JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 35
·46641
·
IF 1.901
Xuelin Huang,Jing Guo,Yunming Yang,Shenglin Li,Shuang Chen,Yuanfa Liu,Sen Zhang
We synthesized a series of poly(acrylonitrile- co -allyl glycidyl ether)- graft -methoxypoly(ethylene glycol) (PAA- g -MPEG) copolymers as novel polymeric solid–solid phase-change materials by grafting methoxypoly(ethylene glycol) (MPEG) to the main chain of poly(acrylonitrile- co -allyl glycidyl ether) (PAA). PAA was the skeleton, and MPEG was a functional side chain, which stored and released heat during its phase-transition process. Fourier transform infrared spectroscopy and 1 H-NMR spectroscopy analysis were performed to investigate the chemical structures. The crystalline morphology and crystal structures were also measured with polarized optical microscopy and X-ray diffraction. Moreover, the thermal-energy-storage properties, thermal stability, and thermal reliability of the PAA- g -MPEG copolymers were characterized by differential scanning calorimetry and thermogravimetric analysis (TGA) methods. These analysis results indicate that the MPEG chains were successfully grafted onto PAA, and we found that the PAA- g -MPEG copolymers had typical solid–solid phase-transition temperatures in the range 11–54 °C and high latent heat enthalpies between 44 and 85 J/g. In addition, the as-prepared PAA- g -MPEG copolymers showed reusability and thermal reliability, as shown by the thermal cycle testing and TGA curves. Therefore, the synthesized PAA- g -MPEG copolymers have considerable potential for thermal energy storage. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46641.
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Polymer Chemistry
·
2016
·Vol. 7
·期 39
·6120-6132
·
IF 5.687
Cai Wang,Yudong Zheng,Yi Sun,Jinsheng Fan,Qiujing Qin,Zhenjiang Zhao
A novel block polyurethane was designed and synthesized based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), 4,4′-diphenylmethanediisocyanate (MDI) and poly(ethylene glycol) (PEG). The obtained polyurethanes were characterized by proton nuclear magnetic resonance (1H NMR), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). Furthermore, the biodegradability of the synthesized polyurethanes was evaluated at 37 °C in phosphate buffer solution (PBS) at pH 7.4. The results showed that these PHBV-based polyurethanes were degradable in PBS, as indicated by weight loss measurements, scanning electron microscopy (SEM) and FTIR. The cytotoxicity of the novel polyurethane was evaluated using the cell counting kit-8 (CCK8) assay in vitro. Preliminary evaluation of hemocompatibility was carried out via the hemolysis test, dynamic blood coagulation time and platelet adhesion. The current work provides a promising approach to prepare nontoxic and biodegradable polyurethanes with excellent mechanical properties and good hemocompatibility. This new material may find potential application in blood vessel tissue engineering.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 12
·4705-4712
·
IF 4.58
Chen Lihua,Lv Shuli,Gao Zhigang,Chen Chuangfu
The authors describe a voltammetric immunoassay for the carcinoembryonic antigen (CEA). A GCE was modified by electrodeposition of poly(3,4-ethylenedioxythiophene) (PEDOT) doped with tannic acid (TA). Subsequently, four-armed poly(ethylene glycol) (PEG) was assembled onto the modified surface through hydrogen bonding. The fabrication steps were characterized by scanning electron microscopy, energy dispersive spectroscopy, fourier transform infrared spectroscopy, contact angle measurements, electrochemical impedance spectroscopy and differential pulse voltammetry. The PEG/TA-PEDOT surface is shown be super-hydrophilic and to possess anti-fouling capability. Antibody against CEA was then covalently immobilized on the electrode. By using hexacyanoferrate as an electrochemical probe and at a working potential of 0.18 V vs SCE, the amperometric response is linear in the 10 ag·mL −1 to 1.0 ng·mL −1 CEA concentration range, and the detection limit is as low as 4.8 ag·mL −1 (at an S/N ratio of 3). The assay was applied to the quantification of CEA in 1:10 diluted human serum samples. Recoveries ranged from 103.7 to 108.7%, and relative standard deviations from 2.9 to 4.8%.
