ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yuzhuo Song,Shuang Han,Shiwei Liu,Ruonan Sun,Le Zhao,Chen Yan
Improving the drug loading and delivery efficiency of biodegradable nanomaterials used for targeting prostate cancer (PCa) remains a challenging task. To accomplish this task, herein, a new surface molecularly imprinted polymer (ZIF-8/DOX-HA@MIP) was designed and constructed with a hyaluronic acid (HA)-modified zeolitic imidazolate framework-8 (ZIF-8) metal–organic framework loaded with doxorubicin (DOX) as a substrate and a responsive molecularly imprinted polymer film as a shell. Owing to the large surface area of ZIF-8, DOX was successfully loaded into the ZIF-8/DOX-HA@MIP with a high drug loading efficiency (more than 88%). In vitro cell experiments have shown that the strengthened targeting ability of ZIF-8/DOX-HA@MIP to PCa cells was realized through the synergistic effect of HA and the molecularly imprinted membrane. Under the condition of simulated tumor microenvironment solution, Zn species were released and the particle size of ZIF-8/DOX-HA@MIP decreased gradually by the synergistic effect of hyaluronidase, pH, and glutathione, showing excellent biodegradability. In vivo antitumor research indicated the excellent antitumor activity and biocompatibility of ZIF-8/DOX-HA@MIP. The multifunctional ZIF-8/DOX-HA@MIP constructed herein provides a novel impetus for the development of targeted drug delivery in PCa treatment and a new strategy for treating other tumors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 14
·5025-5045
·
IF 6.6
Qinhua Zuo,Tiantian Li,Linghong Huang,Zonghua Liu,Wei Xue
Tumor vaccine therapy, which can induce tumor antigen-specific cellular immune responses to directly kill tumor cells, is considered to be one of the most promising tumor immunotherapies. How to elicit effective tumor antigen-specific cellular immunity is the key for the development of tumor vaccines. However, current tumor vaccines with conventional antigen delivery systems mainly induce humoral immunity but not effective cellular immunity. In this study, based on pH-sensitive, ordered macro-microporous zeolitic imidazolate framework-8 (SOM-ZIF-8) and hexadecylsulfonylfluoride (HDSF), an intelligent tumor vaccine delivery system SOM-ZIF-8/HDSF was developed to elicit potent cellular immunity. Results demonstrated that the SOM-ZIF-8 particles could efficiently encapsulate antigen into the macropores, promote antigen uptake by antigen-presenting cells, facilitate lysosomal escape, and enhance antigen cross-presentation and cellular immunity. In addition, the introduction of HDSF could up-regulate the lysosomal pH to protect antigens from acid degradation, which further promoted antigen cross-presentation and cellular immunity. The immunization tests showed that the tumor vaccines based on the delivery system improved antigen-specific cellular immune response. Moreover, the tumor vaccines significantly inhibited tumor growth in B16 melanoma-bearing C57BL/6 mice. These results indicate that SOM-ZIF-8/HDSF as an intelligent vaccine delivery system could be used for the development of novel tumor vaccines.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Bohai Guo,Yun Sun,Qiuyue Guan,Zheng Luo,Lian Zhou,Zhenlan Xu,Jianzhong Han,Daofeng Qu
A smart film was developed to detect the freshness of pork by incorporating blueberry anthocyanins (BAs) and hinokitiol (HIN) loaded zeolite-imidazolium framework (HIN@ZIF-8) with into a sodium alginate matrix, and its microstructure and physicochemical properties were studied. The SA matrix was doped with BAs and HIN@ZIF-8 nanoparticles (SA-BAs/HIN@ZIF-8) to increase its tensile strength and reduce its water vapor permeability. HIN@ZIF-8 has low cytotoxicity, and SA-BAs/HIN@ZIF-8 membranes have long-lasting antimicrobial and highly sensitive color development properties against Escherichia coli and Staphylococcus aureus . The results of pork preservation experiments showed that SA-BA/HIN@ZIF-8 could extend the shelf life of pork to 6 days at 4 ℃. E-nose evaluation experiments showed that SA-BAs/HIN@ZIF-8 could inhibit compounds that cause unpleasant and irritating odours. Therefore, SA-BAs/HIN@ZIF-8 was considered to be an effective method to improve the freshness of pork, and the results showed that it has a promising application in food preservation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Hui Ouyang,Jiaxin Xian,Jiaqi Gao,Lvxia Zhang,Wenwen Wang,Zhifeng Fu
