Acta Pharmaceutica Sinica B
·
2024
·
IF 14.7
Danni Liu,Yaoqi Wang,Qi Sun,Dong Mei,Xiaoling Wang,Yan Su,Jie Zhang,Ran Huo,Yang Tian,Siyu Liu,Shuang Zhang,Chunying Cui
Ferroptosis has received great attention as an iron-dependent programmed cell death for efficient cancer therapy. However, with the accumulation of iron in tumor cells, the antioxidant system is activated by reducing glutathione (GSH) with glutathione peroxidase 4 (GPX4), which critically limits the ferroptosis therapeutic effect. Herein, an iron and GPX4 silencing siRNA (siGPX4) co-encapsulated ferritin nanocage (HFn@Fe/siGPX4) was developed to enhance ferroptosis by disruption of redox homeostasis and inhibition of antioxidant enzyme synergistically. The siGPX4 were loaded into the nanocages by pre-incubated with iron, which could significantly improve the loading efficiency of the gene drugs when compared with the reported gene drug loading strategy by ferritin nanocages. And more iron was overloaded into the ferritin through the diffusion method. When HFn@Fe/siGPX4 was taken up by human breast cancer cell MCF-7 in a TfR1-mediated pathway, the excess iron ions in the drug delivery system could for one thing induce ferroptosis by the production of reactive oxygen species (ROS), for another promote siGPX4 escaping from the lysosome to exert gene silencing effect more effectively. Both the in vitro and in vivo results demonstrated that HFn@Fe/siGPX4 could significantly inhibit tumor growth by synergistical ferroptosis. Thus, the developed HFn@Fe/siGPX4 afforded a combined ferroptosis strategy for ferroptosis-based antitumor as well as a novel and efficient gene drug delivery system.
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Food Bioscience
·
2024
·
IF 4.8
Xiaoxu Ren,Xiaofu Wang,Xinping Lin,Sufang Zhang,Chaofan Ji
Natto, a nutritious fermented soybean product, is known for its health benefits. Modern production methods use Bacillus subtilis as the starter culture to ensure consistent quality. However, this method overlooks the potential positive effects of other microbial species present in traditionally, naturally fermented natto. This study explored the effects of ARTP-induced mutants of B. subtilis var. natto and several strains of lactic acid bacteria (LAB) on natto quality. The results showed that these two types of bacteria have complementary roles in fermentation. B. subtilis var. natto , with enhanced extracellular protease activity, promotes the hydrolysis of soy protein and enhances the product's ACE inhibitory and fibrinolytic activities. Meanwhile, two strains of Lactiplantibacillus plantarum reduced the content of total volatile basic nitrogen (TVB-N) while increasing the content of folic acid in the final product. In addition, B. subtilis var. natto and LAB produce different profiles of volatile compounds (VOCs). Subsequently, B. subtilis var. natto and Lpb. plantarum were used to co-ferment natto in different ratios. The results showed that the two types of bacteria could co-colonize and enhance fermentation quality through their respective strengths. Specifically, Lpb. plantarum strains co-metabolized with B. subtilis var. natto to elevate the content of pyrazines, characteristic VOCs in natto. The optimal quality of natto was achieved when Lpb. plantarum HIS6, Lpb. plantarum LP3 and B. subtilis var. natto Y15-11 were combined in a 2:1:2 ratio. This study not only identified effective combinations of starter cultures with complementary benefits but also elucidated the metabolic pathways of key volatile compounds. Our findings also provide technical insights for improving natto quality, enhancing consumer acceptance, and supporting industrial production.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiani Xu,Tingwei Cai,Hanchang Hu,Chen Meng,Xia Dong,Qiangqiang Zhao,Jinxin He
This work primarily discusses the construction of physically cross-linked polyacrylamide copolymer containing 2-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)ethyl methacrylate (PAM-co-UPyMA, short for PAU) hydrogels with topological entanglement by designing high concentrations of acrylamide (AM) monomers and introducing “bridging” flexible non-covalent bonds. This method overcomes the poor stretchable performance of chemically cross-linked hydrogels, as well as the limited improvement in mechanical properties due to the low dissipation energy of physically cross-linked hydrogel (non-covalent bonding) under an external force. This new hydrogel exhibits low modulus (0.12 MPa), a certain fracture strength (0.2 MPa), and high toughness with an elongation at a break of 5700 %, demonstrating excellent tensile strain sensitivity with a gauge factor (GF) of 16.14, capable of detecting tiny deformations of 0.2 %. It also exhibits fast strain response, long-term stability, and performs well in applications such as human joints and voice monitoring. Furthermore, this work elucidates the relationship between the microstructure of PAU hydrogels and sensing performance, proving that the rate of microstructure change serves as an essential mechanism. The less cross-linked and highly entangled PAU hydrogel strain sensor increases the cross-linked domain size under tensile load, leading to ion channel blockade with a rapid increase in resistance during deformation, thus resulting in an improved sensitivity.