Schematic of an electrochemical immunosensor for the carcinoembryonic antigen (CEA). It is based on the use of tannic acid (TA) and poly(ethylene glycol) (PEG), both deposited on a glassy carbon electrode (GCE), and using hexacyanoferrate as the electrochemical probe. The sensor has a wide linear range and a 4.8 ag·mL −1 detection limit.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2009
·Vol. 47
·期 24
·6962-6976
·
IF 3.821
Peng-Fei Gou,Wei-Pu Zhu,Ning Xu,Zhi-Quan Shen
Well-defined drug-conjugated amphiphilic A 2 B 2 miktoarm star copolymers [(PCL) 2 -(PEG) 2 -D] were prepared by the combination of controlled ring-opening polymerization (CROP) and “click” reaction strategy. First, bromide functionalized poly(ε-caprolactone) (PCL-Br) with double hydroxyl end groups was synthesized by the CROP of ε-caprolactone using 2,2-bis(bromomethyl)propane-1,3-diol as a difunctional initiator in the presence of Sn(Oct) 2 at 110 °C. Next, the bromide groups of PCL-Br were quantitatively converted to azide form by NaN 3 to give PCL-N 3 . Subsequently, the end hydroxyl groups of PCL-N 3 were capped with ibuprofen as a model drug at room temperature. Finally, copper(I)-catalyzed cycloaddition reaction between ibuprofen-conjugated PCL-N 3 and slightly excess alkyne-terminated poly(ethylene glycol) (A-PEG) led to ibuprofen-conjugated A 2 B 2 miktoarm star copolymer [(PCL) 2 -(PEG) 2 -D]. The excess A-PEG was removed by dialysis. 1 H NMR, FTIR and SEC analyzes confirmed the expected miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). In addition, the drug-loading capacity of these drug-conjugated miktoarm star copolymers as well as their nondrug-conjugated analogs were also investigated in detail. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2009
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JOURNAL OF MICROENCAPSULATION
·
2019
·
IF 2.04
Yingting Wang,Along Zuo,Xiaoyan Huang,Ying Ying,Xinsheng Shu,Xianxiong Chen,Yatao Yang,Junxian Ma,Guimiao Lin,Xiaomei Wang,Lin Mei,Gan Liu,Yingying Zhao
Taxane-based chemotherapy-loaded drug delivery systems have great potential for cancer treatment. The docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate)-b-d-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PBLG-b-TPGS) nanoparticles and the docetaxel (DTX)-loaded PAMAM-based poly (γ-benzyl-l-glutamate) (PAM-PBLG) nanoparticles were designed using a modified nanoprecipitation method. The particle size, encapsulation efficiency (EE), and in vitro release characteristics of the nanoparticles were tested. The effects of the two nanoparticles on the cellular uptake and cell viability on human cervical cancer cell line Hela and the human breast cancer cell line MCF-7 were compared. Furthermore, their antitumor efficiency was evaluated through in vivo tumour growth experiment in comparison with free DTX. PAM-PBLG-b-TPGS nanoparticles displayed high EE, smaller diameter, and a nice releasing profile. Besides, based on the high EE and ‘self-controlled’ drug release of the DTX-loaded PAM-PBLG-b-TPGS nanoparticles, they exhibited stronger cytotoxicity (lower survival rate) and higher uptake rate than DTX-loaded PAM-PBLG nanoparticles in Hela cells and MCF-7 cells. Furthermore, compared with DTX-loaded PAM-PBLG nanoparticles and free DTX, DTX-loaded PAM-PBLG-b-TPGS nanoparticles produced a potent anti-tumour effect. Thus, the DTX-loaded PAM-PBLG-b-TPGS nanoparticles provide a novel attractive nanocarrier for the DTX delivery of chemotherapy to human breast cancer cells and human cervical cancer cells.