Superior to traditional nanoscale catalysts, single-atom site catalysts (SASCs) show such merits as maximal catalysis efficiency and outstanding catalytic activity for the construction of analytical methodological platforms. Hereby, an in situ etching strategy was designed to prepare yolk-shell Co SASCs derived from ZIF-8@SiO2 nanoparticles. On the basis of direct chemical interactions between precursors and supports, the Co element with isolated atomic dispersion was anchored on ZIF-8@SiO2 nanoparticles. The Co SASCs possess high Fenton-like activity and thus can catalyze the decomposition of H2O2 to produce massive superoxide radical anions instead of singlet oxygen and hydroxyl radicals. With the activity for producing superoxide radical anion, Co SASCs can greatly improve the chemiluminescent (CL) response of a luminol system by 3133.7 times. Furthermore, the SASCs with active sites of Co–O5 moieties were utilized as the CL probes for establishment of an immunoassay method for sensitive detection of mycotoxins by adopting aflatoxin B1 as a mode analyte. The quantitation range is 10–1000 pg/mL, and the limit of detection is 0.44 pg/mL (3σ) for aflatoxin B1. The proof-of-principle work elucidates the practicability of direct chemical interactions between precursors and supports for forming SASCs with ultrahigh CL response, which can be extended to the exploitation of more sorts of SASCs for tracing biological binding events.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
·
2023
·
IF 2.3
Lai Yuwen,He Jin,Li Yanchun,Zhou Shilin,Yan Wentao,Zhou Yong,Gao Congjie
Metal–organic frameworks (MOFs) are widely employed in designing nanocomposite membranes owing to their excellent performance and diversity. However, their inherent hydrophobicity limits their application in nanocomposite membranes. In order to improve the hydrophilicity of zeolitic imidazolate framework-8 (ZIF-8), tannic acid (TA) was utilized to etch-modify it, resulting in a TA-ZIF-8 nanostructure with a hydrophilic shell. TA-ZIF-8 was subsequently introduced into the aqueous phase and used to prepare a nanocomposite matrix reverse osmosis membrane through interfacial polymerization (IP). The prepared nanocomposite reverse osmosis membrane had a surface with good hydrophilicity and a pure water flux increased to 55.28 L m −2 h −1 (approximately 1.74 times). Additionally, the introduction of TA-ZIF-8 significantly enhanced the electronegativity of the membrane surface, and the nanoparticles were compatible with the polyamide layer, leading to a salt rejection rate of up to 99.5% for a NaCl solution with a concentration of 32000 ppm. These results indicate great potential for applying hydrophilically modified ZIF-8 to reverse osmosis membranes.
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2023
·
IF 8.3
Kai Wei,Yuankun Wei,You Zhang,Valeryia Kasneryk,Maria Serdechnova,Hao Wang,Zhe Zhang,Yujie Yuan,Carsten Blawert,Mikhail L. Zheludkevich,Fei Chen
A strategy based on in situ host-guest nanoconfinement was used to assist the synthesis of a ZIF-8 host loaded with a corrosion inhibitor 8-hydroxyquinoline (8-HQ) guest by a facile one-step process at room temperature. Results showed that a Zn-(bis-8-hydroxyquinoline) guest encapsulated ZIF-8 host composite (Q@ZIF-8) was formed. The Q@ZIF-8 proves to have an inhibition efficiency of over 91% to protect the aluminum alloy substrate against corrosion in the corrosive solution after 2 days. Additionally, the pH-responsive Q@ZIF-8 can release 8-HQ species in form of hydroxyquinoline zinc complex and improves the corrosion resistance of the epoxy coating.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yong Chen,Yong Liu,Xiaobo Gong,Jianlong Wang