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Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 25
·9284-9292
·
IF 5.7
Chengxue Du,Dangli Gao,Xiaochun Hou,Xiangyu Zhang,Qing Pang,Sining Yun
The development of luminescent materials for optical information encryption has received great attention in recent years. However, single-mode luminescent materials greatly limit their information capacity and encryption level. Here, a broad range of gadolinium gallate-based oxide persistent material systems with tuneable persistent luminescence (PersL) are rationally designed by the construction of electron–hole defect pair structures between Bi3+ and a set of lanthanide ions (Ln3+) (Ln = Eu, Sm, Tb, Dy, Pr and Ce). These phosphors exhibited excellent quadruple-mode luminescence including photoluminescence (PL), PersL, thermoluminescence (TL) and photo-stimulated luminescence (PSL). In particular, a quadruple-mode ‘morning glory’ encrypted pattern using these multimode persistent phosphors as storage media demonstrates multilevel optical information storage accompanied with dynamical encryption. These findings described here provide a universal methodology to construct a novel class of persistent materials with tuneable PersL emission and high information storage capacity.
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Nanoscale Advances
·
2025
·
IF 4.6
Yu Ma,Lan Yang,Shangdi Wu,Liran Xu,Hua Huang
Polydopamine (PDA) is a widely utilized photothermal conversion material recognized for its ease of synthesis and environmental friendliness. However, its relatively weak light absorption capabilities lead to lower photothermal efficiency, restricting its application in solar steam generation (STG) processes. To effectively enhance light absorption, this study introduces a deep co-deposition method for the microstructural design of STG membranes. Unlike traditional surface co-deposition methods, which coat a layer of PDA on the membrane surface, the deep co-deposition method allows for the incorporation of PDA within the internal nanohydrogel structural units of the membrane. This approach significantly increases the PDA loading, resulting in a marked enhancement of light absorption capabilities. In the near-infrared region (800–2500 nm), where the light absorption of PDA is relatively weak, the absorbance improved from 70.18% (surface co-deposition) to 88.20% (deep co-deposition). While PDA has been extensively studied across various fields, its application as a structural and functional additive in hydrogels remains limited, particularly in comparison to the rapid advancements in PDA-based surface-engineered hydrogels. Thus, this study may provide valuable insights for related research areas.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Dan Li,Youbing Li,Yu Zhang,Yunsheng Xu,Xianming Zhang,Minna Hakkarainen
Production of high-performance polyesters with tailored degradability remains a challenge. Here, a series of poly(ethylene-co-isosorbide terephthalate) (PEIT) copolyesters were synthesized by varying the isosorbide (IS) content (0–20 mol %) using tetrabutyl titanate (TBT) as the catalyst. By variation of the IS content, the thermal, mechanical, and optical properties of the copolyesters were effectively tailored. As the IS content increased, the Tg was raised from 80 to 101 °C, and the tensile strength from 58.8 to 68.7 MPa. Moreover, excellent transparency was maintained (up to 90% light transmittance). Interestingly, the susceptibility to hydrolytic degradation was significantly enhanced by the incorporation of IS, with PEIT-20 showing approximately 3.5 times higher weight loss compared to PET after 50 days of alkaline degradation in 0.1 M NaOH solution. This outlines an attractive approach for developing high-performance copolyesters with tunable properties and degradation rates, suitable for applications in transparent thermal packaging materials.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yanan Hu,Ziyang Tao,Jiawei Yang,Qiang Zhao,Jinping Li,Guang Liu
