BIOSENSORS & BIOELECTRONICS
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2022
·
IF 12.545
Haomin Fu,Zhiyuan Xu,Tianrui Liu,Jianping Lei
Coreactant electrochemiluminescence (ECL) is one of the most popular pathways in commercial analysis, which can provide simplicity and convenience for getting intense ECL emission. However, the low efficiency of intermolecular electron transfer could weaken ECL intensity. In this work, we developed an enhanced ECL strategy through in situ coordination interactions between metal-organic framework emitters and coreactants. First, a metal-organic framework (MOF) emitter was synthesized with 1,1,2,2-tetrakis(4-(pyridin-4-yl)phenyl)ethane (TPPE) as aggregation-induced emission linkers and Zn as nodes. Interestingly, compared to TPPE ligand, the resulted MOF nanoemitters demonstrated 49.5 folds enhancement of ECL emission in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) as the coreactant. More significantly, different from the constant ECL intensity using TPrA coreactant, DABCO exhibited time-dependent ECL intensity due to the intrareticular electron transfer through coordination interaction between DABCO and Zn 2+ , which was confirmed by X-ray photoelectron spectroscopy and Fourier transform infrared spectral experiments. The enhanced ECL was then applied to construct a sensitive ECL method to detect dopamine in serum samples. The coordination interaction between emitters and coreactants not only provides a universal way to enhance ECL, but also expands the applications of coreactant ECL system in convenience route.
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CHEMICO-BIOLOGICAL INTERACTIONS
·
2023
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IF 5.1
Dongjie Li,Chengzhu Song,Chunpu Song,Xinrui Tian,Huaibo Zhang,Jie Zhang,Xiaoyan Zhao
SUN , a multi-targeted tyrosine kinase inhibitor , exerts cardiotoxicity which hinders its clinical use. It is necessary to elucidate molecular mechanism of SUN-induced cardiotoxicity. To elucidate molecular mechanism of SUN-induced cardiotoxicity and whether it is related to Nrf2-dependent ferroptosis , in vitro model with H9c2 cells derived from rat heart tissue and in vivo model (C57BL/6J male mouse) were used in the present study. In vivo model was established by oral treatment of SUN at dose of 10, 20, 40 mg/kg for 14 days. Body weight, ECG , plasma enzyme activities , histology staining were performed to evaluate heart function. Western-blot was performed to analyze the level of ferroptosis-related proteins. In vitro results indicated that SUN markedly induced ferroptosis embodied as collapsed MMP, accumulated iron and elevated ROS . In vivo results showed that SUN significantly impaired cardiac function. Abnormal electrocardiogram, increased serum CK and lactate LDH levels were significantly observed in SUN groups. Histology staining showed that SUN caused structural injuries and fibrosis deposition. Moreover, SUN increased the level of MDA and Fe 2+ content, decreased the level of GSH. Both in vitro and in vivo experiments indicated that SUN reduced the expression of Nrf2, HO-1, NQO1, GPX4 and FTH1, enhanced the TfR expression. This study suggested that oxidative stress and Nrf2-dependent ferroptosis played a vital role in SUN-induced cardiotoxicity.
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ONCOLOGY REPORTS
·
2023
·Vol. 50
·期 2
·1-13
·
IF 4.2
Xiao Wang,Simin Rong,Yunxiao Sun,Baohui Yin,Xiancong Yang,Xiaoqing Lu,Hongfang Sun,Yunfei Yan,Guangbin Sun,Yan Liang,Pingyu Wang,Shuyang Xie,Youjie Li
Imatinib resistance in chronic myelogenous leukemia (CML) is a clinical problem. The present study examined the role of N‑Myc downstream regulatory gene 3 (NDRG3) in imatinib resistance in CML. Quantitative PCR demonstrated that NDRG3 was highly expressed in patients with CML. Cell Counting Kit (CCK)‑8 experiments proved that NDRG3 promoted the proliferation of K562 CML cells and enhanced imatinib resistance. Dual‑luciferase assay showed that microRNA (miR)‑204‑5p inhibited expression of NDRG3 and immunofluorescence experiments showed that NDRG3 promoted accumulation of β‑catenin in the nucleus, thereby increasing the expression of downstream drug resistance‑ and cell cycle‑associated factors (c‑Myc and MDR1). At the same time, cell proliferation experiments showed that β‑catenin played a role in cell proliferation and drug resistance. Co‑transfection with small interfering (si)‑β‑catenin partially reversed the effect of NDRG3. This finding indicated that NDRG3 plays an important role in imatinib resistance and miR‑204‑5p and β‑catenin are involved in the biological behavior of NDRG3. The present results provide theoretical support for overcoming drug resistance in CML.