Photocatalytic hydrogen peroxide (H 2 O 2 ) production and its application in advanced oxidation processes (AOPs) are regarded as low-cost and environmentally friendly wastewater treatment processes. Herein, by modifying a small amount of sulphide on the zeolitic imidazolate framework-8 (ZIF-8), a ZnS@ZIF-8 composite and used for photocatalytic H 2 O 2 production to degrade chlorinated organic pollutants under simulated sunlight (SSL). ZnS@ZIF-8 composite could enhance the separation of photo-induced charge carriers, promote electron transfer from zinc sulphide (ZnS) to ZIF-8, which exhibited good selectivity for the two-electron oxygen reduction reaction (2e - -ORR) and two-electron water oxidation (2e - -WOR) pathways. Based on oxygen (O 2 ) activation, the developed ZnS@ZIF-8/O 2 /SSL system could achieve 6.43 mmol/L H 2 O 2 production within 150 min, which was approximately 8.66 and 10.36 times higher than that of the ZnS/O 2 /SSL and ZIF-8/O 2 /SSL systems, respectively. In the ZnS@ZIF-8/O 2 /SSL system, the ORR, WOR and H 2 O 2 photolysis led to the generation of hydroxyl radical (•OH), while the photochemical behavior of ZnS in ZnS@ZIF-8 composite resulted in the generation of active hydrogen (*H). Benefitting from the high concentration of H 2 O 2 and the coexistence of redox species in the ZnS@ZIF-8/O 2 /SSL system, various chlorinated organic pollutants could be dechlorinated and mineralized. In addition, a possible mechanism for photocatalytic H 2 O 2 production was also proposed. Importantly, the proposed process did not involve an additional sacrificial agent or Fenton-like catalysts. This work provides insights into the potential application of ZnS@ZIF-8 composite for H 2 O 2 production and wastewater treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Jianmin He,Weixiang Xu,Hao Liu,Qiuyan Luo,Juguo Dai,Yiting Xu,Birong Zeng,Guorong Chen,Conghui Yuan,Lizong Dai
Designing new additives has been an effective way to improve the anti-corrosion performance of organic coatings . Inorganic materials, layer double hydroxide (LDH), with lamella structure which can improve the barrier property and the porous zeolite imidazole frameworks (ZIF) with corrosion inhibitor can impart the active protective ability to organic coatings. Here we synthesized a new kind of ZIF/LDH composite, named AZLT loaded with 2-amino benzothiazole by in-situ growth method and further grew TEOS film on the surface. XRD , FT-IR, BET, XPS, SEM and TEM verified the successful synthesis of AZLT. UV–Vis test was applied to study the pH-responsive release behaviour. The better mechanical performance and hydrophobicity of AZLT/EP coated on Q215 steel enrich itself with better resistance ability to corrosion media. Moreover, the AZLT/EP composite coatings show the best anti-corrosion performance in the EIS study in 28 days of immersion and the salt spray test in 14 days in comparison with pure EP.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Wenbo Wu,Xiaoli Yu,Jiaxiang Sun,Yuanyuan Han,Yuanye Ma,Guoqing Zhang,Qingming Ma,Qiang Li,Hongfei Xiang
Background As a broad-spectrum antitumorigenic agent, doxorubicin (DOX) is commonly used as a chemotherapeutic drug for treating osteosarcoma (OS). Still, it is associated with significant cell toxicity and ineffective drug delivery, whereas the zeolite imidazolate framework is extensively applied in the biomedical field as a carrier owing to its favorable biocompatibility, high porosity, and pH-responsiveness. Therefore, we need to develop a drug delivery platform that can effectively increase the antitumorigenic effect of the loaded drug and concurrently minimize drug toxicity.Methods In this study, a Fe3O4@ZIF-8 nanocomposite carrier was prepared with ZIF-8 as the shell and encapsulated with Fe3O4 by loading DOX to form DOX- Fe3O4@ZIF-8 (DFZ) drug-loaded magnetic nanoparticles. Then, we characterized and analyzed the morphology, particle size, and characteristics of Fe3O4@ZIF-8 and DFZ by TEM, SEM, and Malvern. Moreover, we examined the inhibitory effects of DFZ in vitro and in vivo. Meanwhile, we established a tumor-bearing mouse model, evaluating its tumor-targeting by external magnetic field guidance.Results DFZ nanoparticles possessed have a size of ~110 nm, with an encapsulation rate of 21% and pH responsiveness. DFZ exerted a superior cytostatic effect and apoptosis rate on K7M2 cells in vitro compared to DOX(p<0.01). In animal experiments, DFZ offers up to 67% tumor inhibition and has shown a superior ability to induce apoptosis than DOX alone in TUNEL results(p<0.01). Tumor-targeting experiments have validated that DFZ can be effectively accumulated in the tumor tissue and enhance anticancer performance.Conclusion In summary, the DFZ nano-delivery system exhibited a more substantial anti-tumorigenic effect as well as superior active tumor targeting of DOX- Fe3O4@ZIF-8 compared to that of DOX alone in terms of biocompatibility, drug loading capacity, pH-responsiveness, tumor-targeting, and anti-tumorigenic effect, indicating its chemotherapeutic application potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2021
