the synergism of DOX and PLB, and demonstrates a promising combinatorial approach for treating HCC.
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高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-10
·
IF 5.3
Yang Shuning,Tian Li,Feng Yongbo,Song Yujia,Li Ruidan,Guo Yanjia,Li Huiling,Li Chao,Lu Juan
A highly sensitive molecularly imprinted electrochemiluminescence (MIECL) sensor was developed for detecting rifampicin (RIF) based on luminol@Co-MOF. Co-MOF had a significant enhancement of ECL signaling in the luminol-O 2 system. Molecular imprinted polymers (MIPs) with the introduction of RIF provide new properties for the specific recognition of RIF. A noteworthy decrease in ECL intensity was observed with higher concentrations of RIF. Consequently, the ECL signal was controlled by RIF elution from and adsorption by the MIP, thus establishing a new method for RIF detection. Under optimal conditions, this sensor exhibited linear detection ranges of RIF between 1.0 × 10 −11 mol L −1 and 1.0 × 10 −6 mol L −1 , with a detection limit of 3.3 × 10 −12 mol L −1 ( S / N = 3). The recoveries ranged between 98.1 and 106.0% in fish samples. This method can be used as a sensitive and rapid method to detect RIF in real samples. Graphical
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Mengqiu Guan,Wenhan Han,Kailei Lu,Yuhong Xie,Zijie Li,Yucheng Ye,Guixin Wang,Jianqi Qi,Tiecheng Lu
In response to the urgent demand for windows with multi-mode self-calibrated temperature feedback operating over a wide range in extreme environments, herein, Pr 3+ –Er 3+ co-doped Y 2 Zr 2 O 7 (YZO) transparent ceramics were developed. After annealing treatment to remove defects, these ceramics exhibit high transparency and temperature-dependent wide-range photoluminescence, in which the in-line transmittance is up to 77.8% at 760 nm (theoretical limit is 78%), and the luminescence band spans blue to red. Furthermore, based on the luminescence intensity ratio technology, a multi-mode temperature sensing window using highly transparent YZO:Pr/Er ceramics was designed. The developed photothermal window shows relatively high sensitivity, in which absolute sensitivity ( S a ) and relative sensitivity ( S r ) reached 0.0105 K −1 at 363 K and 1.295% K −1 at 301 K, respectively. The developed thermometer could provide a reference for self-calibrated thermometer window, and its wide spectral operating range ensures the reliability of temperature measurement, which has the potential to be used in some extreme conditions.
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高影响因子
Journal of Environmental Chemical Engineering
·
2017
·
IF 0
Gaoxiang Qi,Lian Xiong,Mutan Luo,Qianlin Huang,Chao Huang,Hailong Li,Xuefang Chen,Xinde Chen
Co-culture of Clostridium acetobutylicum and Saccharomyces cerevisiae was used to enhance solvents (acetone-butanol-ethanol, ABE) production from cassava without amylolytic enzymes addition. Under the simultaneous inoculation condition of C. acetobutylicum and S. cerevisiae with the inoculation level of 5% (v/v) for both strains, 21.74 g/L solvents was produced from 75 g/L cassava with the yield of 0.36 g solvents/g glucose. The solvents titer and yield obtained in the co-culture process increased by 14.3% and 9.1%, respectively, compared to those achieved in ABE fermentation. For further improvements in total solvents titer and yield from cassava, ABE fermentation and co-culture process from higher cassava concentration media were conducted. 42.56 g/L total solvents was achieved from 150 g/L cassava by co-culture with the yield of 0.46 g solvents/g glucose. The solvents titer and yield obtained in the co-culture process increased by 141.0% and 43.8%, respectively, compared to those obtained from ABE fermentation. The results showed great potential for the use of co-culture of C. acetobutylicum and S. cerevisiae for solvents production from starchy substrate.
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JOURNAL OF CATALYSIS
·
2018
·
IF 6.759
Xiaobin Dong,Songlin Chao,Fanfan Wan,Qingxin Guan,Guichang Wang,Wei Li
Acetylene hydrochlorination is a major technology for producing vinyl chloride in coal-rich areas, but its development is restricted by its utilizing the toxic mercury chloride (HgCl 2 ) catalyst. Lately, several nitrogen-doped carbon materials have been studied and are considered to be a feasible alternative. Here, we propose an approach based on sulfur doping to effectively improve the pyridinic N content in N-doped carbon material. According to high-resolution XPS and C 2 H 2 TPD results, C atoms adjacent to pyridinic N were proved to be active sites, and thus the co-doped carbon catalyst exhibited a higher acetylene conversion than the N-doped carbon sample. Furthermore, the co-doped catalyst processed in NH 3 exhibits preferable catalytic activity and competitive stability owing to its high specific surface area, mesoporous structure, and high nitrogen level. Good performance, combined with the features of low cost and ecofriendliness, makes sulfur and nitrogen co-doped carbon a promising catalyst for acetylene hydrochlorination.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2018
·Vol. 36
·期 9
·1063-1069
·
IF 2.016
Chen Lu,Cheng Hui-Hui,Xiong Jiang,Zhu Ya-Ting,Zhang Hong-Peng,Xiong Xi,Liu Yu-Man,Yu Jian,Guo Zhao-Xia
Gelatin, a natural proteinous polymer, was used to co-electrospin with poly(butylene succinate) (PBS) in order to improve the mechanical properties of PBS membrane and facilitate its applications in biomedical field. The PBS/gelatin blend membranes have narrower distribution of fiber diameter and smoother surface than neat PBS membrane. The contact angles, water absorption rates and water uptakes of the PBS/gelatin blend membranes were measured, showing increased hydrophilicity. The interaction between PBS and gelatin was investigated by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC). The mechanical properties of PBS/gelatin blend membranes in both dry and wet states were evaluated by uniaxial tensile tests. In the dry state, the PBS/gelatin blend membrane containing 10% gelatin has a 3-times increase in tensile strength without any adverse effect on ductility because of the existence of interaction between the two blend components, little change in crystallinity of PBS, and possible interaction between any adjacent fibers; the tensile strength and elongation at break are even better in the wet state attributed to some gelatin on fiber surfaces, which act as a binder in the presence of water. The potential applications of PBS/gelatin blend membranes were demonstrated by successful immobilization of thrombin, a clinically-used hemostatic drug. The thrombin-loaded membrane could be used for rapid hemostasis.
