Materials Today Communications
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2022
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IF 3.662
Lianlian Yang,Junhong Ling,Nan Wang,Yongjun Jiang,Yuqing Lu,Li-Ye Yang,Xiao–kun Ouyang
Here, glycidyl methacrylate (GMA) was used for modification of carboxymethyl chitosan (CMCS). The double bond on the side group of CMCS was polymerized and cross-linked with N-N′-bis(acryloyl) cysteamine (BAC), containing a disulfide bond, and modified with folic acid (FA) to obtain nanogels for the targeted delivery of doxorubicin (DOX). Effectiveness of DOX delivery and release were subsequently investigated. The drug encapsulation efficiency (EE) and loading capacity (LC) of DOX were 94.77 ± 0.83% and 15.6 ± 0.12%, respectively. The particle size of the GCMCS-FA-DOX nanoparticles loaded with DOX was 220.4 ± 38.4 nm. The experimental results showed that GCMCS-FA-DOX had a high glutathione and pH response performance. GCMCS-FA-DOX showed an improved inhibitory effect on tumor cell proliferation compared to free DOX. GCMCS-FA-DOX significantly improved the efficiency of drug uptake by cells, and the cytotoxicity of GCMCS-FA-DOX in HCT-116 tumor cells was higher than that in HepG-2 tumor cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Junjie Wang,Yu Yang,Lijie Huang,Lili Kong,Xing Wang,Jingru Shi,Yinghua Lü,Haibo Mu,Jinyou Duan
Vancomycin (Van) remains one of the first-line drugs for the treatment of wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, the unsatisfactory bioavailability of vancomycin alone has greatly limited its potential health benefits. Here a responsive chitosan-based hydrogel was developed as the delivery system which not only would reduce this side effect but also increase efficacy of vancomycin. The hydrogel was prepared by grafting chitosan and cinnamaldehyde-based thioacetal (CTA) together with ginipin (G) as the crosslinker. Upon exposure to reactive oxygen species which were enriched in the bacterial wound, the hydrogel can locally degrade and sustainably release the loaded vancomycin near the lesion to compete with the troubling MRSA. Compared with vancomycin alone, the chitosan-based hydrogel loaded with vancomycin demonstrated accelerated acute wound healing. This achievement reveals that this multi-functional hydrogel may be a promising drug-delivery device for improving the efficacy of local antibiotic therapy.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2022
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IF 2.712
Shuang Yang,Linhao Lan,Mingda Gong,Ke Yang,Xiaoming Li
An effective dressing is essential for wound healing. In fact, the wettability performance is one of the most important factors of a wound dressing. The fundamental functions of a wound dressing involve the absorption of excess exudates and maintenance of optimal moisture at the wound by controlling water evaporation. Here, we designed a type of chitosan (CS) sponge and PCL nanofibrous membrane composite dressing with asymmetric wettability surfaces as wound healing materials for biomedical applications. The hydrophobic surfaces of the composite dressing were waterproof and could efficiently control the water vapor transmission rate, whereas the hydrophilic surface of the CS sponge had good cytocompatibility and water-absorbing capability. Insulin-like growth factor-2 (IGF-2) was added to the CS sponge, and exhibited a stimulatory effect on fibroblasts migration and proliferation. Therefore, the fabricated CS sponge and PCL membrane composite dressing had excellent cytocompatibility, vapor transmission rate, and liquid absorption and asymmetric wettability, suggesting its potential as a promising alternative to traditional wound dressing.