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ANALYTICA CHIMICA ACTA
·
2023
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IF 6.2
Lei Wang,Yuhao Han,Yaqi Zhang,Haoyuan Geng,Zihan Zhu,Panpan Chen,Xiaoqing Cui,Xiao Wang,Chenglong Sun
Carbohydrates play crucial regulatory roles in various physiological and pathological processes. However, the low ionization efficiency and the presence of linkage pattern, monosaccharide composition and anomeric configuration isomers make their in-depth analysis very challenging, especially for heterogeneous biological tissues. In this study, we propose a high-sensitive and isomer-specific imaging approach to visualize the spatial distributions of monosaccharide and disaccharide isomers by integrating chemical derivatization and matrix-assisted laser desorption/ionization tandem mass spectrometry imaging (MALDI-MS 2 I). 2-Pyridinecarbohydrazide (PYD) is developed as a novel derivatization reagent which can not only improves the MS sensitivity of carbohydrates, but also enables the identification and visualization of ketose and aldose monosaccharide isomers, as well as linkage pattern, monosaccharide composition and anomeric configuration disaccharide isomers by mass spectrometry imaging of isomer-specific MS/MS fragment ions. Moreover, we build quantitative MALDI-MS 2 and MALDI-MS 2 I methods for disaccharide isomers based on the diagnostic fragment ions, and good linear relationships could be achieved both in solution and on glass slides. We expect that this study should provide new ideas for in-depth profiling of the spatial signatures of carbohydrates in biological tissues and lay the foundation for a deeper understanding of carbohydrates’ structure.
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Nanomaterials
·
2023
·Vol. 13
·期 14
·2125
·
IF 5.3
Tingting Hu,Panpan Feng,Liping Guo,Hongqi Chu,Fusheng Liu
A series of Ti2O3@TiO2core-shell heterojunction composite photocatalysts with different internal electric fields were synthesized using simple heat treatment methods. The synthesized Ti2O3@TiO2core-shell heterojunction composites were characterized by means of SEM, XRD, PL, UV–Vis, BET, SPV, TEM and other related analytical techniques. Tetracycline (TC) was used as the degradation target to evaluate the photocatalytic performance of the synthesized Ti2O3@TiO2core-shell heterojunction composites. The relevant test results show that the photocatalytic performance of the optimized materials has been significantly enhanced compared to Ti2O3, while the photocatalytic degradation rate has increased from 28% to 70.1%. After verification via several different testing and characterization techniques, the excellent catalytic performance is attributed to the efficient separation efficiency of the photogenerated charge carriers derived from the built-in electric field formed between Ti2O3and TiO2. When the recombination of electrons and holes is occupied, more charges are generated to reach the surface of the photocatalyst, thereby improving the photocatalytic degradation efficiency. Thus, this work provides a universal strategy to enhance the photocatalytic performance of Ti2O3by coupling it with TiO2to build an internal electric field.Keywords:photocatalysis;Ti2O3@TiO2core-shell heterojunction;built-in electric field
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INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Hui Fu,Kai Wang,Hao Wu,Chris R. Bowen,Zhi Fang,Zebin Yan,Shuheng Jiang,Deliu Ou,Yang Yang,Jinju Zheng,Weiyou Yang
Currently, the intrinsic instability of organic–inorganic hybrid perovskite nanocrystals (PNCs) at high temperature and high humidity still stands as a big barrier to hinder their potential applications in optoelectronic devices. Herein, we report the controllable in-situ-grown PNCs in polyvinylidene fluoride (PVDF) polymer with profoundly enhanced hygrothermal stability. It is found that the introduced tetradecylphosphonic acid (TDPA) ligand enables significantly improved binding to the surface of PNCs via a strong covalently coordinated P–O–Pb bond, as evidenced by density functional theory calculations and X-ray photoelectron spectroscopy analyses. Accordingly, such enhanced binding could not only make efficient passivation of the surface defects of PNCs but also enable the remarkably suppressed desorption of the ligand from the PNCs under high-temperature environments. Consequently, the photoluminescence quantum yield (PL QY) of the as-fabricated MAPbBr3–PNCs@PVDF film exhibits almost no decay after exposure to air at 333 K over 1800 h. Once the temperatures are increased from 293 to 353 K, their PL intensity can be kept as 88.6% of the initial value, much higher than that without the TDPA ligand (i.e., 42.4%). Moreover, their PL QY can be maintained above 50% over 1560 h (65 days) under harsh working conditions of 333 K and 90% humidity. As a proof of concept, the as-assembled white light-emitting diodes display a large color gamut of 125% National Television System Committee standard, suggesting their promising applications in backlight devices.