Improving the kinetics of oxygen evolution is crucial for enhancing the performance of photoelectrochemical (PEC) water splitting. Herein, this study utilizes a chemical self-growth method to grow NiFe tannic acid complex (NFTA) and Co(OH) 2 on the surface of BiVO 4 photoanode (BiVO 4 /NFTA/Co). As a result, the synergistic effects of NFTA and Co(OH) 2 layers promote the efficiency and stability of BiVO 4 photoanode towards PEC water oxidation . The photocurrent density of the obtained BiVO 4 /NFTA/Co photoanode reaches 4.97 mA cm −2 , which is significantly greater than those of BiVO 4 /NFTA (4.36 mA cm −2 ), BiVO 4 /Co (2.51 mA cm −2 ), BiVO 4 (1.34 mA cm −2 ), respectively. Detailed analysis confirms that NFTA could provide an efficient way to hasten the transfer of photo-generated holes on the photoanode surface and diminish the surface charge transfer resistance . In other hand, Co(OH) 2 could be served as a cocatalyst to accelerate charge transfer for efficient oxygen evolution reaction as well as a protective layer to maintain the long-term stability of NFTA on the surface of BiVO 4 during water oxidation. Such double oxygen evolution co-catalysts decoration strategy paves an effective pathway to enhance the PEC water oxidation performance of BiVO 4 photoanode.
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INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Yongzhi Xiong,Wei Zhao,Changzhou Chen,Mengyuan Qiu,Yingrui Dong,Yajun Liu,Jianchun Jiang,Mengmeng Fan,Kui Wang
In this study, a novel Co-modified MoS 2 loaded spherical biochar (Co-MoS 2 @BC) derived from renewable biomass was synthesized as an efficient anodic HMFOR electrocatalyst. In the HMFOR process, the Co-MoS 2 @BC required a potential of only 1.426 V for the current density of 100 mA/cm 2 , significantly outperforming that of the MoS 2 loaded on spherical biochar (MoS 2 @BC) and the Co nanoparticles loaded on spherical biochar (Co@BC). Furthermore, the HMF conversion ratio reached 99.6 %, FDCA selectivity was 99.7 %, and Faradaic efficiency was 99.3 %. The Mechanistic studies reveal that the modified-Co on the MoS 2 modulated the electronic structure of Co-MoS 2 @BC, which not only enhanced the interaction between Co-MoS 2 @BC and the electrolyte, thereby facilitating the evolution of the catalysts toward highly active species, but also improved the adsorption of HMF and the H + transfer e - coupling step during the HMFOR process.
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MOLECULES
·
2024
·Vol. 29
·期 15
·3633
·
IF 4.2
Shihao You,Jing Di,Tao Zhang,Yufeng Chen,Ruiqin Yang,Yesong Gao,Yin Li,Xikun Gai
To explore advanced oxidation catalysts, peroxymonosulfate (PMS) activation by Co-Ni-Mo/carbon nanotube (CNT) composite catalysts was investigated. A compound of NiCo2S4, MoS2, and CNTs was successfully prepared using a simple one-pot hydrothermal method. The results revealed that the activation of PMS by Co-Ni-Mo/CNT yielded an exceptional Rhodamine B decolorization efficiency of 99% within 20 min for the Rhodamine B solution. The degradation rate of Co-Ni-Mo/CNT was 4.5 times higher than that of Ni-Mo/CNT or Co-Mo/CNT, and 1.9 times as much than that of Co-Ni/CNT. Additionally, radical quenching experiments revealed that the principal active groups were1O2, surface-bound SO4•−, and •OH radicals. Furthermore, the catalyst exhibited low metal ion leaching and favorable stability. Mechanism studies revealed that Mo4+on the surface of MoS2participated in the oxidation of PMS and the transformation of Co3+/Co2+and Ni3+/Ni2+. The synergism between MoS2and NiCo2S4reduces the charge transfer resistance between the catalyst and solution interface, thus accelerating the reaction rate. Interconnected structures composed of metal sulfides and CNTs can also enhance the electron transfer process and afford sufficient active reaction sites. Our work provides a further understanding of the design of multi-metal sulfides for wastewater treatment.