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APPLIED SURFACE SCIENCE
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2022
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IF 7.392
Yuangan Chen,Bo Feng,Jinxiu Peng,Ziming Wang
An effective reagent combination plays a crucial role in the flotation separation of galena and sphalerite. In this work, potassium permanganate (KMnO 4 ) was used to amplify the property difference between galena and sphalerite, carboxylated chitosan (CCS) was used to selectively depress sphalerite. The mechanism of CCS in the separation of galena and sphalerite was investigated by microcalorimetric measurements, X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy. The results indicated that the rate of sphalerite oxidation by KMnO 4 is significantly faster than galena, and more metal oxides will be produced on the surface of sphalerite. The metal oxides provided active sites for CCS to adsorb on the surface of sphalerite via chemisorption, and the adsorption of CCS hindered the further adsorption of potassium butylxanthate (PBX). Meanwhile, the slower oxidation rate of galena means that fewer metal oxides are produced. In addition, CCS is mainly adsorbed on the surface of galena through physical adsorption, which is easy to fall off, so the surface of galena can further adsorb PBX. Thus, flotation separation of galena and sphalerite is achieved.
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ACS Biomaterials Science & Engineering
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2022
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IF 5.395
Xinhu Gong,Caimei Zhao,Yang Wang,Ying Luo,Chaoqun Zhang
Through a simple strategy of immersion in a mixed solution of water/ethylene glycol (EG)/lithium chloride (LiCl), self-healing carboxymethyl chitosan (CA) hydrogels, that is, CA/N-vinylpyrrolidone-EG-Li+ hydrogels (CEH) with an ultra-low-temperature freezing resistance below −70 °C were fabricated. The introduction of electrolyte ions and small-molecule polyol also made these hydrogels highly conductive (0.8 S m–1) and imparted antidrying property to them, showing stable and reversible sensitivity to finger-wrist bending as well as 150 cycles of stretching. Such hydrogels also presented highly efficient self-healing ability, with a stress–strain healing efficiency of over 90%. Furthermore, the CEH-based sensors maintained a stable sensing performance over a wide range of temperatures below the freezing point (from −10 to −70 °C) and exhibited stable sensitivity to temperatures with fast response and no significant hysteresis. The present work is expected to provide a simple and sustainable route for the preparation of multifunctional antifreezing conductive hydrogels based on CA, leading to a wide range of potential applications in soft sensor devices.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Jia-Lin Miao,Jia-Qi Ren,Hui-Jing Li,Da-Gang Wu,Yan-Chao Wu
A mesoporous crosslinked chitosan-activated clinoptilolite biocomposite (CS-GA/ACP) was prepared with chitosan (CS) as the substrate and glutaraldehyde (GA) as the crosslinking agent. Structural analysis of the CS-GA/ACP composite beads was performed using FTIR, SEM , and BET techniques. The adsorption properties of the CS-GA/ACP for Congo red (CR) and methylene blue (MB) removal were examined using a batch method. The effects of CS loading, CS-GA/ACP dosages (0.005–0.25 g), pH values (3−11), initial concentrations (30–300 mg/L), contact time (5–120 min), ionic strength , and temperatures (25–65 ℃) on the adsorption of CR and MB on the CS-GA/ACP composite beads were investigated. The pseudo-second-order kinetics could better describe the adsorption process than the pseudo-first-order kinetics, and the Langmuir isotherms model agreed well with the experimental data. The maximum adsorption capacities of the CS-GA/ACP for CR and MB were 180.59 mg/g and 143.67 mg/g at 25 ℃, respectively. The proposed mechanism studies showed that the possible interaction between the adsorbent and dye molecules were Yoshida H-bonding, dipole-dipole H-bonding, electrostatic interaction and n-π interaction. The CS-GA/ACP can be recycled to remove dyes without significant loss of efficacy, and the adsorption of dyes on the CS-GA/ACP is spontaneous endothermic adsorption. Overall, the CS-GA/ACP showed an excellent performance for dyes removal in aqueous solution and could be a practical candidate for industrial applications.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Hao Li,Min Long,Huiyu Su,Lei Tan,Xiaowen Shi,Yumin Du,Yan Luo,Hongbing Deng
Immunoglobulin Y (IgY) proves advantageous to IgG in prophylaxis and diagnosis. Quantification of IgY is therefore becoming a topic of interest. Here, we demonstrate a piezoelectric biosensor with carboxymethyl chitosan (CMCS) as the immobilization matrix. Gelation and hydrophilic nature of CMCS are favored to form a crosslinked matrix for antibody immobilization, and a comparison was made between carboxymethyl cellulose (CMC) and CMCS to investigate the benefits of such substitution. Calibration from 500 ng/mL to 200 μg/mL was established in buffer with the detection limit (LOD) down to 270 ng/mL, confirming its feasibility. As-prepared biosensor effectively prevents non-specific binding of bovine serum albumin (BSA) and lysozyme . Each real-time assay took 15 min including sensor regeneration, which can be further reduced to 4 min for signal readout only, ready for both repeated measurements after regeneration and disposable devices. Thus, as-prepared biosensor offers a rapid, label-free and cost-effective approach for IgY quantification.