·Vol. 16
·期 19
·2952-2957
·
IF 4.568
Fengwei Zhang,Mengmeng Liu,Qiang Liu,Jingjing Li,Boyang Li,Zhengping Dong
Graphical A facile and in-situ methanol-mediated strategy was proposed to fabricate Pd@ZIF-8 catalyst for efficient and size-selectivity alkenes hydrogenation. In-situ encapsulation of tiny and well-dispersed Pd nanoparticles (Pd NPs) in zeolitic imidazolate frameworks (ZIFs) was firstly achieved using a one-pot and facile methanol-mediated growth approach, in which methanol served as both solvent and a mild reductant. The microstructure, morphology, crystallinity, porosity as well as evolution process of the catalysts were determined by TEM, XRD, N 2 adsorption and UV-vis spectra. Due to the complete encapsulation of such Pd NPs combined with ultrahigh surface area and uniform microporous structure of ZIF-8, the resulting Pd@ZIF-8-60 min nanocomposite exhibited more superior catalytic activity for olefins hydrogenation with TOF of 7436 h −1 and excellent size selectivity than previously reported catalysts. Furthermore, the catalyst displays excellent recyclability for 1-octene hydrogenation and without any loss of the Pd active species.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2021
·Vol. 11
·期 5
·533
·
IF 4.146
Jing Chen,Yingchun Guo,Tengteng Kang,Xingchi Liu,Xiaomei Wang,Xu Zhang
It is wise to mimic a bioinspired system to design a nanoreactor as a catalyst containing multiple components for a cascade reaction. Here, we report the uniform growth of well-dispersed nano-scale ZIF-8 crystals on the pore walls of 3DOM TiO2via the TEA-assisted crystallization process. The UV-vis spectra indicate that the ZIF-8 photosensitizer can extend the visible-light absorption of 3DOM TiO2. The obtained nanoreactor can efficiently catalyze the one-pot aromatic alcohol oxidization and Knoevenagel condensation cascade reaction for larger molecules. This work offers an important strategy for preparing semiconductor–MOF multifunctional composites with a spatially separated compartmentation for the cascade reaction.Keywords:crystal growth;cascade reaction;nanoreactor;semiconductor–MOF composite
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Jingjing He,Yu Wan,Wenjun Zhou
Developing high-efficient hybrids carbon catalysts for PMS-based advanced oxidation process (AOPs) are crucial in the field of environmental remediation. In this work, novel carbon nanocubes (xFe‒N‒C) with three-dimensional porous structure and abundant well-dispersed FeN x sites were obtained via a skillful cage-encapsulated-precursor pyrolysis strategy. The as-synthesized xFe‒N‒C exhibited superb activity for phenol degradation by activating peroxymonosulfate (PMS). Besides, the catalytic system not only possessed good recycling performance, wide pH adaptation and relatively low activation energy, but also had high resistance to environmental interference. Singlet oxygen ( 1 O 2 ) dominated non-radical process was responsible for phenol degradation rather than traditional radical pathways. Impressively, the doping level of Fe could regulate FeN x contents in catalysts, and the catalytic activity of xFe‒N‒C was greatly enhanced with increasing FeN x contents. Based on density functional theory calculations (DFT), the introduction of FeN x sites regulated the electronic structure of catalysts. Such electron-deficient Fe center acted as electron acceptor to receive electrons transmitted by the adsorbed PMS , thus generating highly reactive 1 O 2 for rapid phenol oxidation. This work provides a new insight into the innovation in transition metal-nitrogen hybrid carbon catalysts and highlights the pivotal roles of FeN x sites in 1 O 2 generation during PMS activation process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）