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高影响因子
MACROMOLECULAR BIOSCIENCE
·
2014
·Vol. 14
·期 10
·1415-1428
·
IF 3.65
Xiaoyu Ai,Jin Sun,Lu Zhong,Chunnuan Wu,Handong Niu,Tao Xu,He Lian,Xiaopeng Han,Guolian Ren,Wenya Ding,Jia Wang,Xiaohui Pu,Zhonggui He
A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P 5k SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxorubicin (DOX)-loaded P 5k LV (P 5k LV-DOX) nanomicelles are further prepared. Then head-to-head comparison of P 5k SSLV-DOX, P 5k LV-DOX and DOX-Sol is performed concerning in vitro release, cytotoxicity, cellular uptake and apoptosis. Results show that P 5k SSLV-DOX nanomicelles have a faster DOX release, a higher anti-tumor activity and more DOX concentrating in the nucleus than P 5k LV-DOX nanomicelles. In conclusion, the redox-responsive P 5k SSLV nanomicelles might hold a great potential to improve chemotherapy by tumor-triggering intracellular rapid release. The outcomes of this study also address the significance of such head-to-head comparison studies in translational research of nanomedicine.
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Xinxin Sheng,Dexuan Dong,Xiang Lu,Li Zhang,Ying Chen
Phase change materials (PCMs) have attracted great interest from researchers and have been widely developed in the field of solar thermal energy storage. Herein, a novel bio-based pomelo peel foam (PPF)/polyethylene glycol (PEG) composite PCM was designed and prepared via the simple impregnation process, which is further modified with low loading of MXene nanosheets for the purpose of improving its light-to-thermal conversion efficiency, thermal energy storage capability and thermal conductivity . With the incorporation of MXene nanosheets into PPF, the light-to-thermal conversion efficiency was improved obviously, the loading of PEG in form-stable composites phase change materials (FCPCMs) increased from 86.9 wt% (FCPCM-1) to 96.2 wt% (FCPCM-2, FCPCM-3 and FCPCM-4), and the thermal conductivity of obtained PPF@MXene/PEG FCPCMs was also improved (from 0.25 W/mK to 0.42 W/mK). It shows that the obtained PPF@MXene/PEG FCPCMs can be fully utilized in the field of solar thermal energy storage.
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Frontiers in Chemistry
·
2022
·
IF 5.545
Parvaiz Ahmad Naik,N. Indumathi,B. Ganga,S. Charles,A. K. Abdul Hakeem,Zahoor Iqbal,ElSayed Tag-ElDin,Jian Zu
The topic of two-dimensional steady laminar MHD boundary layer flow across a wedge with non-Newtonian hybrid nanoliquid (CuO-TiO2/C2H6O2) with viscous dissipation and radiation is taken into consideration. The controlling partial differential equations have been converted to non-linear higher-order ordinary differential equations using the appropriate similarity transformations. It is demonstrated that a number of thermo-physical characteristics govern the transmuted model. The issue is then mathematically resolved. When the method’s accuracy is compared to results that have already been published, an excellent agreement is found. While the thermal distribution increases with an increase in Eckert number, radiation and porosity parameters, the velocity distribution decreases as porosity increases.
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International Journal of Nanomedicine
·
2023
·
IF 8
Jing Lin,Chaoyue Zhao,Cuijuan Liu,Shiyao Fu,Luying Han,Xinping Lu,Chunrong Yang
Introduction The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR).Materials and methods This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity. Moreover, the redox-responsive mixed micelles, F127-folate (FA)/FSST/P123 (FFSSTP), based on FSST, Pluronic F127-FA, and Pluronic P123, were prepared to load paclitaxel (PTX).Results The in vitro release study demonstrated that FFSSTP/PTX accelerated the PTX release through the breakage of disulfide bond in reductive environment. In cellular experiment, FFSSTP/PTX induced significant apoptosis in PTX-resistant MCF-7/PTX cells through inhibiting adenosine triphosphate (ATP)-binding cassette proteins from pumping out PTX by interfering with the mitochondrial function and ATP synthesis. Furthermore, FFSSTP/PTX induced apoptosis through elevating the intracellular levels of ROS.Conclusion FFSSTP could become a potential carrier for the treatment of MDR tumors.