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Surfaces and Interfaces
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2022
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IF 6.137
Junjie Cai,Bo Liu,Wei Liu,Lina Liu,Zhe Fan,Song Lin
Biomimetic materials are of great significance in wide applications. As a bioactive polysaccharide , chitosan (CS) has attracted much attention in multiple fields. Inspired by the natural shark skin interface, herein, we proposed a methodology to obtain serial biomimetic CS/glycerol membranes via a facile mold casting and solvent evaporation process under mild aqueous conditions. The surface morphology , chemical structures , and physical characteristics of the developed membranes were determined by scanning electron microscopy, Fourier transformed infrared spectroscopy , tensile measurement, water vapor transmission rate, liquid uptake behavior, solubility, and dynamic water contact angle tests. Furthermore, in vitro and in vivo biological assays were performed, including antibacterial ability, hemostatic performance, hemolytic reaction, cytotoxicity evaluation, and contaminated wound healing assessment. Compared with the flat membranes, the micro-patterned CS/glycerol membranes show the higher water-absorbing ability (up to ca . [email protected] min), moderate tensile strength (8.5–14.7 MPa), superior bacteriostasis (84.9% to 98.6% against S. aureus , 84.3% to 99.6% against E. coli ), decent hemostat efficacy (within 75.7 s), low hemolysis rates (less than 0.5%), and benign cytotoxicity (84.2% to 98.4% of viability), which favor promoting contaminated wound healing. Thus, the biomimetic micro-patterned membranes improve bioactive performance and show the merits of simple operation, low cost, and easy scale-up. All these properties indicate that the hybrid micro-patterned membrane could be used as a suitable candidate for dermal wound dressings and open up the insights for developing other bionic interfaces in future potential applications.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Meng Wang,Huihua Huang,Chaokang Huang,Shujun Liu,Xiaohong Peng
Bacterial infection and oxidative stress seriously delay wound healing. Here, magnolol-grafted-chitosan hydrochloride (CSCl-MAG) was synthesized and crosslinked with genipin to form hydrogel (CSM H). By embedding magnolol-loaded chitosan nanocapsules (MCNGs) into CSM H, we designed a novel nanocapsule- embedded hydrogel dressing (MCNG-H) with sustained antibacterial and antioxidant properties. The swelling, rheology , cytotoxicity, antibacterial and antioxidant properties of MCNG-H were studied. MCNG-H exhibited good swelling properties and biocompatibility. The antibacterial and antioxidant assays in vitro demonstrated the corporative effect of CSM-H and MCNGs in inhibiting bacteria and eliminating reactive oxygen species (ROS). Moreover, MCNG-H revealed the pH-responsive release profiles of loaded MAG, and ensured sustained release of MAG with the dual protective effects of MCNG and CSM H, which helped to maintain long-term antibacterial and antioxidant activities. Finally, MCNG-H significantly accelerated wound healing in a splinted excisional dermal wound model, promising a competitive dressing for the treatment of infected wounds.