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TALANTA
·
2023
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IF 6.1
Ying Wang,Xiaodan Wu,Guansong Shao,Bowen Zhai,Zihan Wang,Bingyang Qin,Tao Wang,Zhiguo Liu,Yujie Fu
An oleanolic acid (OA) surface molecularly imprinted polymer silylated porous composite aerogels (OA-MIP@Si-PC-aerogels) adsorbent material was successfully prepared and characterized. The material not only has a great selectivity for the target molecule OA but also has other noteworthy qualities including high stability, excellent repeatability, and a sizable adsorption capacity. via cellulose and sodium alginate as the main materials, the carrier Si-PC-aerogels were made through ionic cross-linking, chemical cross-linking, and silylation procedures. By adopting a surface molecular imprinting approach on Si-PC-aerogels, OA-MIP@Si-PC-aerogels were effectively created utilizing OA as the template molecule and MAA as the functional monomer . Due to the presence of a specific imprinted layer on the aerogel surface, the adsorption capacity of OA-MIP@Si-PC-aerogels for OA could reach 66.20 mg g −1 . OA-MIP@Si-PC-aerogels could achieve a 68.86% yield of OA from the extracts of lingonberry (Vaccinium Vitis-Idaea L .). The adsorption capacity remained at 90% after five consecutive adsorption-desorption cycles. HepG2 cells were exposed to OA that was effectively enriched with OA-MIP@Si-PC-aerogels in lingonberry (Vaccinium Vitis-Idaea L .) fruit homogenates. This OA significantly inhibited the growth of HepG2 cells in vitro. It further demonstrated that OA-MIP@Si-PC-aerogels could efficiently target OA enrichment and separation with good recovery.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Na Li,Yong Li,Ruitao Lou,Rongwei Xiong,Hong Xu
The release of internal pollutants in shallow lakes is a widely concerning environmental issue. Colloids widely existing in eutrophic shallow lakes will affect the release and migration of pollutants. In this context, the different effects of two colloids [humic acid (HA) and silica (SiO 2 )], either individual or in coexistence, on the adsorption and migration of ammonia nitrogen (NH 4 + -N) in sediments under different ionic strengths (IS) were analyzed, through a series of batch and column experiments. It was found that, under a relatively low IS condition (1 mM Na + ), SiO 2 colloids greatly enhanced the mobility of NH 4 + -N in sediments. With IS increased (20 mM Na + ), the presence of colloids exhibited an impeding effect on the mobility of NH 4 + -N due to colloidal flocculation and precipitation. While HA colloids largely suppressed the mobility of NH 4 + -N in sediments under either low or high IS conditions. HA colloids are more likely to form aggregates and have more adsorption sites than SiO 2 colloids. In the NH 4 + -N–SiO 2 –HA system, HA colloids also showed a retardant effect on the transport of both SiO 2 colloids and NH 4 + -N, and the retardant effect increased with the increase of HA colloid concentration. Exchange coordination and hydrogen bond force, as well as the decreased stability of the colloid system, played an important role in such a retardant effect, which consequently resulted in more NH 4 + -N adsorption. The transport of colloids in the NH 4 + -N–colloids co-transport system can be successfully described by Derjaguin–Landau–Verwey–Overbeek (DLVO) theory. In addition, with an increase of IS, NH 4 + -N transport was enhanced because of competitive adsorption of the cations and NH 4 + -N on colloids and the porous medium . These results implied that abundant HA colloids and low ion concentration can reduce the risk of NH 4 + -N release and migration in sediments and consequently its exchange flux across the sediment-water interface.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Li-Hui Yang,Ze-Qin Lin,Man-Ting Liao,Wen-Jian Yang,Jian-Xin Pan,Wei Li,Cao Yang,Yan-Juan Wu,Guang-Zhao Wang,Si-Hao Lv
Perovskite oxides have emerged as a new category of catalysts for NO 3 RR, yet their low intrinsic catalytic activity results in unsatisfactory performance. Oxygen vacancy engineering has recently been found to be effective for improving the NO 3 RR performance of perovskite oxides. Herein, a novel and efficient strategy of electrochemical activation for in-situ oxygen vacancies (OVs) creation in perovskite oxide La 0.9 FeO 3-δ was reported. The results showed that the NO 3 − -N removal rate increased 2.6-fold on activated La 0.9 FeO 3-δ in comparison to pristine La 0.9 FeO 3-δ . The enhanced NO 3 RR performance was attributed to the presence of more OVs, which served to increase the adsorption energy of NO 3 − while also promoting atomic H* formation for NO 3 − -N hydrogenation. Furthermore, a continuous experiment lasting 240 h found the activated La 0.9 FeO 3-δ exhibited extremely high stability. Additionally, we demonstrated that the electrochemical activation method was applicable to other typical perovskite oxides, such as LaCoO 3 , indicating its generalizability. This study provides a simple and scalable approach for the preparation of a high-performance perovskite oxide-type electrocatalysts for NO 3 RR.