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ELECTROPHORESIS
·
2018
·Vol. 40
·期 4
·521-529
·
IF 2.569
Feng Chang,Yunfang Yue,Zihui Yang,Si Huang,Zhihua Liu,Kunmiao Wang,Yan Peng,Yingzhuang Chen,Ming Ma,Bo Chen
The easy shrinkage and swelling of polymer monolithic column when exposed to mobile phase with different polarity is a problem that cannot be ignored. To overcome this drawback, a convenient aqueous two-phase polymerization approach was used to prepare poly (polyethylene glycol diacrylate, PEGDA) monolithic porous layer open tubular (mono-PLOT) columns (150 μm). The poly(PEGDA) mono-PLOT column with homogeneous polymer porous layer was synthesized successfully. A maximum plate number of 41,500 plates per meter for allyl thiourea was obtained under a velocity of 1.8 mm/s. Several kinds of polar molecule were separated on the proposed mono-PLOT column and a typical hydrophilic interaction retention mechanism was observed. High speed separation of benzoic acids was also carried out, baseline separation of five benzoic acids was successfully achieved within 5 min with a 70 cm mono-PLOT column at 50°C. Furthermore, the resulting PLOT column was also successfully applied to separate standard analytes of three DNA oxidative damage products and RNA-modified nucleosides and four chlorophenols. At last, the column could separate alcohols, alkanes, and aromatic isomers via GC. It had more than 20,000 plates per meter for butanol – higher than commercial coatings open tubular columns.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2014
·Vol. 41
·期 8
·5311-5321
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IF 1.54
Huang Pingzhen,Gu Aijuan,Wang Jinxing
Efficient production of 5-hydroxymethylfurfural (HMF) through the dehydration of sugars was achieved by developing a new catalyst caprolactam hydrogen sulfate ([CPL]HSO 4 ) ionic liquid or using metal halide as the co-catalyst in a new water/proprylene glycol monomethyl ether solvent system. With an optimum synthesis condition, the yield of HMF derived from fructose dehydration at 105 °C for 90 min is as high as 80.5 % in the presence of [CPL]HSO 4 . The nature behind the attractive results was revealed by proposing the catalysis mechanism of the fructose dehydration. The yield of HMF is about 70 % using [CPL]HSO 4 as the catalyst for fructose dehydration after being reused five times. The catalyst system [CPL]HSO 4 /metal halide was used for the dehydration of sucrose, and the optimum yield is as high as 64–68 %.
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International Journal of Nanomedicine
·
2016
·
IF 4.32
Fei Tong,Xiangyuan Tang,Xin Li,Wenquan Xia,Daojun Liu
The aim of this study was to observe the therapeutic effect of insulin-loaded linear poly(ethylene glycol)-brush-like poly(l-lysine) block copolymer poly(ethylene glycol)-b-(poly(ethylenediamine l-glutamate)-g-poly(l-lysine)) (PEG-b-(PELG-g-PLL) on renal ischemia/reperfusion-induced lung injury through downregulating hypoxia-inducible factor (HIF) as compared to free insulin. Sprague Dawley rats were pretreated with 30 U/kg insulin or insulin/PEG-b-(PELG-g-PLL) complex, and then subjected to 45 minutes of ischemia and 24 hours of reperfusion. The blood and lungs were collected, the level of serum creatinine and blood urea nitrogen were measured, and the dry/wet lung ratios, the activity of superoxide dismutase and myeloperoxidase, the content of methane dicarboxylic aldehyde and tumor necrosis factor-α, and the expression of HIF-1α and vascular endothelial growth factor (VEGF) were measured in pulmonary tissues. Both insulin and insulin/PEG-b-(PELG-g-PLL) preconditioning improved the recovery of renal function, reduced pulmonary oxidative stress injury, restrained inflammatory damage, and downregulated the expression of HIF-1α and VEGF as compared to ischemia/reperfusion group, while insulin/PEG-b-(PELG-g-PLL) significantly improved this effect.
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