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Journal of Environmental Chemical Engineering
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2022
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IF 7.968
Jianming Wu,Zihui Dong,Xiuping Li,Peng Li,Jiedong Wei,Mei Hu,Lihong Geng,Xiangfang Peng
Facing the serious environmental problem caused by water pollution , it is still challenging to develop a kind of acidic wastewater treatment adsorbent with high adsorption efficiency. In this study, the negative charged cellulose nanofibrils (CNF) were used to enhance the acid-resistance of the positive charged chitosan (CTS) via both ionic and hydrogen-bonding crosslinking interactions. The prepared CTS/CNF composite membrane presented an excellent acid-resistant property (approximately 95% acid-resistant degree) and 14.71 mg/g of adsorption capacity for methylene blue in the strong acidic environment (pH = 1.22), surpassing almost reported adsorbents. Besides, the adsorption process for methylene blue conformed to the pseudo-first-order kinetic model and the Langmuir isotherm model better. Furthermore, the obtained CTS/CNF composite membrane presented excellent recyclability (about 85% desorption rate) after five recycles of adsorption-desorption. Consequently, as a novel and efficient adsorbent, the CTS/CNF composite membrane showed an outstanding application potential in the treatment of acidic wastewater.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Shiyuan Liu,Yuehua Deng,Weiqi Liu,Zhiqiang Li,Libo Li,Rui Zhang,Yanbin Jiang
The utilization of natural polymer gel to achieve drug polymorph control is usually a challenging issue, and the interplay of gelation and crystallization has been neglected in many studies. In this work, a modified chitosan (Cs) hydrogel was used to encapsulate drug Isonicotinamide (IN), where competitive crystallization and gelation was constructed for a better control of different assembly processes. It was found that the crystalline outcome of drug (cocrystals or IN Form I) depends on different crosslinking agents used. Spectral analysis and MD simulation reveal that the interplay of crosslinking effect of Cs, dimerization of crosslinking agents and aggregation of IN determines the crystalline outcome, among which the affinity to crosslinking agents of Cs chain plays the significant role. To our knowledge, it is the first time that Cs hydrogel acts as a template to regulate polymorphism of drug. This work offers a promising way for drug delivery system design.
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MOLECULAR PHARMACEUTICS
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2022
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IF 5.364
Xiaozhu Chen,Hong Zhang,Chu Wang,Yue Su,Min Xiong,Xiaohua Feng,Daishi Chen,Zhaoyang Ke,Lu Wen,Gang Chen
Overexpression of apoptotic factors in the inner ear is generally proven to induce ototoxicity. This has aroused research interest in various antiapoptotic drugs, the most representative of which is curcumin (CUR). In this study, two nanoformulations of CUR were developed with sustained-release behavior to improve their protective effects against ototoxic hearing loss (HL), which were the nanoparticles of CUR-loaded poly(lactic acid–glycolic acid) (CUR-PLGA NPs) and CUR-loaded chitosan-coated PLGA NPs (CUR-CS/PLGA NPs). The obtained results revealed that both CUR-NPs provided otoprotection in vitro and in vivo, and their effective doses in guinea pigs were much less than that of dexamethasone, which was clinically used to treat HL. Moreover, relative to CUR and CUR-PLGA NPs, CUR-CS/PLGA NPs exhibited the highest accumulation in HEI-OC1 cells and guinea pigs’ cochlea. In pharmacodynamic experiments, the optimal administration timing was investigated, and CUR-CS/PLGA NPs showed sustained efficacy and the best hearing improvement at all tested sound frequencies. Lastly, the protective effect of CUR nanoformulations was further validated via inhibition of Caspase-3 and Bax activation, thereby reducing the concentration of reactive oxygen species and protecting mitochondrial integrity in hair cells. Collectively, CUR-CS/PLGA NPs demonstrated potent and lasting effects against ototoxic HL, making our novel formulation a promising candidate for the alleviation of sensorineural HL.
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