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高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Miao Xu,Liang Huang,Youxing Fang,Lei Han,You Yu,Shaojun Dong
Co-based electrocatalysts were prepared by facilely low-temperature multi-step calcination using ordered mesoporous carbons (OMCs) and cobalt salt as the precursors. According to the chemical reaction of cobalt compound , the calcined product of each step could be used as different catalysts, which could complete the full water splitting in alkaline solution together. The introduction of ordered mesoporous carbon not only make the morphology was well inherited, but also enhanced the catalytic activity. The OMCs/CoP exhibited overpotential of 134 mV in acidic media and 143 mV in basic media with a current density of 10 mA cm −2 for hydrogen evolution reaction (HER). While, in basic solution, the OMCs/Co 3 O 4 had an overpotential value of 350 mV at 10 mA cm −2 for oxygen evolution reaction (OER). Moreover, the different Co-based electrocatalysts were assembled into one system for the full water splitting in 1 M KOH solution. This work provided a facile and efficient candidate for water splitting.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2017
·
IF 3.582
Yinghui Sun,Guojie Zhang,Jiwei Liu,Peiyu Zhao,Peng Hou,Ying Xu,Riguang Zhang
CH 4 CO 2 reforming to syngas was investigated over three different activated carbon catalysts. To better understand the influence of the supports on the catalytic properties , catalysts were analyzed by some characterization methods, such as nitrogen adsorption–desorption isotherms, XRD , H 2 -TPR, NH 3 -TPD, CO 2 -TPD, FTIR, TEM and EDX . The results showed that the catalyst with AC 2 as the support provided the best catalytic activity . The CH 4 conversion and CO 2 conversion were 92% and 98% at 900 °C, respectively; best selectivity with the H 2 /CO ratio was close to 1 among the three supports used. It also showed a better stability at 900 °C. H 2 -TPR analysis showed that Co species in Co/AC 2 catalyst were strong interaction with the support. It was observed that active metals were well dispersed on the AC 2 support by the TEM. In addition, the ratio of CH 4 /CO 2 also had great influence on the CH 4 and CO 2 conversion.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yanan Hu,Ziyang Tao,Jiawei Yang,Qiang Zhao,Jinping Li,Guang Liu
Improving the kinetics of oxygen evolution is crucial for enhancing the performance of photoelectrochemical (PEC) water splitting. Herein, this study utilizes a chemical self-growth method to grow NiFe tannic acid complex (NFTA) and Co(OH) 2 on the surface of BiVO 4 photoanode (BiVO 4 /NFTA/Co). As a result, the synergistic effects of NFTA and Co(OH) 2 layers promote the efficiency and stability of BiVO 4 photoanode towards PEC water oxidation . The photocurrent density of the obtained BiVO 4 /NFTA/Co photoanode reaches 4.97 mA cm −2 , which is significantly greater than those of BiVO 4 /NFTA (4.36 mA cm −2 ), BiVO 4 /Co (2.51 mA cm −2 ), BiVO 4 (1.34 mA cm −2 ), respectively. Detailed analysis confirms that NFTA could provide an efficient way to hasten the transfer of photo-generated holes on the photoanode surface and diminish the surface charge transfer resistance . In other hand, Co(OH) 2 could be served as a cocatalyst to accelerate charge transfer for efficient oxygen evolution reaction as well as a protective layer to maintain the long-term stability of NFTA on the surface of BiVO 4 during water oxidation. Such double oxygen evolution co-catalysts decoration strategy paves an effective pathway to enhance the PEC water oxidation performance of BiVO 4 photoanode.
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POLYMER BULLETIN
·
2025
·
IF 4
Wang Guoqiang,Wang Yueying,Wei Deyu,Hui Yunfeng,Yu Yiheng,Zhang Mengke,Shi Longqing,Hu Jing
Polylactic acid (PLA) is a kind of bio-based polyester with high tensile strength and poor ductility. Poly(butylene sebacate-co-terephthalate) (PBSeT) is a kind of biodegradable polyester with good ductility. To improve the ductility of PLA, PBSeT with high molecular weight was synthesized and melt blended with PLA to obtain PLA/PBSeT blends with high ductility in this study. Their structures and properties were characterized by differential scanning calorimetry, thermogravimetric analysis (TGA), dynamic mechanical analysis (DMA), and scanning electron microscopy (SEM). Although SEM, DMA, and TGA suggested poor compatibility between PBSeT and PLA, PBSeT can still improve the ductility of PLA. When the PBSeT content was 30 wt%, the elongation at break of the blend increased to 85.9%. PBSeT debonds with the PLA matrix to form internal cavitation and the shear band to absorb a large amount of energy to induce plastic deformation. Meanwhile, PBSeT can reduce the complex viscosity of PLA.
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