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Advanced Science
·
2024
·
IF 14.3
Jieran Yao,Zhenhong Luo,Jiaying Lin,Na Meng,Jiangna Guo,Hui Xu,Rongwei Shi,Linhui Zhao,Jiateng Zhou,Feng Yan,Bin Wang,Hailei Mao
The escalating spread of drug-resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug-resistance and transmission of pathogenic microbes. Here, imidazolium-type poly(ionic liquid)/porphyrin (PIL-P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL-P-Ce) are developed. The obtained PIL-P-Ce membrane exhibits high and stable efficiency in eradicating various microorganisms (bacteria, fungi, and viruses) and decomposing microbial antibiotic resistance genes and viral nucleic acids under light. The nuclease-mimetic and photocatalytic mechanisms of the PIL-P-Ce are elucidated. Co-infection wound models in mice with methicillin-resistant S. aureus and hepatitis B virus demonstrate that PIL-P-Ce integrate the triple effects of cationic polymer, photocatalysis, and nuclease-mimetic activities. As revealed by proteomic analysis, PIL-P-Ce shows minimal phototoxicity to normal tissues. Hence, PIL-P-Ce has potential as a “green” wound dressing to curb the spread of drug-resistant bacteria and viruses in clinical settings.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Huagen Liang,Anhu Wang,Ruolin Cheng,Fu Chen,Palanisamy Kannan,Costas Molochas,Panagiotis Tsiakaras
The emerging photocatalytic production of hydrogen peroxide (H 2 O 2 ) using graphitic carbon nitride (g-C 3 N 4 ) has attracted a lot of attention for its potential applications in various fields. However, However, the catalytic activity of pure g-C 3 N 4 is still limited. Herein, Bi, K co-doped g-C 3 N 4 (Bi x K y -CN) was prepared by co-thermal polymerization of a mixture of potassium nitrate, bismuth nitrate, melamine, and urea. The obtained Bi 3.6 K 3 -CN composite possesses more negative conduction and valence band positions that can, to some extent, enhance photocatalytic performance by lowering the energy barrier of redox reactions and by enhancing electron absorption capacity. Additionally, the pyrolysis process of the potassium nitrate and bismuth nitrate has a considerable impact on the formation of the morphology of g-C 3 N 4 , generating a porous lamellar-structure with nitrogen defects, resulting in increased oxygen adsorption and utilization capacity. These synergistic effects enable Bi 3.6 K 3 -CN to exhibit excellent photocatalytic activity and cycling stability for H 2 O 2 production. After 3 hours of visible light irradiation, the production of H 2 O 2 catalyzed by Bi 3.6 K 3 -CN can reach 1207.72 μmol L -1 , which is 57 times higher than that of pure g-C 3 N 4 .
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ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Lei Wang,Yang Ruan,Zenghui Diao,Diyun Chen,Lingjun Kong
Supported Co-based catalysts have shown attractive prospects for peroxymonosulfate (PMS) activation. In this work, Co-doped hydroxyapatite (H-Co/HAP) composites were prepared by a simple hydrothermal method. The Co content in H-Co/HAP could reach 71.2 mg/g, while the Co leaching rate remained relatively low. By right of the excellent catalytic performance, the as-prepared H-Co/HAP could achieve 99.02% degradation of Rhodamine B (RhB) within 10 min in the presence of 0.5 mM PMS and a first-order kinetic rate constant of 0.876 min −1 . Even after 8 cycles, the RhB degradation efficiency remained at 81.96%. In addition, the effects of vital reaction parameters, including catalyst dosage, PMS dosage, initial pH, humic acid, and coexisting anions, on the catalytic performance in the H-Co/HAP10/PMS system were systematically investigated and discussed. The degradation mechanism of a non-radical ( 1 O 2 ) as the dominant active specie and a radical (•O 2 − and SO 4 •− ) as the minor active specie was identified through quenching experiments and electron paramagnetic resonance testing. Moreover, possible degradation pathways of RhB were proposed in the H-Co/HAP10/PMS system. Overall, this study offers a meaningful strategy for designing high-content Co-based catalysts to degrade dye molecules in wastewater.
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