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CANCER CHEMOTHERAPY AND PHARMACOLOGY
·
2023
·Vol. 92
·期 3
·211-221
·
IF 3
Wang Dongbo,Wu Huina,Wu Qian,Liu Qi,Li Yamei,Wu Jiyong,Nie Jing
Purpose Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent cancer. In recent years, the modification of platinum(II) into platinum(IV) derivative compounds, by introducing biologically active molecules, has been extensively employed to develop novel platinum-based prodrugs. We investigated the anti-proliferative activity against HNSCC of a new veratric acid (COX-2 inhibitor)-platinum(IV) complex. Methods In this study, a new veratric acid (COX-2 inhibitor)–platinum(IV) complex, termed veratricplatin, was synthesized. We evaluated the anti-tumor effect of in vitro and in vivo by western blotting, flow cytometry and DNA damage analysis. Results Veratricplatin displayed remarkable anti-proliferative activity against various cancer cell lines, including A549, FaDu, HeLa, and MCF-7. Furthermore, veratricplatin demonstrated significantly stronger cytotoxicity than either platinum(II) or veratric acid monotherapy or their combination. Importantly, the synthesized prodrug exhibited less toxicity toward normal cells (MRC-5), while dramatically enhanced DNA damage in FaDu cells inducing apoptosis. Moreover, veratricplatin markedly reduced the migration ability of FaDu cells compared to the control or monotherapy. In vivo, veratricplatin displayed potent anti-tumor activity with no apparent toxicity in BALB/c nude mice bearing FaDu tumors. In addition, tissue immunofluorescence analysis revealed that veratricplatin could substantially inhibit the formation of tumor blood vessels. Conclusion Veratricplatin demonstrated remarkable drug efficacy, in terms of increased cytotoxicity in vitro and high efficiency with low toxicity in vivo.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Jun Shi,Xiaoshan Zhang,Sabarinathan Ravichandran,Shirong Sun,Yulong Li,Ruoyu Wu,Wanxuan Luo,Hongmei Xing,Wenli Zhang
We report here the synthesis of N-doped porous carbon (PC) through a convenient melamine pre-grafting strategy. The melamine derivative with a monolayer structure was first grafted on the surface of the micropores of PC using a suitable diazotization reaction of melamine in an aqueous solution. After pyrolysis , PC grafting with melamine derivative was converted to the obtained N-doped PC. Meanwhile, more nitrogen dopants were grafted, and nitrogen functionalities were reconstructed to generate more graphitic N and pyridinic N atoms, in which the mesopores volume was consequently enlarged. Because of the unique structures mentioned above, the as-obtained N-doped PC exhibited enhanced oxygen reduction activity under alkaline compared with the N-doped PC from the standard physical mixture of PC and melamine. Besides, the obtained N-doped PC showed a comparable half-wave potential, remarkable durability, and good methanol tolerance compared with the commercial 20% Pt/C electrocatalyst . The results presented here could guide the development of new and improving metal-free nitrogen-doped porous carbon catalysts toward oxygen reduction reaction.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Chen Jiadong,Chen Chunhong,Qin Minkai,Li Ben,Lin Binbin,Mao Qing,Yang Hongbin,Liu Bin,Wang Yong
Noble metal electrocatalysts (e.g., Pt, Ru, etc.) suffer from sluggish kinetics of water dissociation for the electrochemical reduction of water to molecular hydrogen in alkaline and neutral pH environments. Herein, we found that an integration of Ru nanoparticles (NPs) on oxygen-deficient WO 3-x manifested a 24.0-fold increase in hydrogen evolution reaction (HER) activity compared with commercial Ru/C electrocatalyst in neutral electrolyte. Oxygen-deficient WO 3-x is shown to possess large capacity for storing protons, which could be transferred to the Ru NPs under cathodic potential. This significantly increases the hydrogen coverage on the surface of Ru NPs in HER and thus changes the rate-determining step of HER on Ru from water dissociation to hydrogen recombination.
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